Neuroimaging or brain imaging is the use of various techniques to either directly or indirectly image the structure, function, or pharmacology of the nervous system. It is a relatively new discipline within medicine, neuroscience, and psychology
Nuclear Medicine.................
Radioactivity………………
Gamma camera………………
PET scan and SPECT scan…...........
Nuclear Medicine Studies…………..
Nuclear Medicine Team……………
Safety in Nuclear Medicine…………
Radio imaging techniques are the noninvasive imaging of various organs,
tissues using radioisotopes for the purpose of formulation development,
improvement of dosage form or diagnosis and treatment of disease.
Single-photon emission computed tomography is a nuclear medicine tomographic imaging technique using gamma rays. It is very similar to conventional nuclear medicine planar imaging using a gamma camera. but is able to provide true 3D information
1-definition of SPECT :Single Photon Emission Computed Tomography.
2-differs from BET scan and SPECT.
3-divaice of SPECT.
4-SPECT scan for brain.
5-clinical application
6-patient preparation
7-ADVANTAGE & DISADVANTAGE
Neuroimaging or brain imaging is the use of various techniques to either directly or indirectly image the structure, function, or pharmacology of the nervous system. It is a relatively new discipline within medicine, neuroscience, and psychology
Nuclear Medicine.................
Radioactivity………………
Gamma camera………………
PET scan and SPECT scan…...........
Nuclear Medicine Studies…………..
Nuclear Medicine Team……………
Safety in Nuclear Medicine…………
Radio imaging techniques are the noninvasive imaging of various organs,
tissues using radioisotopes for the purpose of formulation development,
improvement of dosage form or diagnosis and treatment of disease.
Single-photon emission computed tomography is a nuclear medicine tomographic imaging technique using gamma rays. It is very similar to conventional nuclear medicine planar imaging using a gamma camera. but is able to provide true 3D information
1-definition of SPECT :Single Photon Emission Computed Tomography.
2-differs from BET scan and SPECT.
3-divaice of SPECT.
4-SPECT scan for brain.
5-clinical application
6-patient preparation
7-ADVANTAGE & DISADVANTAGE
Austin Journal of Clinical Case Reports is an open access scholarly journal. The goal of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments by publishing case reports in all aspects of Clinical Medicine. Case Reports is an open access journals. The goal of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments by publishing case reports in all aspects of Clinical Medicine.
The aim of this open access journal is to offer service for scientists and academicians to promote, share, and discuss various new issues and developments by publishing clinical case reports in all aspects.
Austin Journal of case repots are a reflective analysis of one, two, or three clinical cases. All clinical case reports submitted must have been approved by an ethics committee or institutional review board.
Austin Journal of Clinical Case Reports is an open access scholarly journal. The goal of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments by publishing case reports in all aspects of Clinical Medicine. Case Reports is an open access journals. The goal of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments by publishing case reports in all aspects of Clinical Medicine.
Austin Journal of Clinical Case Reports is an open access scholarly journal. The goal of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments by publishing case reports in all aspects of Clinical Medicine. Case Reports is an open access journals. The goal of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments by publishing case reports in all aspects of Clinical Medicine.
The aim of this open access journal is to offer service for scientists and academicians to promote, share, and discuss various new issues and developments by publishing clinical case reports in all aspects.
Austin Journal of case repots are a reflective analysis of one, two, or three clinical cases. All clinical case reports submitted must have been approved by an ethics committee or institutional review board.
Austin Journal of Clinical Case Reports is an open access scholarly journal. The goal of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments by publishing case reports in all aspects of Clinical Medicine. Case Reports is an open access journals. The goal of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments by publishing case reports in all aspects of Clinical Medicine.
Journal of Disease Markers is a peer-reviewed, open access journal published by Austin Publishers. It provides easy access to high quality Manuscripts covering wide aspects of dynamic and powerful approaches in understanding the spectrum of disease with applications in observational and analytic epidemiology, randomized clinical trials, screening, diagnosis and prognosis reflecting the entire spectrum of disease from the earliest appearances to the fatal stages.
Austin Publishing Group is a successful host of more than hundred peer reviewed, open access journals in various fields of science and technology with intent to bridge the gap between academia and research access.
