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DEFINITIONS
APPROACHES OF
EPIDEMIOLOGY
The study of the distribution and determinants of
health-related states in specified populations, and
the application of this study to control health
problems
Distribution: occurrence of cases by time, place and
person
Eg: according to study of deaths in country X in 2008,
1034 cervical cancer deaths occurred among women
between the ages of 45-54
Determinants: All the causes and risk factors for the
occurrence of a disease, including physical,
biological, social, cultural, and behavioral factors
Eg: Smoking was a risk factor or determinant for the
greater number of cancer deaths among women ages
45-54
Health related states: Diagnosis of specific disease or
cause of death
Eg: according to study of deaths in country X in 2008,
1034 cervical cancer deaths occurred among women
between the ages of 45-54
Specified population: A measurable group, defined by
location, time, demographics, and other characteristics
Eg: women aged 45-54 living in a rural village in country
X from 2001 through 2009

Application: analysis, conclusion, distribution, and timely use of
epidemiologic information to protect the health of the population.
Eg: As a result of the country X study, free cervical cancer
screening programs were implemented. They targeted women
living in remote areas in hopes of finding women with cervical
cancer at an earlier stage of cancer in order to prevent death
Application :

 To measure frequency of disease
 To asses distribution of disease
- who is getting disease?
- where is disease occurring?
- when is disease occuring?
 To form hypotheses about causes and preventive
factors
 To identify determinants of disease
Purpose of epidemiology
Approach/ Consideration Clinical Medicine Epidemiolgy
Focus Individuals populations
Main goal Diagnosis and treatment Prevention and control
Questions What is wrong with this
patient?
What are the leading
causes death or disability
in this population? Risk
factor?
Treatment What treatment is
appropriate?
What can be done to
reduce or prevent disease
or risk factors?
Who is involved? Physician, laboratorian,
nurse, and others
Epidemiologists,
statisticians, and others
from diverse disciplines
Approaches in Medicine vs
Epidemiology

 Descriptive epidemiology
- Studies the pattern of health events and their frequency in
populations in terms of: place, person, time
- Purpose: to identify problems for further study. To plan,
provide and evaluate health services
 Analytic epidemiology
- Studies the association between risk factors and disease
- Purpose: to determine why disease rates are high in a
particular group
Approaches to epidemiology

 Public health surveillance
 Investigation
 Data analysis
 Intervention
 Evaluation
 Communication
 Management and team work
Function of Epidemiology
Not communicable, especially with reference to a disease that is NOT
transmitted through contact with an infected or afflicted person (not infectious)
• Non-communicable diseases (NCDs), also known as chronic diseases.
• Long duration and generally slow progression.
• Random genetic abnormalities, heredity, lifestyle or environment can
cause non-communicable diseases, such as cancer, diabetes, asthma,
hypertension and osteoporosis.
• Autoimmune diseases, trauma, fractures, mental disorders, malnutrition,
poisoning and hormonal conditions are in the category of non-
communicable diseases.
DEFINITION
RTA
CANCER
S
HEART DISEASES DIABETES
MELLITUS
EPILEPSYCHRONIC RESPIRATORY
DISEASES
MENTAL
ILNESSES
CHRONIC KIDNEY
DISEASES
EXAMPLES

Genetic Diseases Environmental Diseases
• Achondroplasia
• Albinism
• Bardet-Biedl syndrome
• Bipolar disorder
• Canavan disease
• Color blindness
• Cystic fibrosis
• Down's syndrome
• Fragile X syndrome
• Galactosemia
• Hemophilia
• Krabbe disease
• Muscular dystrophy
• Neurofibromatosis
• Noonan syndrome
• Osteogenesis
• Patau syndrome
• Sickle-cell disease
• Tay-Sachs disease
• Triple X syndrome
• Turner syndrome
• Usher syndrome
• Von Hippel-Lindau syndrome
• Waardenburg syndrome
• Wilson's disease
• Xeroderma pigmentosum
• Appendicitis
• Anorexia nervosa
• Arteriosclerosis
• Asthma
• Carpal tunnel syndrome
• Chronic obstructive pulmonary
diseases
• Empyema
• Fetal alcohol syndrome
• Glaucoma
• Fibromyalgia
• Hyperthyroidism
• Hypothyroidism
• Irritable Bowel Syndrome
• Liver cirrhosis
• Narcolepsy
• Osteoporosis
• Sudden infant death syndrome
(SIDS)
• Tick paralysis
• Annual Death : 36.25 millions
• 80% of it occurs in low- and middle-
income countries

