Forensic anthropology involves analyzing differences between human and animal bones. This document provides details on distinguishing features of the skull, dentition, and postcranial skeleton between humans and animals. It also summarizes differences between male and female skulls, pelvises, and long bones that can aid in determining the sex of skeletal remains. Key stages of cranial suture closure and ossification centers and times are outlined to help estimate age.
The appendicular skeleton consists of the
shoulder girdle with the upper limbs and the
pelvic girdle with the lower limbs
Shoulder girdle and upper limb:
Each shoulder girdle consists of:
•1 clavicle
•1 scapula.
Each upper limb consists of the following bones:
1 humerus, 1 radius, 1 ulna, 8 carpal bones, 5 metacarpal bones and 14 phalanges.
The appendicular skeleton consists of the
shoulder girdle with the upper limbs and the
pelvic girdle with the lower limbs
Shoulder girdle and upper limb:
Each shoulder girdle consists of:
•1 clavicle
•1 scapula.
Each upper limb consists of the following bones:
1 humerus, 1 radius, 1 ulna, 8 carpal bones, 5 metacarpal bones and 14 phalanges.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
2. Analysing the differences between animal and human
bones.
● Differential Skeletal Anatomy of Humans and Animals: Cranium
● Differential Skeletal Anatomy of Humans and Animals: Dentition
● Differential Skeletal Anatomy of Humans and Animals: Post cranium
3. HUMAN ANIMAL
Large bulbous vault, small face Small vault, large face
Vault relatively smooth Pronounced muscle markings, sagittal crest Inferior
Inferior Foramen Magnum Posterior Foramen Magnum
Chin present Chin absent
Orbits at front, above nasal aperture Orbits at sides, posterior to nasal aperture
"U"- shaped mandible (no midline separation) "V"- shaped mandible (separates at midline)
Differential Skeletal Anatomy of Humans and Animals: Cranium
4. HUMAN ANIMAL
Omnivorous Carnivorous; Herbivorous; Omnivorou
Dental formula 2:1:2:3 Basic dental formula 3:1:4:3
incisors (maxillary) are larger than other
mammals
Horse maxillary incisors are larger
than human
incisors
Canines small Carnivores have large conical
canines; Herbivores have small or
missing canines
Premolars and molars have low,
rounded cusps divided by distinct
grooves
Carnivores have sharp, pointed
molars and premolar teeth;
Herbivores have broad, flat
premolars and molars with parallel
furrows and ridges
Differential Skeletal Anatomy of Humans and Animals: Dentition
5. Differential Skeletal Anatomy of Humans and Animals: Post cranium
Human Animal
Upper limbs less robust Robust upper limbs
Radius and ulna are separate bones Radius and ulna often fused
Large, flat and broad vertebral bodies with short
spinous
processes
Small vertebral bodies with convex/ concave
surfaces and
long spinous processes
Sacrum with 5 fused vertebrae, short and broad Sacrum with 3 or 4 fused vertebrae, long and
narrow
Pelvis is broad and short, bowl - shaped Pelvis is long and narrow, blade - shaped
Femur is longest bone in body, lineaaspera is
singular
feature
Femur is similar length to other limb bones,
lineaaspera
double or plateau
Separate tibia and fibula Tibia and fibula are often fused
Foot is long and narrow, weight borne on heel
and toes
Foot is broad, weight borne mainly on toes
6.
7. TRAIT MALE FEMALE
General size Larger, more massive Smaller, slender
Long bones Ridges, depression and process are
more prominent. Bones of arms and
legs are 8% longer
Less prominent
Shaft of long bones Rougher Smoother, thinner with relatively wider
medullary cavity
Articular surface Larger Smaller
Metacarpal bones Longer and broader Shorter and narrower
Weight 4.5 kg 2.75 kg
Comparison of Male and Female Skeleton
8. TRAIT MALE FEMALE
General Appearance Larger, longer Smaller, lighter, walls thinner
Architecture Rugged, muscle ridges more marked,
especially in occipital and temporal areas
Smooth
Glabella More prominent Small or absent
Forehead Steeper less rounded Vertical, round, full
Orbits Square, set lower on the face, relatively
smaller, rounded margins
Rounded higher, relatively larger, sharper
margins
Supraorbital ridges Prominent Less prominent or absent
Zygomatic arch More prominent Less prominent
Nasal aperture Higher and narrower. Margins sharp Lower and broader
Frontal eminences Small Large
Parietal eminences Small Large
Occipital area Muscle lines and protuberance prominent Not prominent
Comparison of Male and Female Skull
9. TRAIT MALE FEMALE
Occipital area Muscle lines and protuberance
prominent
Not prominent
Mastoid process Medium to large, round, blunt. Small to medium, smooth, pointed
Palate Larger, broader, tends more to be u-
shape.
