Hello Guys,
This presentation consists of the updated guidelines under National tuberculosis elimination programme of India (MOHFW). The presentation includes case definitions and diagnostic algorithms for Pulmonary, Extrapulmonary and Drug resistant TB(MDR/ XDR TB) and the tratment protocols in pediatric cases.
Hope you find it useful.
Hello Guys,
This presentation consists of the updated guidelines under National tuberculosis elimination programme of India (MOHFW). The presentation includes case definitions and diagnostic algorithms for Pulmonary, Extrapulmonary and Drug resistant TB(MDR/ XDR TB) and the tratment protocols in pediatric cases.
Hope you find it useful.
National Vector Borne Disease Control Programme (NVBDCP)Vivek Varat
The National Vector Borne Disease Control Programme (NVBDCP) is an umbrella programme for prevention and control of malaria and other vector borne diseases. Under the programme, it is ensured that the disadvantaged and marginalised sections benefit from the delivery of services so that the desired National Health Policy and Rural Health Mission goals are achieved. The Directorate of NVBDCP under the Directorate General of Health Services, Ministry of Health and Family Welfare, Government of India, is the nodal agency responsible for planning, coordination, implementation, monitoring and evaluation of NVBDCP programme at all levels.
WORLD TUBERCULOSIS DAY 2023 AWARENESS.pptxanjalatchi
World TB Day 2023, with the theme 'Yes! We can end TB!', aims to inspire hope and encourage high-level leadership, increased investments, faster uptake of new WHO recommendations, adoption of innovations, accelerated action, and multisectoral collaboration to combat the TB epidemic.
Adolescent Friendly Health Service is a service provided by health institutions that focuses on the welfare of adolescents (10-19 years of age) through the guidance on how to maximize the use of health care services in the adolescents.
Samundratar Health Post, Nuwakot is providing AFHS with its limited resources given.
National Vector Borne Disease Control Programme (NVBDCP)Vivek Varat
The National Vector Borne Disease Control Programme (NVBDCP) is an umbrella programme for prevention and control of malaria and other vector borne diseases. Under the programme, it is ensured that the disadvantaged and marginalised sections benefit from the delivery of services so that the desired National Health Policy and Rural Health Mission goals are achieved. The Directorate of NVBDCP under the Directorate General of Health Services, Ministry of Health and Family Welfare, Government of India, is the nodal agency responsible for planning, coordination, implementation, monitoring and evaluation of NVBDCP programme at all levels.
WORLD TUBERCULOSIS DAY 2023 AWARENESS.pptxanjalatchi
World TB Day 2023, with the theme 'Yes! We can end TB!', aims to inspire hope and encourage high-level leadership, increased investments, faster uptake of new WHO recommendations, adoption of innovations, accelerated action, and multisectoral collaboration to combat the TB epidemic.
Adolescent Friendly Health Service is a service provided by health institutions that focuses on the welfare of adolescents (10-19 years of age) through the guidance on how to maximize the use of health care services in the adolescents.
Samundratar Health Post, Nuwakot is providing AFHS with its limited resources given.
After the successful NSP 2017-2025,Goi is lauching NSP 2017-2025 for elimination of TB on 24th march( World TB day ) 2017. Module is on MOHFW site but i have try to keep it brief,hope its ll be useful specially for academic and administrative purposes.
My Powerpoint on Tuberculosis, includes:
What is the incidence and prevalence?
What are the symptoms?
How is it diagnosed?
How is it treated?
What are the treatment guidelines?
Standards for TB care in India, RNTCP challenges: India, Maharashtra & Mumbai...Amol Patil
This presentation contains TB statistics- Global, India, Maharashtra and Mumbai till 2015.
Details of TB control strategies will be covered in Subsequent parts.
Medical entomology "the need to know about little creatures"vckg1987
very important tpic for public health expertise. this presentation includes the from womgb to tomb of mosquitoes. which in clear sense means from their larval life cycle to control management.
Improving malaria treatment and control through enhanced diagnostic practiceACT Consortium
Professor David Schellenberg, director of the ACT Consortium, presents at the European Congress on Tropical Medicine and International Health in Basel, Switzerland on 7 September 2015.
This ppt contains all the information about Revised NationalTuberculosis Control programme (RNTCP) It is useful for students of the medical field learning Preventive and social medicine, Swasthavritta (Ayurved) and everyone who is interested in in knowing about it.
National Tb pragramme, Has been in operation since 1962
Inadequacies that led to RNTCP :
Treatment success rates were unacceptably low.
There is no unique diagnostic method.
No Treatment Protocol.
Only 30% is diagnosed, so death and default rates remained high.
In 1993 to overcome the drawbacks mentioned, the NTP was revitalized and RNTCP was formulated.
Implemented in a phased manner, by 2000 it covered the whole country.
