The document discusses barbiturate and morphine/opioid poisoning. It provides details on the classification, mechanism of action, signs and symptoms, and management of barbiturate poisoning. It describes how barbiturates bind to GABA receptors and prolong opening of chloride channels, inhibiting the central nervous system. Signs of acute poisoning include depression, amnesia, respiratory issues and death from respiratory arrest. Management involves cardio-respiratory support, preventing drug absorption, and removing barbiturates from the body through charcoal, diuresis or dialysis. For morphine/opioid poisoning, it notes respiratory depression as a major risk and describes treatment with naloxone to reverse effects or intubation to ensure
Biopharmaceutics: Mechanisms of Drug AbsorptionSURYAKANTVERMA2
Biopharmaceutics is defined as the study of factors influencing the rate and amount of drug that reaches the systemic circulation and the use of this information to optimise the therapeutic efficacy of the drug products.
Malignancy is most familiar as a characterization of cancer.Chemotherapy is a category of cancer treatment that uses one or more anti-cancer drugs as part of a standardized chemotherapy regimen
Biopharmaceutics: Mechanisms of Drug AbsorptionSURYAKANTVERMA2
Biopharmaceutics is defined as the study of factors influencing the rate and amount of drug that reaches the systemic circulation and the use of this information to optimise the therapeutic efficacy of the drug products.
Malignancy is most familiar as a characterization of cancer.Chemotherapy is a category of cancer treatment that uses one or more anti-cancer drugs as part of a standardized chemotherapy regimen
All about barbiturate poisoning , causes , clinical symptoms , types of poisoning , barbiturates classification , adverse effects and toxic effects of barbiturate poisoning , Management of barbiturate poisoning , Scandinavian method , support vital function , prevention and further absorption .
this will give brief about the peptic ulcer and give information about the drug used for peptic ulcer and classification of drugs including drugs and there use adverse effect.
The phenomenon of complex formation of drug with protein is called as Protein drug binding. The proteins are particularly responsible for such an interaction. A drug can interact with several tissue components.
In this presentation Pharmacology III Unit V covered
Following points are included;
Various Definitions:
Acute toxicity
Subacute toxicity
Chronic toxicity
Genotoxicity,
Carcinogenicity,
Teratogenicity
Mutagenicity
General principles of treatment of poisoning
Clinical symptoms and management of various poisoning conditions.
like Barbiturate poisoning, Morphinpoisoning, Organophosphoruspoisoning, Lead poisoning, mercury poisoning, Arsenin poisoning, And its specific antidote
All about barbiturate poisoning , causes , clinical symptoms , types of poisoning , barbiturates classification , adverse effects and toxic effects of barbiturate poisoning , Management of barbiturate poisoning , Scandinavian method , support vital function , prevention and further absorption .
this will give brief about the peptic ulcer and give information about the drug used for peptic ulcer and classification of drugs including drugs and there use adverse effect.
The phenomenon of complex formation of drug with protein is called as Protein drug binding. The proteins are particularly responsible for such an interaction. A drug can interact with several tissue components.
In this presentation Pharmacology III Unit V covered
Following points are included;
Various Definitions:
Acute toxicity
Subacute toxicity
Chronic toxicity
Genotoxicity,
Carcinogenicity,
Teratogenicity
Mutagenicity
General principles of treatment of poisoning
Clinical symptoms and management of various poisoning conditions.
like Barbiturate poisoning, Morphinpoisoning, Organophosphoruspoisoning, Lead poisoning, mercury poisoning, Arsenin poisoning, And its specific antidote
Intravenous Anaesthetics are a group of fast-acting
compounds that are used to induce a state of impaired
awareness of complete sedation.
These are drugs that, when given intravenously in an
appropriate dose, cause a rapid loss of consciousness.
Define Muscle relaxants
Classification and pharmacology properties .
Toxicology of muscle relaxants
How to investigate muscle relaxant toxicity and managing.
Common medication used for anesthesia, there action; dosage; adverse effect; duration of action.
They Include {inhalation + Induction + Muscle relaxant + Anticholinergic + Analgesic + Resuscitation}
Ondansetron
Class
• Seratonin ( 5-HT3) antagonist.
Uses
1. The management of nausea and vomiting induced by chemotherapy and
radiotherapy .
2. In the prevention and treatment of PONV
Main action
• Antiemetic.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
2. • Barbiturates are chemical derivatives of barbituric acid.
• Depending on their duration of action, they can be classified as long
acting (>6 hours), intermediate acting (3-6 hours) and short acting (<3
hours).
• They are classified under sedatives and hypnotics category.
• Barbiturates are frequently involved in over dosage, and are generally
taken with suicidal intent.
• The poisoning occurs after the ingestion of total dose of 3g for short
acting drugs and 5g for long acting drugs.
• The poisonous effect of barbiturates is potentiated by alcohol, narcotics,
tranquilisers and antidepressants.
3. MECHANISM OF POISONING
All barbiturates bind to Gamma amino butyric acid (GABA) receptors and prolong the
opening of chloride channels, thus inhibiting excitable cells of the central nervous system.
4. SIGNS AND SYMPTOMS
• It is characterized by progressive CNS depression culminating in paralysis of brainstem and medulla.
• Acute Poisoning - Signs and Symptoms:
• Depression,
• amnesia,
• lowered body temperature,
• depressed circulation (marked fall in blood pressure),
• respiratory embarrassment and cyanosis,
• limbs are flaccid,
• retention of urine is common,
• corneal reflexes may be absent,
• ataxia,
• deep coma,
• possible shock,
• cold extremities,
• death due to respiratory arrest (frequently associated with marked cardio-vascular depression) or pneumonia.
