The document summarizes the widespread epidemics and population decline among Native Americans following European contact and conquest. Smallpox, measles, and influenza brought by the Spanish devastated communities with populations dropping by over 90% in some areas, such as Hispaniola, due to lack of immunity. It also outlines the Columbian Exchange that resulted from global interactions between Europe, Africa and the Americas, involving crops, livestock, diseases and more. New goods transformed societies while the emerging slave trade had immense human costs as it forcibly transported over 11 million Africans to the Americas over centuries.