Journal of Disease Markers accepts original research articles, review articles, case reports, mini reviews, rapid communication, opinions and editorials on all the related aspects of disease bio markers.
Austin Journal of Civil & Legal Sciences is an open access, peer reviewed, scholarly journal dedicated to publish articles covering all areas of civil and legal sciences.
Austin Journal of Civil & Legal Sciences follows open access policies and published articles are provided to the readers without collecting any changes. Journal provides a platform for mutual exchange of ideas and views covering wide areas of civil & legal sciences.
Austin Publishing Group also brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
CT scan and MRI are the techniques for body imaging. Computed Tomography or Computerized Axial Tomography is commonly referred to as a CT scan.
C- computed (Use of computer) and T- tomography (Greek word “Tomos” means “slice” and “Grapho” means “ To write”
The first commercial CT scanner was invented by Sir Godfrey Hounsfield in United Kingdom.
It is a diagnostic imaging procedure that uses a combination of X-rays and computer technology to produce images of the inside of the body. It shows detailed images of any part of the body including the bones, muscles, fat, organs and blood vessels.
CT scans may be performed to help diagnose tumors, investigate internal bleeding, or check for other internal injuries or damage.
Computed Tomography or Computerized Axial Tomography is commonly referred to as a CT scan.
C- computed (Use of computer) and T- tomography (Greek word “Tomos” means “slice” and “Grapho” means “ To write”
The first commercial CT scanner was invented by Sir Godfrey Hounsfield in United Kingdom.
It is a diagnostic imaging procedure that uses a combination of X-rays and computer technology to produce images of the inside of the body. It shows detailed images of any part of the body including the bones, muscles, fat, organs and blood vessels.
CT scans may be performed to help diagnose tumors, investigate internal bleeding, or check for other internal injuries or damage. Computed Tomography or Computerized Axial Tomography is commonly referred to as a CT scan.
C- computed (Use of computer) and T- tomography (Greek word “Tomos” means “slice” and “Grapho” means “ To write”
The first commercial CT scanner was invented by Sir Godfrey Hounsfield in United Kingdom.
It is a diagnostic imaging procedure that uses a combination of X-rays and computer technology to produce images of the inside of the body. It shows detailed images of any part of the body including the bones, muscles, fat, organs and blood vessels.
CT scans may be performed to help diagnose tumors, investigate internal bleeding, or check for other internal injuries or damage. MRI stands for Magentic Resonance Imaging which is a non-invasive medical imaging test that produces detailed images of almost every internal structure in the human body, including the organs, bones, muscles and blood vessels.
MRI scanners create images of the body using a large magnet and radio waves.
No ionizing radiation is produced during an MRI exam, unlike X-rays. These images give your physician important information in diagnosing your medical condition and planning a course of treatment.
Raymond Damadian, the inventor of the first magnetic resonance scanning machine performed the first full-body scan of a human being in 1977.
The Nobel Prize was awarded to the American chemist, Paul Lauterbur, and the British physicist, Peter Mansfield, for developing a method to represent the information gathered by a scanner as an image. This is fundamental for the way the technology is used today.
brief but informative knowledge about what basically CT is and what is the phenomenon behind this machine ... easy to understand as well as presenting during lectures and in classes . share it
Brief explanation of what is PET, the main components for a PET system along with their basic functions. The principle behind PET inclusive of positron emission and emission detection. Acquisition and reconstruction of the collected data to produce the final image. Finally the pros and cons of Positron emission tomography.
stellar fusion:A star is a hot ball of mostly hydrogen gas; the Sun is an example of a typical, ordinary star.
In the core of the star, the temperature and densities are high enough to sustain nuclear fusion reactions, and the energy produced by these reactions works its way to the surface and radiates into space as heat and light.
The process of building up heavier elements from lighter ones by nuclear reactions, is called stellar evolution.The stars' fuel for energy generation is the stuff they are made of -- hydrogen, helium, carbon, etc. -- which they burn by converting these elements into heavier elements.
"Burning" in this context does not refer to the kind of burning we are familiar with, such as the burning of wood or coal, which is chemical burning.
It refers to nuclear burning, in which the nuclei of atoms fuse into nuclei of heavier atoms.
