1) Personalized medicine aims to provide customized medical care tailored to individual patients based on their genes, proteins, and environment. This involves optimizing drug therapy based on a patient's predicted response and risk factors.
2) Customized drug delivery systems and 3D printing allow for personalized dosages forms and treatments. Telepharmacy uses technology to provide pharmacy services to remote areas.
3) Pharmacogenomics studies how a patient's genes affect their response to drugs to optimize treatment. It can help identify non-responders, avoid adverse events, and determine the proper drug dosage. Pharmacogenetic testing provides this genetic information.
hi.friends this is my first slide presentation which contain the information about the PERSONALIZED MEDICINES.this is the future medicinal treatment so,I hope you people like my presentation.
‘Targeted drug delivery system is a special form of drug delivery system where the medicament is selectively targeted or delivered only to its site of action or absorption and not to the non-target organs or tissues or cells.’
hi.friends this is my first slide presentation which contain the information about the PERSONALIZED MEDICINES.this is the future medicinal treatment so,I hope you people like my presentation.
‘Targeted drug delivery system is a special form of drug delivery system where the medicament is selectively targeted or delivered only to its site of action or absorption and not to the non-target organs or tissues or cells.’
Personalized medicine also known as individualized medicine, it is the ability to offer right drug to the right patient, at right time, with right dosage form
A vaccine is a biological preparation that improves immunity to a particular disease. A vaccine typically contains an agent that resembles a disease causing microorganism and is often made from weakened or killed forms of the microbe, its toxins or one of its surface proteins. The agent stimulates the body's immune system to recognize foreign agents, destroy it, and keep a record of it, so that the immune system can more easily recognize and destroy any of these microorganisms that it later encounters.
This will provide you the introduction about the tumor, its Anatomy & Physiology,How they are monitored?, Classification and grades of tumor, Tumor Targeting Techniques, strategies and Principles. Also provide you some examples of Marketed products.
Myself Omkar Tipugade , PG Student of Department of Pharmaceutics. today I will discus on the topic Gene Therapy . In that we discus about the method for gene therapy & its application for disease treatment.
Precision medicine is an emerging strategy that considers individual variability in genes, environment, and lifestyle to diagnose, treat, forecast, and prevent disease. As regulatory health authorities begin to develop clearer regulatory pathways in precision medicine, industries must prepare to swiftly adopt to any regulatory changes. This white paper aims to provide a broad overview on the following key topics in precision medicine:
1. Genomics and Pharmacogenetics
2. Precision Medicine vs Personalized Medicine
3. Foundation of Precision Medicine as A Treatment Tool
4. Examples of Precision Medicine as A Treatment, Predictive, and Preventative Tool
5. Precision Medicine and Cancer
6. Challenges, Next Step & Opportunities in Precision Medicine
7. Regulatory insight on Precision medicine
Personalized medicine also known as individualized medicine, it is the ability to offer right drug to the right patient, at right time, with right dosage form
A vaccine is a biological preparation that improves immunity to a particular disease. A vaccine typically contains an agent that resembles a disease causing microorganism and is often made from weakened or killed forms of the microbe, its toxins or one of its surface proteins. The agent stimulates the body's immune system to recognize foreign agents, destroy it, and keep a record of it, so that the immune system can more easily recognize and destroy any of these microorganisms that it later encounters.
This will provide you the introduction about the tumor, its Anatomy & Physiology,How they are monitored?, Classification and grades of tumor, Tumor Targeting Techniques, strategies and Principles. Also provide you some examples of Marketed products.
Myself Omkar Tipugade , PG Student of Department of Pharmaceutics. today I will discus on the topic Gene Therapy . In that we discus about the method for gene therapy & its application for disease treatment.
