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Omeprazole
This document provides information on the drug Omeprazole including its indications, dosage, administration instructions, drug interactions, and safety. It can be used by healthcare professionals and patients to understand how to safely use Omeprazole to treat conditions like ulcers and gastroesophageal reflux disease. Key details include that Omeprazole is available as capsules, tablets, and suspensions, is usually taken once daily with food, and common side effects include hypomagnesaemia and allergic reactions. Medical advice should be sought for any questions or concerns about use.
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Omeprazole
- 1. Disclaimer “ Use atyour own risk” “This data is not medical advice” “Consult physician and qualified health professional for medical condition ”
- 2. Who Can Use? oInformation can be used by those who need updated and good quality knowledge about medicine. o Healthcare providers, such as doctors, pharmacists or nurses and allied health care professionals to help them prescribe ,dispense and administer medicines safely. o Patients or their care givers, Researchers and General public.
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- 4. Dosage form • Capsule •Tablet • Powder for oral Suspension • Powder for Solution for Infusion Route of Administration • Oral • IV • NG • PEG tubes of size 6 Fr to 16 Fr. Strength • 10mg • 20 mg • 40mg
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- 7. Treatment and Preventionof relapse, duodenal and gastric ulcers. 20mg OD, can be increased to 40mg OD for 2 to 8 weeks depending upon prognosis Treatment and Prevention of NSAID-associated gastric and duodenal ulcers. 20mg OD for 4 weeks depending upon prognosis can be increased to 8 weeks. H. pylori eradication in peptic ulcer in combination with antibiotics. Treatment of reflux oesophagitis 20mg OD for 4 weeks depending upon prognosis can be increased to 8 weeks. Treatment of symptomatic gastro-oesophageal reflux disease 20mg OD x 4 Treatment of Zollinger-Ellison syndrome 60mg OD initial dose 20-120mg OD maintenance dose ( >80mg should be in divided doses).
- 8. Paediatric use Children over1 year of age and ≥10 kg Treatment of reflux esophagitis Symptomatic treatment of heartburn and acid regurgitation in GERD Children and adolescents over 4 years of age In combination with antibiotics in treatment of duodenal ulcer caused by H. pylori When selecting appropriate combination therapy, consideration should be given to official national, regional and local guidance regarding bacterial resistance, duration of treatment (most commonly 7 days but sometimes up to 14 days), and appropriate use of antibacterial agents
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- 10. • •It is recommendedto take Omeprazole capsules or delayed-release capsules in the morning, swallowed whole with half a glass of water. •Omeprazole tablets may be taken with food or on an empty stomach. •Take omeprazole powder for oral suspension on an empty stomach at least 1 hour before a meal. •For patients receiving continuous feeding through a tube, feeding should be temporarily stopped about 3 hours before and 1 hour after administration of omeprazole powder for oral suspension. •The capsules must not be chewed or crushed. For patients with swallowing difficulties and for children who can drink or swallow semi-solid food •Patients can open the capsule and swallow the contents with half a glass of water or after mixing the contents in a slightly acidic fluid e.g., fruit juice or applesauce, or in non-carbonated water. •Patients should be advised that the dispersion should be taken immediately (or within 30 minutes) and always be stirred just before drinking and rinsed down with half a glass of water.
- 11. • •Omeprazole is tobe administered in an intravenous infusion for 20-30 minutes. What if my child is sick (vomits)? •If your child is sick less than 30 minutes after having a dose of omeprazole, give them the same dose again. •If your child is sick more than 30 minutes after having a dose of omeprazole, you do not need to give them another dose. Wait until the next normal dose.
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- 13. Store below 25°C Constitutedsuspension for oral use: 28 days. The constituted suspension should be stored in a refrigerator (2°C - 8°C). For up to 2 days it may be stored below 25°C. Indoor Guidelines for Reconstituted solution: below 25°C. Chemical and physical in-use stability has been demonstrated for 12 hours when dissolved in NaCl 0.9% solution. •For 6 hours in 5% glucose when reconstituted under controlled aseptic conditions and stored at 2-8°C •Chemical and physical in-use stability has also been demonstrated for 24 hours in both NaCl 0.9% solution and 5% glucose. From a microbiological point of view, the product should be used immediately.
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- 15. •Co-administration of atazanavirwith proton pump inhibitors is not recommended. If the combination of atazanavir with a proton pump inhibitor is judged unavoidable, close clinical monitoring (e.g virus load) is recommended in combination with an increase in the dose of atazanavir to 400 mg with 100 mg of ritonavir; omeprazole 20 mg should not be exceeded. •Omeprazole, as all acid-blocking medicines, may reduce the absorption of vitamin B12. •Increased Chromogranin A (CgA) level may interfere with investigations for neuroendocrine tumours. To avoid this interference, omeprazole treatment should be stopped for at least 5 days before CgA measurements. If CgA and gastrin levels have not returned to reference range after initial measurement, measurements should be repeated 14 days after cessation of proton pump inhibitor treatment
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- 17. • If you'repregnant, it's always better to try to treat indigestion without taking a medicine. •Results from three prospective epidemiological studies (more than 1000 exposed outcomes) indicate no adverse effects of omeprazole on pregnancy or on the health of the fetus/newborn child. Omeprazole can be used during pregnancy. •Omeprazole is excreted in breast milk but is not likely to influence the child when therapeutic doses are used.
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- 19. •If you usuallytake it once a day, take the missed dose as soon as you remember, unless it's within 12 hours of your next dose, in which case skip the missed dose. •If you usually take it twice a day, take the missed dose as soon as you remember, unless it's within 4 hours of your next dose, in which case skip the missed dose.
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- 21. Severe hypomagnesaemia hasbeen reported in patients treated with PPIs like omeprazole for at least three months, and in most cases for a year. If your child develops a rash, swelling of the face, lips, tongue or throat, or has difficulty breathing or swallowing, they may be allergic to omeprazole
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- 23. •Hepatic impairment Omeprazole hasnot shown any tendency to accumulate with once daily dosing. Renal impairment The pharmacokinetics are unchanged in patients with reduced renal function. Elderly The metabolism rate of omeprazole is somewhat reduced in elderly subjects (75-79 years of age). Paediatric patients During treatment with the recommended doses to children from the age of 1 year, similar plasma concentrations were obtained as compared to adults.
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- 25. •Treatment, if needed,is symptomatic.
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- 27. • BNF 77(March-September 2019) • Electronic medicines compendium (emc). • Mayo Foundation for Medical Education and Research.(MFMER)©1998-2020. • RxList Inc. Copyright © 2020.