Objectives:
Achievement of at least 85 percent cure rates of infectious cases of TB.
Augmentation of case finding activities through quality sputum microscopy to detect atleast 70 percent of estimated cases.
1. Intensified active case finding
2. Diagnostic Criteria Changes :
Changes in few definitions like Defaulters → Loss to follow up , Relapse Tb → Recurrent TB.
In Adults – CBNAAT/ True NAAT is done in all cases of TB ( earlier CBNAAT was performed only for high risk cases )
In Paediatric age group – Chest X-ray and TST to be done first.
3. Treatment Criteria Changes :
Regimens with injectable agents are no longer recommended. Currently, for any case of TB only All Oral regimens are initiated
For Drug Sensitive TB 2months of HRZE and 4 months of HRE
For INH resistant TB – RZE + Levofloxacin for 6 months
In All oral MDR Rx regimen : only continuous phase for 18 months
✓ BEDAQUILINE or DELAMANID × 6 months
✓ LEVOFLOXACIN , LINEZOLID , CLOFAZAMINE , CYCLOSERINE × 18 months
Isoniazid Preventive therapy is given for all contact.
Decentralized Tuberculosis unit and DMC (Designated microscopy
centre) and Peripheral Health Institute at the door steps of the patients.
SMEAR MICROSCOPY FOR ACID FAST BACILLI
RAPID DIAGNOSTIC MOLECULAR TESTING
RADIOGRAPHY where available
TUBERCULIN SKIN TEST
CULTURE
S.No CBNAAT TruNAAT
1 PCR based PCR based
2 Cartridge based Chip based
3 AC environment needed No need
4 Cartridge to be stored in cold atmosphere No need
5 Continuous power supply needed Battery operated
6 Less manual work Semi automatic (Technician oriented )
7 Detects MTB as well as Rif resistance simultaneously Need separate chips for MTB and Rif resistance detection
8 Cross contamination unlikely Cross contamination possible
9 TAT : 112 min TAT : 60 min for MTB
60 min for Rif resistance
10 Intermediate level labaratories Point of care level
MTB not Detected
MTB detected, High/medium/low/very low, rifampicin resistance detected
MTB detected, High/medium/low/very low , rifampicin resistance not detected
MTB detected, High/medium/low/very low , rifampicin resistance indeterminate, Repeat the test in new sample.
Invalid result (Retest in fresh specimen)
Error (Repeat the test in same sample)
Clinical evaluation Laboratory based evaluation
History and physical examination Random blood sugar (RBS)
Height HIV testing following counselling
Weight Complete blood count (Hb, TLC, DLC, platelet count)
Psychiatric evaluation if required Liver function tests(including serum proteins)
TSH levels
Urine examination –
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
2. India has highest TB burden
6%
5%
5%
4%
3%
3%
2%
2%
2%
1%
1%
India
Other
South Africa
Indonesia
Pakistan
Bangladeshd
Philippines
Ethiopia
DR Congo
Myanmar
Nigeria
Mozambique
Russian Federation
Vietnam
Kenya
23%
10%
10%
Data source: Global TB Report 2016, WHO
Global annual incidence = 10.4
million
India annual incidence = 2.84
million
3. TB Burden
Global India
Incidence
TB
104 lakh 28.4 lakh
Mortality
of TB *
14 lakh 4.8 lakh
Incidence
HIV TB
12 lakh 1.13lakh
Mortality
of HIV-TB
*
4.0 lakh 37,000
MDR-TB 5. 8 lakh 1.3 lakh
4.
5.
6.
7.
8. National Strategic Plan for TB Control
2012-2017
Universal Access
to quality TB
diagnosis and
treatment for all
TB patients in
the community
A TB FREE
INDIA Early and improved
diagnosis(90%)
Access to high-quality treatment(90%)
Scale-up access to effective
DR TB treatment
Decrease the morbidity and
Mortality in HIV TB
Extend RNTCP services to
patients in Private Sector
9. Evolving Strategies – Case Finding
Passive
Intensified
Active
ZN &
LED
Microsc
opy
Radiol
ogy
Molecu
lar
diagnos
tics
Culture
& DST
Linkage
s
Co
morbiditi
es
Key
Populati
ons
Slums
Migran
ts
Communi
ties
10.
11. Evolution in TB Diagnosis
• LED microscopy.
• MODS-Microscopic Observation Drug Susceptibility
• LPA refinement for smear negative MDR TB suspects
• Rapid Identification of species by strip speciation test
• Breathalyzer screening test
• First generation loop mediated isothermal
amplification technology platform (LAMP)
• Urinary Lipo-arabinomannan (LAM) or any other
antigen detection tests
• Rapid automated 2nd and 3rd generation NAATs for
first and second line DST
12.