When stars start their lives, they consist mostly of hydrogen, some helium, and small amounts of heavier elements, such as carbon, nitrogen, and oxygen.
In 1938, Hans Albrecht and Weizsacker analyzed two process in stars, p-p chain and CNO cycle and believed to be the source of energy in Stars. They showed the possibility to converting hydrogen into helium through nuclear reaction. These reactions take place at high temperature and high densities.
The energy of sun comes from nuclear fusion reaction. P-P cycle is dominant.
This starts with fusion of hydrogen nuclei, to produce deuterium :
The deuterium then fuses with more hydrogen to produce 3He via electromagnetic interaction :
And finally, two 3He nuclei fuse to form 4He via the nuclear strong interaction:
A very large amount of energy is released in this reaction
because 4He Doubly magic nucleus and so is very tightly bound.
Combing these equations we have ,
Because the temperature of the Sun is 107K, matter in this state
is referred to as a plasma.
The positrons produced above will annihilate with electrons in
the plasma to release a further 1.02 MeV and so the total energy
released is 26.72 Mev.
Another interesting cycle is the carbon, or CNO chain.
The CNO cycle (for carbon–nitrogen–oxygen) is one of the two known sets of fusion reactions by which stars convert hydrogen to helium hydrogen, using carbon, nitrogen, and oxygen , the other being the proton–proton chain reaction (pp-chain reaction).
Fusion processes continue to produce heavier elements until the core of the stellar object is composed mainly of nuclei with A 56, i.e.( the peak of the
binding energy per nucleon curve).
Heavier nuclei are produced in supernova explosions, but this is properly the subject of astrophysics and
we will not pursue it further.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
1. NUCLEAR PHYSICS
Course Instructor: Dr. Waseem Ahmad
Presentation On: Medical Imaging use radiation
Presented by : Mehak Tariq
Ghazi University DG Khan
3. Introduction:
There are several techniques for producing images
useful for diagnostic purposes.
The study of medical imaging is concerned with all forms
of an images from the observed technology.
Radiation for medical imaging:
The use of an external source of radiation for
medical imaging is of long-standing and well
known. Basically, the system consists of a
source placed some distance in front the patient
and a detector (usually a special type of
sensitive film) placed immediately behind the
patient.
4. Projection X-ray Imaging
the radiation is absorbed according to an exponential law,
a measurement of the intensities just before and after the
patient yields information on the integrated mean free path
of the photons in the body.
ln
𝐼1
𝐼2
=
𝑥1
𝑥2
𝜇 𝑥 𝑑𝑥
X-ray
Source
Object X-ray Detector
m(x,y,z)
Id(x,y)
5. Energy source
incident (x-rays)
Or
Injected (radioactive
material)
Tissue properties
Employed in
Medical imaging
Detection system
e.g. computer,
Radiographic film, etc
Medical image
Interacts,
Penetrates,
Or reflected
Medical images are pictures of tissue characteristics that influence the way
energy is emitted, transmitted, reflected and so on, by the human body.
6. Images can also be
obtained using an internal source of radiation.
This is done by the patient ingesting, or being
injected with, a substance containing a radioactive
𝛾-emitting isotope.
As photon detectors are very sensitive, the
concentration of the radioisotope can be very low
and any risk to the patient is further minimized by
choosing an isotope with a short lifetime.
7. Computed tomography
The term CT stands for " computed tomography"
“A procedure that uses a computer linked to an x-
ray machine to make a series detailed pictures of
areas inside the body.”
Tomography scan allows doctors to see inside the
body. It uses a combination of x- ray and
computer to create pictures of organs,bones,and
other tissues. It shows more details than regular
x- ray
8. We can get CT scan on
any part of body How
does computed
tomography work.
The term CT refers to a
computerized X- ray
imaging procedure in
which narrow beam of x-
ray is aimed at patient
and quickly rotated
around the body
producing signals that
are processed by
machines .computer to
create cross sectional
images or slices of body.
9. Uses:
The most commonly
performed CT scan is of
brain, to determine the
cause of stroke or assess
serious head injuries .To
detect the abnormalities in
the body such as tumors
,abnormal blood vessels etc.