The encapsulation technology is implemented for ingredients such as vitamins, minerals, sweeteners, phytonutrients, antioxidants, enzymes, probiotics and essential oils, which are highly volatile.
To Read More : https://bit.ly/3tYLY3w
The encapsulation technology is implemented for ingredients such as vitamins, minerals, sweeteners, phytonutrients, antioxidants, enzymes, probiotics and essential oils, which are highly volatile.
To Read More : https://bit.ly/3tYLY3w
This presentation is brief introduction about preservatives employed in pharmaceutical dosage forms to prevent formulation from oxidation and microbial attack during storage and patient usage.it includes classification of preservatives, uses and method of analysis of preservatives and also introduction about pharmacopoeial evaluation of preservatives that is preservative activity test (PAT)
International Journal of Drug Research and Technology covers: Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Drug Synthesis, Pharmaceutical Chemistry, Pharmacology and Toxicology, Pharmaceutical Technology, Pharmacognosy and Phytochemistry, Pharmaceutics, Pharmacy Practice, Biopharmaceutics, Pharmacokinetics and Drug Metabolism, Pharmaceutical Analysis and Quality Assurance, Clinical and Hospital Pharmacy, Pharmaceutical Biotechnology, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Clinical Research, Pharmaceutical Management & Regulatory Affairs and Nanotechnology related to Drug Discovery and all the branches of Medical Science or related disciplines.
International Journal of Drug Research and Technology IJDRT.COM, Research Article, Review Article,innovative papers, literature reviews, mini-reviews, current topics health journal, journal online, free journal, pharmaceutical journal, scientific journal,web journal.
Excipients have been defined in many ways, including as inert substances used as vehicles and diluents for drugs. The problem with this definition is that in recent years excipients have proved to be anything but inert, not only possessing the ability to react with other ingredients in the formulation, but also to cause adverse and hypersensitivity reactions in patients. These range from a mild rash to a potentially life-threatening reaction. Different brands of the same drug may contain different excipients, especially preservatives and colourants. The Consumer Medicines Information provides a list of excipients, and information on the safety of individual excipients can be found in drug reference guides.
Pharmaceutical excipients are pharmacologically inert substances which are included in the manufacturing process or are contained in a finished pharmaceutical product dosage form to alter the functions.
This presentation is brief introduction about preservatives employed in pharmaceutical dosage forms to prevent formulation from oxidation and microbial attack during storage and patient usage.it includes classification of preservatives, uses and method of analysis of preservatives and also introduction about pharmacopoeial evaluation of preservatives that is preservative activity test (PAT)
International Journal of Drug Research and Technology covers: Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Drug Synthesis, Pharmaceutical Chemistry, Pharmacology and Toxicology, Pharmaceutical Technology, Pharmacognosy and Phytochemistry, Pharmaceutics, Pharmacy Practice, Biopharmaceutics, Pharmacokinetics and Drug Metabolism, Pharmaceutical Analysis and Quality Assurance, Clinical and Hospital Pharmacy, Pharmaceutical Biotechnology, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Clinical Research, Pharmaceutical Management & Regulatory Affairs and Nanotechnology related to Drug Discovery and all the branches of Medical Science or related disciplines.
International Journal of Drug Research and Technology IJDRT.COM, Research Article, Review Article,innovative papers, literature reviews, mini-reviews, current topics health journal, journal online, free journal, pharmaceutical journal, scientific journal,web journal.
Excipients have been defined in many ways, including as inert substances used as vehicles and diluents for drugs. The problem with this definition is that in recent years excipients have proved to be anything but inert, not only possessing the ability to react with other ingredients in the formulation, but also to cause adverse and hypersensitivity reactions in patients. These range from a mild rash to a potentially life-threatening reaction. Different brands of the same drug may contain different excipients, especially preservatives and colourants. The Consumer Medicines Information provides a list of excipients, and information on the safety of individual excipients can be found in drug reference guides.
Pharmaceutical excipients are pharmacologically inert substances which are included in the manufacturing process or are contained in a finished pharmaceutical product dosage form to alter the functions.
“It is define has an substance or Pharmaceutical material is encapsulated over the surface of solid, droplet of liquid and dispersion of medium is known has Microencapsulation”
Microencapsulation may be defined as the packaging technology of solids, liquid or gaseous material with thin polymeric coatings, forming small particles called microcapsules .
Different types of dosage forms have different properties so according to their handling and storage conditions we have to select containers accordingly
3. INTRODUCTION
• Is a process in which tiny particles or dropletsIs a process in which tiny particles or droplets
are surrounded by a polymeric material toare surrounded by a polymeric material to
form capsules.form capsules.
• Micro particles consist of two components a)Micro particles consist of two components a)
Core materialCore material
b) Coat or wall or shell materialb) Coat or wall or shell material
3
4. REASONS
• Protect sensitive substances from the externalProtect sensitive substances from the external
environmentenvironment
• Mask the organoleptic properties.Mask the organoleptic properties.
• Obtain controlled and target release of theObtain controlled and target release of the
drug substancedrug substance
• For safe handling of the toxic materialsFor safe handling of the toxic materials
• To avoid adverse effects like gastric irritationTo avoid adverse effects like gastric irritation
of the drug.of the drug.
