Omeprazole injection is used to suppress gastric acid hypersecretion. It works by inhibiting the proton pump in the stomach. It is indicated for acute gastric ulcer, duodenal ulcer, reflux esophagitis, Zollinger-Ellison syndrome, and preventing acid aspiration where oral medication is not appropriate. For ulcers and reflux esophagitis, the recommended dose is 40 mg once daily. For Zollinger-Ellison syndrome, the initial dose is 60 mg daily and may be increased or divided into twice daily dosing. It is also recommended at 40 mg 1 hour before surgery for acid aspiration prophylaxis.

1. Presentation
on
…an expert to suppress
gastric acid hyper-
secretion
Omeprazole Injection
Biplob Kumar Sarker
B. Pharm, M. Pharm

2. Product Profile
O Brand name: Omex IV Injection
O Generic name: Omeprazole BP
O Pharmacologic class: PPI
O Therapeutic class: Antiulcerant
O Available Strength: 40 mg IV Injection
O M. R. P.: Tk. 87

3. Mechanism of Action

4. Indications
O Acute gastric ulcer
O Duodenal ulcer
O Reflux oesophagitis
O Zollinger-Ellison syndrome
O Prevention of acid aspiration where oral
medication is inappropriate

5. Dosage & Administration
O Duodenal ulcer, gastric ulcer or reflux
oesophagitis: 40 mg once daily is recommended.
O Zollinger-Ellison syndrome: The recommended
initial dose is 60 mg daily. Higher daily doses may be
required and the dose should be adjusted
individually. When doses exceed 60 mg daily, the
dose should be divided and given twice daily.
O For prophylaxis of acid aspiration: 40 mg is
recommended 1 hr. prior to surgery.

6. Key Selling Points
O Emergency treatment option in patient with
GERD & Acute gastric ulcer
O Unique choice in the treatment of Duodenal ulcer
O Effective in H. pylori induced peptic ulcer
O Suitable option for prophylaxis of acid aspiration
O Effectively prevents upper gastrointestinal
bleeding.
O Excellent option for the treatment of Zollinger-
Ellison syndrome

7. Target Doctor
O EMO (Emergency Medical Officer)
O Indoors of Clinics/Hospitals
O GP
O RMP/PC and
O Doctor-Cum-Chemist