This document provides an overview of Neha Roy's 6-day industrial training project report at Albert David Limited in Kolkata. It describes several departments and processes at the company, including their small volume parenterals production, tablet manufacturing, oral liquid preparation, quality control and quality assurance, reverse osmosis water plant, raw material storage, and bulk drug production. The report also acknowledges those who supported and guided Neha during her training placement.
Pilot Plant:-
“Defined as a part of pharmaceutical industry where a lab scale formula is transformed into viable product by the development of liable practical procedure for manufacture”.
Scale-up:-
“The art of designing of prototype using the data obtained from the pilot plant model”
Pilot plant Techniques and Product consideration for liquid dosage forms.D.R. Chandravanshi
CONTENTS:-
DEFINITION
INTRODUCTION
OBJECTIVES
LIQUID DOSAGE FORM
STEPS INVOLVED IN PILOT PLANT FOR ORAL LIQUID
GENERAL CONSIDERATION
Reporting responsibility
Personal requirements
Space requirements
Review of formula
Raw materials
Relevant processing equipments
Process evaluation
GMP consideration
Assurance
PILOT PLANT SCALE UP FOR SUSPENSION
PILOT PLANT SCALE UP FOR EMULSION
REFERENCES
Hello guys,
Welcome to my profile.
Practice School Report
Yh practice school report B.Pharm ke 7th semester me bnayi jati hi, jo bhi aap school training me sikhte ho wahi sb is report me mention krna hota hai.
#bpharmacy
#careerinpharmacy
#bpharmanotes
#bpharmacynotes
#careerinpharmacyfield
#bpharmacy
#bpharm
#careerinpharma
#bpharmacylectures
#handwrittennotes
#pharmalectures
#akkuvibes
Granularity of Technology Transfer Process, Documentation, Premises and equipment Qualification and Validation. Premises and equipments. Quality control: Analytical Method Transfer. Qualification and Validation
Quality control on secondary packaging materialsAnupriyaNR
Presentation on quality control tests for the secondary packaging materials. Includes the materials used for secondary packaging, ideal properties of the secondary packaging material and various test procedures used for the quality control of the packaging materials.
Pilot Plant:-
“Defined as a part of pharmaceutical industry where a lab scale formula is transformed into viable product by the development of liable practical procedure for manufacture”.
Scale-up:-
“The art of designing of prototype using the data obtained from the pilot plant model”
Pilot plant Techniques and Product consideration for liquid dosage forms.D.R. Chandravanshi
CONTENTS:-
DEFINITION
INTRODUCTION
OBJECTIVES
LIQUID DOSAGE FORM
STEPS INVOLVED IN PILOT PLANT FOR ORAL LIQUID
GENERAL CONSIDERATION
Reporting responsibility
Personal requirements
Space requirements
Review of formula
Raw materials
Relevant processing equipments
Process evaluation
GMP consideration
Assurance
PILOT PLANT SCALE UP FOR SUSPENSION
PILOT PLANT SCALE UP FOR EMULSION
REFERENCES
Hello guys,
Welcome to my profile.
Practice School Report
Yh practice school report B.Pharm ke 7th semester me bnayi jati hi, jo bhi aap school training me sikhte ho wahi sb is report me mention krna hota hai.
#bpharmacy
#careerinpharmacy
#bpharmanotes
#bpharmacynotes
#careerinpharmacyfield
#bpharmacy
#bpharm
#careerinpharma
#bpharmacylectures
#handwrittennotes
#pharmalectures
#akkuvibes
Granularity of Technology Transfer Process, Documentation, Premises and equipment Qualification and Validation. Premises and equipments. Quality control: Analytical Method Transfer. Qualification and Validation
Quality control on secondary packaging materialsAnupriyaNR
Presentation on quality control tests for the secondary packaging materials. Includes the materials used for secondary packaging, ideal properties of the secondary packaging material and various test procedures used for the quality control of the packaging materials.