1. Cardiovascular Disease
(17.3mil.)
2. Cancer (7.6mil.)
3. Respiratory Disease (4.2mil.)
4. Diabetes (1.3mil.)
Death Causes



MAIN CAUSE OF DEATH
IN INDIA
 CARDIOVASCULAR DISEASE
 DIABETES MELLITUS
 CHRONIC OBSTRUCTIVE PULMONARY DISEASE
 CANCER
Top 4 NCD

LUNG CANCER
STOMACH CANCER
COLORECTAL CANCER
LIVER
BREAST CANCER
COMMON CANCER


TOBACCO USE
PHYSICAL INACTIVITY
OVERWEIGHT/OBESITY
HIGH BLOOD PRESSURE
HIGH CHOLESTEROL LEVELS
HIGH BLOOD GLUCOSE LEVELS
LEADING RISKS
FACTOR

 2004 : USD 9.1 Billion out-of-pocket were spent on
test, treatment and medical devices to manage NCD
 2005 : India experienced “highest loss in potentially
productive years of life”
 2006-2015 : the projected cumulative loss of national
income for India due to NCD mortality will be
USD237 billion
WHY?
In Malaysia



 Arthritis was the most common non-communicable disease
(NCD), followed by HBP, diabetes, asthma and CHD.
 Older females were more likely than males to have arthritis
and HBP, but males were more likely to have asthma.
 Diabetes and CHD were most prevalent among Indians, while
arthritis and HBP were most prevalent among the Indigenous
groups.
 Older people were more likely to report poor health if they
suffered from NCD, especially CHD.
 Chinese that had HBP were more likely to report poor health
compared to other ethnic groups with the same disease.
 Among those with arthritis, Indians were more likely to report
poor health.

CARDIOVASCULAR
DISEASE
CANCER
RESPIRATORY
DISEASE
DIABETES
UNINTENTIONAL
INJURIES
Main NCD

RISK
FACTORS
TOBACCO
SMOKING
EXCESSIVE
ALCOHOL
INTAKE
PHYSICAL
INACTIVITY
OBESITY
LIFESTYLE INTERVENTIONS

 Replace saturated & trans – fat with unsaturated fat
 consumption of vegetables, fruits and whole
grains
 sodium intake and excessive calories
HEALTHY DIET


Schools :provide not only good nutrition curricula but also
healthy meals
Workplace : Not only inform about role of physical activity
but also promote use of non-motorized transportation
Mass media : promote healthy lifestyle
Health centres : promote healthy lifestyle etc..

URBAN DESIGN AND
TRANSPORTATION POLICY
Use public and non – motorized transport, more
walking and using bicycle.

NATIONAL
TRANSPORTATION
POLICY
AUTOMOBILE
USE
DEPENDENCY
BAD Low taxes on
gasoline, free parking,
wide street design
QUITE GOOD
Narrow streets,
limited parking, high
gasoline costs
HIGH INCOME
COUNTRIES
BAD Lowering taxes,
simplify registration
procedures, allow
foreign finance
QUITE GOOD
Restrict funding,
down payment 40
to 50 %, high taxes
MIDDLE AND
LOW INCOME
COUNTRIES



POLICY
Fortify foods with micronutrients
Limit advertising for unhealthy foods
Provide incentives for food manufacturers to replace unhealthy ingredients with
healthy ones
Netherlands reduced the
trans fat content of the food
supply from about 6 percent
of the energy content to
approximately 1 percent in a
single decade.
government policies
replaced commonly used
palm oils for cooking with
soybean oil, which reduced
the intake of fatty acids and
lowered serum cholesterol
levels.
MEDICAL INTERVENTION

