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Tropenklinik,
Tuebingen-Germany
EPN FORUM 2016
Plenary 2
General Overview of epidemiology
and priority Non-Communicable
Diseases (NCDs) in Church Health
Institutions (CHIs)
MBChB, MSc Clinical Epidemiology
Chidzewere Nzou
Programme Manager
Zimbabwe Association of Church
related Hospitals (ZACH)
Email: nzou@zach.org.zw
Presentation Outline…
1. Definition of Non-Communicable Disease (NCD)
2. Approaches: Medicine vs Epidemiology
3. Risk factors and priority NCDs in CHIs
4. Global NCDs burden and measurements
Definition of Non-
Communicable Disease (NCD)
PART ONE
A disease that has a prolonged course,
that does not resolve spontaneously, and
for which a complete cure is rarely
achieved
(McKenna, et al, 1998)
N.B Do not result from an (acute)
infectious process and hence are ‘not
communicable’
Extended Definition:
In some definitions, NCDs also include:
• chronic mental diseases and
• injuries, which have an acute onset, but
may be followed by prolonged
convalescence and impaired function.
Characteristics of NCDs
●Multiple risk factors
●Complex etiology (causes)
●Long latency period
●Non-contagious origin (non-communicable)
●Prolonged course of illness
●Functional impairment or disability
●Incurability
Approaches: Medicine
vs Epidemiology
PART TWO
Risk Factors and
Priority NCDs in CHIs
PART THREE
Risk Factor
“An aspect of personal behavior or
lifestyle, an environmental exposure, or
an inborn or inherited characteristic that
is associated with an increased
occurrence of disease or other health-
related event or condition”
Cardiovascular
Major modifiable risk factors
- High blood pressure
- Abnormal blood lipids
- Tobacco use
- Physical inactivity
- Obesity
- Unhealthy diet (salt)
- Diabetes
Other modifiable risk factors
- Low socioeconomic status
- Mental ill health (depression)
- Psychosocial stress
- Heavy alcohol use
- Use of certain medication
- Lipoprotein(a)
Non-modifiable risk factors
- Age
- Heredity or family history
- Gender
- Ethnicity or race
“Novel” risk factors
- Excess homocysteine in blood
- Inflammatory markers (C-reactive
protein)
- Abnormal blood coagulation (elevated
blood levels of fibrinogen)
Diabetes
Major modifiable Risk Factors
- Unhealthy diets
- Physical Inactivity
- Obesity or Overweight
- High Blood Pressure
- High Cholesterol
Other Modifiable Risk Factors
- Low socioeconomic status
- Heavy alcohol use
- Psychological stress
- High consumption of sugar-
sweetened beverages
- Low consumption of fiber
Non-modifiable Risk Factors
- Increased age
- Family history/genetics
- Race
- Distribution of fat
Other Risk Factors
- Low birth weight
- Presence of autoantibodies
Cancers
Cancer type Risk Factors
Cervical Cancer • Human papilloma virus infection (HPV)
• Smoking
• Immune Deficiencies
• No access to PAP screening
• Family history of cervical cancer
Lung Cancer • Smoking pipes or cigars now or in the past
• Second-hand smoke
• Radiation therapy to the breast or chest
• Being exposed to 1) asbestos 2) radon 3) chromium 4)
nickel 5) arsenic 6) soot or 7) tar
• Air pollution
Cancer type Risk Factors
Breast Cancer • Hormone therapies, Weight, physical activity, Genetics or
family history
• Age is the most reliable risk factor
‒Risk increases with age
Prostate Cancer • age , obesity, weight gain
Liver cancer • Chronic hepatitis infections and Cirrhosis
• Diabetes
• Heavy alcohol consumption
• Obesity
Cancer type Risk Factors
Colorectal cancer ‒Aging and Black race
‒Unhealthy diet and low exercise
‒Diabetes
‒Family history of colorectal cancer
Stomach Cancer • Smoking
• Family history of stomach cancer
• Helicobacter pylori infections and ulcers or polyps
• Diet
‒ High salt foods
‒ smoked foods
‒ pickled foods
Cancer Pictures
Chronic respiratory diseases
Genes
Infections
Socio-economic
status
Aging
Populations
Priority NCDs and common Risk Factors
Global NCDs burden and
measurements
PART FOUR
Global Trends Causes of Deaths
0
5
10
15
20
25
30
2004 2015 2030 2004 2015 2030 2004 2015 2030
Deaths(millions)
High income Middle income Low income
HIV, TB, malaria
Other infectious
Mat//peri/nutritiona
l
CVD
Cancers
Other NCDs
Road traffic accidents
Other unintentional
Intentional injuries
27
Epidemiological Shift:
A transition from predominance of infectious diseases to
chronic, degenerative, or man-made diseases and relates
well to demographic shift