INDUSTRIAL TRAINING REPORT (B-pharmacy ) Zentiva pharmaceutical industry PrakashKumar721
Location:- GIDC Estate Ankleswar
393002, Dist. Bharuch ,Gujrat India
Zentiva is a producer of high-quality affordable medicines serving patients in Europe and beyond. With a dedicated team of more than 4,700 people and a network of production sites - including flagship sites in Prague, Bucharest and Ankleshwar - Zentiva strives to be the champion of branded and generic medicines in Europe to better supportpeople’s daily healthcare needs. At Zentiva it is our aspiration that healthcare should be a right and not a privilege. More than ever, people need better access to high quality affordable medicines and healthcare. We work in partnership with physicians, pharmacists, wholesalers, regulators and governments to provide the everyday solutions that we all depend on.
About Zentiva’s Ankleshwar site
Established in 1987, the Ankleshwar manufacturing site has a chemistry and biotechnology development center, and manufactures both intermediates and pharmaceutical formulations. A large producer of tablets, the Ankleshwar site manufactures more than 6 billion tablets annually.
Mission &Values:-
Zentiva is a leading developer and supplier of high-quality affordable prescription medicines and consumer brands. As Zentiva grows more people get the medicine they need. Our business is built on trust and responsibility with the patient at the heart of everything we do. Zentiva has established 6 shared SuperpowerZ which frame the values and behaviours we expect of our team and how we will build a healthy business that we can all be proud of.
TABLET-SECTION
Tablet:-
A tablet is a mixture of active substances and excipients, usually in powder form, pressed or compacted into a solid. The excipients include binders, Glidants (flow aids) and lubricants to ensure efficient tabletting, disintegrates to ensure that the tablet breaks up in the digestive tract; sweeteners or flavors to mask the taste of bad-tasting active ingredients; and pigments to make uncoated tablets visually attractive. A coating may be applied to hide the taste of the tablet's components, to make the tablet smoother and easier to swallow, and to make it more resistant to the environment, extending its shelf life.
Advantage
• Production aspect
Large scale production at lowest cost
Easiest and cheapest to package and ship
High stability
• User aspect (doctor, pharmacist, patient)
Easy to handling.
Lightest and most compact.
Greatest dose precision & least content variability.
Coating can mark unpleasant tastes & improve pt. acceptability.
PHARMACEUTICAL PRODUCT BY ZENTIVA PHARMACEUTICAL PVT.LTD:-
1. Avil -25 mg
2. Trental-400
3. Paracetamol-500mg
4. Ramilich-( 5, 25mg)
5. Ramipril-25mg
6. Zuglimate-500mg
7. Clopidogrel-75mg
8. Metformin-100mg
QUALITY CONTROL AND QUALITY ASSUARANCE
Quality control is the part of GMP that deals with sampling, specification, and testing, as well as organisation, documentation, and release procedures to ensure that necessary and
Oral Dispersible Film is a Novel Drug Delivery System intended to bypass the hepatic first pass metabolism and also many other benefits over the conventional oral dosage forms. It provides the user to administer the drug without the use of water and without ant expertise in administration.
A Primer on Hard Gelatin Capsule ManufacturingVivek Sinha
31/03/2015
Hard gelatin capsule shells are used as soluble containers for incorporation of drugs or nutritional
supplements, usually in the form of powders, pellets or granules in the healthcare industry. They are
commonly intended for oral administration having its advantages over other dosage forms that are
used widely by pharmaceutical companies to develop different medicaments and ensure stability of
the product throughout the shelf life. Since it serves as a major excipient for the manufacture of
pharmaceutical products, the quality attributes of hard capsule shells is very vital for performance
and stability of the final product.
Pharmaceutical products are categorized as high quality and high risk product administered to fight
various types of acute and chronic illnesses where the performance of the product should be
reproducible every time it is administered. The capsule shell consists of two cylindrical parts i.e. the
cap and body; both are open at one extreme. Other extreme of both is hemispherical; the open end
of cap overlaps the open end of body and maintains a closure with a typical lock system. Hence, it is
very important that the product achieves the label claim as set forth and is not contaminated and
readily available to the patients. Benchmarking of developments and manufacturing processes in the
pharmaceutical industry as against other industries led to the concept of Quality by Design or QbD.