Smaller, tends more to be parabolic
shape
Foramen magnum Relatively large and long Relatively small and round
Mandible Larger and thicker Smaller and thinner
Ascending ramus Greater breath Smaller breath
Mandible Condyles Larger Smaller
Angle of body and
ramus
Less obtuse (under 125º) More obtuse, and not prominent
Teeth Larger Smaller
Comparison of Male and Female Skull
14. Comparison of Male and Female Pelvis
Trait Male Female
Bony framework Massive, rougher, marked
muscle sites.
Less massive, slender,
smoother
General Deep funnel Flat bowl
Acetabulum Large and directed laterally Small and directed antero-
laterally
Obturator Foramen Large, often oval with base
upward
Small, triangular with apex
forward
Body of pubis Narrow, triangular Broad, square, pits on
posterior surface if borne
children
Ramus of pubis It is like continuation of body of
pubis.
Has a constricted or
narrowed appearance
and is short and thick
Sacrum Longer, narrower, with more
evenly distributed curvatures,
prominently well marked.
Body of first sacral vertebra
larger. Shorter, wider,
upper half almost straight,
curve forward in lower half,
prominently less marked.
Coccyx Less movable More movable
15. Comparison of Male and Female Pelvis
Trait Male Female
Pre-auricular sulcus
(attachment of anterior
sacroiliac ligament)
Not frequent, narrow, shallow More frequent, broad and deep
Greater sciatic notch Smaller, narrower, deeper Larger, wider, shallower
16. Comparison of Male and Female Pelvis
Trait Male Female
Symphysis High Low and distance between
two pubic tubercles greater.
The dorsal border is irregular
and shows depressions or
pits (scars of parturition)
Subpubic
angle
V-shaped, sharp angle 70º
to 75º
U-shaped, rounded, broader
angle, 90 to 100º
Pelvic brim Heart shaped Circular or elliptical, more
spacious, diameter longer
Pelvic inlet Conical and funnel shaped Broad and rounded
21. Male vs. female (greater in males)
Maximum length
Maximum Vertical Diameter of the Head
Maximum Transverse Diameter of the Head
Bone weight (in gm)
22. Male vs. female (greater in males)
Maximum length
Maximum Vertical Diameter of the Head
Maximum Transverse Diameter of the
Less curve of bone for males than female
23. Male vs. female (greater in males)
Maximum length
Bone weight
Size
Shape of head of bone less globular
24. Male vs. female (greater in males)
Maximum length
Maximum Vertical Diameter of the Head
Bicondylar width
Maximum Trochanteric length
Angle formed by neck & Shaft axis If low
denotes masculine character
25. Male vs. female (greater in males)
Maximum length
Bicondylar width
Weight
26. Male vs. female (greater in males)
Diameter of middle of bone
Bone weight
27. Male vs. female (greater in males)
Glenoid breadth
Total spine length
Weight
28. Male Female
The thoracic cage is longer
and narrower.
It is shorter and wider.
Ribs are thicker and
comparatively massive in
texture.
Ribs are thinner and
delicate in texture.
Ribs have lesser curvatures. Ribs have greater
curvatures.
Manubrium Manubrium is
somewhat smaller.
It is somewhat bigger.
29. Sutures of the skull, also known as cranial
sutures, are fibrous joints with a fracture-like
appearance found between the bones of the skull.
Sutures are formed during embryonic
development.
They are sites for bone expansion, ensuring
craniofacial growth during the embryonic,
postnatal, and later growth periods.
The cranial sutures ossify at different rates, but
most sutures have ossified by the age of 20.
Sutures of an adult skull are categorized
as synarthroses ( a type of joint that, under
normal circumstances, is immobile.)
30. Figuíe 1: Vault sutuíe closuíe stages. Illustíation of degíees of closuíe foí
sagittal sutuíe at obelion.
0 open; there is no evidence of any
ectocranial closure
1 minimal closure; the score is
assigned to any minimal to moderate
closure, from single bony bridge to
about 50% synostosis
2 significant closure; there is a
marked degree of closure but some
portions still not completely fused
3 complete obliteration; the site is
completely fused.
31. In neonates, the sutures are incompletely fused,
leaving membranous gaps
called fontanelles.
Fontanelles are also often called soft spots.
