The document discusses key concepts regarding peri-implantitis and peri-implant mucositis. Some of the main points made include:
1) Peri-implantitis is not the same as periodontitis and should be considered a distinct disease process with its own diagnostic criteria and treatment approaches.
2) Peri-implant mucositis is also distinct from gingivitis and may require longer than 3 weeks for resolution of inflammation.
3) Some amount of marginal bone loss within the first year of implant placement should be considered normal remodeling rather than a disease process.
4) Periodontal indices alone cannot adequately assess peri-implant health and disease status due to differences in
This document discusses implant maintenance, including plaque biofilm and its role in peri-implant diseases like mucositis and periimplantitis. It describes the implant maintenance appointment procedure and criteria for assessing implant health, such as probing depth and bleeding. Factors that can contribute to crestal bone loss and early or late implant failures are also outlined. The importance of establishing a baseline, evaluating occlusion, and taking annual radiographs is emphasized for monitoring implant health over time.
1. Controversies exist in many areas of periodontology including disease diagnosis and classification, microbial aspects, pathogenesis, and various treatment modalities such as periodontal, implant, and mucogingival therapies.
2. Dogmas that were previously held as undisputed truths are now being challenged by new evidence, with debates around issues like the definition of biologic width, need for splinting, and thresholds for peri-implant disease diagnosis.
3. Mapping techniques can help explore controversies through non-controversial elements, literature analysis, review of opinions, networks of relationships, and chronologies to better understand disagreements.
The document discusses several key considerations for implant site development and primary stability. It addresses the impact of periodontitis, the importance of eliminating inflammation prior to placement, and how implant design and positioning can affect stability. Factors like bone quality and quantity, biotype, gap dimensions, and plate preservation are evaluated. A variety of techniques for managing defects including grafts, barriers, and flap management are presented. Maintaining adequate bone for implant placement and achieving primary stability are emphasized.
When not to use regenerative materials in periodonticsR Viswa Chandra
“When not to use regenerative materials”- Guest lecture as a part of Dr NTRUHS Zonal CDE programme at Sri Sai College of Dental Surgery, Vikarabad, India on 26/5/2016.
“Sinus lifts- Alternative techniques and Strategies” and “When not to use regenerative materials”- Guest lecture as a part of Dr NTRUHS Zonal CDE programme in G Pulla Reddy Dental College and Hospital, Kurnool, India on 07/10/2016.
This document provides an overview of periimplantitis, including its definition, classification systems, epidemiology, etiology, pathogenesis, diagnosis, and treatment. Periimplantitis is defined as an inflammatory process involving both soft and hard tissues around a dental implant, resulting in loss of supporting bone. It is distinguished from peri-implant mucositis, which only involves inflammation of soft tissues. The document discusses various classification systems for periimplantitis and reviews potential etiologic factors such as plaque, biomechanical overload, genetic factors, and iatrogenic causes. Diagnosis involves clinical parameters like bleeding, probing depth, and radiographic bone loss. Treatment aims to eliminate infection and may include nonsurgical and surgical
This document discusses implant maintenance, including plaque biofilm and its role in peri-implant diseases like mucositis and periimplantitis. It describes the implant maintenance appointment procedure and criteria for assessing implant health, such as probing depth and bleeding. Factors that can contribute to crestal bone loss and early or late implant failures are also outlined. The importance of establishing a baseline, evaluating occlusion, and taking annual radiographs is emphasized for monitoring implant health over time.
1. Controversies exist in many areas of periodontology including disease diagnosis and classification, microbial aspects, pathogenesis, and various treatment modalities such as periodontal, implant, and mucogingival therapies.
2. Dogmas that were previously held as undisputed truths are now being challenged by new evidence, with debates around issues like the definition of biologic width, need for splinting, and thresholds for peri-implant disease diagnosis.
3. Mapping techniques can help explore controversies through non-controversial elements, literature analysis, review of opinions, networks of relationships, and chronologies to better understand disagreements.
The document discusses several key considerations for implant site development and primary stability. It addresses the impact of periodontitis, the importance of eliminating inflammation prior to placement, and how implant design and positioning can affect stability. Factors like bone quality and quantity, biotype, gap dimensions, and plate preservation are evaluated. A variety of techniques for managing defects including grafts, barriers, and flap management are presented. Maintaining adequate bone for implant placement and achieving primary stability are emphasized.
When not to use regenerative materials in periodonticsR Viswa Chandra
“When not to use regenerative materials”- Guest lecture as a part of Dr NTRUHS Zonal CDE programme at Sri Sai College of Dental Surgery, Vikarabad, India on 26/5/2016.
“Sinus lifts- Alternative techniques and Strategies” and “When not to use regenerative materials”- Guest lecture as a part of Dr NTRUHS Zonal CDE programme in G Pulla Reddy Dental College and Hospital, Kurnool, India on 07/10/2016.