Over the past few years, QbD has gained considerable acceptance throughout pharmaceutical
industry and has been successfully applied. The key quality attributes of capsules that determine the
process ability on the high speed filling machine are the dimensional characteristics and weight
variability.
The potential variations of empty hard capsules as an input material and its potential impact on
finished product quality has been studied and high consistency within the specification of the critical
quality parameters is confirmed. Annual product quality review needs to be performed using defined
sampling size against set of verification criteria. The built-in quality approach begins at the
development stage of new product where even factors impacting the performance of hard capsules
i.e. formulation, filling machine type, etc., is given due consideration. The selection of proper raw
material, the process validations and stability studies are to be conducted for suitability. The process
conditions should be maintained along with appropriate in-process quality checks. Final release of
product can be done by QA after product and document review. The data on process capability,
trends of quality parameters, technical specification and the evaluation procedure should be
maintained and submitted based on the current level of quality standards.
Appreciated by customers across the nation for supplying, trading and wholesaling a broad array of high quality pharmaceutical hygiene & cleanRoom
products, June Enterprises started its operations in December 2013.
In a short span of time, the company expanded its breadth of operations to provide CleanRoom Products to the Indian pharmaceutical industry &
neighboring countries.
The product range offered by June Enterprises includes: – Sterilization Monitoring & Validation Products, ATCC Culture, Cleanroom Garments &
Accessories, Cleanroom Supplies, Critical Cleaning Products, Products for Food & Facilities, Sterilization Packaging & Sealing Products, Products for
Stores & Warehouses, USP Class Silicone Tubing among others.
In order to ensure high standards of quality, the offered range of Cleanroom Products is procured and sourced from trusted and reliable Leaders in their
® ® respective product ranges for example Sterilization Products by Mesa Labs, Cleaning & disinfectants by Contec & ATCC by Microbiologics.
With years of experience, expertise and a proven track-record of helping many companies with its CleanRoom Products & Sterilization needs, June
Enterprises has established an enviable position in the PHARMA, FOOD & HOSPITAL segments.
JUNE Enterprises is an ISO 9001:2015 certified company.
Learn More: https://www.juneenterprises.com/
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Antibiotic Stewardship by Anushri Srivastava.pptxAnushriSrivastav
Stewardship is the act of taking good care of something.
Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials (including antibiotics), improves patient outcomes, reduces microbial resistance, and decreases the spread of infections caused by multidrug-resistant organisms.
WHO launched the Global Antimicrobial Resistance and Use Surveillance System (GLASS) in 2015 to fill knowledge gaps and inform strategies at all levels.
ACCORDING TO apic.org,
Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials (including antibiotics), improves patient outcomes, reduces microbial resistance, and decreases the spread of infections caused by multidrug-resistant organisms.
ACCORDING TO pewtrusts.org,
Antibiotic stewardship refers to efforts in doctors’ offices, hospitals, long term care facilities, and other health care settings to ensure that antibiotics are used only when necessary and appropriate
According to WHO,
Antimicrobial stewardship is a systematic approach to educate and support health care professionals to follow evidence-based guidelines for prescribing and administering antimicrobials
In 1996, John McGowan and Dale Gerding first applied the term antimicrobial stewardship, where they suggested a causal association between antimicrobial agent use and resistance. They also focused on the urgency of large-scale controlled trials of antimicrobial-use regulation employing sophisticated epidemiologic methods, molecular typing, and precise resistance mechanism analysis.
Antimicrobial Stewardship(AMS) refers to the optimal selection, dosing, and duration of antimicrobial treatment resulting in the best clinical outcome with minimal side effects to the patients and minimal impact on subsequent resistance.
