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MEASLES
PRESENTATION BY:
SUSHAN GAIRE
B.PHARMACY, 2ND
SEMESTER
CRIMSON COLLEGE
OF TECHNOLOGY8/28/2018 PHARMACEUTICAL SEMINAR 1st
Contents:
2
 Introduction
 History
 Epidemiology
 Cause
 Signs and symptoms
 Mode Of Transmission
 Complications
 Diagnosis
 Prevention
 Treatment
 Conclusion
 References
8/28/2018PHARMACEUTICAL SEMINAR 1st
Introduction
3
• Measles is a highly contagious,
acute, exanthematous
respiratory disease.
 It causes eruption on the buccal
mucous cavity.
 It is caused by measles virus.
 It is characterised by high fever,
cough and conjuctivitis with
Lacrimation.
8/28/2018PHARMACEUTICAL SEMINAR 1st
History
4
 The first systematic
description of measles,
and its distinction from
smallpox
and chickenpox, is
credited to
the Persian physician Rh
azes (860–932 AD), who
published ’’The Book of
Smallpox and Measles’’.
8/28/2018PHARMACEUTICAL SEMINAR 1st
TYPES OF MEASLES
5
 There are two types of measles
a) Rubeola or regular measles:-
Full-body red or reddish-brown rash & last
about 7 to 14 days.
b) German measles or rubella:-
Pink or light red spotted rash & last about
three days.
8/28/2018PHARMACEUTICAL SEMINAR 1st
Measles German Measles
1. It is also called rubeola. 1. It is also called rubella.
2. It is caused by measles virus. 2. It is caused by rubella virus.
3. It is a serious illness. 3. It is milder than measles.
4. It lasts for several days. 4. It lasts for 3 days.
5. Rash of measles is full-body
red or reddish-brown rash.
5. Rash of rubella is pink or light
red spotted.
6
8/28/2018PHARMACEUTICAL SEMINAR 1st 6
Epidemiology
7
 During Pre-vaccination era in U.S measles
epidemic occured every 2-5 yrs in winter and
spring in which roughly half a million cases of
measles were reported.
 In year between 1993-1996, fewer than 1000 cases
were reported annually in U.S , 309 cases were
reported in 1995 and 116 cases in 2001.
 But in developing countries where MMR
vaccination is still not available its prevalence is
high.
8/28/2018PHARMACEUTICAL SEMINAR 1st
Reported cases
8/28/2018PHARMACEUTICAL SEMINAR 1st
8
WHO-Region 1980 1990 2000 2005 2014
African Region 1,240,993 481,204 520,102 316,224 71,574
Region of the
Americas
257,790 218,579 1,755 66 19,898
Eastern
Mediterranean
Region
341,624 59,058 38,592 15,069 28,031
European Region 851,849 234,827 37,421 37,332 16,899
South-East Asia
Region
199,535 224,925 61,975 83,627 112,418
Western Pacific
Region
1,319,640 155,490 176,493 128,016 213,366
Worldwide 4,211,431 1,374,083 836,338 580,287 462,186
Measles Vaccination Worldwide
9
8/28/2018PHARMACEUTICAL SEMINAR 1st
Causes
10
 It is caused by paramyxo virus.
 It is only member of the genus
Morbillivirus that infects humans.
 Measles virions are pleomorphic
spherical structures having a
diameter of 100-250 nm.
An electron micrograph of the
measles virus.
8/28/2018PHARMACEUTICAL SEMINAR 1st
11
Clinical Manifestations
INCUBATIO
N PERIOD
10-14 Days
MOST
CONTAGIOUS
PERIOD
3 And 4 Days

RECOVERY
10-14 Days
8/28/2018PHARMACEUTICAL SEMINAR 1st
Signs and Symptoms
12
 Koplik’s spots
 Cough
 Conjuctivitis with lacrimation
 Fever ( 40 degree celsius)
 Nasal discharge
 Rash
 Desquamation
 Coryza
8/28/2018PHARMACEUTICAL SEMINAR 1st
Mode Of Transmission
8/28/2018PHARMACEUTICAL SEMINAR 1st
13
 Direct:
Direct contact with an infected person.