This document provides an overview of periimplantitis, including its definition, classification systems, epidemiology, etiology, pathogenesis, diagnosis, and treatment. Periimplantitis is defined as an inflammatory process involving both soft and hard tissues around a dental implant, resulting in loss of supporting bone. It is distinguished from peri-implant mucositis, which only involves inflammation of soft tissues. The document discusses various classification systems for periimplantitis and reviews potential etiologic factors such as plaque, biomechanical overload, genetic factors, and iatrogenic causes. Diagnosis involves clinical parameters like bleeding, probing depth, and radiographic bone loss. Treatment aims to eliminate infection and may include nonsurgical and surgical
The document discusses diagnosis and treatment of peri-implant disease. It begins by introducing the history of dental implants and defines peri-implant mucositis and peri-implantitis. The main causes are bacterial infection and biomechanical overload. Treatment involves non-surgical and surgical approaches to arrest disease progression and maintain the implant site. The document then examines the histology and microbiology of healthy and diseased peri-implant tissues.
This document discusses periodontal regeneration and repair. It defines regeneration as the replacement of damaged tissues with new tissues that restore the original structure and function, while repair involves the reattachment of existing fibers and is inferior. True regeneration requires the formation of a new epithelial seal, connective tissue fibers inserted into the root, and new cementum and alveolar bone. However, complete regeneration may be difficult to achieve due to the complexity of biological factors involved. New approaches utilize scaffolds, growth factors, stem cells, and tissue engineering to help guide and stimulate regeneration. The future of regeneration may rely on combining technologies and biological concepts to attract cells needed for full regeneration.
The document discusses guided tissue regeneration (GTR) in treating endodontic-periodontal lesions. It describes how GTR involves placing a barrier membrane to prevent non-bone cells from migrating first to the root surface, facilitating new bone formation. For combined lesions, both endodontic therapy and periodontal regenerative procedures are needed. A case example is provided where a patient with a deep probing defect and tooth mobility underwent root canal treatment, scaling and root planing, and later GTR using an autogenous bone graft and membrane.
This document discusses guided tissue regeneration (GTR) for treating endodontic-periodontal lesions. It describes that GTR involves placing a barrier membrane to prevent non-bone cells from migrating first to the root surface. The success rate of treating these lesions without GTR is only 27-37%, but increases to 95% with GTR. A case example is provided of a patient with a deep periodontal pocket and bone loss treated with root canal therapy, scaling and root planing, and later GTR using an autogenous bone graft and membrane. Radiographs alone are not reliable for assessing bone fill after surgery.
Dental implants are a common treatment for replacing missing teeth. They involve surgically placing a titanium implant into the jawbone, which fuses with the bone through osseointegration during a 4 month healing period. The implant then protrudes through the gum line to support either a single crown or multiple tooth replacement. While implants have high success rates of around 95%, factors like patient health, bone quality, oral hygiene and excessive forces can lead to issues like peri-implantitis or failure of the implant to integrate with the bone. Thorough patient screening is required to ensure implants are only used in individuals where the risks do not outweigh the benefits.
Clinical significance of junctional epitheliumJignesh Patel
The junctional epithelium forms the border between the tooth surface and gingival sulcus. It acts as a barrier against pathogenic bacteria through rapid turnover and the expression of antimicrobial molecules. Loss of integrity in the junctional epithelium can initiate pocket formation in periodontitis as bacteria colonize the exposed tooth surface. The junctional epithelium has a remarkable ability to regenerate after injury or probing within a few days through rapid cell division. Maintaining a healthy junctional epithelium is important to prevent periodontal diseases from developing at this site of bacterial accumulation.
“Perio-Implant Synergy”- Two lectures on “Lost Buccal Plate- Complications and Management” and “Failing to Plan is Planning to Fail”. Organized by the Society of Periodontists and Implantologists of Kerala” at PMS Dental College, Trivandrum, India on 17/9/2018.
This document provides information on various ridge augmentation techniques. It begins with an introduction describing how tooth loss leads to bone resorption and impaired function. It then discusses the history of using autogenous bone grafts for ridge augmentation. The objectives of ridge augmentation are also outlined. Key techniques discussed include ridge preservation, ridge splitting, use of autogenous bone blocks, and distraction osteogenesis. Advantages and disadvantages of different graft sources and incision designs are compared. The document emphasizes the importance of adequate bone volume for successful implant placement and summarizes various methods to augment bone.
This document discusses implants in patients with bruxism. It defines implants and osseointegration. Bruxism can overload implants and cause biological and biomechanical complications like bone loss, screw loosening, and fracture. Bruxism is diagnosed through tooth wear, muscle hypertrophy, and jaw pain/fatigue. While some research shows bruxism does not affect implants, occlusal considerations are important for implant prostheses given their rigid fixation. Management of bruxism includes night guards and pharmacological therapies to reduce forces. More research is still needed on the effects of bruxism on dental implants.
1) The document discusses healthy peri-implant tissues, which include a keratinized oral epithelium continuous with a sulcular epithelium facing the implant, and connective tissue with small inflammatory cell infiltrates.
2) It then discusses peri-implant mucositis and peri-implantitis. Peri-implant mucositis is a reversible inflammation of soft tissues around functioning implants, while peri-implantitis additionally involves loss of supporting bone.