5. • Chronic Poisoning - Signs and Symptoms:
• Skin rash,
• slurred speech,
• cyanosis,
• amnesia,
• anorexia, (reduced appetite)
• emotional instability,
• ataxia and
• constipation.
MANAGEMENT OF BARBITURATE POISONING
1. CARDIO-RESPIRATORY SUPPORT:
• A clear airway is ensured by thorough suctioning and insertion of oral airway.
• The passage of barbiturates across the BBB into CNS may be facilitated during
hypoventilation and respiratory acidosis.
• If the patient is comatose, prompt intubation (without waiting for the partial oxygen to fall
to dangerously low levels) is strongly advocated .
• Dehydration is corrected by guided fluid therapy.
• If hypotension persists, IV infusion of plasma volume expanders and vasopressors are
started.
6. 2. MEASURES TO PREVENT ABSORPTION
• a. Gastric lavage: It is done within 2-4 hours of ingestion.
• b. Activated charcoal:. 1g/Kg is administered through nasogastric tube.
• Cathartic agent like magnesium sulphate can be used along with it for further removal of
barbiturates but hypermagnesemia can occur.
3. MEASURES FOR REMOVAL OF BARBITURATES
• a. Frequent doses of activated charcoal : These adsorb the barbiturates when they
reenter the GIT through enterohepatic circulation. 1g/Kg initial dose is followed by
0.5g/kg every 2-4 hours.
• b. Forced diuresis with alkalinisation of urine:
• This is especially useful in long acting barbiturates which are largely excreted by the
kidney.
• At high rates of urine flow (by the use of diuretics), the renal clearance of barbiturates is
increased.
• Thus, it shortens the duration of coma and decreases plasma concentration of barbiturates.
7. • This should be avoided in older patients as it can cause pulmonary oedema,
hyponatraemia.
• In addition to diuresis, phenobarbitol excretion can be enhanced ten fold by urinary
alkalinization (pH 7.8 -8.0).
• Alkalinising urine causes ionization of phenobarbitone after its filtration into renal tubular
cells and trapping the agent, thereby inhibiting its re-absorption from renal tubules and
increasing its excretion.
• c. Haemodialysis and haemoperfusion: Is now being used extensively.
• Single six hour haemodialysis can remove more amount of barbiturate.
• Removal of short acting barbiturates is more limited because of lower plasma
concentrations and greater binding to plasma proteins.
• Supportive care: The most important aspect of management in these cases is close
observation and quality nursing care.
• Prophylactic antibiotics should be started.
• Good oral hygiene, temperature maintenance, and posture change at regular intervals.
9. • Morphine is a pain medication belonging to opioid family.
• Naturally extracted from poppy (Papaver somniferum)
• Acts directly on CNS.
• MOST COMMON DRUG OF ABUSE
• Increases feeling of pleasure and warm, relaxation and reduced pain.
• Can be taken through various routes.
• Max effect - within 20min (IV) & 60min (oral)
• Duration of effect - 3 to 7 hours
• General use: Treatment of pain due to myocardial infraction, kidney
stones and during labor.
• Can produce other opioids like hydromorphone, heroin & oxymorphone.
10. Causes:
• Due to excessive consumption of any opioids (may be suicidal/intentional/accidental)
• Majorly due to drug dependence or detoxification.
• Co-ingestion with benzodiazepines or alcohol.
Signs & Symptoms:
• Respiratory depression (major reason for death)
• Hypoxia
• Miosis
• Unconsciousness
• Stupor
• Hepatic injury
• Renal failure
• Hypothermia
• Rhabdomyolysis
11. Mechanism of Poisoning:
• Morphine binds specifically to the neurological opioid receptors called Mu (μ)
receptors.
• Mu (μ) receptors found in cerebral cortex and thalamus.
• It evokes analgesic, sedative and euphoric effects.
• Over activation of Mu (μ) receptors occurs.
• It leads to permanent brain damage
from cerebral hypoxia or neurotoxicity.
12. TREATMENT
• Management of Overdose:
• Patients with Opnea need a pharmacologic or mechanical stimulus in order to breathe. For
patients with stupor, ventilation should be provided.
• Naloxone, the antidote for opioid overdose, is a competitive mu opioid–receptor
antagonist that reverses all signs of opioid intoxication.
• It is active in parenteral, intranasal, or pulmonary route of administration.
• An alternative to administration of naloxone is orotracheal intubation, a procedure that
safely ensures oxygenation and ventilation while providing protection against aspiration.
• Initial dose of naloxone for adults is 0.04 mg;
• If there is no response, the dose should be
increased every 2 minutes according to the
schedule to a maximum of 15 mg.
13. TREATMENT
• Clonidine: Clonidine is generally considered a safe, non-narcotic medication
used to help patients withdraw from opioids.
• It is a centrally acting alpha-2 adrenergic agonist and works to minimize the
noradrenergic hyperactivity seen in opioid withdrawal.
• For opioid withdrawal, clonidine is typically dosed at 0.1 mg to 0.3 mg orally up
to every 6 hours.
• The use of clonidine in opioid withdrawal is limited because of its hypotensive
and sedative adverse effects.
• Naltrexone. Naltrexone is a mu-receptor antagonist.
• It also antagonizes the kappa-receptor, and weakly antagonizes the delta-receptor.
• When used in conjunction with clonidine for opioid withdrawal, naltrexone is
usually dosed between 50 mg and 100 mg daily and can also be dosed 3 times
weekly.