Precision medicine is an emerging strategy that considers individual variability in genes, environment, and lifestyle to diagnose, treat, forecast, and prevent disease. As regulatory health authorities begin to develop clearer regulatory pathways in precision medicine, industries must prepare to swiftly adopt to any regulatory changes. This white paper aims to provide a broad overview on the following key topics in precision medicine:
1. Genomics and Pharmacogenetics
2. Precision Medicine vs Personalized Medicine
3. Foundation of Precision Medicine as A Treatment Tool
4. Examples of Precision Medicine as A Treatment, Predictive, and Preventative Tool
5. Precision Medicine and Cancer
6. Challenges, Next Step & Opportunities in Precision Medicine
7. Regulatory insight on Precision medicine
Personalised medicines -pharmacogentics and pharmacogenomicsAlakesh Bharali
This seminar basically introduces and explains the learner about what is personalised medicines, what is the need for it, how personalised medicines work. For this, the concept of pharmacogenetics and pharmacogenomics are considered. After going through the presentation, the learner will be able to understand about the concept of pharmacogentics and pharmacogenomics. Certain examples of personalised medicines are included in this seminar.Although personalised medicines are specific and helpful, ins spite of having lots of advantages , it also have some disadvantages which are also specified in this seminar.Although , we speak about personalised medicines, we never saw personalised medicines in our local market. So here is an approach given that , when will we see personalised medicines at the local pharmacy. Again, certain marketed products are also listed in the seminar.Also, the future of personalised medicines is depeicted in the seminar. How medicines will be in a an around 2050 is shown in the seminar. After going through the seminar, the learner would be able to understand about personalised medicines and all its aspects in detail.
Personalized Medicines - Enhancers of Life's Quality and Their Future SindhBiotech
This lecture is presented by our volunteer Bushra Umer, she is from Karachi, Pakistan, and she is covering "Personalized Medicines - Enhancers of Life's Quality and Their Future ".
For video: https://www.youtube.com/watch?v=BSrgJaBYuxg
Pharmacogenomics is new science about how the systematic identification of all the human genes, their products, interindividual variation, intraindividual variation in expression and function over time affects drug response/metabolism, etc.
Improve drug safety and reduce ADRs. The presentation explained the advantages of pharmacogenomics. Explained Goals of Pharmacogen(etics)omics.
Personalised Medicine is a young but rapidly advancing field.
The term 'Personalised Medicine' is described as providing "the right patient with the right drug at the right dose at the right time".
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
1. Presented By : Facilitated To:
Sachin.J.Gaddimath Dr. Anita Desai
M.Pharm 1st year HOD and Professor
Dept. of Pharmaceutics Dept. of Pharmaceutics
HSKCOP, BAGALKOT. HSKCOP, BAGALKOT
1
2. CONTENTS
Personalized medicine.
1) Dosage forms for personalized medicine.
2) Categories of patients for personalized medicine.
Customized drug delivery systems.
3D printing of pharmaceuticals.
Telepharmacy.
Bioelectric Medicines
2
3. DOSAGE FORMS FOR PERSONALIZED MEDICINE:
INTRODUCTION:
Personalized medicine also referred as precision
medicine holds great promise to improve health care.
According to the “National Cancer Institute”
personalized medicine integrates information about
person’s genes, proteins, diagnosis and treat disease.
It is the form of medicine that uses information from
patient‘s genotype to; Initiate a preventative measure
against the development of disease or condition.
Select the most appropriate therapy for a disease or
condition that is suited to that patient.
3
4. Definition:
Personalized medicine is defined as of medical treatment
to the individual characteristics of each patient that not
only improves our ability to diagnose and treat disease, but
offers the potential to detect disease at an earlier stage and
to treat it effectively.
Understanding human
genome
Simpler methods identify
genetic information
Genetic information
specific to individual
Preselect effective drug
No
toxicity
Less trial &
error
4
5. Associated Definitions:
1. Genomics- Study of the entire set of genetic instructions
found in a cell (DNA)
2. Pharmacogenomics (PGx)– It is a branch of
pharmacology concerned with using DNA and amino acid
and sequence data to inform drug development and
testing.
Application of genomics to study human variability in drug
response.
3. Pharmacogenetics (PGt)– The study or clinical testing of
genetic variation that assists in individual patient’s
differentiation response to drugs.
Effect of genetic variation on drug response.
PGx and PGt are expected to play important role in
development of better medicines with improved
benefits/risk ratio for individuals.
5
6. Pharmacogenomics:
The study of how genes affect a person’s response to
drugs.
PHARMACOLOGY
(Science of Drugs)
GENOMICS
(Study of genes and
their functions)
PHARMACOGENOMICS
6
7. Pharmacogenomics:
Pharmacogenomics can play an important role in
identifying responders and non-responders to
medications, avoiding adverse events, and optimizing drug
dose.
Pharmacogenomics is the field of study & examines impact
of genetic variation & drug responses via biomarkers.
Personalized Medicine utilizes the biomarkers, which are
simply genes and proteins that can be measured to
diagnose diseases.
Pharmacogenomics shows how genes determine individual
variability to drug response.
Pharmacists would easily predict how a patient may
respond to drug, with the help of a genetic test before
prescribing a drug.