Type
1
•Insulin
injection
Type
2
•Insulin
injection(severe)
+ change in diet
and lifestyle +
oral glucose
lowering agents
CHALLENGES: Access to insulin very low in African nations
Glycemic control costs less than managing complications that
arises in its absence.
Anticlotting agents (aspirin , heparin) –
prevent venous thromboembolism
Benzathine penicillin injection –
rheumatic fever
ACE inhibitors : For CHF and HT
Anti coagulants : mitral stenosis
and atrial fibrillation
Others



PRIMARY
PREVENTION
•Eliminates exposure to cancer
causing agent
SECONDARY
PREVENTION
•Detecting and treating pre-
cancerous lesions
TREATMENT
•Surgery, Chemotheraphy,
Radiotheraphy
PALLIATIVE
CARE
•Physical and physiological comfort
from diagnosis through death

PRIMARY
Immunizing
against infectious
agents, dietary
interventions,
tobacco control
programs,
reducing excessive
alcohol
consumption,
chemoprophylaxis
SECONDARY
Screening programs
to detect and treat
precursors of cancer
TREATMENT
Surgery, radiation
therapy,
chemotherapy
PALLIATIVE
CARE
End of life care
DEVELOPMENTAL AND
CONGENITAL DISORDERS

Genetic screening and
counselling for couples
Vaccinating against
Hib & Meningitis
(Neurological damage)
+ Rubella vaccine
Readdressing
nutritional deficiencies
among pregnant
women
Screening for
metabolic disorders
(develop neurological
damage after ingesting
certain foods)
Screening for sickle
cell anemia + penicillin
prophylaxis
Screening and
treatment for
congenital
hypothyroidism
Prompt treatment for
cerebral malaria
HEALTH
INTERVENTIONS

Stop alcohol use
during pregnancy
Eliminating
environmental
exposure to
toxins such as Lead
BEHAVIOURAL
INTERVENTION

 Treatment ensues
What if Prevention fails?
•Blood transfusion with washed
RBCThalassemia
•Treat with analgesics if severe
bone pain
•Nutrition, rehabilitation, special
education to reduce impairment
Sickle cell
disease

 Interventions at associated health conditions
 Address environmental constraints on participation
in family and social life
IF BOTH PREVENTION
AND TREATMENT
FAILS..
DOWN SYNDROME
• Therapy for poor vision and hearing
• Congenital heart defect
• Low mental capacity
Wheelchair accessible mass transit, buildings, restrooms
Social support network
Eliminating social stigma, promote inclusiveness
UNINTENTIONAL INJURIES

FIRST
•Manage exposure to
risk
•Substitute safe mode of
transport from more
dangerous one
•Minimize high – risk
scenarios (raise legal
age for riding
motorcycle)
SECOND
•Construct safer roads
•Place speed bumps
•Separate vehicle lanes
from paths used by
pedestrians and
bicycles
•Construct median
barriers
•Provide passing lanes
•Improve street lighting
THIRD
•Encourage people to
adopt safer behaviors
(Education)
•Introduce legislation
and enforce it in
relation to Speed limit,
Blood alcohol level,
wearing helmets..
Interventions
TOBACCO USE

Increase
tobacco
taxes
Disseminate
info about
tobacco’s
health risks
Restrict
smoking in
public
places and
workplaces
Banning
tobacco
advertising
Increase
access to
cessation
therapies
Interventions

ALCOHOL USE
Legislative
measures
and taxes
•Increase alcohol
taxing
•Restricting sales to a
limited number of
licensed retail outlets
Improved
Law
enforcem
ent
•Strict drunk
driving laws
Mass
media
campaigns
•Bans on advertising
alcohol products
•Manufacturers
substitute other
methods of
marketing Eg:
Sponsoring sporting
events
Education
POPULATION
LEVEL
• School based
education about
risks of drinking
alcohol

Educational
sessions
•Discussing
risks of
drinking
alcohol
Psychosocial
counselling
PERSONAL
LEVEL



