Nucleus: Structure and function
nuclear membrane
nuclear lamins
Nuclear pore complexe
nuclear matrix, composition and its role
cajal bodies
SFCs
nuclear speckles
PML bodies
Nucleolus
RNA is a ribonucleic acid that helps in the synthesis of proteins in our body. This nucleic acid is responsible for the production of new cells in the human body. It is usually obtained from the DNA molecule.
Nucleus” is a Latin word meaning Kernel
It is the “CONTROL CENTER” of the cell
Average diameter of nucleus is 6um, which occupies around 10% of cell volume
Nuclear Envelope
Nuclear Pores and complex
Nuclear lamina
Chromosomes & Chromatin
Nucleolus
Nucleoplasm
Nucleus: Structure and function
nuclear membrane
nuclear lamins
Nuclear pore complexe
nuclear matrix, composition and its role
cajal bodies
SFCs
nuclear speckles
PML bodies
Nucleolus
RNA is a ribonucleic acid that helps in the synthesis of proteins in our body. This nucleic acid is responsible for the production of new cells in the human body. It is usually obtained from the DNA molecule.
Nucleus” is a Latin word meaning Kernel
It is the “CONTROL CENTER” of the cell
Average diameter of nucleus is 6um, which occupies around 10% of cell volume
Nuclear Envelope
Nuclear Pores and complex
Nuclear lamina
Chromosomes & Chromatin
Nucleolus
Nucleoplasm
Details of cytoskeleton element-microtubule. The Microtubule associated protein-type and function, Treadmilling and dynamic instability, Structure of cilia and flagella
Presentation include Nucleus and its components like nuclear envelope, nucleolus, chromatin fibers, ultra structure of nucleus and its general functions.
This ppt explains the different forms of giant chromosomes, polytene and lamp brush chromosomes, its structure and functions. It helps the Genetics, Human genetics and molecular biology, Genetic engineering, Entomology students to learn about the giant chromosomes.
DNA is tightly packed in the nucleus of every cell. DNA wraps around special proteins called histones, which form loops of DNA called nucleosomes. These nucleosomes coil and stack together to form fibers called chromatin. Chromatin in turn forms larger loops and coils to form chromosomes.
DNA packaging is crucial because it makes sure that those excessive DNA are able to fit nicely in a cell that is many times smaller.
The DNA in bacterial cells are either circular or linear. To accommodate the size of bacterial cell, supercoiled DNA are folded into loops with each loop resembles shape of bead-like packets containing small basic proteins that is analogous to histone found in Eukaryotes.
Discovered by an English biologist Robert Brown in 1831.
It is also know as the, “Brain of the cell” or “Control centre of the cell”
On the basis of absence and presence of nucleus cell may be divided into Prokaryotes and Eukaryotes respectively.
NUMBER- Mostly uninucleate
Binucleate – Hepatocytes,Chondryocytes, fungi
Polynucleate- Tapetal cell, myocytes
Anucleated Cell- Red Blood cell
Sieve tube element
Component of Nucleus Nuclear membrane
Nuclear pore
Nucleoplasm
Nucleolus
Chromatin
Nuclear Membrane :Also called the nuclear envelope, is a double membrane layer that separates the contents of the nucleus from the rest of the cell.
The nuclear membrane is a lipid bilayer, meaning that it consists of two layers of lipid molecules.
Outer Layer: The outer layer of lipids has ribosomes, structures that make proteins, on its surface. It is connected to the endoplasmic reticulum.
Inner Membrane: Network of fibers and proteins attached to the inner membrane is called the nuclear lamina. It structurally supports the nucleus, plays a role in repairing DNA, and regulates events in the cell cycle such as cell division and the replication of DNA.
Details of cytoskeleton element-microtubule. The Microtubule associated protein-type and function, Treadmilling and dynamic instability, Structure of cilia and flagella
Presentation include Nucleus and its components like nuclear envelope, nucleolus, chromatin fibers, ultra structure of nucleus and its general functions.
This ppt explains the different forms of giant chromosomes, polytene and lamp brush chromosomes, its structure and functions. It helps the Genetics, Human genetics and molecular biology, Genetic engineering, Entomology students to learn about the giant chromosomes.