7
8. Pharmacogenomics Goals are:
1. Optimizing proper drug therapy, dosage for patients –
increasing efficacy & safety.
2. Other benefits are by monitoring biomarkers -
reduces time, cost & failure rates in clinical trials in
developing new medications and increases
opportunities to develop novel therapeutics.
Example: Genotyping variants of Cytochrome P450
involved in metabolism of warfarin.
8
10. Drug Response: Environmental factors and genetic
factors.
• Pharmacogenetic disorders (ex: plasma cholinesterase
deficiency, drug acetylation deficiency)
• Pharmacogenomic tests: ex: (Tests for variations in
(HLA) genes)
• Genes influencing drug metabolism.
• Drug targets such as the epidermal growth factor
receptor HER2, tyrosine kinase inhibitors and the
main target for warfarin is vitamin K epoxide reductase
(VKOR).
10
12. Advantages of Pharmacogenomics:
To predict a patient’s response to drugs.
To develop “customized” prescriptions.
To minimize or eliminate adverse events.
To improve efficacy and patient compliance.
To improve rational drug development.
Pharmacogenetic test need only be conducted once
during the life time.
To improve the accuracy of determining appropriate
dosage of drugs to screen and monitor certain
diseases.
To develop more powerful, safer vaccines.
To allow improvements in drug discovery and
development.
12
13. PHARMACOGENETICS IN CLINICAL PRACTICE:
• The development has been slowed by various scientific,
commercial, political and educational barriers.
3 major types of evidence that should accumulate in
order to implicate a polymorphism in clinical care.
1) Screens of tissues from multiple humans linking the
polymorphism to a trait;
2) Complementary preclinical functional studies
indicating that the polymorphism is linked with the
phenotype;
3) Multiple supportive clinical phenotype/genotype
studies
13
14. CATEGORIES OF PATIENTS FOR PERSONALISED
MEDICINE:
Patients are mainly classified depending upon the
genetic polymorphism:
Cytochrome p450 genetic polymorphism.
Different families of enzymes polymorphism.
14
15. Focusing on genomics, we have identified three
categories:
1) Optimizing drug response: gene-drug
interactions:
A person's genetic constitution can be determined in
order to address gene-drug interactions. The aim is to
optimize drug efficacy and to minimize adverse events
from drug treatment.
Applications include genetics-based and genomics-
based tests that commonly target medicines that are
administered to populations with a specific gene
variant.
In gene-drug interactions, the focus is directed to
either metabolism genes or genes related to the
immune system.
15
16. 2) Gene-based drug targeting:
Another area of individualization is the development
of molecular mechanism specific treatment, also
called gene-based drug targeting.
Most research efforts are seen in the field of oncology
(somatic variations) and increasing attention is being
paid to genetically based diseases, such as Cystic
Fibrosis.
Apart from this, many research efforts are undertaken
in disease areas in which there is a significant genetic
association with the disease, as in the case with the
VKORC1 gene in thrombosis patients.
16
17. 3) Prediction and diagnosis:
Lastly, individualization efforts are undertaken to
1. Diagnose more accurately (detailed disease
characterization or diagnosis of hereditary diseases
that are not well-understood yet)
2. Predict risk of disease
3. These efforts provide greater insight into a patient’s
constitution, contributing to a better diagnosis.
17
18. Asthma:
Inhaled β2-adrenergic (e.g.Salbutamol) and
corticosteroids (e.g., Beclomethasone) is the
cornerstone of asthma treatment.
One of the characteristics of asthma is resistance or
reduced responsiveness to treatment.
Until now, pharmacogenetic studies have mainly
concerned the β2-adrenegic receptor gene. Additional
research is needed in order to evaluate the clinical
utility of genomic testing.
18
19. Diabetes:
Diabetes also concerns a large patient group. While
diabetes is divided into two clinical categories (type I
and type II), there are at least 27 single gene mutation
subtypes of diabetes that have been identified.
The genetic make-up determines the clinical
categorization which has been shown for several genes
that cause of the syndrome designated as maturity-
onset diabetes of the young (MODY).
MODY patients with specific mutations often have
high sensitivity to sulfonylurea’s (e.g. Glipizide).
Treatment of these patients could be improved by
changing the insulin regimen into a sulfonylurea’s
therapy.
19
20. CUSTOMIZED DRUG DELIVERY SYSTEMS:
INTRODUCTION
Customized drug delivery, also termed personalized
medicine, is a medical procedure that separates
patients into different groups—with medical
decisions, practices, interventions and/or products to
the individual patient based on their predicted
response or risk of disease. The terms personalized
medicine contains P4 medicines.