13. PREVIOUS RECOMMENDATIONS :
• Commercial molecular line probe assays for 1st-line anti-TB drugs:
For use at central/regional reference laboratory level for rapid
detection of rifampicin (alone or with isoniazid) resistance. Suitable
for use on smearpositive specimens or culture isolates.
• NOT recommended for 2nd line drugs.
14.
15. Automated NAAT
(GeneXpert / Xpert MTB/RIF)
• Result in 90m
• M TB – Y / N
• Rif res – Y / N
• 70% additional
yield in smear
negative TB
15Gokulam 21-03-2014
21. URINARY LAM TEST
• Detection of lipoarabinomannan (a lipopolysaccharide
component of MTB cellwall) antigen in urine.
• Single clinical visit, results in ½ hr.
• sensitivity is 28.2 %
• But sensitivity increases to 66.7% when CD4 cell count <50
• In HIV pts, LAM + Smear microscopy increases sensitivity
comparable to GeneXpert MTB/RIF .
22. BREATHALYZER TEST
• Uses optical detection technology with fluorometry.
• The collection tube was designed to collect aerosols and
particles coughed out by the patient.
• Result can be obtained in 10min.
• Sensitivity is 74% and specificity is 79%
31. MAIN CHANGES IN 2016 UPDATE
• A shorter MDR-tb treatment regimen under specific
conditions.
• Medicines used in the MDR tb treatment regimens are now
regrouped differently.
• MDR-tb treatment is recommended for all pts of RR-TB
regardless of confirmation of isoniazid resistance.
• Clarithromycin and other macrolides are no longer included
in the treatment of MDR-tb.
32. Earlier WHO classification of anti TB drugs
Group Drugs
Group 1. First line oral drugs Isoniazid, Rifampicin
Ethambutol, Pyrazinamide
Rifabutin, Rifapentine
Group 2. Injectable anti-TB drugs Streptomycin (First line)
Kanamycin, Amikacin, Capreomycin
Group 3. Fluoroquinolones Ofloxacin, Levofloxacin
Moxifloxacin
Group 4. Oral bacteriostatic second-line anti-TB
drugs
Ethionamide, Prothionamide
Cycloserine, Terizidone
Para-aminosalicylic acid
Group 5. Anti-TB drugs with limited
data on efficacy and/or long term
safety in the treatment of drug-resistant
TB
Bedaquiline
Delamanid
Linezolid
Clofazimine
Amoxicillin/ clavulanate
Imipenem/cilastatin; Meropenem
High-dose isoniazid
Thioacetazone
Clarithromycin
33.
34.
35.
36. • The shorter MDR-TB treatment regimens were standardized in
content and duration and split into two distinct parts.
• The first was an intensive phase of four months (extended up to a
maximum of six months in case of lack of sputum smear conversion)
and included the following drugs: gatifloxacin (or moxifloxacin),
kanamycin, prothionamide, clofazimine, high-dose isoniazid,
pyrazinamide and ethambutol.
37. • This was followed by a continuation phase of five months with the
following medicines:
• gatifloxacin (or moxifloxacin), clofazimine, pyrazinamide and
ethambutol.
38. Introduction of Bedaquiline
BDQ-CAP (Conditional access programme)
• Six sites identified to roll
out BDQ CAP
• Guidelines have been
prepared
• National Training of
trainers(TOT) done at
NTI Bangalore in Jan
2016
• BDQ CAP rolled out in six
pilot sites in 2016.
Rajas than
Gujarat
Maharas htra
Oriss a
Karnataka
Madhya Prades h
Bihar
Uttar
Pradesh
Jam m u &
Kas hm ir
Tam il Nadu
Assam
Telangana
Chhattis garh
Andhra Pradesh
Jhark hand
Punjab
W est B engal
Kerala
Haryana
Himac hal
Pradesh
Manipur
Mizoram
Andam an & N icobar
Dam an & Diu
Uttarakhand
Sikkim
Arunachal
Pradesh
N aga lan d
Tripura
41. TB – HIV co-morbidity
Status 2015
• 79% TB patients know their HIV status
• 92% TB HIV patients are receiving ART
• 93% TBHIV patients receiving CPT
42. 3 I’s
• Intensified case finding (ICF)
• Isoniazid preventive therapy (IPT)
• Infection control for Tuberculosis (IC)
43. Intensified TB case finding and treatment at high
burden Anti-Retroviral Therapy (ART) centres
Single window service delivery
for TB & HIV
Intensified case finding
TB diagnosis through CBNAAT
Daily Regimen
Better management of side
effects- Pharmacovigilance
Use of newer technology for
treatment monitoring
Isoniazid Preventive Therapy
Air Borne Infection control
Progress so far
45419 PLHIV tested for TB
6389 diagnosed as TB
185 diagnosed as Rif
Resistance
6073 put on Daily Anti TB
treatment
149 Rif /R put on CAT IV
Country-wide expansion by 2nd October
2016
51. Screening DM patients for TB
Tertiary Care Centers
DM Patients screened for TB DM Patients diagnosed as TB
(68%)
(13%)
52. TB –Diabetes and Tobacco Collaborative Activities
TB-DM
• A national collaborative workshop was
held between RNTCP and NPCDCS
• The joint framework aims at reduction in
morbidity and mortality by doing
bi-directional screening, early detection
and prompt management of DM and TB.