DNA is tightly packed in the nucleus of every cell. DNA wraps around special proteins called histones, which form loops of DNA called nucleosomes. These nucleosomes coil and stack together to form fibers called chromatin. Chromatin in turn forms larger loops and coils to form chromosomes.
DNA packaging is crucial because it makes sure that those excessive DNA are able to fit nicely in a cell that is many times smaller.
The DNA in bacterial cells are either circular or linear. To accommodate the size of bacterial cell, supercoiled DNA are folded into loops with each loop resembles shape of bead-like packets containing small basic proteins that is analogous to histone found in Eukaryotes.
Discovered by an English biologist Robert Brown in 1831.
It is also know as the, “Brain of the cell” or “Control centre of the cell”
On the basis of absence and presence of nucleus cell may be divided into Prokaryotes and Eukaryotes respectively.
NUMBER- Mostly uninucleate
Binucleate – Hepatocytes,Chondryocytes, fungi
Polynucleate- Tapetal cell, myocytes
Anucleated Cell- Red Blood cell
Sieve tube element
Component of Nucleus Nuclear membrane
Nuclear pore
Nucleoplasm
Nucleolus
Chromatin
Nuclear Membrane :Also called the nuclear envelope, is a double membrane layer that separates the contents of the nucleus from the rest of the cell.
The nuclear membrane is a lipid bilayer, meaning that it consists of two layers of lipid molecules.
Outer Layer: The outer layer of lipids has ribosomes, structures that make proteins, on its surface. It is connected to the endoplasmic reticulum.
Inner Membrane: Network of fibers and proteins attached to the inner membrane is called the nuclear lamina. It structurally supports the nucleus, plays a role in repairing DNA, and regulates events in the cell cycle such as cell division and the replication of DNA.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
2. WHAT IS NUCLEOPLASM OR
NUCLEAR MATRIX ?
•IT IS A TRANSPARENT SEMI-FLUID
AND COLLOIDAL SUBSTANCE WHICH
FILLS THE NUCLEUS.
•IT CONTAINS THE NUCLEOLUS AND
CHROMATIN.
•SOME OF THE PROTEIN IN
NUCLEOPLASM ARE ESSENTIAL FOR
SPINDLE FORMATION.
3. NUCLEOLUS
• NUCLEOLI ARE SPHERICAL STRUCTURES PRESENT IN THE
NUCLEOPLASM.
• IT IS A NON MEMBRANE BOUND STRUCTURE.
• SITE OF ACTIVE RIBOSOMAL RNA SYNTHESIS.
• NUCLEOLUS STORES NUCLEOPROTEINS.
4. DIFFERENCE BETWEEN
NUCLEOPLASM AND CYTOPLASM
cytoplasm nucleoplasm
• It lies outside the nucleus. • It lies inside the nucleus
• Single membrane envelope • Double membrane envelope.
• Possesses cell organelles • Possesses chromatin , matrix and nucleolus.
• Contains Endomembranes. • Endomembranes are absent
5. CHROMATIN
• NUCLEUS HAS A LOOSE AND INDISTINCT
NETWORK OF NUCLEOPROTEIN FIBRES CALLED
CHROMATIN.
• CHROMATIN OCCURS IN THE FORM OF FINE
OVERLAPPING AND COILED FIBRES WHICH
APPEAR TO PRODUCE A NETWORK CALLED
CHROMATIN RETICULUM.
• CHROMATINS ARE OF TWO TYPES
EUCHROMATIN AND HETERO CHROMATIN.
6. CHROMOSOME
.
• CHROMOSOMES ARE THREAD LIKE
STRUCTURES MADE UP OF DNA AND
HISTONES PROTEINS.
• DURING DIFFERENT STAGES OF CELL
DIVISION, CELLS SHOW STRUCTURED
CHROMOSOMES IN PLACE OF THE
CHROMATIN
• A HUMAN CELL HAS 23 PAIRS OF
CHROMOSOMES.
7. DIFFERENCE BETWEEN CHROMATIN AND
CHROMOSOMES
Chromatin chromosomes
• Uncondensed • Condensed
• Observable in the interphase
nucleus.
• Observable during nuclear
division.
• It is active in controlling
metabolism and other activities
of the cell.
• Chromosomes are mainly
meant for distribution of
genetic information to the
daughter cells.