Global Health Observatory (GHO) http://www.who.int/gho/en/
Provides data and analyses on global health priorities
• Noncommunicable diseases
• Mortality/morbidity
• Risk Factors
• Country statistics and health data
Media centre fact sheets http://www.who.int/mediacentre/factsheets/en/
• Key facts
• Symptoms
• Risk factors
• Burden of disease
Incidence Rate- The development of new cases of a disease that occur
during a specified period of time in previously disease-free or
condition-free (“at risk”) individuals per 100,000 people
Cumulative incidence- PROPORTION of individuals who become
diseased during a specified period of time Range: 0 to 1.0
Prevalence- The number of existing cases divided by the population
count. Measured at a point in time rather than over some interval
Typically shown as a percentage
Mortality/Crude mortality- Number of deaths in a given time or place
Measurements of disease burden
Years of life lost (YLL)
Measures the years of life lost due to
premature mortality
Years of life with disability (YLD)
Measures years of healthy life lost due to
living in states of less than full health
Disability-Adjusted Life Year (DALY)
Represents the total number of years lost to illness,
disability (health utility), or premature death
within a given population
Quality-Adjusted Life Year (QALY)
Gives us an idea of how many extra months or
years of life of reasonable quality a person might
gain as result of treatment
Example- DALYs
Example
Mortality DALYS
%
1. High blood pressure 12.8
2. Tobacco use 8.7
3. High blood glucose 5.8
4. Physical inactivity 5.5
5. Overweight and obesity 4.8
6. High cholesterol 4.5
7. Unsafe sex 4.0
8. Alcohol use 3.8
9. Childhood underweight 3.8
10. Indoor smoke from solid fuels 3.3
59 million total global deaths in 2004
%
1. Childhood underweight 7.8
2. High blood pressure 7.5
3. Unsafe sex 6.6
4. Unsafe water, sanitation, hygiene 6.1
5. High blood glucose 4.9
6. Indoor smoke from solid fuels 4.8
7. Tobacco use 3.9
8. Physical inactivity 3.8
9. Suboptimal breastfeeding 3.7
10. High cholesterol 3.3
1.5 billion total global DALYs in 2004
THANK YOU!

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Dr C Nzou General Overview of epidemiology and priority NCDs in CHIs -C Nzou

  • 2. Plenary 2 General Overview of epidemiology and priority Non-Communicable Diseases (NCDs) in Church Health Institutions (CHIs)
  • 3. MBChB, MSc Clinical Epidemiology Chidzewere Nzou Programme Manager Zimbabwe Association of Church related Hospitals (ZACH) Email: nzou@zach.org.zw
  • 4. Presentation Outline… 1. Definition of Non-Communicable Disease (NCD) 2. Approaches: Medicine vs Epidemiology 3. Risk factors and priority NCDs in CHIs 4. Global NCDs burden and measurements
  • 5. Definition of Non- Communicable Disease (NCD) PART ONE
  • 6. A disease that has a prolonged course, that does not resolve spontaneously, and for which a complete cure is rarely achieved (McKenna, et al, 1998) N.B Do not result from an (acute) infectious process and hence are ‘not communicable’
  • 7. Extended Definition: In some definitions, NCDs also include: • chronic mental diseases and • injuries, which have an acute onset, but may be followed by prolonged convalescence and impaired function.
  • 8. Characteristics of NCDs ●Multiple risk factors ●Complex etiology (causes) ●Long latency period ●Non-contagious origin (non-communicable) ●Prolonged course of illness ●Functional impairment or disability ●Incurability
  • 10.
  • 11. Risk Factors and Priority NCDs in CHIs PART THREE
  • 12. Risk Factor “An aspect of personal behavior or lifestyle, an environmental exposure, or an inborn or inherited characteristic that is associated with an increased occurrence of disease or other health- related event or condition”
  • 13. Cardiovascular Major modifiable risk factors - High blood pressure - Abnormal blood lipids - Tobacco use - Physical inactivity - Obesity - Unhealthy diet (salt) - Diabetes Other modifiable risk factors - Low socioeconomic status - Mental ill health (depression) - Psychosocial stress - Heavy alcohol use - Use of certain medication - Lipoprotein(a) Non-modifiable risk factors - Age - Heredity or family history - Gender - Ethnicity or race “Novel” risk factors - Excess homocysteine in blood - Inflammatory markers (C-reactive protein) - Abnormal blood coagulation (elevated blood levels of fibrinogen)
  • 14.
