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PHONGTHORN TUNTIVARARUT
POLICE GENERAL HOSPITAL, THAILAND
Obscure GI Bleeding
 Bleeding from the small intestine remains a
relatively uncommon event
~5–10% of all patients presenting with GI bleeding
 Up to 90% of lesions responsible for GI bleeding
are within the reach EGD and colonoscopy
Am J Gastroenterol 2015; 110:1265–1287
Obscure GI Bleeding
Small Bowel Bleeding
Which one??
Obscure GI Bleeding
 Overt obscure bleeding refers to the presence of
hematemesis, melena, or hematochezia
 Occult obscure bleeding occurs in the patients with
positive fecal occult blood test with or without iron-
deficiency anemia
Schwartz's Principles of Surgery, 10ed
Common causes of small
bowel bleeding
Under age 40 years
 Inflammatory bowel disease
 Dieulafoy’s lesions
 Neoplasm
 Meckel’s diverticulum
 Polyposis syndrome
Over age 40 years
 Angiodysplasia
 Dieulafoy’s lesions
 Neoplasm
 NSAID ulcers
Am J Gastroenterol 2015; 110:1265–1287
Rare causes of small bowel
bleeding
 Henoch-Schoenlein purpura
 Small bowel varices in patient with portal HT
 Amyloidosis
 Peutz-Jeghers syndrome
 Kaposi’s sarcoma in HIV patient
 Hemobilia
 Aorto-enteric fistula
Am J Gastroenterol 2015; 110:1265–1287
Management of OGIB
 Initial assessment and resuscitation
 Localization of the bleeding point
 Definitive treatment
Medication
Endoscopic
Intervention
Surgery
Bleeding localization
 Second-look endoscopy or Repeated of EGD and
Colonoscopy are recommended
 Missing lesion can be found ranging from 2 to 25%
in repeated EGD and 6 to 23% on repeated
colonoscopy
Am J Gastroenterol 2015; 110:1265–1287
EGD and Colonoscopy
 During the colonoscopy, every effort should be
made to intubate the terminal ileum
 Instead of repeating EGD, a push enteroscopy may
be performed to examine the distal duodenum and
proximal jejunum
Schwartz's Principles of Surgery, 10ed
Push enteroscopy
 Push enteroscopy : Performed with a long endoscope such as
a pediatric colonoscope or commercial scope
Length of the scope is around 250 cm
 Commercial push enteroscope : 70 cm from ligament of treitz
 Colonoscopy : 45-60 cm distal to ligament of treitz
 Diagnostic yield : 3-70%
Am J Gastroenterol 2015; 110:1265–1287
Subacute ongoing small bowel bleeding
Massive small bowel bleeding
Am J Gastroenterol 2015; 110:1265–1287
Am J Gastroenterol 2015; 110:1265–1287
Schwartz's Principles of Surgery, 10ed
Video Capsule Endoscopy
(VCE)
 First clinical use in US in 2001
 Capsule 26x11 mm with frame rate of 2 frames/sec
 Evaluation of the entire small bowel in 79-90% of patients
 Diagnostic yield in small bowel bleeding : 38-83%
Duration of bleeding, time from bleeding, bleeding amount
World J Gastroenterol 2007 December 14; 13(46): 6140-6149
VCE limitation
 Diagnostic tool
 Inability to control its movement
 Localization difficulty
 Miss duodenal lesion due to rapid transit
 False negative rate : 10-36%
Cannot exclude SB lesion if negative
 Capsule retention
Am J Gastroenterol 2015; 110:1265–1287
Deep Enteroscopy
Deep Enteroscopy
 First described in 2001 by Yamamoto
 Both diagnostic and therapeutic tool
 Diagnostic yield
DBE : 60-80%
SBE : 33%
 Complication : ileus, perforation (overall 1.2%)
Am J Gastroenterol 2015; 110:1265–1287
Spiral enteroscopy
Am J Gastroenterol 2015; 110:1265–1287