Fontanelle Location closure
frontal fontanelle
(anterior
fontanelle)*
at the junction of the
coronal and sagittal
sutures.
closes between 12
and 18 months of
age
occipital fontanelle
( posterior
fontanelle)*
at the junction
between the sagittal
and lambdoid
suture
closes at 6-8 month
of birth
sphenoid
fontanelle (2)
located between
the sphenoid, temp
oral, frontal,
and parietal bones.
closes at 2 months
after birth
mastoid
fontanelle (2)
situated between the
temporal, occipital,
and parietal bones.
closes at 2 months
after birth
32. The metopic suture is present in
newborns.
The metopic suture divides the
frontal
bone along the midline.
Metopic suture closes at 2-4 years
but may extend up to six years.
33. Sutures of neurocranium
Sutures Location ossification
sagittal suture (2) formed by the
two parietal
bones articulating
with each other.
Fusion begins
around 25 years &
completed by 30 -
35 Years
Coronal suture (2) formed at the junction
between the parietal
bones and frontal
bone.
Fusion begins around
28 years & completed
by 35 - 40 Years
lambdoid
suture (2)
formed at the
articulation
between the
occipital bone
and parietal
bones.
Fusion begins
around 30 years &
completed by 50 -
55 Years
squamous suture (2) formed by the
parietal bone and
temporal bone.
Fusion begins around
50 - 55 years &
completed by 70 Years
34. Sutures Location ossification
Occipito-mastoid
suture (2)
Formed by the
articulation of
the occipital
bone and the
temporal
bone's
mastoid part
Fusion begins
around 60 - 65
years &
completed by 80
Years
Parieto-mastoid
suture (2)
formed at the
Junction
between the
parietal and
temporal
bones.
Fusion begins
around 60 - 65years
& completed by 80 -
82 Years
Spheno
Parietal suture
(2)
suture between
parietalbone and
the sphenoid
bone.
Fusion begins
around 60 - 65
years &
completed by 80
- 85 Years
35. Landmark location Fusion
bregma It is the intersection of the
coronal and sagittal sutures.
site of the frontal fontanelle in
neonates and young children,
which usually fuses around
the age of 2.
lambda formed at the convergence
between the sagittal and
lambdoid sutures.
site for the occipital
fontanelle was located, which
usually closes around 2
months of age.
obelion is formed at the intersection of
the sagittal suture and an
imaginary line that connects
the two parietal foramina.
-
suture-associated landmarks
36. Landmark location
Asterion (2) site of
the previously located
mastoid fontanelle
at the junction of the
parietomastoid,
occipitomastoid and
lambdoid sutures.
closes by 80 years
Pterion (2) H-shaped point of junction
between four bones:
the sphenoid, temporal, fr
ontal and parietal bone.
starts closing at 40 years and
completely closes by 65 years
Asterion
suture-associated landmarks
37. Skeletal Age and Ossification
The human bones develop from a number of ossification centers.
At 11- 12th week of intrauterine life, there are 806 ossification centers that at
birth are reduced to about 450.
Adult human is made up of 206 bones.
determination
of age
time of appearance of center of ossification
process of union of the epiphysis with the
diaphysis at the metaphysis
Limitations: Hereditary factors Growth and
development Geographical variation Climate
Dietary habits Association with diseases
39. Centers of bones Appearance Fusion
Sternum 5 month IUL 60-70 years
Manubrium Body
Ist segment)
IInd segment
IIIrd segment
IVth segment
5 month IUL
7 month IUL
7 month IUL
10 month IUL
14-25 years from
below upwards;
3rd and 4th -15
years
2 nd & 3rd -20
years
1 st & 2nd -25
years
Xiphoid process 3 years >40 years with
the body
40. Centers of bones Appearance Fusion
Humerus (upper end)
Head
Greater tubercle
Lesser tubercle
1 year
3 years
5 years
18 years
4-5 years with head
5-7 years with
greater tubercle
Humerus (Lower end)
Medial Epicondyle
Capitulum
Trochlea
Lateral Epicondyle
5-6 years
1 year
9-10 years
10-12 years
Capitulum, trochlea
& lateral epicondyle
form conjoint tendon
at 14 years, unites
with shaft at 15
years Medial
epicondyle unites at
16 years
41. Centers of bones Appearanc
e
Fusion
Scapula
Coracoid base
Acromion
process
10-11 year
14-15 year
14-15 years
17-18 years
43. Centers of bones Appearance Fusion
Head of Ist
metacarpal
Head other
metacarpals
2 years
1½ to 2½
years
15-17 years
15-19 years
44. Centers of bones Appearance Fusion
Hip bone
• Iliac crest
• Ischial tuberosity
• Sacrum
14-15 years
15-16 years
8 months
IUL
18-20
years 20-
22 years
25 years
This Photo by Unknown Author is licensed under CC BY
45. Centers of bones Appearance Fusion
Femur (Upper end)
• Head
• Greater trochanter
• Lesser trochanter
Femur (Lower end)
1 year
4 years
14 years
9 month IUL
17-18 years
17 years
15-17 years
17-18 years
47. Type of bone Age of ossification
Trapezium
Trapezoid
Capitate
Hamate
Pisiform
Triquetrum
Lunate
Capitate
4-5 months
4-5 months
2 months
3 months
9-12 years
3 months
4 months
2 months
2 months
48. Type of bone Age of ossification
Calcaneum
Cuboid
Lateral cuneiform
Medial cuneiform
Intermediate
cuneiform
Navicular
Talus
5 months
10 months
1 year
2 years
3 years
3 years
7 months
49. Non dominant hand
Widely spread of fingers
Focus at carpal
Maturation (proximal to
distal) & fusion (distal
side)
Carpal
Phalanges
Radius ulna (terminal
fusion)
Girls have advance age 1-2
Source: https://www.youtube.com/watch?v=uxJ11zyhQ1Q
58. Maturation score for estimation of skeletal age:
● To minimize the errors of epiphyseal union, Mckern and Stewart in 1957 suggested a
scheme of scoring involving seven combinations of various segments.
