Parathyroid hormone

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The document summarizes the roles and mechanisms of parathyroid hormone and calcium regulation in the body. It discusses how parathyroid hormone regulates calcium levels through its effects on the kidneys, intestines, and negative feedback loops. It also covers causes of and treatments for conditions related to abnormal parathyroid hormone levels, including hypoparathyroidism, primary and secondary hyperparathyroidism, and the Chvostek sign seen in hypocalcemia.

Education Health & Medicine

Parathyroid hormone Dr. Sadaf Mumtaz 03/03/11

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Parathyroid hormone (PTH), parathormone or parathyrin, is secreted by the chief cells of the parathyroid glands as a polypeptide containing 84 amino acids. It acts to increase the concentration of calcium (Ca2+) in the blood, whereas calcitonin (a hormone produced by the parafollicular cells (C cells) of the thyroid gland) acts to decrease calcium concentration. PTH acts to increase the concentration of calcium in the blood by acting upon the parathyroid hormone 1 receptor (high levels in bone and kidney) and the parathyroid hormone 2 receptor (high levels in the central nervous system, pancreas, testis, and placenta).PTH half-life is approximately 4 minutes. It has a molecular mass of 9.4 kDa.

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