Forensic science PowerPoint presentation on Injury and it's medico-legal importance.
The slide is made for medical students. Mainly for BAMS students. It covers maximum points.
The slide is full of example with pictures which make it easy to understand the concept. It contains post-mortem findings as well as medico-legal importance of the each type of injury.
Forensic science PowerPoint presentation on Injury and it's medico-legal importance.
The slide is made for medical students. Mainly for BAMS students. It covers maximum points.
The slide is full of example with pictures which make it easy to understand the concept. It contains post-mortem findings as well as medico-legal importance of the each type of injury.
Gliese 12 b, a temperate Earth-sized planet at 12 parsecs discovered with TES...Sérgio Sacani
We report on the discovery of Gliese 12 b, the nearest transiting temperate, Earth-sized planet found to date. Gliese 12 is a
bright (V = 12.6 mag, K = 7.8 mag) metal-poor M4V star only 12.162 ± 0.005 pc away from the Solar system with one of the
lowest stellar activity levels known for M-dwarfs. A planet candidate was detected by TESS based on only 3 transits in sectors
42, 43, and 57, with an ambiguity in the orbital period due to observational gaps. We performed follow-up transit observations
with CHEOPS and ground-based photometry with MINERVA-Australis, SPECULOOS, and Purple Mountain Observatory,
as well as further TESS observations in sector 70. We statistically validate Gliese 12 b as a planet with an orbital period of
12.76144 ± 0.00006 d and a radius of 1.0 ± 0.1 R⊕, resulting in an equilibrium temperature of ∼315 K. Gliese 12 b has excellent
future prospects for precise mass measurement, which may inform how planetary internal structure is affected by the stellar
compositional environment. Gliese 12 b also represents one of the best targets to study whether Earth-like planets orbiting cool
stars can retain their atmospheres, a crucial step to advance our understanding of habitability on Earth and across the galaxy.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Nutrition is the science that deals with the study of nutrients and their role in maintaining human health and well-being. It encompasses the various processes involved in the intake, absorption, and utilization of essential nutrients, such as carbohydrates, proteins, fats, vitamins, minerals, and water, by the human body.
word2vec, node2vec, graph2vec, X2vec: Towards a Theory of Vector Embeddings o...Subhajit Sahu
Below are the important points I note from the 2020 paper by Martin Grohe:
- 1-WL distinguishes almost all graphs, in a probabilistic sense
- Classical WL is two dimensional Weisfeiler-Leman
- DeepWL is an unlimited version of WL graph that runs in polynomial time.
- Knowledge graphs are essentially graphs with vertex/edge attributes
ABSTRACT:
Vector representations of graphs and relational structures, whether handcrafted feature vectors or learned representations, enable us to apply standard data analysis and machine learning techniques to the structures. A wide range of methods for generating such embeddings have been studied in the machine learning and knowledge representation literature. However, vector embeddings have received relatively little attention from a theoretical point of view.
Starting with a survey of embedding techniques that have been used in practice, in this paper we propose two theoretical approaches that we see as central for understanding the foundations of vector embeddings. We draw connections between the various approaches and suggest directions for future research.
FAIRSpectra - Towards a common data file format for SIMS imagesAlex Henderson
Presentation from the 101st IUVSTA Workshop on High performance SIMS instrumentation and machine learning / artificial intelligence methods for complex data.
This presentation describes the issues relating to storing and sharing data from Secondary Ion Mass Spectrometry experiments, and some potential solutions.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
This report details the geological observations and interpretations made during a field investigation of the Kaptai Rangamati road-cut section, located in southeastern Bangladesh. The purpose of this report is to document the exposed rock units, their characteristics, and the geological structures present within the road cut.