● The total score is applied to the prediction equation for more accurate age estimation.
Degree of union Scoring
No union
¼ th union
½ union
¾ th union
Complete union
1
2
3
4
5
59.
60. Racial Characteristics of the Skull
Trait Mongoloid Caucasoid Negroid
Skull Length Long Short Long
Skull Breadth Broad Broad Narrow
Skull Height Middle High Low
Sagittal Contour Arched Arched Flat
Face Breadth Very wide Wide Narrow
Face Height High High Low
Orbital Opening Rounded Rounded Rectangular
61. Racial Characteristics of the Skull
Trait Mongoloid Caucasoid Negroid
Nasal Opening Narrow Moderately Wide Wide
Nasal Bones Wide Flat Narrow
Arched
Narrow
Lower Nasal Margin Sharp Sharp Troughed
Facial Profile Straight Straight Downward
slant
Palate Shape Broad U-shaped V-shaped U-shaped
Shovel-shaped
incisors
90% Less than 5 % Less than 5%
62.
63. measuring all bones constituting the components of
stature, summing those measurements and correcting
for the missing soft tissue
employing a regression formula with the
measurement of a complete bone.
employing incomplete limb bones, non-limb bones
and alternative statistical methods
Alternate statistical approaches (e.g., maximum
likelihood estimation) exist to estimate stature.
64. Method Do’s
Anatomical
Method
(Complete Skeleton
Method)
skeletal elements constituting
stature minimally damaged.
ancestry and sex of the
individual cannot be estimated
anomalous number of
vertebrae
individual’s limb bones appear
to be atypical in length.
65. Bones typically measured in these methods are the
height of the skull
the heights of each of the vertebrae (a missing vertebra estimate the height by
averaging the heights of the vertebra immediately above and below)
the lengths of the femur and tibia
and the height of the ankle
66. Christensen, A. M., Passalacqua, N. V., & Bartelink, E. J. (2019). Stature estimation and other skeletal
metrics. Forensic Anthropology, 351–368. doi:10.1016/b978-0-12-815734-3.00011-7
67. Christensen, A. M., Passalacqua, N. V., & Bartelink, E. J. (2019). Stature estimation and other skeletal
metrics. Forensic Anthropology, 351–368. doi:10.1016/b978-0-12-815734-3.00011-7
68. Method Do’s
Complete Limb
Bones
(Mathematical
Method or
Regression
Approach)
limb bone length or bone lengths
selecting the most appropriate
regression formula by sex and
ancestry, inserting the
measurement into the formula, and
calculating the estimated stature
limb bone measurements are
usually maximum lengths
he formula with the smallest
prediction interval should be the
most accurate and precise, and
should be employed in the
stature estimation
69. Christensen, A. M., Passalacqua, N. V., & Bartelink, E. J. (2019). Stature estimation and other skeletal
metrics. Forensic Anthropology, 351–368. doi:10.1016/b978-0-12-815734-3.00011-7
70. Method Do’s
Fragmentary Limb
Bones
Some of these methods require
estimating bone length and then
estimating stature based on the
estimated bone length, thus
compounding the error present in the
estimation.
fragmentary remains estimate stature
directly from the fragment, without
requiring the second step of the
previous method.
71. Method Do’s
Non-Limb Bones Non-limb bones (e.g., skulls,
innominates, and bones of the
hands or feet) may also be
used to estimate stature