3) The main risk factor for both is plaque accumulation on the titanium surface leading to biofilm formation. Peri-implantitis can progress faster than periodontitis since there is no periodontal ligament barrier between inflammation and bone.
“Horizontal Ridge Augmentation- Worth or Vain?”- Guest lecture as a part of “Perio Interactions- Edition IX” conducted by Saveetha Dental College and Hospitals, Chennai on 20/12/2017.
This document discusses biologic width, which refers to the combined width of connective tissue and epithelial attachment above the alveolar bone crest. It provides definitions, a brief history of the concept, and an overview of the significance of maintaining biologic width to preserve periodontal health. Violations of the biologic width can lead to inflammation, attachment loss, bone loss, and recession. The document outlines methods for evaluating biologic width violations and categorizing biologic widths, and reviews surgical and orthodontic techniques for correcting violations. It also discusses considerations for margin placement in relation to biologic width for restorations.
This document discusses bone graft materials and techniques. It begins by defining a bone graft as material used to achieve 100% living bone tissue formation when placed in a compatible area. It then discusses various graft materials including particulate and block grafts, as well as growth enhancers. The document goes on to discuss factors that determine graft selection, the fate of grafts over time, and techniques for creating an ideal environment for graft incorporation.
Diagnosis & treatment plan for periimplant desease/ dental implant coursesIndian dental academy
This document discusses diagnosis and treatment of peri-implant disease. It begins by describing the history of dental implants and defines peri-implant mucositis and peri-implantitis. Peri-implant tissue breakdown can result from microbial and mechanical factors. Treatment aims to arrest disease progression and maintain implant sites. Bacterial infection and biomechanical overload are major causes of peri-implant bone loss. Implant shape, surface, and soft tissue attachment can also influence peri-implant health.
Indian Dental Academy: will be one of the most relevant and exciting training center with best faculty and flexible training programs for dental professionals who wish to advance in their dental practice,Offers certified courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic Dentistry, Periodontics and General Dentistry.
Is Flap Surgery Being Undermined in this Era of ImplantologyR Viswa Chandra
1) Saving natural teeth with periodontal therapy or placing dental implants are both options for replacing teeth with poor prognoses, with various factors to consider.
2) Periodontal therapy can initially be as effective as implants but has higher long-term survival rates, though implants have fewer complications if retained successfully.
3) Periodontal therapy has lower initial costs than implants but implants require additional costs if complications like peri-implantitis occur.
4) Both procedures have risks, but with proper maintenance, periodontally compromised teeth treated with regenerative materials and flaps have survival rates of 92-93%.
Periodontal Regeneration- The right way forwardR Viswa Chandra
This document discusses various approaches to periodontal regeneration, including tissue engineering and regenerative medicine techniques. It describes using scaffolds, growth factors, stem cells, and micrografts to promote the reconstitution of damaged periodontal tissues. Specific methods mentioned include using platelet-rich fibrin, titanium granules, or stevia gel as scaffold materials and incorporating cell types like periodontal ligament stem cells, dental pulp stem cells, and gingival mesenchymal stem cells. The document also discusses manufacturing techniques for scaffolds, such as combining collagen with fibroblast growth factor 2 or silver nanoparticles. Finally, it outlines surgical approaches to periodontal regeneration like papilla preservation flaps or using connective tissue grafts.
The document discusses diagnosis and treatment of peri-implant disease. It begins by introducing the history of dental implants and defines peri-implant mucositis and peri-implantitis. The main causes are bacterial infection and biomechanical overload. Treatment involves non-surgical and surgical approaches to arrest disease progression and maintain the implant site. The document then examines the histology and microbiology of healthy and diseased peri-implant tissues.
This document discusses periodontal regeneration and repair. It defines regeneration as the replacement of damaged tissues with new tissues that restore the original structure and function, while repair involves the reattachment of existing fibers and is inferior. True regeneration requires the formation of a new epithelial seal, connective tissue fibers inserted into the root, and new cementum and alveolar bone. However, complete regeneration may be difficult to achieve due to the complexity of biological factors involved. New approaches utilize scaffolds, growth factors, stem cells, and tissue engineering to help guide and stimulate regeneration. The future of regeneration may rely on combining technologies and biological concepts to attract cells needed for full regeneration.
The document discusses guided tissue regeneration (GTR) in treating endodontic-periodontal lesions. It describes how GTR involves placing a barrier membrane to prevent non-bone cells from migrating first to the root surface, facilitating new bone formation. For combined lesions, both endodontic therapy and periodontal regenerative procedures are needed. A case example is provided where a patient with a deep probing defect and tooth mobility underwent root canal treatment, scaling and root planing, and later GTR using an autogenous bone graft and membrane.
This document discusses guided tissue regeneration (GTR) for treating endodontic-periodontal lesions. It describes that GTR involves placing a barrier membrane to prevent non-bone cells from migrating first to the root surface. The success rate of treating these lesions without GTR is only 27-37%, but increases to 95% with GTR. A case example is provided of a patient with a deep periodontal pocket and bone loss treated with root canal therapy, scaling and root planing, and later GTR using an autogenous bone graft and membrane. Radiographs alone are not reliable for assessing bone fill after surgery.