• Inderect:
Through articles ,freshly soiled with nasal and
throat secretions.
Complications
14
 Laryngitis
 Headache
 Nausea
 Diarrhea
 Bronchitis
 Pneumonia
 Croup
8/28/2018PHARMACEUTICAL SEMINAR 1st
Diagnosis
15
 Koplik’s spots
 Immunofluorescent staining of a smear of respiratory
secretion for measles antigen
 Examination of secretion microscopically for
multinucleated gaint cells
 Saliva Test
 Serologic tests
 Enzyme immunoassay
8/28/2018PHARMACEUTICAL SEMINAR 1st
Prevention
16
MMR vaccine (Prophylaxis)
 1st dose on the age of 12-15 months ( 0.5 ml).
 2nd dose on the age of 4-6 yrs old (0.5 ml).
Immune globulin (Post exposure Prophylaxis)
 Given intramuscularly within 6 days of exposure.
 Dose: 0.25ml/kg (normal people)
0.5 ml/kg (immuno-compromised patients)
8/28/2018PHARMACEUTICAL SEMINAR 1st
Treatment
8/28/2018PHARMACEUTICAL SEMINAR 1st
17
 Antibiotics
 Supportive care
 Vitamin A
 Ribavirin
18
Aquasol(vitamin A) Virazole(ribavirin)
MRR Vaccine Immune globulin Vaccine
8/28/2018PHARMACEUTICAL SEMINAR 1st
Conclusion
19
 Measles is the acute communicable disease but have
become an unusual disease due to preventable
methods.
 However, it is still a cause of deaths of childrens in
the rural area.
8/28/2018PHARMACEUTICAL SEMINAR 1st
References
20
1. Harrison TR (2005), Principles of Internal
Medicine, 16th Ed., McGraw-Hill Medical
usblishing Division, Newyork, USA; pp (1148-1151).
2. URL: https://en.wikipedia.org/wiki/Measles
(Assessed on 17th July 2018)
8/28/2018PHARMACEUTICAL SEMINAR 1st
8/28/2018PHARMACEUTICAL SEMINAR 1st 21

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Measles

  • 1. 1 MEASLES PRESENTATION BY: SUSHAN GAIRE B.PHARMACY, 2ND SEMESTER CRIMSON COLLEGE OF TECHNOLOGY8/28/2018 PHARMACEUTICAL SEMINAR 1st
  • 2. Contents: 2  Introduction  History  Epidemiology  Cause  Signs and symptoms  Mode Of Transmission  Complications  Diagnosis  Prevention  Treatment  Conclusion  References 8/28/2018PHARMACEUTICAL SEMINAR 1st
  • 3. Introduction 3 • Measles is a highly contagious, acute, exanthematous respiratory disease.  It causes eruption on the buccal mucous cavity.  It is caused by measles virus.  It is characterised by high fever, cough and conjuctivitis with Lacrimation. 8/28/2018PHARMACEUTICAL SEMINAR 1st
  • 4. History 4  The first systematic description of measles, and its distinction from smallpox and chickenpox, is credited to the Persian physician Rh azes (860–932 AD), who published ’’The Book of Smallpox and Measles’’. 8/28/2018PHARMACEUTICAL SEMINAR 1st
  • 5. TYPES OF MEASLES 5  There are two types of measles a) Rubeola or regular measles:- Full-body red or reddish-brown rash & last about 7 to 14 days. b) German measles or rubella:- Pink or light red spotted rash & last about three days. 8/28/2018PHARMACEUTICAL SEMINAR 1st
  • 6. Measles German Measles 1. It is also called rubeola. 1. It is also called rubella. 2. It is caused by measles virus. 2. It is caused by rubella virus. 3. It is a serious illness. 3. It is milder than measles. 4. It lasts for several days. 4. It lasts for 3 days. 5. Rash of measles is full-body red or reddish-brown rash. 5. Rash of rubella is pink or light red spotted. 6 8/28/2018PHARMACEUTICAL SEMINAR 1st 6