  • 15. Diabetes Major modifiable Risk Factors - Unhealthy diets - Physical Inactivity - Obesity or Overweight - High Blood Pressure - High Cholesterol Other Modifiable Risk Factors - Low socioeconomic status - Heavy alcohol use - Psychological stress - High consumption of sugar- sweetened beverages - Low consumption of fiber Non-modifiable Risk Factors - Increased age - Family history/genetics - Race - Distribution of fat Other Risk Factors - Low birth weight - Presence of autoantibodies
  • 16.
  • 18. Cancer type Risk Factors Cervical Cancer • Human papilloma virus infection (HPV) • Smoking • Immune Deficiencies • No access to PAP screening • Family history of cervical cancer Lung Cancer • Smoking pipes or cigars now or in the past • Second-hand smoke • Radiation therapy to the breast or chest • Being exposed to 1) asbestos 2) radon 3) chromium 4) nickel 5) arsenic 6) soot or 7) tar • Air pollution
  • 19. Cancer type Risk Factors Breast Cancer • Hormone therapies, Weight, physical activity, Genetics or family history • Age is the most reliable risk factor ‒Risk increases with age Prostate Cancer • age , obesity, weight gain Liver cancer • Chronic hepatitis infections and Cirrhosis • Diabetes • Heavy alcohol consumption • Obesity
  • 20. Cancer type Risk Factors Colorectal cancer ‒Aging and Black race ‒Unhealthy diet and low exercise ‒Diabetes ‒Family history of colorectal cancer Stomach Cancer • Smoking • Family history of stomach cancer • Helicobacter pylori infections and ulcers or polyps • Diet ‒ High salt foods ‒ smoked foods ‒ pickled foods
  • 23.
  • 24. Priority NCDs and common Risk Factors
  • 25. Global NCDs burden and measurements PART FOUR
  • 26. Global Trends Causes of Deaths 0 5 10 15 20 25 30 2004 2015 2030 2004 2015 2030 2004 2015 2030 Deaths(millions) High income Middle income Low income HIV, TB, malaria Other infectious Mat//peri/nutritiona l CVD Cancers Other NCDs Road traffic accidents Other unintentional Intentional injuries
  • 27. 27 Epidemiological Shift: A transition from predominance of infectious diseases to chronic, degenerative, or man-made diseases and relates well to demographic shift
  • 28. Global Health Observatory (GHO) http://www.who.int/gho/en/ Provides data and analyses on global health priorities • Noncommunicable diseases • Mortality/morbidity • Risk Factors • Country statistics and health data Media centre fact sheets http://www.who.int/mediacentre/factsheets/en/ • Key facts • Symptoms • Risk factors • Burden of disease
  • 29. Incidence Rate- The development of new cases of a disease that occur during a specified period of time in previously disease-free or condition-free (“at risk”) individuals per 100,000 people Cumulative incidence- PROPORTION of individuals who become diseased during a specified period of time Range: 0 to 1.0 Prevalence- The number of existing cases divided by the population count. Measured at a point in time rather than over some interval Typically shown as a percentage Mortality/Crude mortality- Number of deaths in a given time or place
  • 31. Years of life lost (YLL) Measures the years of life lost due to premature mortality Years of life with disability (YLD) Measures years of healthy life lost due to living in states of less than full health
  • 32. Disability-Adjusted Life Year (DALY) Represents the total number of years lost to illness, disability (health utility), or premature death within a given population Quality-Adjusted Life Year (QALY) Gives us an idea of how many extra months or years of life of reasonable quality a person might gain as result of treatment
  • 34. Example Mortality DALYS % 1. High blood pressure 12.8 2. Tobacco use 8.7 3. High blood glucose 5.8 4. Physical inactivity 5.5 5. Overweight and obesity 4.8 6. High cholesterol 4.5 7. Unsafe sex 4.0 8. Alcohol use 3.8 9. Childhood underweight 3.8 10. Indoor smoke from solid fuels 3.3 59 million total global deaths in 2004 % 1. Childhood underweight 7.8 2. High blood pressure 7.5 3. Unsafe sex 6.6 4. Unsafe water, sanitation, hygiene 6.1 5. High blood glucose 4.9 6. Indoor smoke from solid fuels 4.8 7. Tobacco use 3.9 8. Physical inactivity 3.8 9. Suboptimal breastfeeding 3.7 10. High cholesterol 3.3 1.5 billion total global DALYs in 2004
  • 35.

Editor's Notes

  1. Explain that the 2002 World Health Report showed communicable diseases, maternal and perinatal and nutritional deficiencies at 42% and NCDs and injuries at approx. 57%. According to this graph, by 2020, communicable will decrease to approx. 32% and NCDs and injuries will increase to 67% (2 min)