According to the 2019 report, in the US, more than 2.8 million antibiotic-resistant infections occur each year, and more than 35000 people die. In addition to this, it also mentioned that 223,900 cases of Clostridoides difficile occurred in 2017, of which 12800 people died. The report did not include viruses or parasites
VISION
Being proactive
Supporting optimal animal and human health
Exploring ways to reduce overall use of antimicrobials
Using the drugs that prevent and treat disease by killing microscopic organisms in a responsible way
GOAL
to prevent the generation and spread of antimicrobial resistance (AMR). Doing so will preserve the effectiveness of these drugs in animals and humans for years to come.
being to preserve human and animal health and the effectiveness of antimicrobial medications.
to implement a multidisciplinary approach in assembling a stewardship team to include an infectious disease physician, a clinical pharmacist with infectious diseases training, infection preventionist, and a close collaboration with the staff in the clinical microbiology laboratory
to prevent antimicrobial overuse, misuse and abuse.
to minimize the developme
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CHAPTER 1 SEMESTER V - ROLE OF PEADIATRIC NURSE.pdfSachin Sharma
Pediatric nurses play a vital role in the health and well-being of children. Their responsibilities are wide-ranging, and their objectives can be categorized into several key areas:
1. Direct Patient Care:
Objective: Provide comprehensive and compassionate care to infants, children, and adolescents in various healthcare settings (hospitals, clinics, etc.).
This includes tasks like:
Monitoring vital signs and physical condition.
Administering medications and treatments.
Performing procedures as directed by doctors.
Assisting with daily living activities (bathing, feeding).
Providing emotional support and pain management.
2. Health Promotion and Education:
Objective: Promote healthy behaviors and educate children, families, and communities about preventive healthcare.
This includes tasks like:
Administering vaccinations.
Providing education on nutrition, hygiene, and development.
Offering breastfeeding and childbirth support.
Counseling families on safety and injury prevention.
3. Collaboration and Advocacy:
Objective: Collaborate effectively with doctors, social workers, therapists, and other healthcare professionals to ensure coordinated care for children.
Objective: Advocate for the rights and best interests of their patients, especially when children cannot speak for themselves.
This includes tasks like:
Communicating effectively with healthcare teams.
Identifying and addressing potential risks to child welfare.
Educating families about their child's condition and treatment options.
4. Professional Development and Research:
Objective: Stay up-to-date on the latest advancements in pediatric healthcare through continuing education and research.
Objective: Contribute to improving the quality of care for children by participating in research initiatives.
This includes tasks like:
Attending workshops and conferences on pediatric nursing.
Participating in clinical trials related to child health.
Implementing evidence-based practices into their daily routines.
By fulfilling these objectives, pediatric nurses play a crucial role in ensuring the optimal health and well-being of children throughout all stages of their development.
We understand the unique challenges pickleball players face and are committed to helping you stay healthy and active. In this presentation, we’ll explore the three most common pickleball injuries and provide strategies for prevention and treatment.
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Project report on industrial training at albert david ltd.
1. PROJECT REPORT ON INDUSTRIAL TRAINING AT -
SUBMITTED BY:
NEHA ROY
B.PHARM. 3RD
YEAR
SESSION : 2016-20
UNIVERSITYREG.NO. : 161860210059
UNIVERSITYROLL NO. : 18601916080
GURUNANAK INSTITUTE OF PHARMACEUTICAL SCIENCE
AND TECHNOLOGY
2. INDEX
ACKNOWLEDGEMENT
SMALL VOLUME PARENTERALS (SVP)
TABLET
ORAL LIQUIDS
QUALITY CONTROL (QC)
QUALITY ASSURANCE (QA)
REVERSE OSMOSIS (RO) PLANT
RAW MATERIAL STORAGE (RMS)
BULK DRUGS
OINTMENT PREPARATION
CONCLUSION
3. ACKNOWLEDGEMENT
It is a matter of great pleasure and privilege for me to present this
report of six days industrial training. Through this report, I would like
to thank numerous people whose consistent support and guidance
has been the standing pillar in the architecture of this report.
