This document provides information on menopause, including its definition, causes, symptoms, effects, diagnosis, and treatment options. It can be summarized as follows:
1. Menopause is defined as the permanent cessation of menstruation resulting from loss of ovarian follicles, with an average age of onset being 51 years. It can occur prematurely before age 45 due to various causes.
2. Short term symptoms include hot flashes, mood swings, sleep problems, and vaginal dryness. Long term risks include osteoporosis and increased risk of heart disease.
3. Diagnosis is based on cessation of periods for 12 months and elevated FSH levels. Treatment options include hormone
Ovarian reserve refers to the reproductive potential left within a woman's two ovaries based on number and quality of eggs. Diminished ovarian reserve is the loss of normal reproductive potential in the ovaries due to a lower count or quality of the remaining eggs
Healthy Choices are the key!
Healthy diet including raw foods & avoiding processed food or high fat diet is the best way to eliminate toxins from your body. Toxins damage your egg follicles.
Menopause: Symptoms, Concerns, and Management StrategiesSummit Health
Presentation about menopause, including information about common symptoms such as hot flashes, sleeplessness, and weight gain as well as other physiologic changes such as bone loss and cardiovascular risks. Dr. Gibbons and Dr. Cummings will offer recommendations on treatment and management options that can help you navigate this important life transition.
Luteal phase insufficiency is one of the most important aspect of fertility treatment . But due to lack of proper understanding many unwanted medications are prescribed . This ppt will give an idea on the best evidence based luteal phase support for an ivf cycle.
Ovarian reserve refers to the reproductive potential left within a woman's two ovaries based on number and quality of eggs. Diminished ovarian reserve is the loss of normal reproductive potential in the ovaries due to a lower count or quality of the remaining eggs
Healthy Choices are the key!
Healthy diet including raw foods & avoiding processed food or high fat diet is the best way to eliminate toxins from your body. Toxins damage your egg follicles.
Menopause: Symptoms, Concerns, and Management StrategiesSummit Health
Presentation about menopause, including information about common symptoms such as hot flashes, sleeplessness, and weight gain as well as other physiologic changes such as bone loss and cardiovascular risks. Dr. Gibbons and Dr. Cummings will offer recommendations on treatment and management options that can help you navigate this important life transition.
Luteal phase insufficiency is one of the most important aspect of fertility treatment . But due to lack of proper understanding many unwanted medications are prescribed . This ppt will give an idea on the best evidence based luteal phase support for an ivf cycle.
Eventi estivi, contributo per l'affitto, abbattimento delle tasse locali per le nuove attività, riqualificazione urbana, sicurezza, semplificazione della disciplina edilizia e Parco del Rubicone: tutte le misure 2016 per una nuova vitalità del centro storico di Savignano sul Rubicone
Marcella Marletta - IX Conferenza Nazionale sui Dispositivi MediciMarcella Marletta
La traccia del discorso tenuto dalla dottoressa Marcella Marletta in occasione della IX Conferenza Nazionale sui Dispositivi Medici, importante evento di settore.
Marcella Marletta - Programma VIII Congresso Nazionale SihtaMarcella Marletta
Il programma dell'ottava edizione del Congresso Nazionale Sihta, tenutosi a Roma dal 1° al 3 ottobre, con la partecipazione, tra gli altri, della dottoressa Marcella Marletta.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
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Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
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NVBDCP.pptx Nation vector borne disease control programSapna Thakur
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
2. Permanent cessation of menstruation resulting from the
loss of ovarian follicles (WHO).
DEFINITION
• Effects every woman
• Cessation of menstruation for the
past twelve months
• Average Age - 51 years
3. Need...
Global population of age 60
yrs.
Currently -580 million
• 2020 - One billion
• 75% -Elderly
• 50% -Postmenopausal
women
5. Premenopause
The time period of
endocrine changes
before cessation of
menstruation.
Climacteric/
Perimenopause
The period of
endocrine changes
surround the
menopause is called
Climacteric
Postmenopause
The time period of
endocrine changes
After cessation of
menstruation
what is meant by Climacteric?
6. Actual change
around 35 years
sensitive germ
cells eleminated
germ cells
resistant to
normal
gonadotrophins
anovulation and
menstrual
irregularity
rise in
gonadotrophin
levels restores
ovulation and
normal
menstruation
compensated
ovarian failure
Pathophysiology
7. A time comes when raised
gonadotropins level fails to achieve
any significant follicular growth and
estrogen produced is not sufficient to
cause endometrial growth results in
cessation of menstruation and hence
menopause
Pathophysiology
11. Short term effects
•Menstrual irregularities
•Unintended pregnancy
•Hot flushes
•Palpitation
•Muscle And Joint Pain
•Low Backache
•Vaginal Dryness
•Urinary Leak
•Urinary Frequency
•Fatigue
•Mood Swings
•Depression
•Sleeping Problems
•Memory Lapse
•Decreased Libido
•Weight Gain
•Dryness Of Skin
•Hair Loss
12. • 75% women
• Intense heat (face,forehead,neck,chest,earlobe)
• Associated with night sweats,irritability,lethargy,insomnia and
tiredness
• More pronounced in premature and surgically induced menopause
Hot flushes
13. What can you do about Hot flushes
To reduce an attack
- Avoid spicy food, coffee,
tea, alcohol
- Wear loose cotton clothes
- Avoid hot water bath just
before sleeping
- Medical treatment options
14. (i) Urinary
• Dysuria
• Frequency
• Urgency
• voiding
difficulties
(ii) Genital
• Dyspareunia
• Apareunia
• genital tract
trauma
• loss of libido and
• uterovaginal
prolapse
Genitourinary Symptoms
16. A young women is a gift of nature,
An old woman is a work of art.
