1. DEPARTMENT OF PHARMACEUTICS
SHRI B. M. SHAH COLLEGE OF PHARMACEUTICAL EDUCATION AND REASERCH,
MODASA-2013
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2. CONTENTS
Introduction
Classification
Advantages and Disadvantages
Raw Material Specifications
Departmental Layout of Liquid Manufacture
Quantitative Layout Of Liquid Preparation
Important Questions
References
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3. INTRODUCTION
Liquid dosage form are one class of dosage form, which are
meant for either internal, external or parenteral use.
Liquid dosage forms are prepared by dissolving active
ingredients in an aqueous or non-aqueous solvent, by
suspending the drug or by incorporating the drug into one
of the two phases of an oil and water systems.
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4. CLASSIFICATION
LIQUIDS
MONOPHASIC
ORAL
USE
BIPHASIC
EXTERNAL PARENTERAL SPECIAL LIQUID IN
USE
USE
LIQUID
SOLUTION
DRAUGHTS
DROPS
LINCTUSES
SYRUPS
ELIXIRS
Oral use
Used in Oral Used in other
cavity
than oral cavity EMULSION
SOLIDS IN
LIQUID
External use
LINIMENTS
Parenteral
Oral
SUSPENSION
External
LOTION
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5. ADVANTAGES
1. Immediately available for absorption
2. Easy administration
3. They are most suitable dosage forms for infants, children, geriatric and
mentally disturbed patients.
4. Bitter and obnoxious drugs can be easily given in sweetened, colored and
flavored vehicles.
5. Doses can easily be varied as per the requirement of the patients.
DISADVANTAGES
1 . Less stable compare to solid dosage forms.
2. Liquid dosage forms are bulky and therefore inconvenient to carry, transport
and store.
3. Incompatibility is more in liquid dosage forms as compare to solid dosage
forms.
4. Patients have no accurate measuring device.
5. In case of accidental breakage of the container, it may result in loss of the
whole dosage forms.
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6. Raw Material Specifications
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7. DEPARTMENTAL LAYOUT OF LIQUID
MANUFACTURING
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8. •An area requirement for installation of equipment minimum 30 m 2.
Arrival of
goods
Entrance for
visitors
QC
Entrance for
Workers
Offices
Shipment of
goods
Canteen
Gowning
Incoming
goods
Corridor
Shipping
Corridor
Corridor
Raw
Materials
&
Packaging
Storage
Weighing
Processing
Washing
Filling
Packaging
Finished
Products
Storage
Machine
Shop
Utilities and Services
Corridor
Waste Treatment
Material flow
People flow
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9. QUANTITATIVE LAYOUT OF LIQUID PREPARATION
Making Liquid Syrup
Suppose, Plant Capacity:- 1,00,000boottles/day
For preparing:- 1,00,000 bottles (each containing 50ml of liquid syrup)
So, total syrup making:- 5000 L
Raw material Quantity:•Drugs:- 10 Kg
•Std granulated sugar:- 2750 Kg
•Other excipients:- 1000 Kg
•Purified water:- q.s
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10. WASHING AREA
10sq.M
FILLING & SEALING 10sq.M
LABELING
20sq.M
PACKAGING
20sq.M
FINISHED PRODUCT
STORAGE AREA
OFFICE
30sq.M
C O R R I D O R
WASHING
WASHING
EQUIPMENT
STORAGE
AREA
10sq.M
EMPTY
BOTTLE
STORAGE
AREA
GOWNING ROOM
CHANGE ROOM
Q.C
OFFICE
Temp:-25˚C
If hygroscopic
Temp:-<25˚C
If sterile area
Temp:-18˚C
I.P.Q.C.
SEMI FINISHED STORE
Humidity:-40%
If hygroscopic
Humidity> 40%
MEDICINE PREPERATION AREA
30sq.M
RAW MATERIAL LIQUID &
API &
SOLVENT
EXCIPIENT
10sq.M
EXCISE DUTY
syrup
DISTILLATION
UNIT
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11. IMPORTANT QUESTIONS
(GTU EXAMS)
1. Explain departmental layout with specific requirement
of equipments for oral liquid dosage forms. 05
2. How will you prepare qualitative and quantitative
departmental layout with equipments required for liquid
dosage forms? 05
3. Explain qualitative and quantitative deparmental layout
for liquid orals. 05 NOTE:-2 TIMES IN BOARD
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12. REFERENCE
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13. Thank you very much
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14. Ph. No. :- +91-8460378336
Address:- 44, Assiyana Society;
Dugarvada Road,
Taluko & City : Modasa
State: Gujarat
Country: India
Email: sahil.pharm4@gmail.com
BEST OF LUCK TO ALL . . . . . . . . . . . . . .
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