Dental implants are a common treatment for replacing missing teeth. They involve surgically placing a titanium implant into the jawbone, which fuses with the bone through osseointegration during a 4 month healing period. The implant then protrudes through the gum line to support either a single crown or multiple tooth replacement. While implants have high success rates of around 95%, factors like patient health, bone quality, oral hygiene and excessive forces can lead to issues like peri-implantitis or failure of the implant to integrate with the bone. Thorough patient screening is required to ensure implants are only used in individuals where the risks do not outweigh the benefits.
Clinical significance of junctional epitheliumJignesh Patel
The junctional epithelium forms the border between the tooth surface and gingival sulcus. It acts as a barrier against pathogenic bacteria through rapid turnover and the expression of antimicrobial molecules. Loss of integrity in the junctional epithelium can initiate pocket formation in periodontitis as bacteria colonize the exposed tooth surface. The junctional epithelium has a remarkable ability to regenerate after injury or probing within a few days through rapid cell division. Maintaining a healthy junctional epithelium is important to prevent periodontal diseases from developing at this site of bacterial accumulation.
“Perio-Implant Synergy”- Two lectures on “Lost Buccal Plate- Complications and Management” and “Failing to Plan is Planning to Fail”. Organized by the Society of Periodontists and Implantologists of Kerala” at PMS Dental College, Trivandrum, India on 17/9/2018.
This document provides information on various ridge augmentation techniques. It begins with an introduction describing how tooth loss leads to bone resorption and impaired function. It then discusses the history of using autogenous bone grafts for ridge augmentation. The objectives of ridge augmentation are also outlined. Key techniques discussed include ridge preservation, ridge splitting, use of autogenous bone blocks, and distraction osteogenesis. Advantages and disadvantages of different graft sources and incision designs are compared. The document emphasizes the importance of adequate bone volume for successful implant placement and summarizes various methods to augment bone.
This document discusses implants in patients with bruxism. It defines implants and osseointegration. Bruxism can overload implants and cause biological and biomechanical complications like bone loss, screw loosening, and fracture. Bruxism is diagnosed through tooth wear, muscle hypertrophy, and jaw pain/fatigue. While some research shows bruxism does not affect implants, occlusal considerations are important for implant prostheses given their rigid fixation. Management of bruxism includes night guards and pharmacological therapies to reduce forces. More research is still needed on the effects of bruxism on dental implants.
1) The document discusses healthy peri-implant tissues, which include a keratinized oral epithelium continuous with a sulcular epithelium facing the implant, and connective tissue with small inflammatory cell infiltrates.
2) It then discusses peri-implant mucositis and peri-implantitis. Peri-implant mucositis is a reversible inflammation of soft tissues around functioning implants, while peri-implantitis additionally involves loss of supporting bone.
3) The main risk factor for both is plaque accumulation on the titanium surface leading to biofilm formation. Peri-implantitis can progress faster than periodontitis since there is no periodontal ligament barrier between inflammation and bone.
“Horizontal Ridge Augmentation- Worth or Vain?”- Guest lecture as a part of “Perio Interactions- Edition IX” conducted by Saveetha Dental College and Hospitals, Chennai on 20/12/2017.
This document discusses biologic width, which refers to the combined width of connective tissue and epithelial attachment above the alveolar bone crest. It provides definitions, a brief history of the concept, and an overview of the significance of maintaining biologic width to preserve periodontal health. Violations of the biologic width can lead to inflammation, attachment loss, bone loss, and recession. The document outlines methods for evaluating biologic width violations and categorizing biologic widths, and reviews surgical and orthodontic techniques for correcting violations. It also discusses considerations for margin placement in relation to biologic width for restorations.
This document discusses bone graft materials and techniques. It begins by defining a bone graft as material used to achieve 100% living bone tissue formation when placed in a compatible area. It then discusses various graft materials including particulate and block grafts, as well as growth enhancers. The document goes on to discuss factors that determine graft selection, the fate of grafts over time, and techniques for creating an ideal environment for graft incorporation.
Diagnosis & treatment plan for periimplant desease/ dental implant coursesIndian dental academy
This document discusses diagnosis and treatment of peri-implant disease. It begins by describing the history of dental implants and defines peri-implant mucositis and peri-implantitis. Peri-implant tissue breakdown can result from microbial and mechanical factors. Treatment aims to arrest disease progression and maintain implant sites. Bacterial infection and biomechanical overload are major causes of peri-implant bone loss. Implant shape, surface, and soft tissue attachment can also influence peri-implant health.
Indian Dental Academy: will be one of the most relevant and exciting training center with best faculty and flexible training programs for dental professionals who wish to advance in their dental practice,Offers certified courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic Dentistry, Periodontics and General Dentistry.
Is Flap Surgery Being Undermined in this Era of ImplantologyR Viswa Chandra
1) Saving natural teeth with periodontal therapy or placing dental implants are both options for replacing teeth with poor prognoses, with various factors to consider.
