The document discusses the role and types of non-ionic surfactants in pharmaceutical product development, focusing on their mechanism of action, classification, and applications. It details various surfactants like castor oil ethoxylates and fatty alcohol ethoxylates, emphasizing their use as emulsifiers and solubilizing agents across different industries including cosmetics and pharmaceuticals. The document highlights the importance of these surfactants in enhancing product formulations by reducing surface tension and improving compatibility of immiscible materials.

1. Pharmaceutical Product
Development
Non-ionic Surfactants & Their Applications
By
Kaushal Kumar

2. TABLE OF CONTENTS
01 02 03 04
Overview Mechanism Classification Application

3. surfactant, also called surface-active agent,
substance such as a detergent that, when added to
a liquid, reduces its surface tension, thereby
increasing its spreading and wetting properties.
Surfactants are termed as surface-active agents also
wetting agents, emulsifying agents or suspending
agents depending on its properties and use.
Surfactants : Surfactants are compounds that lower
the surface tension between two liquids, between a
gas & liquids, or between a liquid & a solid.
INTRODUCTION

4. Mechanism Of Action
Roll-up mechanism : The surfactant lowers the oil/solution & fabric/solution interfacial tension
and in this way lifts the stain of the fabric.
Emulsification : The surfactants lowers the oil solution interfacial tension and makes easy
emulsification of the oil.
Solubilization : Interaction with the micelles of a surfactant in a solvent a substance dissolve to
form a stable & clear solution.

5. Classification
☺Non-ionic
☺Amphoteric
☺Cationic
☺Anionic
Surfactants

6. R
Classification Of Surfactants
Cationic surfactants are quaternary
Ammonium compounds & they are
widely used for their disinfectant &
preservative properties as they have
good bactericidal properties. They are
used on skin for cleansing wounds or
burn.
These surfactants have excellent
dermatological properties. They
are frequently used in shampoos
& other cosmetic products, also in
handwashing liquids because of
their high foaming properties.
These surfactants have polar
head groups that are not electrically
charged. Nonionic surfactants have
covalently bonded oxygen-containing
hydrophilic groups, which are bonded to
hydrophobic parent structures. These
surfactants, are not ionized in water, and
contain both hydrophilic groups.
These surfactants are the most
widely used type of surfactants for
preparing shampoos because of
its excellent properties and high
hair conditioning effects.

7. Application
Caster Oil Ethoxylates
Castor oil ethoxylates capable of mixing immiscible materials like oil and
water. These are non-ionic surfactants which are widely used in oral,
topical & pharmaceutical formulations. They can be used as emulsifying
or solubilizing agent as well and suitable for the production of Aqueous
liquid preparations.
In Cosmetics -
Used as solubilizing agents for the perfume bases & Hand lotions.
Castor oil has Pale yellow viscous liquid. The most important property of
castor oil ethoxylates is that it has many uses both in soap production and
as antistatic and antibacterial surfactant.

8. Application
Alkylphenol Ethoxylate
Alkylphenol ethoxylates are nonionic surfactants, consisting of branched-
chain alkylphenols.
Used As -
Used as emulsifiers for polymerization.
Production of lubricating oil additives.
Laundry & dish detergents.
Emulsifiers & Solubilizers.
Pesticides formulations.
Personal care products, especially hair products.

9. Application
Fatty Alcohol Ethoxylates
These Non-ionic Surfactants contain both hydrophobic tail portion and
hydrophilic polar head groups. Therefore, they tend to dissolve in both
aqueous and oil phase reducing the surface tension of liquids.
Used As -
Emulsifiers & in emulsifier blend formations.
Wetting, Printing & Dye leveling Agent (Textile Industries)
Detergents & Solubilizers textile processing.
Emulsifiers in agrochemicals.
Production of lubricating oil additives.
Anti-corrosion agents in oil& gas
Sanitizers, dispersants, stabilizers, and anti-foaming agents.

10. Application
Fatty Amines Ethoxylates
Alcohol ethoxylates are a class of non-ionic surfactants that contain a
hydrophobic alkyl chain attached via an ether linkage to a hydrophilic
ethylene oxide chain.
Used As -
►Textile & cosmetics industries
Emulsifying & Solubilizing agents
►Cosmetics, agriculture, textile & other
Wetting & cleansing agents
►Personal Care
Cream base & foaming agent
►Washing
Detergent

11. THANKS!
Do you have any questions?
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