Mouth ulcer Jelly formulation. Here showed that how mouth ulcer jelly formulation is beneficial over a conventional drug. Patient compliance is increase because it is easy for administration. Advantages of mouth ulcer jelly

1. • DOMAIN NAME : NOVEL HERBAL
DRUG DELIVERY SYSTEM
• SUBMITTED BY – SUDARSHAN B
GANGURDE
• UNDER GUIDANCE – PROF. TEJASHRI
DUGAJE
• PRN NO. 2052811823008
• ROLL NO. 56

2. NOVEL HERBAL DRUG
AS A ANTIULCER
JELLY FORMULATION

3. INDEX
1. INTRODUCTION
2. AIM
3. MARKETED PREPARATION AVAILABLE IN THE MARKET
4. FORMULATION
5. JELLIES AS A ANTI ULCER
6. PROCEDURE
7. REFERENCE

4. INTRODUCTION
•
• THE ULCER MAINLY CAUSES DUE TO THE DEFICIENCY OF
VIT B12, IN THIS WE CAN GIVE THE VIT B12 TO THE
PERSON BY JELLIES.
• MAINLY IN WOMEN IT WILL USED AS DIAETERY
SUPPLEMENT..
• THE JELLIES ARE EASY TO ADMINISTERED.THAT’S WHY WE
USE THE JELLY TO CARRY THOSE MEDICAMENT.
• IT CAN GIVE THE SITE OF ACTION.
• CHILDRENS AND WOMENS CAN EASILY ADMINISTERED.

5. • Different marketed preparations
available in the market
• Smilogen
• Olarcare
• Bicasule
• Pan DSR
• Many synthetic and some herbal preparations are available
in the market .
• But for the fast action and increase it’s effectiveness we
making here the herbal + synthetic

6. DIFFERENT FORMULATIONS OF
ANTI ULCER
• TABLET AS A ANTIULCER
1. PPI – RABEPRAZOLE
2. H2 ANTIHISTAMINE – RANITIDINE, CIMETIDINE,
3. ANTI H PYLORIC DRUG – AMOXICILLIN,
CLARITHROMYCINE

7. SYRUP AS ANTIULCER
• SUCRADIL O – SUCRALFATE & OXETACAINE
SUSPENSION ( FOR ULCER HEALING )
• RANITIDINE ORAL SUSPENSION
• YECCO ANTIULCER – HERBAL SYRUP
• DIZZER – DRIED ALUMINIUM HYDROXIDE, .
MAGNESIUM HYDROXIDE & .
SIMETHICONE SUSPENSION

8. OINTMENT AS A ANTIULCER
• OLARCARE – VITAMINS B. COMPLEX
• ORAGEL – BENZOCAINE , BENZALKONIUM, ZINC CL
• MUCOPAIN - BENZOCAINE
• ORASORE – CHOLINE SALICYLATE , LIGNOCAINE,
BENZALKONIUM CHLORIDE, GLYCERINE
• SMILOGEL - TANNIC ACID, CHOLINE SALICYLATE,
BENZALKONIUM CHLORIDE , MENTHOL GEL

9. CAPSULES AS A ANTI ULCER
• OMEE – OMEPRAZOLE
• OMEE D – OMEPRAZOLE AND DOMPERIDONE
• RABEZ 20 – RABEPRAZOLE
• ENTERIC COATED RABEPRAZOLE SODIUM AND
LEVOSULPHANIRIDE (SR) CAPSULE

10. JELLIES
• JELLIES ARE TRANSLUCENT, TRANSPARENT OR
NON-GREASY SEMISOLID PREPARATIONS MEANT
FOR EXTERNAL AND INTERNAL APPLICATIONS.
NATURAL GELLING AGENT SUCH AS PECTIN,
SODIUM ALGINATE OR FROM SYNTHETIC
DERIVATIVES OF NATURAL SUBSTANCE SUCH AS
METHYL CELLULOSE, AND SODIUM
CARBOXYMETHYL CELLULOSE FOR THE
PREPARATION OF JELLIES.

11. WHAT IS THE NEED OF ANTIULCER
JELLIES
• THE RECENT ADVANCES IN NOVEL DRUG DELIVERY SYSTEMS
(NDDS) AIMS TO IMPROVE SAFETY AND EFFICACY OF DOSAGE
FORM FOR ADMINISTRATION AND TO ACHIEVE BETTER
PATIENT COMPLIANCE AND CONVENIENCE, HENCE APPROACH
LEADING TO DEVELOPMENT OF ORAL MEDICATED JELLY.
• THERE ARE VARIOUS PREPARATIONS LIKE TABLETS, CAPSULES,
PILLS, SYRUP, EMULSION, ETC. FOR ORAL ADMINISTRATION,
WHICH ARE NOT EASILY ACCEPTED BY PATIENT WITH
DYSPHAGIA, PEDIATRIC AND GERIATRIC PATIENTS, HENCE
PATIENT COMPLIANT DOSAGE FORM PROVES BENEFICIAL OVER

12. WHAT IS THE NEED OF ANTIULCER
JELLIES
• DEVELOPMENT OF THIS TYPE OF FORMULATION
1. INCREASE IN BIOAVAILABILITY,
2. HELPS TO BYPASS EXTENSIVE HEPATIC FIRST PASS METABOLISM,
3. REDUCTION OF DOSAGE WASTAGE, DOSE DUMPING, STABILITY
AND TASTE MASKING.
4. NOW-A-DAYS, JELLIES CANDIES ARE EASILY ACCEPTED BY
CHILDREN WITH FULL DENTITION AS THEY ENJOY THE TASTE AND
THE CHEWING PROPERTY OF THE JELLIES BECAUSE THEY ARE
OFTEN FLAVOURED WITH FRUIT JUICES, EXTRACTS AND HAVE
SWEETNESS PROPERTY.