MENTAL HEALTH

Mental
Health
Depression
Schizophrenia
Bipolar
Disorder
Anxiety
Disorders
Dementias
Epilepsy
Alzheimer's
Disease
Parkinson's
Disease

INTERVENTIONS
Pharmacological
treatment
Psychosocial
therapies
Relieving
symptoms
Easing burden
on Patient’s
family

Pharmacological
Treatment
• Antidepressants
• Antipsychotic
• Antimanic
Psychosocial
therapies
• Cognitive
behavioural
therapy
• Group therapy
Relieving
symptoms
• Eg: Hypertension
in anxiety( give
anti-hypertensives)
Easing burden
on patients
family
• Training caregivers
about proper diet
• Establishing bowel
and bladder habits

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Non-communicable Diseases And Interventions to minimize it

  • 2. The study of the distribution and determinants of health-related states in specified populations, and the application of this study to control health problems
  • 3. Distribution: occurrence of cases by time, place and person Eg: according to study of deaths in country X in 2008, 1034 cervical cancer deaths occurred among women between the ages of 45-54
  • 4. Determinants: All the causes and risk factors for the occurrence of a disease, including physical, biological, social, cultural, and behavioral factors Eg: Smoking was a risk factor or determinant for the greater number of cancer deaths among women ages 45-54
  • 5. Health related states: Diagnosis of specific disease or cause of death Eg: according to study of deaths in country X in 2008, 1034 cervical cancer deaths occurred among women between the ages of 45-54
  • 6. Specified population: A measurable group, defined by location, time, demographics, and other characteristics Eg: women aged 45-54 living in a rural village in country X from 2001 through 2009
  • 7.  Application: analysis, conclusion, distribution, and timely use of epidemiologic information to protect the health of the population. Eg: As a result of the country X study, free cervical cancer screening programs were implemented. They targeted women living in remote areas in hopes of finding women with cervical cancer at an earlier stage of cancer in order to prevent death Application :
  • 8.   To measure frequency of disease  To asses distribution of disease - who is getting disease? - where is disease occurring? - when is disease occuring?  To form hypotheses about causes and preventive factors  To identify determinants of disease Purpose of epidemiology
  • 9. Approach/ Consideration Clinical Medicine Epidemiolgy Focus Individuals populations Main goal Diagnosis and treatment Prevention and control Questions What is wrong with this patient? What are the leading causes death or disability in this population? Risk factor? Treatment What treatment is appropriate? What can be done to reduce or prevent disease or risk factors? Who is involved? Physician, laboratorian, nurse, and others Epidemiologists, statisticians, and others from diverse disciplines Approaches in Medicine vs Epidemiology
  • 10.   Descriptive epidemiology - Studies the pattern of health events and their frequency in populations in terms of: place, person, time - Purpose: to identify problems for further study. To plan, provide and evaluate health services  Analytic epidemiology - Studies the association between risk factors and disease - Purpose: to determine why disease rates are high in a particular group Approaches to epidemiology
  • 11.   Public health surveillance  Investigation  Data analysis  Intervention  Evaluation  Communication  Management and team work Function of Epidemiology
  • 12.
  • 13. Not communicable, especially with reference to a disease that is NOT transmitted through contact with an infected or afflicted person (not infectious) • Non-communicable diseases (NCDs), also known as chronic diseases. • Long duration and generally slow progression. • Random genetic abnormalities, heredity, lifestyle or environment can cause non-communicable diseases, such as cancer, diabetes, asthma, hypertension and osteoporosis. • Autoimmune diseases, trauma, fractures, mental disorders, malnutrition, poisoning and hormonal conditions are in the category of non- communicable diseases. DEFINITION