2. Injuries: Classification and Medicolegal Aspects
Definition
A. Injury (Legal sec 44) BMR is an important concept of Physiology - Body, Mind,
Reputation, Property
CLASSIFICATION
OF INJURIES
Medical Classification
(Mechanical/Thermal/Chemical/Physical
agent/Explosives)
Medicolegal Classification
(Suicidal/Homicidal/Accidental/Self inflicted/Defense/Iatrogenic
injuries)
3. Injuries: Classification and Medicolegal Aspects
CLASSIFICA
TION OF
INJURIES
Legal Classification
(Hurt u/s 319 : BiDI " Bodily pain, Disease, Infirmity
, IPC/Grievous hurt u/s 320, IPC:
1) EMASCULATION
2-3)Permanent privation sight of either eye/ hearing
of either ear
(4) Privation of any member or joint
(5) Destruction or permanent impairing of the powers
of any member or joint
(6) Permanent disfiguration of the head or face
(7) Fracture or dislocation of a bone or tooth .
(8) 20 Days
4. CAUSES OF DEATHS FROM WOUNDS
A.
Immediate
Causes
B. Remote
Causes
Reflex vagal inhibition
Mechanical injury to a vital organ
5. AGE OF WOUNDS
Enzyme Histochemistry
10 minutes: Calpains,
cathepsins,(protease), serotonin
30 minutes: Histamine
(allergic/anaphylactic)
1 Hour: ATPase and esterase
2 Hour: Aminopeptidase
4 Hours: Acid Phosphatase
8 Hours : Alkaline phosphatase
Immunohistochemistry
5 minutes : P selectin (activated
platelets/endothelial cells)
10-20 minutes : Fibronectin
(glycoprotein)
1 hour : E selectin (inflammation)
1.5 hours :ICAM I (Intracellular
adhesion molecule 1) immunoglobulin
molecules
2 days :Tanascin (pro inflammatory)
3 days :Collagen III,IV,V
5 days: Collagen I
6. ANTEMORTEM VS. POSTMORTEM WOUNDS
*Haemorrhage extent source /spurting/coagulation/wound edges/ inflammation
and repair/Enzyme histochemistry)
Source: Agrawal, A. (2016).
7. Mechanical Injuries :ABRASIONS
Salient features:
Force/Effects: scratch
and graze abrasions or
imprint /Healing no
scarring /Weapons/on a
wet skin/On drying i.e
dark and brown
Source: Agrawal, A. (2016).
8. Types of Abrasions: Scratch abrasions [syn, linear abrasions, scrapes,
scratches] length/width
● How produced?
● Direction? Skin heaping in same direction
Source: Agrawal, A. (2016).
9. Types of Abrasions: GRAZE abrasion [syn, glancing, grinding, scraping or
sliding abrasions]
Source: Agrawal, A. (2016).
Comprise of uneven, longitudinal parallel lines (grooves or furrows) with the
epithelium heaped up at the ends of these lines.
10. Types of Abrasions: Pressure abrasions syn,
crushing or friction abrasions]
small pressure/
longer period of time
11. Types of Abrasions: Impact abrasions
[syn, contact or imprint abrasions]
Large pressure/
shorter period of time
Headlamp rim marks, or
radiator grille marks - in
head-on vehicular collisions
12. Types of Abrasions: Pressure abrasions and Impact abrasions (pressure
and impact abrasions)
13. Age of Abrasions
Fresh –
Bright red
1 day –
Blood and
lymph dries
up. Bright
red scab
forms
2-3 days –
Reddish
brown scab
4-7 days –
Scab
becomes
dark brown
>7days –
Scab dries,
shrinks and
falls off,
leaving
depigmented
area.
15. Medico Legal Importance of
Abrasions
Type of offence
Direction of
force
Force of
impact
Foreign
matter
sticking over
abrasions
Weapon
Time of
assault
16. BRUISES (CONTUSIONS): an effusion of blood into the tissues underneath the skin due to rupture of blood vessels
(arterioles, venules and veins). When the effusion of blood is in other tissues and organs (muscles, lung, heart, brain,
spleen, mesentery etc), it is called a contusion
Salient features:
Colour/cause/size/shape
*Factors Modifying Size and Shape (age i.e. children and adults /sex i.e.
female /obesity/color of skin/condition and type of tissue/weapon
Source: Aggrawal, A. (2016).
(a) Petechial hemorrhages – 0.1-2 mm
(b) Ecchymosis – 2-5 mm (c) Bruise –
more than 5 mm.