The Person:
Their DNA
Exposure to environmental factors
Types and amount of stress they experiences
What they eat
20
21. BENEFITS:
Better matching patients to drugs instead of “trial and
error”.
Customized pharmaceuticals may eliminate life-
threatening adverse reactions.
Reduce costs of clinical trials by
Quickly identifying total failures.
Favorable responses for particular backgrounds.
Improved efficacy of drugs.
21
22. DNA POLYMORPHISMS:
It is the natural variations in our genes that plays a role in
risk of getting or not getting certain diseases.
The combination of these variations across several genes
affects each individual’s risk.
SNPs – a major source of variation
Single Nucleotide Polymorphisms (SNPs)
Single base change in DNA
AAGCCTA
AAGCTTA
SNPs arise as a consequence of mistakes during normal
DNA replication
Average frequency 1/1000bp
Other sources of variation are
Insertions, deletions, translocation, duplications
22
24. 3D printing in pharmaceuticals
Introduction:
3D printing is layer by layer production of 3D objects
from digital design.
It include wide variety of manufacturing technologies
which are all based on digitally controlled depositing
of materials to create free-form geometries.
this methods extensively used in field of
biomanufacturing (specially for bone and tissue
engineering ).
It became a standard tool in automotive, aerospace
and consumer goods industries.
More recently 3D printing has gained traction in
pharmaceutical manufacturing illustrated by FDA
approval of 3D printed drug product in August 2015.
It can be used for customized drug delivery system 24
25. Advantages and Applications of 3DP in
Pharmaceutical Drug Delivery:
(a) High production rates due to its fast operating
systems.
(b) Ability to achieve high drug-loading with much
desired precision & accuracy especially for potent
drugs that are applied in small doses.
(c) Reduction of material wastage which can save the
cost of production.
(d)An ability to broad types of pharmaceutical active
ingredients including poorly water-soluble, peptides
and proteins, as well as drug with narrow therapeutic
windows.
25
26. Current 3D printing technologies in
pharmaceutical drug delivery:
1. Inkjet printing
2. Zip dose
3. Thermal inkjet printing
4. Fused deposition modeling
26
27. 1) Inkjet printing:
Powder is used as substrate for spreading ink which
solidifies into solid dosage form.
27
28. 2) Zip dose:
Provide a personalized dose in addition to delivery of
high drug loaded with high disintegration and
dissolution levels by manufacturing highly porous
material.
28
31. Examples of pharmaceutical formulation that
were developed using 3D technology:
3Dprinting Technology Dosage form Active pharmaceutical
ingredients
Inkjet 3DP Nanosuspension Folic acid
Inkjet 3DP Implant Levofloxacin
Thermal injecting printer Solution Salbutamol sulphate
3DP extrusion based printing Encapsulated within polymer
(PLGA) (PVA)
Dexamethasone -21-phosphate
disodium salt
Fused depositing model Tablet 5-aminosalysilic acid (5-ASA
mesalazine) and 4-
amionosalysilic acid
Desktop 3D printer Tablet Guaifenesin
Laboratory scale 3D printing
machine
Capsule Pseudoephedrine hydrochloride
31
33. Telepharmacy:
Audio and video
Still image capture
Store and forward
PURPOSE AND SCOPE
In order to maintain or make pharmacy services
available in areas that have lost their pharmacy or are
in failure of losing their pharmacy, rules are necessary
to permit telepharmacies.
33
34. OPERATIONS
-The remote site is considered to be under the personal
charge of the pharmacist at the central pharmacy.
-A remote site shall be connected to its central pharmacy
via computer link, video link & audio link.
-A remote site should use its central pharmacy’s
processing unit.
-A pharmacist at the central pharmacy must approve
each prescription before it leaves the remote site.
34
35. Counseling must be done by a pharmacist via video
and audio link. The pharmacist must counsel the
patient or the patient’s agent on all new prescriptions
and refills.
A pharmacist must complete monthly inspections of
the remote site. Inspection reports must be included
in the policies and procedures for the site. The
inspection reports must be maintained until the next
Board of Pharmacy Inspection.
35
37. There are 4 types of telepharmacies:
1. Inpatient (remote order-entry review)
2. Remote dispensing (retail/outpatient/discharge)
3.IV admixtures
4.Remote counseling
37
38. 1) Inpatient (remote order-entry review)
Definition
Inpatient Telepharmacy refers to a pharmacist at a
remote location performing remote order-entry
services for an inpatient pharmacy at a hospital. The
remote pharmacist reviews medication orders before
the hospital staff administers the drugs to the patient.