  • 14. RTA CANCER S HEART DISEASES DIABETES MELLITUS EPILEPSYCHRONIC RESPIRATORY DISEASES MENTAL ILNESSES CHRONIC KIDNEY DISEASES EXAMPLES
  • 15.  Genetic Diseases Environmental Diseases • Achondroplasia • Albinism • Bardet-Biedl syndrome • Bipolar disorder • Canavan disease • Color blindness • Cystic fibrosis • Down's syndrome • Fragile X syndrome • Galactosemia • Hemophilia • Krabbe disease • Muscular dystrophy • Neurofibromatosis • Noonan syndrome • Osteogenesis • Patau syndrome • Sickle-cell disease • Tay-Sachs disease • Triple X syndrome • Turner syndrome • Usher syndrome • Von Hippel-Lindau syndrome • Waardenburg syndrome • Wilson's disease • Xeroderma pigmentosum • Appendicitis • Anorexia nervosa • Arteriosclerosis • Asthma • Carpal tunnel syndrome • Chronic obstructive pulmonary diseases • Empyema • Fetal alcohol syndrome • Glaucoma • Fibromyalgia • Hyperthyroidism • Hypothyroidism • Irritable Bowel Syndrome • Liver cirrhosis • Narcolepsy • Osteoporosis • Sudden infant death syndrome (SIDS) • Tick paralysis
  • 16. • Annual Death : 36.25 millions • 80% of it occurs in low- and middle- income countries
  • 17.  1. Cardiovascular Disease (17.3mil.) 2. Cancer (7.6mil.) 3. Respiratory Disease (4.2mil.) 4. Diabetes (1.3mil.) Death Causes
  • 18.
  • 19.
  • 20.
  • 21.  MAIN CAUSE OF DEATH IN INDIA
  • 22.  CARDIOVASCULAR DISEASE  DIABETES MELLITUS  CHRONIC OBSTRUCTIVE PULMONARY DISEASE  CANCER Top 4 NCD
  • 23.  LUNG CANCER STOMACH CANCER COLORECTAL CANCER LIVER BREAST CANCER COMMON CANCER
  • 24.
  • 25.  TOBACCO USE PHYSICAL INACTIVITY OVERWEIGHT/OBESITY HIGH BLOOD PRESSURE HIGH CHOLESTEROL LEVELS HIGH BLOOD GLUCOSE LEVELS LEADING RISKS FACTOR
  • 26.   2004 : USD 9.1 Billion out-of-pocket were spent on test, treatment and medical devices to manage NCD  2005 : India experienced “highest loss in potentially productive years of life”  2006-2015 : the projected cumulative loss of national income for India due to NCD mortality will be USD237 billion WHY?
  • 28.
  • 29.
  • 30.   Arthritis was the most common non-communicable disease (NCD), followed by HBP, diabetes, asthma and CHD.  Older females were more likely than males to have arthritis and HBP, but males were more likely to have asthma.  Diabetes and CHD were most prevalent among Indians, while arthritis and HBP were most prevalent among the Indigenous groups.  Older people were more likely to report poor health if they suffered from NCD, especially CHD.  Chinese that had HBP were more likely to report poor health compared to other ethnic groups with the same disease.  Among those with arthritis, Indians were more likely to report poor health.
  • 31.
  • 34.
  • 36.   Replace saturated & trans – fat with unsaturated fat  consumption of vegetables, fruits and whole grains  sodium intake and excessive calories HEALTHY DIET
  • 37.
  • 38.  Schools :provide not only good nutrition curricula but also healthy meals Workplace : Not only inform about role of physical activity but also promote use of non-motorized transportation Mass media : promote healthy lifestyle Health centres : promote healthy lifestyle etc..
  • 39.  URBAN DESIGN AND TRANSPORTATION POLICY Use public and non – motorized transport, more walking and using bicycle.
  • 40.  NATIONAL TRANSPORTATION POLICY AUTOMOBILE USE DEPENDENCY BAD Low taxes on gasoline, free parking, wide street design QUITE GOOD Narrow streets, limited parking, high gasoline costs HIGH INCOME COUNTRIES BAD Lowering taxes, simplify registration procedures, allow foreign finance QUITE GOOD Restrict funding, down payment 40 to 50 %, high taxes MIDDLE AND LOW INCOME COUNTRIES
  • 41.
  • 42.
  • 43.  POLICY Fortify foods with micronutrients Limit advertising for unhealthy foods Provide incentives for food manufacturers to replace unhealthy ingredients with healthy ones Netherlands reduced the trans fat content of the food supply from about 6 percent of the energy content to approximately 1 percent in a single decade. government policies replaced commonly used palm oils for cooking with soybean oil, which reduced the intake of fatty acids and lowered serum cholesterol levels.