2) Periodontal therapy can initially be as effective as implants but has higher long-term survival rates, though implants have fewer complications if retained successfully.
3) Periodontal therapy has lower initial costs than implants but implants require additional costs if complications like peri-implantitis occur.
4) Both procedures have risks, but with proper maintenance, periodontally compromised teeth treated with regenerative materials and flaps have survival rates of 92-93%.
Periodontal Regeneration- The right way forwardR Viswa Chandra
This document discusses various approaches to periodontal regeneration, including tissue engineering and regenerative medicine techniques. It describes using scaffolds, growth factors, stem cells, and micrografts to promote the reconstitution of damaged periodontal tissues. Specific methods mentioned include using platelet-rich fibrin, titanium granules, or stevia gel as scaffold materials and incorporating cell types like periodontal ligament stem cells, dental pulp stem cells, and gingival mesenchymal stem cells. The document also discusses manufacturing techniques for scaffolds, such as combining collagen with fibroblast growth factor 2 or silver nanoparticles. Finally, it outlines surgical approaches to periodontal regeneration like papilla preservation flaps or using connective tissue grafts.
Periodontitis and Systemic Diseases- A Broken Two-way MirrorR Viswa Chandra
This document summarizes the relationship between periodontitis and systemic diseases like diabetes and cardiovascular disease. It finds that periodontitis is associated with worse diabetes outcomes and increased cardiovascular risk. There is a two-way relationship between the conditions, with periodontitis potentially worsening diabetes and cardiovascular markers, and treatment of periodontitis linked to improved glycemic control and reduced cardiovascular risk factors. However, knowledge about these links among healthcare providers is still lacking. The data on these relationships is also inconsistent and there are no clear guidelines on screening, treatment and management.
Tissue engineering aims to combine scaffolds, cells, and growth factors to regenerate tissues. Periodontal tissue engineering specifically focuses on regenerating damaged periodontal tissues through the use of scaffolds, stem cells, growth factors, and gene therapy. Tissue engineering combines materials science, cell biology, and medical sciences to repair or reconstruct tissues. Bone tissue engineering is an emerging field that uses these techniques to treat bone diseases by overcoming limitations of traditional treatments.
Unidirectional forces that are short and low intensity are considered the most damaging type of tooth-grinding forces. Specifically, eccentric bruxism involving jiggling forces that are short and either low or high intensity is more damaging than centric bruxism involving unidirectional forces that are long and high intensity. Recent theories about the role of tooth-grinding forces have focused on the role of saliva lubricity, trauma from tooth contact during biting and closing, and inflammasome mediation of inflammation.
1. HIF-1 is a transcription factor that is ubiquitously expressed and activated under hypoxic conditions to turn on genes needed for survival.
2. HIF-1 targets various genes including erythropoietin, nitric oxide synthase 2, transferrin, transferrin receptor, and vascular endothelial growth factor which are involved in oxygen delivery.
3. Under hypoxia, HIF-1 transcriptionally upregulates target genes containing hypoxia response elements like GLUT1 and VEGF through hypoxia response proteins.
The documents discuss various factors that influence bone regeneration, including osteogenic cells, osteoconductive scaffolds, growth factors, and the mechanical environment. Optimal bone regeneration requires an environment that supports osteoprogenitor cell recruitment, proliferation and differentiation, angiogenesis, and extracellular matrix formation. A variety of graft materials and their properties are reviewed in relation to supporting bone healing and regeneration.
This document discusses the complex relationship between the host and microbes in the context of periodontal disease. It addresses three levels of interaction: (1) at the microbial level where controlled inflammation benefits commensals; (2) at the host tissue level where the host responds to biofilm formation through immune and inflammatory factors as well as genetic factors; and (3) at the systemic level where dysbiosis can lead to conditions in other parts of the body. The document questions whether periodontal pathogens are generalists or specialists and whether the goal of treatment is to resolve the infection or the inflammation. It ultimately emphasizes that the host plays a key role in driving pathogen variation and the development of periodontal disease.
Cytokines are superfamilies of proteins that are grouped by their structural similarities and receptor activities. They are produced by lymphocytes, monocytes, and other cells and can have pleiotropic, redundant, synergistic, or antagonistic effects on cells. In periodontal disease, T-cell derived cytokines and neutrophil cytokines both play roles, with the potential for a "cytokine storm" of pro-inflammatory signaling contributing to tissue destruction.
Active and passive implants and Microgap around implantsR Viswa Chandra
The document discusses the differences between active and passive implants, how they are placed, and factors that influence microgaps between the implant and bone. For passive implants, drilling extends 1mm beyond the implant length to allow for density differences in bone quality. Active implants are drilled to the exact depth and slightly less than the full width to ensure optimal stability. Microgaps between implants and bone can range from 1.52 to 94 micrometers and influence the bone response.
The document discusses the role of the complement system and its interaction with periodontitis. The complement system is part of the innate immune system and acts as a "defence wall" against pathogens like P. gingivalis, which causes periodontitis. P. gingivalis has developed ways to subvert and exploit the complement system during infection. The document raises questions about how bacteria like A. actinomycetemcomitans and the complement cascade may affect the alveolar bone during periodontitis, as well as potential drug treatments that target the complement cascade.