13. • INGREDIENTS
• GELLING AGENT : GELLAN GUM, GELATIN,
XANTHANGUM, TRAGACANTH, CARRAGEN
• STABILIZERS : PROPYLENE GLYCOL, SORBITOL
• PRESERVATIVES : METHYL PARABEN, CHLORHEXIDNE
ACETATE, PROPYL PARABEN, BENZALKONIUM CHLORIDE,
SODIUM BENZOATE.
KEY INGREDIENTS USED IN JELLY
FORMULATION

14. EXCIPIENT
• VARIOUS HERBAL EXCIPIENT WILL BE USE IN THIS
PREPARATION FOR
• BETTER STABILITY AND EFFICACY.
• EG. HONEY , CLOVE OIL

15. PREPARATION METHOD OF JELLIES
1. ALL THE INGREDIENTS WILL BE WEIGHED ACCURATELY.
2. DRUG DISSOLVES IN SMALL AMOUNT OF SOLVENT (ETHANOL).
3. IN ONE BEAKER SUGAR SYRUP SHOULD BE PREPARED BY ADDING
SUGAR IN BEAKER. GELLING AGENT WILL BE ADDED TO THAT
SOLUTION WITH CONSTANT MECHANICAL STIRRING AND HEATED
TO DISSOLVE TO ACHIEVE DESIRED STIFFNESS.
4. WHEN COMPLETELY DISSOLVE OF GELLING AGENT, STABILIZER
AND CITRIC ACID SHOULD BE PROPERLY ADDED AND REPEAT
STIRRED TO ENHANCE SOFTNESS OF THE JELLY BY MAINTAIN PH
RESPECTIVELY, AND THEN AFTER BOIL FOR FEW MINUTES.

16. PRESERVATIVE SHOULD BE ADDED TO THAT POLYMERIC
SOLUTION AFTER BOILING AND MIXED CONTINUOUSLY
AND UNIFORMLY.
NOW, DISSOLVED DRUGS ADDED BEFORE JELLY IS
ALLOWED TO SET AND MIX CONTINUOUSLY.
WHOLE POLYMERIC SOLUTION SHOULD POURED IN TO
MOULDS AND THEN ALLOWED IT FOR COOLING AND
SETTLING UNDISTURBED BY PROPER ENFOLD THE MOULDS
TO PROTECT EXPOSURE TO EXTERNAL ENVIRONMENT.

17. ADVANTAGES
IT IS CAN BE ADMINISTER ANYWHERE AND ANYTIME WITHOUT WATER
THE TREATMENT CAN BE TERMINATED EASILY AT ANY TIME, IF
REQUIRED.
FLEXIBILITY IN DESIGN.
IMPROVE IN PATIENT COMPLIANCE.
REDUCED DOSE FREQUENCY.
MEDICATED JELLIES ARE FEASIBLE IN LOCAL TREATMENT OF DISEASE
OF SYSTEMIC CONDITION OR ORAL CAVITY.
IMPROVE BIOAVAILABILITY OR BY FIRST PASS METABOLISM.
HIGHLY ACCEPTABLE BY CHILDREN, ELDERLY AND DYSPHAGIC

18. USES :
1. VARIOUS TYPES OF ULCER CAN BE TREATED.
2. IT WILL GIVE PROLONGED ACTION.
3. LOCAL SITE OF ACTION.
4. IT CAN BE USES AS DIATERY SUPPLEMENT.
5. CAN BE USE IN DEFICIENCY BUT B12.

19. REFERENCES
• INDIAN PHARMACOPOEIA
• PHARMACOLOGY KD TRIPATHI
• PRAKASH K, SATYANARAYANA VM. FORMULATION DEVELOPMENT
AND EVALUATION OF NOVEL ORAL JELLIES OF CARBAMAZEPINE
USING PECTIN, GUAR GUM AND GELLAN GUM. ASIAN J PHARM,
2014; 8: 2419. 7.
• NARASIMHARAO N, P.SRINIVASABABU ET AL., FABRICATION AND
EVALUATION OF OROGEL CONTAINING FERROUS FUMARATE.
INDIAN JOURNAL OF RESEARCH IN PHARMACY AND
BIOTECHNOLOGY, 2017
• DUBEY M, SHETH Z, DESIGN AND DEVELOPMENT OF ORAL
MEDICATED JELLY OF PALONOSETRON HCL. PARIPEX-INDIAN

20. THANK YOU !