To begin with, I express my sincere gratitude to Dr. Abhijit Sengupta,
Director & Principal of our college, GNIPST. Thanks to Ms. Jeenatara
Begum & Mr. Samrat Bose, Training & Placement Incharge (Asst.
Prof. of GNIPST); Dr. Lopamudra Datta & Dr. Sumana Chatterjee
(HODs); my mentor Dr. Prerona Saha (Dept. of Pharmaceutical
Chemistry, GNIPST) and all other teachers of our college, who gave
me support, encouragement and valuable suggestions throughout
the tenure of my training days.
I would also like to express my sincere thanks to Mr. Partha Adhikari
(Executive HR & Training Coordinator),who provided me with the
opportunity to undergo training at Albert David Limited, Kolkata.
4. SMALL VOLUME PARENTERALS (SVP)
Parenteral dosage forms are intended for administration as
injections or infusions. Common injection types are intravenous (IV),
intramuscular (IM), subcutaneous (SC). Others may include
intraperitoneal (IP), subdural (SD), etc.
The dept. of SVP is concerned with the formulation of parenteral
drugs. They come in 2 forms :
1. AMPOULES : A small scaled glass capsule containing a liquid,
especially measured qty. for injection.
2. VIALS : A vial is a small glass, or plastic vessel, or a small bottle,
often used to store medicament as liquid powder, or capsule.
They can also be scientific sample vessels.
AMPOULES VIALS
RULES TO BE FOLLOWED BEFORE ENTERING INTO THE SVP :
1. Wear shoecap.
2. Wear apron.
3. Do not leave your hair open.
4. Wear hair mask
5. The SVP dept. has 5 floors, thatare divided into 5 working areas :
Clean-up area
Preparation area
Aseptic area
Quarantinearea
Packaging area
GROUND FLOOR :Here, the raw materials & packaging materials are
stored.
1st
FLOOR :
Pre inspection
Visualinspection
Blister packaging
Ampoule & Vial labelling
2nd
FLOOR :
Ampoule filling Sealing Sterilization
3rd
FLOOR :
Multi-distillation column
4th
FLOOR :
Air Handling Unit
Heating Ventilation Air Condition System
Storageof distilled water
Storageof Water For Injection (WFI)
6. WATER DISTILLATIONDEVICE
STEPS FOR PROCESSING OF PARENTERAL :
Cleaningof containers,closures&equipment
Collectionof materials
Preparationof parenteral products
Filtration
Fillingthe preparationinthe final containers
Sealingthe containers
Sterilization
Evaluationof the parenteral preparation
Labelling&Packaging
FORMULATION OFSVP:
Aqueousvehicle:
Types:Purified Water(PW),WFI,Sterile WFI,BacteriostaticWFI
Preparation:Distillation,Ion-Exchange,or Reverse Osmosis
ExceptPW, all are pyrogen-free
Non-Aqueousvehicle:
For purity,safety&biocompatibility
ADVANTAGESOF SVP:
Quickonsetof action
100% bioavailability
Suitable fordrugs thatcannot be administeredorally
Useful duringemergencies
DISADVANTAGESOF SVP :
7. Injectionsmaybe painful and produce redness&swellingonthe administeredsite
Difficulttoreverse administereddrugeffect
9. METHODS FOR MANUFACTURINGOF TABLETS:
1. Dry Granulation
2. Wet Granulation
3. DirectCompression
,
BLISTER PACKAGINGDEVICE–
ADVANTAGESOFTABLET :
Unit dosage formwithaccuracy, stable dose,greatprecisionandleastvariability
Most stable w.r.t.physical,chemical µbiological attributes
Cheapestoral dosage form,easytohandle, attractive andelegantappearance
DISADVANTAGESOFTABLET :
Drugs that are amorphousinnature and have low densitycharacter,are difficultto
compressintotablet
Hygroscopicdrugsare not suitable forcompressedtablets
Drugs that are sensitive tooxygenmayrequirespecialcoating
10. ORAL LIQUID PREPARATION
The BP 1998 & The EP 1997 definedOral Liquidsas,“solutions,emulsions,orsuspensionscontaining
one or more active ingredient(s) inasuitable vehicle”.
