Salbutamol is a bronchodilator and tocolytic agent classified as a sympathomimetic and beta2-adrenergic agonist. It is formulated as a racemic mixture and stimulates beta2-adrenergic receptors to increase cAMP and relax smooth muscle in the lungs and uterus. Salbutamol has an oral bioavailability of 50%, half-life of 4 hours, onset of action of 30 minutes when taken orally and 5-15 minutes when inhaled, and duration of action of 8-12 hours. It is metabolized in the liver and excreted in the urine as metabolites and unchanged drug.

2. Drug name (generic):
Salbutabol
Therapeutic class:
Bronchodilator Agent
Adrenergic beta-Agonists
Tocolytic agent
Pharmacological class:
Sympathomimetic (beta2-
adrenergic agonist)

3. Chemical structure:

4. Pregnancy category: C

6. Odour :
Odourless
Solubilty:
Sparingly soluble in water; soluble in ethanol
(96%); slightly soluble in ether.
Colour:
A white or almost white, crystalline powder

8. Salbutamol is formulated as a racemic mixture of the
R- and S-isomers.

9. R-isomer:

11. Salbutamol is a beta(2)-adrenergic agonist and thus it
stimulates beta(2)-adrenergic receptors.
Salbutamol increases cAMP production by activating
adenylate cyclase.
Increased intracellular cyclic AMP increases the
activity of cAMP-dependent protein kinase A, which
inhibits the phosphorylation of myosin and lowers
intracellular calcium concentrations.

12. A lowered intracellular calcium concentration leads to
a smooth muscle relaxation and bronchodilation.
Increased cyclic AMP concentrations are also inhibits
the release of bronchoconstrictor mediators such as
histamine, leukotreine from the mast cells in the
airway.

15. Bioavailability :
oral bioavailability 50%
Half life :
half life is 4 hours
(Taken from rang & dell page 168)
Onset of Action:
oral: 30 minutes, Inhalation : 5-15 minutes
Duration of action :
8 to 12 hours
(page 361 R&D)
Metabolism :
It is subject to first pass metabolism in the
liver

16. Exretion :
Readily excreated in the urine as
metabolite and unchanged drug
Some excreate in faeces.

17. Martindale 35th edition page 1016

19. Female reproductive system
Relaxation of uterus (during
pregnancy)

20. From nurses drug hand book page 37

24. Acute bronchospasm:
1 or 2 inhalation of salbutamol i.e 100 microgram 3 or 4
time daily
Severe attack of bronchospasm:
250 microgram i.v insolution form 10 microgram/ml
Premature labour.
I.V infusion 200 microgram with 5% gluse used for
dilution.

26. Brand name Manufacturer Dosage Forms
Name
Ventoline GSK Injection: 0.5 mg
Syrupe: 60 ml
Tablet : 8 mg
Respoline Munawar pharma Tablet : 2 mg
Aeroline Ankaz Syrupe : 60 , 450 ML
Tablet : 2 , 4 MG
Salbutamol Nawab sons Syrupe : 60 ML
Asmatol Siza Injection : 0.5 MG
Tablets : 4 MG
Ventomol Venus Tablets : 2 & 3 MG

27. Taken from martindale 35th edition page 1016

28. Pharmaguid page # 1159

30. Thank you