Albendazole is a broad-spectrum oral anthelmintic agent used primarily for hydatid disease, cysticercosis, and various worm infections, available in tablet and suspension forms. It works by blocking glucose uptake and inhibits microtubule polymerization, with common side effects including gastrointestinal issues and dizziness. Contraindications include hypersensitivity, pregnancy, and severe renal impairment, and it should be stored at room temperature away from light.

1. Albendazole
Presented By :Md. Faysal
Id:151-29-760

2. Albendazole
Generic Name: Albendazole
Dosage Form: Tablet , Suspension
Available Strength: 200 mg, 400 mg/Tablet ,
200mg/5ml suspension.
No. of Manufacturer: Eighty/80
Brand Leader: Eskayef Bangladesh Ltd. (Alben DS)
Group of Drugs: Anti-anthelmintics

3. Introduction
 Albendazole is a broad-spectrum oral anthelmintic agent.
 It is the drug of choice for treatment of hydatid disease and cysticercosis. It is also used in the
treatment of pinworm and hookworm, round worm, whip worm, and thread worm infections.
Mechanism Of Action of albendazole
 Blocks glucose uptake
 Binds with β tubulin & inhibits microtubules polymerization
Side Effects
 Side effects include Epigastric pains,
Diarrhoea,
Dizziness,
Constipation,

4. Contraindication
 Hypersensitivity to Albendazole Tablet is a contraindication. In addition, Albendazole Tablet
should not be used if you have the following conditions: Alcohol
Live vaccines
Pregnancy
Severe renal impairment
 Including prescription and over-the-counter medicines, vitamins, and herbal products.
 Praziquantel
 Cimetidine
Drug Interaction
Storage Condition
Tablet: Store at room temperature and keep away from light.
Keep out of the reach of children.

5. Formulation of Albendazole Tablet
Ingredients Amount Justification
Albendazole 400 mg API
Maize Starch 150 mg Binder
Mannitol 268.9 mg Diluent
Povidone K-30 5 mg Polymer
SLS 4 mg Wetting agent
Sodium Saccharin 4.1 mg Sweetening agent
Croscarmillose Sodium 10 mg Disintegrant
Orange Flavor 5.5 mg Flavor
Magnesium Stearate 2.5 mg Lubricant
Purified Water Q.S
Final weight of tablet = 850 mg API ( Albendazole ) = 400 mg Excipients = 450 mg

6. Method
• The granules are prepared by wet granulation method.
• Albendazole, maize starch, lactose monohydrate, and SLS were loaded into Rapid Mixer to get a
dry mix.
• The above dry mix was granulated with binder solution and dried in the rapid drier at 60C
• the granules were mixed with (CCS), sodium saccharin, orange flavour in a granulator for 10
minutes adding lubricant (MS) and
• Blending and tablet formation by 8 station rotary press tablet compression machine.

7. Required Machineries
 Dispensing ( weight balance)
 Sifter
 Milling equipment(Sieving)
Required Packaging Materials
 Aluminium and PVC blister sheet,
 Paper box,
 Cardboard

8. Product Benefits
 Cheap, available, more potent, safe medication.
 Strength are available for different age as child , adult and old age.
Product Features
 Shape: circular or round shape tablet
 Half life: 8-12 hours
 Shelf life: 5 years
 Solubility: soluble in methanol ,chloroform, ethyl acetate
insoluble in water
 Protein binding: 70%
 Melting point: 208 to 210 °C (406 to 410 °F)