Liquidsfororal use may containsuitable antimicrobialpreservatives,antioxidantsandother
excipients,suchasdispersing&suspendingagents.
Oral Solutions:Oral liquidscontainingone ormore active ingredientsdissolvedinasuitable
vehicle.
Oral Suspensions:Containsone ormore active ingredientssuspendedinasuitable vehicle.
Oral Emulsions:Containsone ormore active ingredients;theyare stabilized,oil-in-water
dispersions(o/w),water-in-oil dispersions(w/o),ormultipleemulsions.Solidsmayalsobe
suspendedinOral Emulsions.
Mixtures: Containsone ormore ingredientsdissolved,suspendedordispensedinasuitable
vehicle.Suspendedsolidsmayseparate slowlyonstanding,butare easilyre-dispersedon
shaking.
Oral Drops: These are oral liquidsintendedtobe administeredinsmall volumeswiththe aid
of a suitable measuringdevice.
Elixirs:Elixirsare clear,flavouredoral liquidscontainingone ormore active ingredients
dissolvedinavehicle,thatusuallycontainsahighproportionof sucrose ora suitable
polyhydricalcohol oralcohols,andmaycontainEthanol (96%).Dilute ethanol elixirstendto
be usedfor potentor nauseousdrugs.Althoughethanol isawidelyusedsolventinelixirs,
highconc. may produce a pharmacological effect.Hence,the inclusionof polyhydricalcohols
such as glycerol,propyleneglycol,orsorbitol asco-solvents.
11. EQUIPMENTS USED IN ORAL LIQUID PREPARATION:
Mixingand Storage Tank
Packaging Equipment
12. ADVANTAGES OF ORAL LIQUIDS :
Easiest route of administration
Dosecan be taken in a measured qty.
No nursing is required, i.e., a patient can take the preparation by
himself/herself
DISADVANTAGES OF ORAL LIQUIDS :
Can’t be administered to an unconscious patient
Delayed onset of action
Not suitable in emergency cases
Sometimes the medication itself is the causeof certain problems of the
GIT, which might lead to stomach ulcers
13. QUALITY CONTROL (QC)
The QC dept. is involved in a procedure or a set of procedures, intended to ensure that a
manufactured product or performed service adheres to defined set of quality criteria, or
meets the requirements of the clients or customer. QC is similar to, but not identical to
Quality Assurance (QA), which ensures the quality of the manufactured product as the
standards which are globally accepted.
INSRTUMENTS/EQUIPMENTS PRESENT IN QC :
UV – Visible Spectrophotometer
Solid – Sample Module (SSM – 5000A)
TOC – V cph (Total Organic Carbon Analyser)
HPLC (High Performance Liquid Chromatography)
Liquid Chromatography
Diode Array Detector
Column Oven
Fluorescence Detector
Dissolution Test Detector
Tap Density Detector
High Precision Multichannel Pump
Disintegration Tester
Friabilator (USP)
Cryoscopic Osmometer Printer
KBr Press
KF & pH meter
14. QUALITY ASSURANCE(QA)
QA ensures the quality of the manufactured products as the standards which are globally
accepted.
STEPS INVOLVED IN QA :
HYGIENE
PROPER SANITATION
TRAINING
CALIBRATION
CONTAMINATION CONTROL
VALIDATION
WATER FOR PHARMACEUTICAL USE
ASEPTIC PROCESS CONTROL
MFG. EQUIPMENT
PACKAGING & LABELLING
PRODUCT CODING
RE-WORK & RE-PROCESSING
WAREHOUSING
RETURNED PRODUCT
PRODUCT RECALL
REJECT/SCRAP DISPOSAL
LABORATORY CONTROL
IN-PROCESS CONTROL
DEVIATION PROCEDURE
STABILITY STUDY
DOCUMENTATION
SELF-AUDIT & CONTRACT MFG.
