metoclopramide definition and mechanisms

1. Metoclopramide
Name: Sayid Omar Ahmed Abdi
MBBS17A

2. Metoclopramide
Metoclopramide is in a class of
medications called prokinetic agents.
That increases the (movements and
contractions) of the stomach and upper
intestine.
It is used to treat certain stomach
problems, nausea and vomiting caused by
chemotherapy.

3. Metoclopramide And also available
it is available 10mg tablet injection
My be oral solution

4. Mechanism of Action
• Dopamine antagonist Antiemetic
agent
• Stimulates upper GI Antiemetic
properties
tract motility
Accelerated gastric empting Antagonist of
central
and intestinal transit and peripheral
dopamine

5. Uses
Nausea and Vomiting in adult
 Diabetic gastroparesis
 GERD(GastroEsophageal Reflex Disease)
 Prophylaxis of postoperative nausea and vomiting (when
nasogastric suction is undesirable)
 Facilitation of small bowel intubation (Tube doesn't pass
pylorus with conventional maneuvers)

6. Usual Dose
 In adults under 60kg : 15mg/day in 3 divided doses
 In adults over 60kg : 30mg/day in 3 divided doses
 In the interval between each dose should be at least
6Hours

7. Contra-indication
• Patients in whom increase in GI motility could be
harmful:
 GI Hemorrhage
 Mechanical Obstruction
 Perforation Pheochromocytoma
 Epilepsy

8. WARNING
 DO NOT ADMISTER TO GILDREN < 18 YEARS OLD
 REDUCE THE THOSE BY HALF IN PATEINT
IMOAIRMENT
 MONITOER USE IN PATEINT >60 YEARS OLD
 IN PATEINT EPILEPSY OR PARKINSON`S DISEASE

9. • Adverse Effects Precautions
Drowsiness, taken 30m before
meals
Confutation Do not combine with
levodopa Dizziness
(antagonism)
Allergic reaction Avoid combination
with CNS
Neuroleptic Malignant Syndrome
depressants
Extrapyramidal symptoms seizures
(specially in epileptics)

10. Storage
• Store metoclopramide at room temperature. Keep it
between (20°C up to 25°C).