The document discusses the mechanism of urine concentration in the kidney through countercurrent flow. It explains how the loop of Henle acts as a countercurrent multiplier and the vasa recta acts as a countercurrent exchanger to generate and maintain an osmotic gradient in the renal medulla. This gradient allows water to be reabsorbed in the collecting ducts under the influence of ADH, resulting in concentrated urine when water intake is low. The kidney thus regulates urine concentration through countercurrent mechanisms to maintain water homeostasis.
Tubular reabsorption (The Guyton and Hall physiology)Maryam Fida
It is the second step of urine formation.
It is defined as;
“ The process by which water and other substances are transported by renal tubules back to blood is called Tubular Reabsorption”.
Tubular reabsorption is highly selective.
Some substances like glucose and amino acids are completely absorbed from tubules. So, the urinary excretion is zero.
Ions such as Na+, Cl-, HCO3- are highly absorbed but rate of absorption and excretion varies, according to body needs.
Materials Not Reabsorbed
Nitrogenous waste products
Urea
Uric acid
Creatinine
Excess water
Tubular reabsorption (The Guyton and Hall physiology)Maryam Fida
It is the second step of urine formation.
It is defined as;
“ The process by which water and other substances are transported by renal tubules back to blood is called Tubular Reabsorption”.
Tubular reabsorption is highly selective.
Some substances like glucose and amino acids are completely absorbed from tubules. So, the urinary excretion is zero.
Ions such as Na+, Cl-, HCO3- are highly absorbed but rate of absorption and excretion varies, according to body needs.
Materials Not Reabsorbed
Nitrogenous waste products
Urea
Uric acid
Creatinine
Excess water
https://userupload.net/8mky0eijld91
An understanding of the physiology of body fluids is essential when considering appropriate fluid resuscitation and fluid replacement therapy in critically-ill patients. In healthy humans, the body is composed of approximately 60% water, distributed between intracellular and an extracellular compartments. The extracellular compartment is divided into intravascular, interstitial and transcellular compartments. The movement of fluids between the intravascular and interstitial compartments, is classically described as being governed by Starling forces, leading to a small net efflux of fluid from the intravascular to the interstitial compartment. More recent evidence suggests that a model incorporating the effect of the endothelial glycoclayx layer, a web of glycoproteins and proteoglycans that are bound on the luminal side of the vascular endothelium, better explains the observed distribution of fluids. The movement of fluid to and from the intracellular compartment and the interstitial fluid compartment, is governed by the relative osmolarities of the two compartments. Body fluid status is governed by the difference between fluid inputs and outputs; fluid input is regulated by the thirst mechanism, with fluid outputs consisting of gastrointestinal, renal, and insensible losses. The regulation of intracellular fluid status is largely governed by the regulation of the interstitial fluid osmolarity, which is regulated by the secretion of antidiuretic hormone from the posterior pituitary gland. The regulation of extracellular volume status is regulated by a complex neuro-endocrine mechanism, designed to regulate sodium in the extracellular fluid.
The basics of autoregulation of Gloemrular filtration rate. This ppt deals with basic renal physiology, tubuloglomerular feedback, myogenic reflex, juxtaglomerular apparatus and renin angiotensin aldosterone system in brief. P.S.- The ppt has animations so kindly view in slide/presentation mode
https://userupload.net/8mky0eijld91
An understanding of the physiology of body fluids is essential when considering appropriate fluid resuscitation and fluid replacement therapy in critically-ill patients. In healthy humans, the body is composed of approximately 60% water, distributed between intracellular and an extracellular compartments. The extracellular compartment is divided into intravascular, interstitial and transcellular compartments. The movement of fluids between the intravascular and interstitial compartments, is classically described as being governed by Starling forces, leading to a small net efflux of fluid from the intravascular to the interstitial compartment. More recent evidence suggests that a model incorporating the effect of the endothelial glycoclayx layer, a web of glycoproteins and proteoglycans that are bound on the luminal side of the vascular endothelium, better explains the observed distribution of fluids. The movement of fluid to and from the intracellular compartment and the interstitial fluid compartment, is governed by the relative osmolarities of the two compartments. Body fluid status is governed by the difference between fluid inputs and outputs; fluid input is regulated by the thirst mechanism, with fluid outputs consisting of gastrointestinal, renal, and insensible losses. The regulation of intracellular fluid status is largely governed by the regulation of the interstitial fluid osmolarity, which is regulated by the secretion of antidiuretic hormone from the posterior pituitary gland. The regulation of extracellular volume status is regulated by a complex neuro-endocrine mechanism, designed to regulate sodium in the extracellular fluid.
The basics of autoregulation of Gloemrular filtration rate. This ppt deals with basic renal physiology, tubuloglomerular feedback, myogenic reflex, juxtaglomerular apparatus and renin angiotensin aldosterone system in brief. P.S.- The ppt has animations so kindly view in slide/presentation mode
3. Renal Block-Water and Electrolyte Balance-MBBS-2024.pptxRajendra Dev Bhatt
Water is the most ubiquitous substance in the chemical reactions of life.
The interactions of various aqueous solutions, solutions in which water is the solvent, are continuously monitored and adjusted by a large suite of interconnected feedback systems in our body.
Understanding the ways in which the body maintains these critical balances is key to understanding good health.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
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- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
2. The composition of the blood ( internal
environment ) is determined not by what the
mouth ingest but by what the kidney keep.
------- SMITH.
3. Objective
At the end of the lecture you should know:
What is concurrent & countercurrent flow
Examples of countercurrent flow
Mechanisms of excretion of dilute & concentrated
urine
Countercurrent multiplier
Countercurrent exchanger
4. Things you need to know before
starting the main topic
Physiological anatomy of nephrons
Cortical & juxtamedullary nephrons
Vasa recta
Mechanism of urine formation
Role of ADH
Osmosis
Concurrent & countercurrent flow
Gradient
5. Physiological anatomy of nephron
Descending limb of LOH is
highly permeable to water,
& less permeable to
solutes.