53. • Activities to improve diagnosis and management of DM
among TB pts :
-Screening of all registered TB pts for DM
-DM management among TB pts
TB among DM patients :
- intensified detection of active TB among DM pts
-TB infection control measures
-TB treatment and management in comorbid pts
56. TB AND TOBACCO
• Main intervention will be counselling of tobacco users at TB
facilities and referral of tobacco users coming at Tobacco
Cessation Centre to DMC for TB screening.
59. INDEX TB Guidelines 2016
• New guidelines
developed for
management of
Extra pulmonary TB
by Central TB
Division , AIIMS, New
Delhi , WHO and
GHA
• Dissemination
Workshop held on
09th July 2016 at
AIIMS New Delhi
• Dissemination and
further develop a
training module
66. NIKSHAY
Case Based Web Based TB Notification System
Public TB
notification
system
DR-TB
lab & RX
centres
Private TB
notification system
Special
projects for
adherence
Developed & powered by CTD & NIC
69. Missed Call Server
Missed Call
Missed call List
Call Center Agent
Agent call to Patient
Server
PatientFeedback
Patient Category wise List
Information
about diagnosis
General
information TB
Adverse drug
reactions due to
TB drugs
Missed Call Campaign
Information about
treatment facilities
Missed call server will be linked with NIKSHAY platform
DTO
70. Web based Monitoring for DR TB patients
e-Smart
Electronic Surveillance and Management of
Drug Resistant Tuberculosis System
- An innovative approach towards better patient
management
71. Vision:
A world free of TB
Zero TB deaths,
Zero TB disease, and
Zero TB suffering
Goal:
End the Global TB
epidemic
Vision, goal, targets, milestones
(2,2 million)
(2.2 lakh)
77. Next Seminar on WEDNESDAY 26/10/16
MEDIASTINUM by DR. SATISH
&
NON-INVASIVE VENTILATION by DR. SANDEEP
Editor's Notes
Finding them early and finding them all
Program is introducing BDQ under RNTCP through Conditional Access Program starting with 6 sites.
The program is mapping out the key population, which has high TB burden.
Of the approximately 3500 TB pts 93% could be screened for DM with Random Blood Sugar with 19% of those screened found to have Diabetes.
Of 20353 DNM pts seen in Diabetes Clinics - 39% were screened for TB.
Of those screened for Tb symptoms only 2% (169) were found to have symptoms suggestive of TB.
Of those 169 pts 68% (115) were actually referred for TB Investigations.
Out of these 115 pts 15 were found to have TB.
Or in other words we missed the opportunity to screen more than 60% of the patients who were visiting these diabetic clinics,
Also among the TB symptomatics identified we missed an opportunity to investigate another 32% of symptomatics.
Photo of launch, guidelines and way forward, few line
For effective programme management, CTD and NIC has developed a Case Based Web Based TB Notification System called Nikshay. It includes TB notification system for patients under RNTCP as well as from private sector. It also includes modules for Culture and DST laboratories and DR-TB patients.
It also has a web version and android mobile based application for hassle free notification by private sector.
Till date more than 60 lakh patients are registered in Nikshay.
Since the Govt Order for TB notification in May 2012, programme is striving hard to promote notification by private sector
Till date more than one lakh private health providers are registered in Nikshay and the notification by private sector is increasing slowly and last year we have 1.7 lakh patients notified.
India showed substantial 29% increase in TB notification in year 2014. This was achieved due to implementation of mandatory notification and NIKSHAY
We have to now move towards new era of SDG and from STOP TB Strategy to END TB Strategy.
Everyone with TB should have access to the innovative tools and services they need for rapid diagnosis, treatment and care. This is a matter of social justice, fundamental to our goal of universal health coverage. Given the prevalence of drug-resistant tuberculosis, ensuring high quality and complete care will also benefit global health security.
Intensify research and development is one of the core component of END TB strategy, it plays a crucial role accelerating reduction in TB incidence and mortality to reach to goal of END TB Strategy. Diagnostic technology , new diagnostic techniques like GeneXpert Omni , New Drugs like Bedaquiline, Delaminide, and few other drugs which in pipeline. The vaccine also needs to be developed for achieving the goal.
Finance: Funding for TB control epidemic needs to be increased in view of achieving the goal of END TB .