This document discusses periodontal pockets, which are pathologically deepened spaces between teeth and gingiva caused by periodontal disease. It defines a pocket and outlines signs and symptoms. Pockets are classified by depth, number of walls, and location. Theories of pocket formation include destruction of gingival fibers or cementum, or proliferation of junctional epithelium. Pockets are chronic inflammatory lesions that undergo constant destructive and reparative processes. Probing and radiographs are used to detect and measure pocket depth.
This document provides guidance for writing and publishing academic manuscripts. It discusses challenges authors may face including lack of familiarity with the publication process and becoming discouraged. It also discusses challenges with journals like space constraints and editorial priorities. The document provides tips for different sections of a manuscript like the introduction, methods, results, and discussion. It discusses referencing styles, matching manuscripts to appropriate journals, common reasons for rejection, and benefits of open access publishing for both authors and readers.
1) A thesis is typically shorter in length (up to 100 pages) and uses existing data, while a dissertation requires original research and is longer (up to 300 pages).
2) A thesis takes considerably less time than a dissertation, which can take much longer than expected due to the need for extensive original research.
3) Dissertations require a thorough investigation of the topic, identification of research gaps, collection of original evidence and data, and make a contribution to existing literature.
“Perio-Spardha” Program on Autologous Platelet Concentrates-Two lectures on “Tweaking the Centrifuge- An important protocol in the generation of PRF” and “Applications and Limitations of PRF in Periodontics and Implantology”. Organized by Bangalore Academy of Periodontology (BAP) and Indian Society of Periodontology at Oxford Dental College Hospital and Research Centre, Bangalore, India on 14/02/2017.
“Workshop on growth factors in Periodontics and Implantology”- Two lectures on “PRF Cytokines- Advantages and Limitations” and “Preparing PRF- What to do, what not to do” followed by a hands-on module of PRF generation and manipulation. Event organized by the Dental Experts and held at Army College of Dental Sciences, Hyderabad, India on 07/8/2016.
“Perio-Spardha” Program on Autologous Platelet Concentrates-Two lectures on “Tweaking the Centrifuge- An important protocol in the generation of PRF” and “Applications and Limitations of PRF in Periodontics and Implantology”. Organized by Bangalore Academy of Periodontology (BAP) and Indian Society of Periodontology at Oxford Dental College Hospital and Research Centre, Bangalore, India on 14/02/2017.
“Program on Ridge Split and Ridge Augmentation for Implant Placement”- Two lectures on “Concepts of Ridge Augmentation” and “Novel and Simpler Approaches to Ridge Augmentation”. Event organized by the Dental Experts and held at Paneenya Mahavidyalaya Institute of Dental Sciences, Hyderabad, India on 18/11/2016.
“Program on Ridge Split and Ridge Augmentation for Implant Placement”- Two lectures on “Concepts of Ridge Augmentation” and “Novel and Simpler Approaches to Ridge Augmentation”. Event organized by the Dental Experts and held at Paneenya Mahavidyalaya Institute of Dental Sciences, Hyderabad, India on 18/11/2016.
“Perio-Implant surgery: Expanding the Horizons”- Three lectures on “Sinus lifts- Alternative techniques and Strategies”, “Preparing PRF- What to do, what not to do” and “When not to use regenerative materials” organized by the Society of Periodontists and Implantologists of Kerala” at Kochi, India on 24/07/2016.
“Sinus lifts- Alternative techniques and Strategies” and “When not to use regenerative materials”- Guest lecture as a part of Dr NTRUHS Zonal CDE programme in G Pulla Reddy Dental College and Hospital, Kurnool, India on 07/10/2016.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
Adhd Medication Shortage Uk - trinexpharmacy.comreignlana06
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
Travel vaccination in Manchester offers comprehensive immunization services for individuals planning international trips. Expert healthcare providers administer vaccines tailored to your destination, ensuring you stay protected against various diseases. Conveniently located clinics and flexible appointment options make it easy to get the necessary shots before your journey. Stay healthy and travel with confidence by getting vaccinated in Manchester. Visit us: www.nxhealthcare.co.uk
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
5. *Consensus report of 7th European Workshop on Periodontology, 2011
It was always
assumed that’s that
the common
etiology for peri-
implant disease is
the presence of a
bacterial biofilm
and excessive
occlusal load*
PERIIMPLANTITIS IS NOT PERIODONTITIS
6. Donath K. Pathogenesis of bony pocket formation around dental implants. J. Dent. Assoc. S. Afr. 1992;47:204–208.
*Bosshardt DD, Brodbeck UR, Rathe F, Stumpf T, Imber JC, Weigl P, Schlee M. Evidence of re-osseointegration after electrolytic cleaning and regenerative
therapy of peri-implantitis in humans: a case report with four implants. Clin Oral Investig. 2022 Apr;26(4):3735-3746.