17. (i) Vascular and loose tissue
(ii) Firm, fibrous, strongly supported tissue
(iii) Good muscle tone
(iv) Resilient areas
23. LACERATIONS:
Lacerations are tears or splits of skin, mucus membrane,
muscle or internal organs, produced by application of blunt
force to the body, which stretches tissues beyond their limits of
elasticity.
● General Characteristics
(Margins irregular, ragged,
uneven /Edges Angular impact
or perpendicular /Depth/Shape
and
size/Gapping/Bruising/Tissue
bridges
Source: Aggrawal, A. (2016).
Source: Aggrawal, A. (2016).
24. Types of Laceration
*CHOP WOUNDS Chop wounds (or slash wounds) are same as cut
lacerations
Tear Laceration Split laceration Stretch
Laceration
Cut laceration Avulsion
25.
26. This Photo by Unknown Author is licensed under CC BY
True incised wound vs. true
lacerated wound
*edges/margins bruise/injuries to by
nerves, tendons/bleeding
27. Age of Lacerations
• Age determination is difficult unless clear signs of healing are
present [eg Fibroblasts, Granulation tissue, Organizing
infiltrate].
AM and PM Lacerations
• Antemortem lacerations would show (1) Bleeding (2) Blood-
staining of margins(3) Bruising (4) Eversion (5) Gaping (6)
Vital reactions. PM lacerations –ve signs
Medicolegal importance
• Age of lacerations/Extraneous material/Manner of
production/Shape of lacerations (patterned Lacerations)
28. INCISED WOUNDS
Salient features: Force/Skips in
pattern/weapons/Characteristics i.e Length, Width, margins,
Shape spindle shaped, Crecent, zigzag, gapping, Direction)
Source: Aggrawal, A. (2016).
Source: Aggrawal, A. (2016).
29.
30.
31.
32. Difference ???????????
1) Site on neck
2) Level from thyroid cartilage
3) Direction
4) Number of wounds
5) Hesitation mark
6) Tailing
7) Weapon
8) Cadaveric spasm
9) Superficial wounds on other body part
33.
34. Age of Incised Wounds
Hematoma
formation
Fresh
•Edges red,
swollen,
adherent with
blood and
lymph
•Leukocytic
infiltration
12
hours
Dried clot in
the form of
crust or scab.
24 h
hours
35. MLI of Incised Wounds
Reconstruction of crime I.E.
(a) the nature of the
weapon – sharp edged
(b) Age of injury and
(c) Direction of force
Manner of injury i.e.
accidental, suicidal or
homicidal
Limitation: Decomposed body,
Body with incised wounds
immersed in water soon after
death
Source: Aggrawal, A. (2016).
36. STAB WOUNDS
● Salient features: How caused i.e.
Punctured wound, Penetrating
wound, Perforating wound (exit &
entry)/
Source: Aggrawal, A. (2016).
Source: Aggrawal, A. (2016).
Source: Aggrawal, A. (2016).
In perforating wounds, wound of
entry is (a) larger (b) has inverted
edges. Exit is (a) smaller [due to
tapering of blade] (b) has everted
edges. In firearm wounds entry is
smaller; exit is larger.
38. MLI of Incised Wounds
Concealed puncture wounds: homicidal.
Depth of wound : Force
Direction and dimension of wounds:
relative position of victim and assailant
Manner of production i.e suicidal,
homicidal, accidental
Multiplicity of wounds: revenge
Shape of wound i.e. single and double
edge
Time of attack i.e. age of wound healing
41. DEFENSE WOUNDS
Salient features:
● 40% seen in homicide
Incidence
● nature of defense wound
● Location : active vs. passive
● defense wound absent ie.
Unconscious, alcohol, victim
demography
● Medicolegal importance i.e.
homicide/sexual assault
Source: Aggrawal, A. (2016).
Source: Aggrawal, A. (2016).
42. THERAPEUTIC WOUNDS
Source: Aggrawal, A. (2016).
Therapeutic or iatrogenic
wounds are wounds
produced by doctors
during treatment (eg.
surgical wounds of chest
and abdomen for drainage
tubes, tracheostomy,
thoracotomy, laparotomy,
cut-open wounds for IV
catheters etc).
43. This Photo by Unknown Author is licensed under CC BY-SA