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Uploaded byHamza Shaheed(H.S)
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Salbutamol

Salbutamol is a bronchodilator and tocolytic agent classified as a sympathomimetic and beta2-adrenergic agonist. It is formulated as a racemic mixture and stimulates beta2-adrenergic receptors to increase cAMP and relax smooth muscle in the lungs and uterus. Salbutamol has an oral bioavailability of 50%, half-life of 4 hours, onset of action of 30 minutes when taken orally and 5-15 minutes when inhaled, and duration of action of 8-12 hours. It is metabolized in the liver and excreted in the urine as metabolites and unchanged drug.

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Drug name (generic): Salbutabol Therapeutic class: Bronchodilator Agent Adrenergic beta-Agonists Tocolytic agent Pharmacological class: Sympathomimetic (beta2- adrenergic agonist)
Chemical structure:
Pregnancy category: C
Odour : Odourless Solubilty: Sparingly soluble in water; soluble in ethanol (96%); slightly soluble in ether. Colour: A white or almost white, crystalline powder
Salbutamol is formulated as a racemic mixture of the R- and S-isomers.
R-isomer:
Salbutamol is a beta(2)-adrenergic agonist and thus it stimulates beta(2)-adrenergic receptors. Salbutamol increases cAMP production by activating adenylate cyclase. Increased intracellular cyclic AMP increases the activity of cAMP-dependent protein kinase A, which inhibits the phosphorylation of myosin and lowers intracellular calcium concentrations.
A lowered intracellular calcium concentration leads to a smooth muscle relaxation and bronchodilation. Increased cyclic AMP concentrations are also inhibits the release of bronchoconstrictor mediators such as histamine, leukotreine from the mast cells in the airway.
Bioavailability : oral bioavailability 50% Half life : half life is 4 hours (Taken from rang & dell page 168) Onset of Action: oral: 30 minutes, Inhalation : 5-15 minutes Duration of action : 8 to 12 hours (page 361 R&D) Metabolism : It is subject to first pass metabolism in the liver
Exretion : Readily excreated in the urine as metabolite and unchanged drug Some excreate in faeces.
Martindale 35th edition page 1016
Female reproductive system Relaxation of uterus (during pregnancy)
From nurses drug hand book page 37
Acute bronchospasm: 1 or 2 inhalation of salbutamol i.e 100 microgram 3 or 4 time daily Severe attack of bronchospasm: 250 microgram i.v insolution form 10 microgram/ml Premature labour. I.V infusion 200 microgram with 5% gluse used for dilution.
Brand name Manufacturer Dosage Forms Name Ventoline GSK Injection: 0.5 mg Syrupe: 60 ml Tablet : 8 mg Respoline Munawar pharma Tablet : 2 mg Aeroline Ankaz Syrupe : 60 , 450 ML Tablet : 2 , 4 MG Salbutamol Nawab sons Syrupe : 60 ML Asmatol Siza Injection : 0.5 MG Tablets : 4 MG Ventomol Venus Tablets : 2 & 3 MG
Taken from martindale 35th edition page 1016
Pharmaguid page # 1159
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