6. Odour :
Odourless
Solubilty:
Sparingly soluble in water; soluble in ethanol
(96%); slightly soluble in ether.
Colour:
A white or almost white, crystalline powder
11. Salbutamol is a beta(2)-adrenergic agonist and thus it
stimulates beta(2)-adrenergic receptors.
Salbutamol increases cAMP production by activating
adenylate cyclase.
Increased intracellular cyclic AMP increases the
activity of cAMP-dependent protein kinase A, which
inhibits the phosphorylation of myosin and lowers
intracellular calcium concentrations.
12. A lowered intracellular calcium concentration leads to
a smooth muscle relaxation and bronchodilation.
Increased cyclic AMP concentrations are also inhibits
the release of bronchoconstrictor mediators such as
histamine, leukotreine from the mast cells in the
airway.
13.
14.
15. Bioavailability :
oral bioavailability 50%
Half life :
half life is 4 hours
(Taken from rang & dell page 168)
Onset of Action:
oral: 30 minutes, Inhalation : 5-15 minutes
Duration of action :
8 to 12 hours
(page 361 R&D)
Metabolism :
It is subject to first pass metabolism in the
liver
16. Exretion :
Readily excreated in the urine as
metabolite and unchanged drug
Some excreate in faeces.
24. Acute bronchospasm:
1 or 2 inhalation of salbutamol i.e 100 microgram 3 or 4
time daily
Severe attack of bronchospasm:
250 microgram i.v insolution form 10 microgram/ml
Premature labour.
I.V infusion 200 microgram with 5% gluse used for
dilution.
25.
26. Brand name Manufacturer Dosage Forms
Name
Ventoline GSK Injection: 0.5 mg
Syrupe: 60 ml
Tablet : 8 mg
Respoline Munawar pharma Tablet : 2 mg
Aeroline Ankaz Syrupe : 60 , 450 ML
Tablet : 2 , 4 MG
Salbutamol Nawab sons Syrupe : 60 ML
Asmatol Siza Injection : 0.5 MG
Tablets : 4 MG
Ventomol Venus Tablets : 2 & 3 MG
