This document discusses techniques for vitreous surgery using 25G instruments. It describes how bimanual 25G vitrectomy allows for simultaneous control of two instruments with better visual control compared to single hand vitrectomy. The techniques emphasized include lifting and cutting membranes under direct visualization, simultaneous fluid-air-silicone oil exchange, soft tip evacuation to control hemorrhage, and peripheral laser treatment. The author reports results from 142 cases using these 25G bimanual techniques showing 35% fewer iatrogenic tears, 50% better vision after silicone oil removal, and 40% less early rebleeding compared to earlier cases using single hand 25G vitrectomy.