PERIIMPLANTITIS IS NOT PERIODONTITIS
Marginal
Bone Loss
OSSEOINTEGRATION*
7. Kotsakis GA, Olmedo DG. Peri-implantitis is not periodontitis: Scientific discoveries shed light on microbiome-biomaterial interactions that may determine disease phenotype. Periodontol 2000. 2021
Jun;86(1):231-240. doi: 10.1111/prd.12372. Epub 2021 Mar 10. PMID: 33690947.
Antibiotic Resistance
Titanium Dissolution Products
8. PERIIMPLANTITIS IS NOT PERIODONTITIS
Mombelli A, Hashim D, Cionca N. What is the impact of titanium particles and biocorrosion on implant survival and complications? A critical review. Clin Oral
Implants Res. 2018 Oct;29 Suppl 18:37-53. doi: 10.1111/clr.13305. PMID: 30306693.
9. PERIIMPLANTITIS IS NOT PERIODONTITIS
1.52 µm-94.00 µm
Gianfreda F, Punzo A, Pistilli V, Bollero P, Cervino G, D'Amico C, Cairo F, Cicciù M. Electrolytic Cleaning and Regenerative Therapy of Peri-implantitis in the
Esthetic Area: A Case Report. Eur J Dent. 2022 Oct;16(4):950-956. doi: 10.1055/s-0042-1750773. Epub 2022 Jul 4. PMID: 35785819; PMCID: PMC9683897
11. • More PMNs
• Less plasma cells
and lymphocytes
• Peri-implant lesion
was less
immunologically
regulated
Peri-implant mucositis has to be diagnosed properly
Peri-implant soft tissues develop a stronger inflammatory
response
Inflammation was reversible only at the biomarker level
3-weeks was not sufficient for inflammation reversal
PERIIMPLANT MUCOSITIS IS NOT GINGIVITIS
12. PERIIMPLANT MUCOSITIS IS NOT GINGIVITIS
Non-surgical therapy has not been shown to be effective for the treatment
of peri-implant mucositis
Peri-implant mucositis appears to be reversible
Peri-implant mucositis may be present for extensive periods of time without
progression to peri-Implantitis
Optimal biofilm control may take longer than 3 weeks
14. Inflammatory connective tissue (ICT) infiltrate of the peri-
implant mucosa in the microgap*
This ICT zone indicates a response of the immune system to
microorganisms and in generally considered as protective**
If the microgap is located more coronally, ie, further from the
alveolar crest, then we should expect less bone loss because of
the greater distance between the bacteria and the alveolar
Crest***
*Ericsson I, Persson LG, Berglundh T, Mariniello CP, Lindhe J, Klinge B. Different types of inflammatory reactions in periimplant soft tissues. J Clin Periodontol 1995;22:255–261.
**Piattelli A, Vrespa G, Petrone G, Iezzi G, Annibali S, Scarano A. Role of the Microgap between implant and abutment: A retrospective histologic evaluation in monkeys. J Periodontol 2003;74:346–352.
***Luongo R, Traini T, Guidone PC, Bianco G, Cocchetto R, Celletti R. Hard and soft tissue responses to the platform-switching technique. Int J Periodontics Restorative Dent. 2008 Dec;28(6):551-7. PMID:
19146050.
PERIIMPLANT MUCOSITIS IS NOT A DISEASE
15. PERIIMPLANT MUCOSITIS IS NOT A DISEASE
The ICT is never in contact with the bone but was
separated from it by an approximately 1-mm-wide layer of
healthy connective tissue*
This should be considered as a sort of barrier or protective
seal capable of preserving bone complementing the
biologic width
IF IT IS PROTECTIVE, WHY IS IT A DISEASE?
*Luongo R, Traini T, Guidone PC, Bianco G, Cocchetto R, Celletti R. Hard and soft tissue responses to the platform-switching technique. Int J Periodontics Restorative Dent. 2008 Dec;28(6):551-7.
**Berglundh T, Lindhe J. Dimension of the periimplant mucosa. Biologic width revisited. J Clin Periodontol 1996;23:971–973
17. PERIODONTAL INDICES CANNOT ASSESS PERIIMPLANTITIS
BOP
PPD
Bone Loss
Deep insertion of the implant
Type and implant diameter
Abutment connection materials
Type of prosthetic suprastructure
Atieh MA, Alsabeeha NH, Faggion CM Jr, Duncan WJ. The frequency of peri-implant diseases: a systematic review and meta-analysis. J Periodontol. 2013;84:1586–1598.
Hammerle CH, Bragger U, Burgin W, Lang NP. The effect of subcrestal placement of the polished surface of ITI implants on marginal soft and hard tissues. Clin Oral Implants Res. 1996;7:111–119.
The diagnostic criteria and treatments for peri-implant diseases are not
currently standardized (Ramanauskaite et al 2016, Natto et al 2019,
Scarano et al 2023).
Peri-implant probing causes over-diagnosis and over-treatment
(Coli & Sennerby 2019, Bornes et al, 2023).