4
6. MICROENCAPSULATION
TECHNIQUES
SPRAY DRYING
• Materials used –Materials used –
modified starch, maltodextrin and gumsmodified starch, maltodextrin and gums
• Preparation of dispersionPreparation of dispersion
• Homogenization of the dispersionHomogenization of the dispersion
• Atomization of the in feed dispersionAtomization of the in feed dispersion
• Dehydration of the atomized particlesDehydration of the atomized particles
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8. SPRAY COOLING
• Air temperature is cooler than that for sprayAir temperature is cooler than that for spray
dryingdrying
• Wall material is a molten fat or wax.Wall material is a molten fat or wax.
• Spray cooling uses a vegetable oil with aSpray cooling uses a vegetable oil with a
melting point in the range of 45-122 C.̊melting point in the range of 45-122 C.̊
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9. SPRAY CHILLING
• Spray chilling uses a fractionated orSpray chilling uses a fractionated or
hydrogenated vegetable oilhydrogenated vegetable oil
(melting point 32-42 C).̊(melting point 32-42 C).̊
• Frozen liquids, heat-sensitive materials andFrozen liquids, heat-sensitive materials and
those not soluble in the usual solvents can bethose not soluble in the usual solvents can be
encapsulated by spray chilling.encapsulated by spray chilling.
• Applications - dry soup mixes, foods withApplications - dry soup mixes, foods with
high fat contents and bakery productshigh fat contents and bakery products
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10. FLUIDISED BED COATING
• Also known as air suspension coatingAlso known as air suspension coating
• It consist of dispersing the solid particulateIt consist of dispersing the solid particulate
core material in supporting air stream andcore material in supporting air stream and
being coated with coating material (usuallybeing coated with coating material (usually
polymeric solution)polymeric solution)
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12. LYOPHILIZATION
• Used dehydration of almost all heat sensitiveUsed dehydration of almost all heat sensitive
materials and aromas.materials and aromas.
• Used to encapsulate water-soluble essencesUsed to encapsulate water-soluble essences
and natural aromas as well as drugs.and natural aromas as well as drugs.
• Mixing of core in a coating solutionMixing of core in a coating solution
• Freeze-drying of the mixtureFreeze-drying of the mixture
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13. NO Microencapsulation
technique
Major steps in encapsulation
1 Spray drying Preparation of dispersion
Homogenization of the dispersion
Atomization of the in feed dispersion
Dehydration of the atomized particles
2 Spray chilling, spray
cooling
Preparation of the dispersion
Homogenization of the dispersion
Atomization of the in feed dispersion
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14. Cont…
3 Fluidized-bed coating Preparation of coating solution
Fluidization of core particles.
Coating of core particles
4 Lyophilization Mixing of core in a coating solution
Freeze-drying of the mixture
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15. IDEAL COATING MATERIALS
• 1. Good rheological properties at high
concentration and easy workability during
encapsulation.
• 2. The ability to disperse or emulsify the
active material and stabilize the emulsion
produced.
• 3. Non-reactivity with the material to be
encapsulated both during processing and
on prolonged storage.
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16. Cont…
• 4. The ability to seal and hold the active
material within its structure during
processing or storage.
• 5. The ability to provide maximum
protection to the active material against
environmental conditions (e.g., oxygen,
heat, light, humidity).
16
17. Cont…
• 6. Solubility in solvents acceptable in the
food industry (e.g., water, ethanol).
• 7. Chemical nonreactivity with the active
core materials.
• 8. Inexpensive.
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21. • Demerits of microenca
• p
• sulation:
•
• No single microencapsulation process is
adaptable to all corematerialcandidateor
product applications
•
• Complicatedprocess and requires skilled 21
22. CASE STUDY 1
Title:-
Microencapsulation of Banana Passion
Fruit(Passiflora tripartita Var. Mollissima): A
NewAlternative as a Natural Additive as Antioxidant
Maritza Gil et al(2014)
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23. Introduction
• Banana passion fruit is one of the most
promising tropical fruits giving its
antioxidant activity to replace synthetic
additives.
• Microencapsulation of the bioactive
compounds in the pulp of banana passion
fruit is a feasible and practical option.
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24. Objective
• Microencapsulate the pulp of banana
passion fruit with several mixtures of
encapsulants.
• Identify which one of these mixtures is
better to preserve its AOA as an
alternative for a natural additive.
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25. Materials and methods
• banana passion fruit
• Maltodextrin
• modified starch
• DPPH
• acetic acid
• Iron trichloride
• Gallic acid
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26. Preparation of the Banana Passion Fruit
Pulp
pulp (9kg)
90 c, 5 min̊
pulper
seed seperation
packing(-20 c,PP bag)̊
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27. Preparation of the Microcapsules
• 30% MD/MS distilled water(100ml)
• Rehydrate 12h,10-20 c̊
pulp(10g)
1:3
homogenize
400 rpm,5 min
spray drying (180+5 c)̲ ̊
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31. Evaluation of the AOA with the DPPH
Method
• 10 μL of the extrct + 90 μL of the
methanolic DPPH• solution (20 mg/L).
30 minutes dark at
room temp
absorbance read(517 nm)
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32. Evaluation of the AOA by the Use of the
Radical Cation Method ABTS●+
• The free radical ABTS●+ was generated
by the oxidation reaction of the ABTS
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33. Quantification of Bioactive Compounds
• By HPLC reading at 280nm.
• To separate bioactive compound
Ultra aqueous column
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34. SEM
• To determine external structure
• 15 KW with a vacuum of 25 Pa.
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38. Conclusions
• Has high antioxidant activity
• Important phenolic compounds present
Caffeic acid
Coumaric acid
Ferulic acid
• spray-drying is suited to protect the AOA
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