15. REVERSEOSMOSIS (RO) PLANT
RO is a water purification technology that uses a semi-permeable membrane to remove
ions, molecule and large particles from drinking water. In RO, an applied pressure is used to
overcome osmotic pressure, a colligative property.
RO can remove many types of dissolved and suspended particles/species fromwater,
including bacteria, and is used in both, industrial processes and in the production of payable
water.
PROCEDURES :
Raw water sourcebore well (Coarsestrainer)
Pre-treatment (Online coagulant, Polyelectrolyte & Hypochloritedosing)
Pre-treated in 20klHDPETank
Oxidation (Oxidation chamber), Filtration (MGF)
StorageTank (100kl) RCC with epoxy-coated inner walls
SMBS Dosing (T-1001,DP-1001), Softener (T-1002,SOF-1001)
Micron CartridgeFilter (MCF-1101, 5 microns)
RO Feed Tank (T-1101)
ReverseOsmosis (ROM-1101A.B)
RO ProductTank (T-1102)
Mixed Bed Unit (MB-2101) Acid Tank + Caustic Tank
1 micron Cartridge Filter (MCF-2101)
Ultra Filtration (UF-2101-A,B,C)
Purified Water Storage Tank (10kl)
16. RAWMATERIAL STORAGE(RMS)
Generally, the raw materials are materials used in the primary
production or manufacturing of goods and the place, wherethe raw
materials are kept or stored.
STEPS INVOLVED IN RMS :
Receiving
Sampling
Storing
Dispensing
PACKING MATERIAL STORAGE:
Receiving of packing material
Storing of packing material
Issuing of packing material
17. BULK DRUGS
Bulk drugs aresubstances represented for use in the compounding,
manufacturing, processing, or packaging of a drug, that become active
ingredient or finished dosage form of the drug. However, “bulk drug
substance” shallnot include intermediates that are used in the synthesis of
substances.
At the Bulk Drug Dept. of Albert David Limited, Kolkata, the preparation of the
API, Sodium Stibogluconate(SSB) was witnessed.
SSG was prepared via chemical route, where all vessels were in contact with
the final productwhich are made up of Stainless Steel (SS).
STEPS INVOLVED IN THE PREPARATION OF BULKDRUG :
Preparation of sodium antimony tartrate
Preparation of antimony pentoxide
Preparation of antimony gluconate
Purification
Concentration and crystallization
Drying and Pulverisation
Packing and Labelling of finished product
18. OINTMENT
Ointment is a semi-solid preparation that contains an API and other suitable
excipients intended for topical application, or application on skin. Itis
generally, a semi-solid, viscous preparation.
TYPES OF OINTMENTS :
Non-Medicated : These ointments do not contain any drug(s). They may
be used as emollients, protectants. Eg.- Petroleum Jelly.
Medicated : These ointments contain drug(s) which show any local or
systemic effects. They may be of the following types :
Dermatologic Ointments
Ophthalmic Ointments
Vaginal Ointments
Nasal Ointments
TYPES OF OINTMENTBASES :
1. Hydrocarbon Base
2. Absorption Base
3. Water- Removal Base (Cream)
4. Water- Soluble Base (Greaseless Ointment)
PREPARATION OF PHARMACEUTICAL OINTMENT:
19. DISPATCH PROCESS :
Raw material entry
Raw material storageat storageroomat roomtemp.
Charging
In-Processmaterialstorageat storagetank
Tub filling
Hand packing
Master box packing and qyarantine
Defective product
Dispatch
20. CONCLUSION
Although the six days of our training at Albert David Limited, Kolkata flew very
quickly, with the cooperation of the authorities and all the personnel, I have
learnt and gathered a lot, about the pharmaceutical industrial field, which will
be helpful for me all the in many aspects. I am thankfulto the respective
authorities of Albert David Limited, who cordially received us and initiated our
curiosity and interest regarding the relevant subjects. I am pleased with
everyone’s behaviour and way of approach at the industry. Thus, I have
completed my training with great satisfaction, and hope that the feeling is
mutual.
Thank You.