Uses
Hospitals and health systems benefit from inpatient
Telepharmacy as it allows for real-time medication
order review and verification. With inpatient
Telepharmacy, remote pharmacists are able to provide
24/7 coverage hours to help supplement and
strengthen the inpatient pharmacy.
38
39. 2) Remote dispensing (retail/outpatient/discharge)
Definition
A remote-dispensing site, or retail community
Telepharmacy, is a licensed brick-and-mortar
pharmacy staffed by a certified pharmacy technician.
A pharmacist supervises the technician, reviews
prescriptions and performs his or her duties from a
remote location via technology.
Uses
It is used in retail community pharmacy and
outpatient/ discharge pharmacy settings,
Telepharmacy gives patients convenient access to a
pharmacist and prescription medication.
Telepharmacy works to reduce readmission rates by
improving patient adherence, helps improve financial
performance and creates a better patient experience.
39
40. 3) IV admixture
Definition
The Joint Commission on Accreditation of Healthcare
Organizations (JCAHO) defines IV admixture as, ‘the
preparation of pharmaceutical product which requires the
measured addition of a medication to a 50ml or greater bag
or bottle of intravenous fluid. ‘In layman’s terms, IV
admixture is the mixture of IV solution administered to
patients in a hospital setting.
Uses
Hospital pharmacies can save time and money by
implementing Telepharmacy in the IV-admixture clean
room. they save the time needed to suit up and enter the
clean room to review the solution. Freeing up pharmacists
time allows them to focus on clinical activities.
40
41. 4) Remote counseling
Definition
Remote- patient counseling equates to pharmacists
providing patient counseling and interactive video
session, or by some means through
telecommunications.
Uses
Remote-patient counseling allows pharmacists to
consult and provide a variety of pharmacy-care
services to patients via secure, live video calls. Beyond
being beneficial to retail independents, community,
clinic and hospital-based pharmacies, remote
counseling also provides opportunities for specialty
counseling, discharge counseling and various clinical
interactions with pharmacists.
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43. Disadvantages:
Complexity and function variation
Requires additional staff training and technical help
Downtime system failure and inflexibility
Cost and space issues
Automated medication dispensing devices:
Small system
-Pyxis medstation
-Baxter ATC 212 dispensing system.
-SCRIPT-PRO 200
Larger system
-Baker cells
-Baxter international
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44. Bioelectric Medicines:
Bioelectric medicine is an instrument, apparatus,
implement, machine, implant , invitro reagent or
other similar or related article, including a component
part
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46. BIOSENSORS:
It is a sensor that integrates a biological element with a
physiochemical transducer to produce an electronic
signal proportional to a single analyte which is then
conveyed to a detector.
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51. Working principle:
Analyte diffuses from the solution to the surface of the
Biosensor.
Analyte reacts specifically & efficiently with the
Biological Component of the Biosensor.
This reaction changes the physicochemical properties
of the Transducer surface.
This leads to a change in the optical/electronic
properties of the Transducer Surface.
The change in the optical/electronic properties is
measured/ converted into electrical signal, which is
detected.
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52. Advantages:
Highly Specific.
Independent of Factors like stirring, pH, etc.
Linear response, Tiny & Biocompatible.
Easy to Use, Durable.
Rapid, Accurate, Stable & Sterilizable.
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53. Types:
Based on bioreceptors:
1) Enzyme biosensors
2) Microbial biosensors
3) Affinity biosensors
Based on transduser:
1) Potentiometric
2) Amperometric
3) Conductometric
4) Optical
5) Piezoelectric
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54. Applications of Biosensors
Food Analysis.
Study of Biomolecules & their Interaction.
Drug Development.
Crime Detection.
Medical Diagnosis (Clin & Lab).
Environmental Field Monitoring.
Quality Control.
Industrial Process Control.
Detection Systems for Biological Warfare Agents.
Manufacture of Pharmaceuticals & Replacement
organs.
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55. REFERENCES
U.S food and administration. Paving the way for
personalized medicine.
Kevin J Tracey ‘Molecular Mechanism of Bioelectrical
Medicine.
3D printing technology in pharmaceutical drug
delivery
Three dimensional printing in pharmaceutics
Personalized medicine-NCBI-NIH
Science Direct; THE Faces of personalized medicine
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