  • 45.  Type 1 •Insulin injection Type 2 •Insulin injection(severe) + change in diet and lifestyle + oral glucose lowering agents CHALLENGES: Access to insulin very low in African nations Glycemic control costs less than managing complications that arises in its absence.
  • 46. Anticlotting agents (aspirin , heparin) – prevent venous thromboembolism Benzathine penicillin injection – rheumatic fever ACE inhibitors : For CHF and HT Anti coagulants : mitral stenosis and atrial fibrillation Others
  • 47.
  • 48.
  • 49.  PRIMARY PREVENTION •Eliminates exposure to cancer causing agent SECONDARY PREVENTION •Detecting and treating pre- cancerous lesions TREATMENT •Surgery, Chemotheraphy, Radiotheraphy PALLIATIVE CARE •Physical and physiological comfort from diagnosis through death
  • 50.  PRIMARY Immunizing against infectious agents, dietary interventions, tobacco control programs, reducing excessive alcohol consumption, chemoprophylaxis SECONDARY Screening programs to detect and treat precursors of cancer TREATMENT Surgery, radiation therapy, chemotherapy PALLIATIVE CARE End of life care
  • 52.  Genetic screening and counselling for couples Vaccinating against Hib & Meningitis (Neurological damage) + Rubella vaccine Readdressing nutritional deficiencies among pregnant women Screening for metabolic disorders (develop neurological damage after ingesting certain foods) Screening for sickle cell anemia + penicillin prophylaxis Screening and treatment for congenital hypothyroidism Prompt treatment for cerebral malaria HEALTH INTERVENTIONS
  • 53.  Stop alcohol use during pregnancy Eliminating environmental exposure to toxins such as Lead BEHAVIOURAL INTERVENTION
  • 54.   Treatment ensues What if Prevention fails? •Blood transfusion with washed RBCThalassemia •Treat with analgesics if severe bone pain •Nutrition, rehabilitation, special education to reduce impairment Sickle cell disease
  • 55.   Interventions at associated health conditions  Address environmental constraints on participation in family and social life IF BOTH PREVENTION AND TREATMENT FAILS.. DOWN SYNDROME • Therapy for poor vision and hearing • Congenital heart defect • Low mental capacity Wheelchair accessible mass transit, buildings, restrooms Social support network Eliminating social stigma, promote inclusiveness
  • 57.  FIRST •Manage exposure to risk •Substitute safe mode of transport from more dangerous one •Minimize high – risk scenarios (raise legal age for riding motorcycle) SECOND •Construct safer roads •Place speed bumps •Separate vehicle lanes from paths used by pedestrians and bicycles •Construct median barriers •Provide passing lanes •Improve street lighting THIRD •Encourage people to adopt safer behaviors (Education) •Introduce legislation and enforce it in relation to Speed limit, Blood alcohol level, wearing helmets.. Interventions
  • 59.  Increase tobacco taxes Disseminate info about tobacco’s health risks Restrict smoking in public places and workplaces Banning tobacco advertising Increase access to cessation therapies Interventions
  • 60.
  • 62. Legislative measures and taxes •Increase alcohol taxing •Restricting sales to a limited number of licensed retail outlets Improved Law enforcem ent •Strict drunk driving laws Mass media campaigns •Bans on advertising alcohol products •Manufacturers substitute other methods of marketing Eg: Sponsoring sporting events Education POPULATION LEVEL • School based education about risks of drinking alcohol
  • 64.
  • 65.
  • 66.
  • 70.  Pharmacological Treatment • Antidepressants • Antipsychotic • Antimanic Psychosocial therapies • Cognitive behavioural therapy • Group therapy Relieving symptoms • Eg: Hypertension in anxiety( give anti-hypertensives) Easing burden on patients family • Training caregivers about proper diet • Establishing bowel and bladder habits