18. PERIODONTAL INDICES CANNOT ASSESS PERIIMPLANTITIS
Renvert S, Persson GR, Pirih FQ, Camargo PM. Peri-implant health, peri-implant mucositis, and peri-implantitis: Case definitions and diagnostic considerations. J Periodontol. 2018 Jun;89 Suppl
1:S304-S312. doi: 10.1002/JPER.17-0588. PMID: 29926953.
19. PERIODONTAL INDICES CANNOT ASSESS PERIIMPLANTITIS
Case Definitions BOP PPD Bone Loss
Periimplant
Mucositis
Erythema & BOP+ & PPD↗ & Absence of bone loss beyond
initial remodeling 2017 World workshop
BOP+ with ≤2 mm in the first year and ≤0.2 mm in each
subsequent year and PD≥5 mm Natto et al 2019
Periimplantitis visual inflammatory changes + PPD↗ + Progressive bone loss
+ evidence of bone loss ≥3 mm with PPD≥6 mm 2017
World workshop
Crestal bone loss of
≥2 mm and PD ≥3 mm Natto et al 2019
21. 6 Months 3 Months 9 Months
MARGINAL BONE LOSS (MBL) WITHIN THE FIRST YEAR IS NOT DISEASE
Early marginal bone loss (MBL)
Is the bone loss pathologic?
How much loss is normal?
What is the acceptable bone loss at 1y, 2y or at 3y?
22. MARGINAL BONE LOSS (MBL) WITHIN THE FIRST YEAR IS NOT DISEASE
Early marginal bone loss (MBL) is a non-infective remodeling
occurring within the first year after implant placement
The estimate for the mean MBL was 0.5 mm within the first year
Implants that lose more than 0.5 mm of marginal bone 6-months
after loading are at great risk of not being radiographically
successful anymore.
Galindo-Moreno P et al. Early marginal bone loss around dental implants to define success in implant dentistry: A retrospective study. Clin Implant Dent Relat Res. 2022 Oct;24(5):630-642.
23. MARGINAL BONE LOSS (MBL) WITHIN THE FIRST YEAR IS NOT DISEASE
Fu PS, Tseng FC, Lan TH, Lai PL, Chen CH, Chen JH, Liu CT, Chen WC, Hung CC. Immediate implant placement with and without provisionalization: A
comparison of a one-year longitudinal study. J Dent Sci. 2023 Jul;18(3):1361-1367.
a person falsely claiming to have a special knowledge or skil
a person who claims to have a supernatural ability to perceive events in the future or beyond normal sensory contact.
Risk factors for periimplant diseases are very similar to periodontitis risk factors
Common etiology for peri-implant disease is the presence of a bacterial biofilm and excessive occlusal load*
Most dental implants have a 2-stage design in which (1) the implant is placed and the surrounding tissues are allowed to heal, and then (2) the abutment is placed and the restoration is completed. To prevent the unsightly metal ring that occurs with supragingival placement of the IAJ, most implants involve subgingival placement. The implant and the abutment cannot be accurately matched because of the precision limit during production . This subgingival placement makes the IAJ inaccessible for routine hygiene care and raises legitimate concerns about bacterial colonization within the IAJ micro-gap.
In vitro studies show that biofilm in sliding contact surfaces could act like a lubricant, resulting in a friction behavior and reducing the mechanical integrity of the joint vs COLD WELDING
Around implant-abutment connections, a lower pH value of 3–4 can induce corrosion at the contacting surfaces. Galvanic corrosion is the most common type of corrosion in dental implants.
The study of the simultaneous degradation by wear and corrosion that occurs at the sliding contacts is known as tribocorrosion
The internal cavity of implant is similar to a reservoir (Nayak et al., 2014; Orsini et al., 2000; Proff et al., 2006). When the abutment is removed and replaced, bacteria can enter the implant internal cavity, where they reside and proliferate. The bacteria with their toxic by-products and small nutritious molecules can freely penetrate into the implant internal cavity or reverse through the IAI microgap.
The destruction of the IAI micromotion is mainly displayed in two aspects. First, micromotion interferes the attachment of soft tissue around the implant neck and disrupts the stability of soft tissue that has completed integration (Passos, Gressler May, Faria, Ozcan, & Bottino, 2013). Second, micromotion causes a micropumping effect (Ericsson, et al., 1995), which intensifies the leakage of bacteria and their toxic by-products and accelerates the blood, saliva, and proteoglycans (including the extracellular matrix and mucus layer) into the internal cavity of implant (Baixe, Tenenbaum, & Etienne, 2016).
Mechanical damages of microgap and micromotion include fretting wear, adhesive wear, and screw loosening (Jorn, Kohorst, Besdo, Borchers, & Stiesch, 2016; Sakamoto et al., 2016). Fretting wear refers to microfracture and chipping between the IAI, whereas adhesive wear is defined as the plastic deformation in the IAI (
The host response to biofilms does not differ substantially at teeth or implants. The most obvious sign clinically is the development of an inflammatory lesion as a result of the bacterial challenge. Gingivitis at teeth or peri-implant mucositis at implants are precursors for more detrimental lesions, and hence have to be diagnosed properly and prevented by applying anti-infective therapy. Non-surgical interventions are usually sufficient for the treatment of both gingivitis and mucositis.