This document provides an introduction to multi-slice CT (MSCT) and describes some of its clinical applications. MSCT allows for faster scanning, improved resolution, and the ability to acquire multiple slices simultaneously. This enables more detailed 3D imaging and angiography of various organs and body systems. Some examples given include MSCT angiography of the brain, thoracic aorta, abdomen, and lower limbs. MSCT is also used to image the liver, biliary system, kidneys, ureters, and bladder. It can detect abnormalities such as cysts, masses, stones, and fractures. In summary, MSCT provides improved imaging capabilities for evaluating many anatomical structures and pathologies.