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Obscure GI Bleeding

  • 2. Obscure GI Bleeding  Bleeding from the small intestine remains a relatively uncommon event ~5–10% of all patients presenting with GI bleeding  Up to 90% of lesions responsible for GI bleeding are within the reach EGD and colonoscopy Am J Gastroenterol 2015; 110:1265–1287
  • 3. Obscure GI Bleeding Small Bowel Bleeding Which one??
  • 4. Obscure GI Bleeding  Overt obscure bleeding refers to the presence of hematemesis, melena, or hematochezia  Occult obscure bleeding occurs in the patients with positive fecal occult blood test with or without iron- deficiency anemia Schwartz's Principles of Surgery, 10ed
  • 5. Common causes of small bowel bleeding Under age 40 years  Inflammatory bowel disease  Dieulafoy’s lesions  Neoplasm  Meckel’s diverticulum  Polyposis syndrome Over age 40 years  Angiodysplasia  Dieulafoy’s lesions  Neoplasm  NSAID ulcers Am J Gastroenterol 2015; 110:1265–1287
  • 6. Rare causes of small bowel bleeding  Henoch-Schoenlein purpura  Small bowel varices in patient with portal HT  Amyloidosis  Peutz-Jeghers syndrome  Kaposi’s sarcoma in HIV patient  Hemobilia  Aorto-enteric fistula Am J Gastroenterol 2015; 110:1265–1287
  • 7. Management of OGIB  Initial assessment and resuscitation  Localization of the bleeding point  Definitive treatment Medication Endoscopic Intervention Surgery
  • 8. Bleeding localization  Second-look endoscopy or Repeated of EGD and Colonoscopy are recommended  Missing lesion can be found ranging from 2 to 25% in repeated EGD and 6 to 23% on repeated colonoscopy Am J Gastroenterol 2015; 110:1265–1287
  • 9. EGD and Colonoscopy  During the colonoscopy, every effort should be made to intubate the terminal ileum  Instead of repeating EGD, a push enteroscopy may be performed to examine the distal duodenum and proximal jejunum Schwartz's Principles of Surgery, 10ed
  • 10. Push enteroscopy  Push enteroscopy : Performed with a long endoscope such as a pediatric colonoscope or commercial scope Length of the scope is around 250 cm  Commercial push enteroscope : 70 cm from ligament of treitz  Colonoscopy : 45-60 cm distal to ligament of treitz  Diagnostic yield : 3-70% Am J Gastroenterol 2015; 110:1265–1287
  • 11. Subacute ongoing small bowel bleeding Massive small bowel bleeding Am J Gastroenterol 2015; 110:1265–1287
  • 12. Am J Gastroenterol 2015; 110:1265–1287
  • 13. Schwartz's Principles of Surgery, 10ed
  • 14. Video Capsule Endoscopy (VCE)  First clinical use in US in 2001  Capsule 26x11 mm with frame rate of 2 frames/sec  Evaluation of the entire small bowel in 79-90% of patients  Diagnostic yield in small bowel bleeding : 38-83% Duration of bleeding, time from bleeding, bleeding amount World J Gastroenterol 2007 December 14; 13(46): 6140-6149
  • 15. VCE limitation  Diagnostic tool  Inability to control its movement  Localization difficulty  Miss duodenal lesion due to rapid transit  False negative rate : 10-36% Cannot exclude SB lesion if negative  Capsule retention Am J Gastroenterol 2015; 110:1265–1287
  • 16.
  • 18. Deep Enteroscopy  First described in 2001 by Yamamoto  Both diagnostic and therapeutic tool  Diagnostic yield DBE : 60-80% SBE : 33%  Complication : ileus, perforation (overall 1.2%) Am J Gastroenterol 2015; 110:1265–1287
  • 20. Am J Gastroenterol 2015; 110:1265–1287

Editor's Notes

  1. In the past, if no source of bleeding was found after an upper and lower endoscopic evaluation, it is called “Obscure GI Bleeding”
  2. Prevalence : Vascular lesion 24% VS Inflammatory (crohn)16-18% VS Mass 11% Asian พบ neoplastic มากกว่า western ที่พบ angiodysplasia ดูจากการซักประวัติ พอบอกได้ Schwartz Angiodysplasia 75% Neoplasm 10% Meckel in children <30 yr
  3. ประวัติจะ guide ให้ ว่าคิดถึงอะไร
  4. ครั้งแรกอาจจะมีเลือดเยอะ
  5. intubate the terminal ileum to visualize the ileal mucosa and to inspect for blood coming from a more proximal location
  6. Video capsule endoscopy CT enterography
  7. Non-invasive ปัจจัยที่ทำให้ yield เพิ่ม ตรงไปตรงมา
  8. Miss duodenal lesion due to rapid transit ใส่ capsule 2 อัน ช่วย improve ได้ 60%
  9. Overtube