The parathyroid gland produces parathyroid hormone (PTH) which regulates calcium levels in the blood. PTH increases calcium levels by mobilizing calcium from bones and enhancing calcium reabsorption in kidneys. PTH release is regulated by calcium levels in the blood - low calcium stimulates PTH release while high calcium inhibits it. PTH acts on bones, kidneys and intestines to increase calcium levels. Calcitonin produced by the thyroid gland acts to decrease calcium levels. Disorders of the parathyroid gland and PTH can lead to bone diseases like osteoporosis.