  • 7. Epidemiology 7  During Pre-vaccination era in U.S measles epidemic occured every 2-5 yrs in winter and spring in which roughly half a million cases of measles were reported.  In year between 1993-1996, fewer than 1000 cases were reported annually in U.S , 309 cases were reported in 1995 and 116 cases in 2001.  But in developing countries where MMR vaccination is still not available its prevalence is high. 8/28/2018PHARMACEUTICAL SEMINAR 1st
  • 8. Reported cases 8/28/2018PHARMACEUTICAL SEMINAR 1st 8 WHO-Region 1980 1990 2000 2005 2014 African Region 1,240,993 481,204 520,102 316,224 71,574 Region of the Americas 257,790 218,579 1,755 66 19,898 Eastern Mediterranean Region 341,624 59,058 38,592 15,069 28,031 European Region 851,849 234,827 37,421 37,332 16,899 South-East Asia Region 199,535 224,925 61,975 83,627 112,418 Western Pacific Region 1,319,640 155,490 176,493 128,016 213,366 Worldwide 4,211,431 1,374,083 836,338 580,287 462,186
  • 10. Causes 10  It is caused by paramyxo virus.  It is only member of the genus Morbillivirus that infects humans.  Measles virions are pleomorphic spherical structures having a diameter of 100-250 nm. An electron micrograph of the measles virus. 8/28/2018PHARMACEUTICAL SEMINAR 1st
  • 11. 11 Clinical Manifestations INCUBATIO N PERIOD 10-14 Days MOST CONTAGIOUS PERIOD 3 And 4 Days  RECOVERY 10-14 Days 8/28/2018PHARMACEUTICAL SEMINAR 1st
  • 12. Signs and Symptoms 12  Koplik’s spots  Cough  Conjuctivitis with lacrimation  Fever ( 40 degree celsius)  Nasal discharge  Rash  Desquamation  Coryza 8/28/2018PHARMACEUTICAL SEMINAR 1st
  • 13. Mode Of Transmission 8/28/2018PHARMACEUTICAL SEMINAR 1st 13  Direct: Direct contact with an infected person. • Inderect: Through articles ,freshly soiled with nasal and throat secretions.
  • 14. Complications 14  Laryngitis  Headache  Nausea  Diarrhea  Bronchitis  Pneumonia  Croup 8/28/2018PHARMACEUTICAL SEMINAR 1st
  • 15. Diagnosis 15  Koplik’s spots  Immunofluorescent staining of a smear of respiratory secretion for measles antigen  Examination of secretion microscopically for multinucleated gaint cells  Saliva Test  Serologic tests  Enzyme immunoassay 8/28/2018PHARMACEUTICAL SEMINAR 1st
  • 16. Prevention 16 MMR vaccine (Prophylaxis)  1st dose on the age of 12-15 months ( 0.5 ml).  2nd dose on the age of 4-6 yrs old (0.5 ml). Immune globulin (Post exposure Prophylaxis)  Given intramuscularly within 6 days of exposure.  Dose: 0.25ml/kg (normal people) 0.5 ml/kg (immuno-compromised patients) 8/28/2018PHARMACEUTICAL SEMINAR 1st
  • 17. Treatment 8/28/2018PHARMACEUTICAL SEMINAR 1st 17  Antibiotics  Supportive care  Vitamin A  Ribavirin
  • 18. 18 Aquasol(vitamin A) Virazole(ribavirin) MRR Vaccine Immune globulin Vaccine 8/28/2018PHARMACEUTICAL SEMINAR 1st
  • 19. Conclusion 19  Measles is the acute communicable disease but have become an unusual disease due to preventable methods.  However, it is still a cause of deaths of childrens in the rural area. 8/28/2018PHARMACEUTICAL SEMINAR 1st
  • 20. References 20 1. Harrison TR (2005), Principles of Internal Medicine, 16th Ed., McGraw-Hill Medical usblishing Division, Newyork, USA; pp (1148-1151). 2. URL: https://en.wikipedia.org/wiki/Measles (Assessed on 17th July 2018) 8/28/2018PHARMACEUTICAL SEMINAR 1st