Ascending limb of LOH is
virtually impermeable to
water, but permeable to
solutes.
Solutes are transported
out of the Thick Ascending
limb of LOH by Na-K-2Cl
co-transporter by active
transport.
6. Cortical & Juxtamedullay nephrons
Juxtamedullary
nephrons have long
LOH, dipping deep into
the medulla.
They are important in
formation of
concentrated urine.
8. Vasa Recta
Efferent arterioles of
the Nephrons further
divide into a set of
capillaries that
surround the
Nephrons.
These capillaries in
case of JMN are
arranged as long
hair-pin loop, k/a
Vasa recta.
10. Osmosis
Movement of solvent
from lower concentration
of solution to higher
concentration.
Movement of water from
tubules to interstitium to
peritubular capillaries
occurs by osmosis.
Solute particles move by
various other transport
processes.
11. Concurrent & Countercurrent Flow
The two fluids flow in the same direction.
variable gradient over the length of the exchanger.
capable of moving half of the property from one
flow to the other, no matter how long the
exchanger is.
Exchange stops when equilibrium is reached and
gradient declines to zero.
12. Concurrent & Countercurrent Flow
The two fluids flow in the opposite direction.
nearly constant gradient between the two flows
over their entire length.
With long length & low flow rate its capable of
transferring all the property from one fluid to the
other.
13. Countercurrent Flow - Examples
Fishes use it in their gills
to transfer O2 from
surrounding water to blood
Birds use it in their legs to
Conserve core body heat.
14. Countercurrent Flow – Examples in humans
To conserve heat in acral
parts of the body.
Human kidney uses CCF in
LOH & VR to produce
concentrated urine.
15. Gradient
A graded change in the
magnitude of some physical
quantity or dimension in a
given direction.
A concentration gradient in
renal medullary interstitium
is present; which is
important in formation of
concentrated urine.
This renal gradient is due to
the CCM in LOH & VR.
16. In steady state water intake and
output must be equal
Water intake (per day)
Ingested fluids - 1200 ml
Ingested food- 1000 ml
Aerobic metabolism- 300 ml
Total- 2500 ml
Water output (per day)
Urine- 1500 ml
Feces- 100 ml
Insensible loss- 900 ml
Skin- 550 ml
Lungs- 350 ml
Total- 2500 ml
Values are indicative only and will vary depending on
diet, physical activity, environmental temperature,
humidity etc.
17. Kidneys maintain water homeostasis
by adjusting the volume of urine
High water intake inc. urine volume (up to 20
l/d, 50 mosmol/l)
Low water intake or, low urine volume
high water loss
(up to 0.5 l/d, 1200 mosmol/l)
18. Renal Mechanism for Dilute urine
Formation of dilute
urine depends on
decreased secretion of
ADH from pituitary.
Kidneys continue to
absorb solute; while
fail to absorb the
water.
19. Renal Mechanism for Conc. Urine
Achieved by
continuing to secrete
the solutes; while
increasing the water
reabsorption.
This requires:
High level of ADH
Highly osmolar renal
medullary interstitium
20. Renal Mechanism for Conc. Urine
ADH increases the
permeability of the
distal tubules &
collecting ducts to
water.
Highly osmolar renal
medullary interstitium
provides osmotic
gradient for water
reabsorption in
presence of ADH.
22. Hyperosmotic Medullary Interstitium
There is a progressively
increasing osmolar gradient
in medulla.
This gradient is due to:
LOH acting as Countercurrent
Multiplier
Vasa Recta acting as
Countercurrent Exchanger
Urea cycling also contributes
to the medullary osmolarity.
23. Countercurrent Multiplier
LOH act as countercurrent
multiplier to produce the
medullary osmotic gradient.
AL pumps out NaCl into the
interstitium & is capable of
producing an osmotic gradient of
200 mosmol/l b/w any part of
tubule & interstitium.
The countercurrent flow in LOH,
with differing permeability of DL &
AL is capable of multiplying this
effect to produce an osmotic
gradient.
24. Steps involved in production of
hyper osmotic medullary interstistium
25. Countercurrent Exchanger
Vasa recta prevents the wash
down of medullary
concentration gradient while
absorbing excess solutes &
water from interstitium.
It does not contribute to the
production of medullary
concentration gradient but
helps to preserve it.
Low blood flow (5-10% of
total) to the medulla also helps
in this.
27. Contribution of Urea to the hyperosmotic renal
medulla
urea contributes about 40 –
50% of the osmolarity of the
renal medullary interstitium.
Unlike sodium chloride, urea is
passively reabsorbed from the
tubule.
When there is water deficit
and blood concentrations of
ADH are high, large amounts
of urea are passively
reabsorbed from the inner
medullary collecting ducts into
the interstitium
31. Obligatory Urine Volume
It is the minimal volume of urine that
must be excreted each day to get rid the
body of the products of metabolism &
ingested ions.
It depends upon the maximal
concentrating ability of the kidney.
Total solutes to be excreted each day in
70 kg man = 600 mosmol
Maximum conc. ability of human kidney =
1200 mosmol/l
OUV = 600/1200 = 0.5 L/day
32. Disorders of urinary concentrating ability
Inappropriate secretion of ADH:
↓ ADH: Central Diabetes Insipidus
↑ ADH: SIADH (Syndrome of Inappropriate
secretion of ADH)
Impairment of countercurrent mechanism:
High flow rate: osmotic diuresis
Inability of tubules to respond to ADH:
Nephrogenic Diabetes Insipidus