Polymerase chain reaction (PCR) is a laboratory technique used to amplify specific DNA sequences. It involves repeated cycles of heating and cooling of the DNA sample in the presence of primers and DNA polymerase. During each cycle, the DNA strands are separated by heating, then primers allow the polymerase to make copies of the target sequence. This results in exponential amplification, producing millions of copies of the target DNA. PCR is commonly used in research, forensics, medicine and many other applications to detect and analyze DNA.