17. • Osteoporosis
• Heart Disease
• Alzeihermen’s Disease
Of Menopause
Of Ageing
• Arthritis
• Diabetes
• Hypertension
• Problems of Hearing, vision
Long term effects
18. • Average rate of bone loss is 3% per annum
• 50% of women by age of 60 years
• Bones at high risk of fracture are
• Distal radius,neck of femur,vertebral body
• Results in structural deformity, Dowagers hump (fracture of vertebrae T8-L4)
Osteoporosis
21. GETTING SHORTER MAY BE JUST THE
BEGINNING
• Bone becomes weak which
leads to multiple breaks in the
spine
• With gradual accumulation of
these breaks people get shorter
• Could lead to a curved back
known as “Dowager’s Hump”
22. A FRACTURE CAN TURN YOUR LIFE
INTO ONE OF DISABILITY
Broken hips cause permanent
disability
One in four people who
suffer a hip fracture due to
osteoporosis will die within
one year
23. Predominant factor increasing risk of cardiovascular
diseases in post menopausal women is decreased
HDL:LDL ratio due to estrogen deficiency
Ischemic Heart Disease
24. • Incidence 3 times more in women aged 65 yrs or more
• Less common in obese women, because of endogenous estrogen
production by adipose tissues
• Prevention by estrogen replacement therapy.
Alzheimer’s disease
25. • Like decrease in bone mass skin thickness also declines after
menopause
• Skin collagen declines by 30 % in first 10 yrs after menopause
• Collagen restored to premenopausal levels within 6 months of initial
hormone replacement therapy.
Skin
26. • Patients in premature menopause fails to have more children
• Reproduction with ovum donation remains only option.
Infertility
29. Hormonal Non Hormonal Add on
•Estrogen
•Tibolone
•SERMS
Raloxifine
• Bisphosphonate
Alendronate
Risedronate
•Others
• Calcium
• Vit D
Analog
•Alfacalcidol
Treatments Therapy
30. (i) Tibolone
• Non hormonal steroid with oestrogenic, progestogenic and
androgenic properties.
• Dose is 2.5 mg/day
• Reduces hot flushes, sleeplessness and improves mood and libido
• Increases bone density by 8 % after 2 years use
• Side effect is irregular bleeding
Non Hormonal therapy
31. (ii) Calcitonin
(iii) Bisphosphonates
Sodium etidronate and clonronate have beneficial effect on bone mass
(iv) Exercise
Decreases incidence of osteoporosis,ischemic heart disease and depression
(v) Calcium Supplements
Calcium alone no effect on osteoporosis
Calcium + estrogen = beneficial effects in lower doses
(vi) Hypnotics,Sedatives,Tranquilizers
Non Hormonal therapy
32. • Indications
(1) Women distressed with perimenopausal symptoms
(2) Women at increased risk of osteoporosis
(3) Women who wants to take it by choice
The risks of HRT must be explained and follow up ensured in such
patients.
Harmone Replacement therapy
33. Before prescribing HRT,benefits and risks associated
with it should be discussed in detail
Blood pressure,weight is recorded
Breasts examined for any lump
Pelvic examination for any mass
Cervical smear is carried out
In some cases pretreatment mammography is
indicated
Pre treatment evaluation
34. Blood sugar estimation
Renal and liver function tests
Lipid profile
Pelvic ultrasonography
Endometrial sampling
Bone densitometry
Investigations not mandatory but indicated in
selective patients
Optional Investigations
35. (A) Short period of time
3 months to one year
For perimenopausal symptoms
(B) Long period of time
5 to 10 yrs
Prevention of cardiac diseases and osteoporosis
Patients taking HRT should have checkups at
regular intervals for benefits and side effects of drug
Treatment duration and follow up
36. (i) Oestrogen alone
In patients where hysterectomy has been performed
Natural oestrogens are prefered over synthetic,coz synthetic
oestrogen are metabollized 100-1000 times more than natural
oestrogen,hence chances of side effects (hypertension and
thromboembolism) is high
Natural oestrogens include
17 beta oestradiol oestriol
Oestrone conjugated equine estrogen
Estrogen and progestogen combination
To eliminate the risk of endometrial hyperplasia and carcinoma in
women with intact uterus progestogens along with estrogens are
given which causes regular endometrial shedding at menstruation
Types of Harmones
37. • Progestogens alone
Indicated in patients cannot tolerate
estrogen/contraindicated
Controls hot flushes and prevent bone loss
Have no cardio protective role as it causes reduction
of HDL
Types of Harmones
38. (i) Absolute
• History of breast
cancer
(ii) Relative
• Hypertension
• Diabetes
• Endometriosis
• Fibroids
• History of
thromboembolism
Contraindications of HRT
39. • (i) return of menstruation in
postmenopausal women
• (ii) premenstrual syndrome like symptoms
(bloating,fluid
retention,mastalgia,headache,depressn)
• (iii) disturbance in lipid profile (reduced
HDL:LDL)
(a) Progestogen
related
• (i) risk of thromboembolism(b) Estrogen related
• (i) Endometrial cancer
• (ii) Ovarian cancer
• (iii) Cervical,Vaginal,Vulval cancers
• (iv) Breast cancer
(c) Hormone
replacement
therapy and Cancers
Risks/side effects of HRT