This document summarizes AVEKA's expertise in processing engineered particles through various methods. It discusses AVEKA's facilities and capabilities, an overview of engineered particles, and challenges in particle processing. It then provides examples of AVEKA applying methods like spray drying, coating, and prilling to address needs like separating cellulose fibers, encapsulating omega-3 oils, and producing monodisperse wax beads. While results were promising, further refinement was sometimes needed, highlighting the importance of testing and understanding materials at multiple scales.
Modern Particle Characterization Techniques Series I: IntroductionHORIBA Particle
Particle characterization is a rich field that touches industries from mining to pharmaceutical production. There are a number of characterization techniques available to the modern analyst. Understanding them is key to selecting the right technique as well as gaining deeper insight into the meaning of measurement results.
This webinar is the beginning of a new series reviewing a number of modern measurement techniques. Dr. Michael Pohl, Vice President of HORIBA Scientific, will describe some common ideas in particle characterization along with common questions to ask when selecting a technique. Mike will also give a very brief overview of some modern techniques before subsequent webinars go into detail.
View recorded webinars:
http://bit.ly/particlewebinars
How and Why to Analyze Ceramic Powder ParticlesHORIBA Particle
Packing density, mechanical strength, and processing of ceramics are all affected by the size distribution of the powders. Therefore, particle size analysis is an important quality control step. Due to its wide size range and flexibility, laser diffraction is often the preferred method of analysis. Laser diffraction can be used for particles with sizes from 10’s of nanometers to millimeters. In this webinar, Dr. Jeff Bodycomb of HORIBA Scientific discusses particle analysis of ceramic particles, including electronic materials and common oxides. He will cover the basic principles of analysis, practical methods for obtaining good data, and example data.
View recorded webinars:
http://bit.ly/particlewebinars
Modern Particle Characterization Techniques Series: Laser DiffractionHORIBA Particle
This part two of the webinar series will introduce participants to basic experimental considerations when choosing laser diffraction for particle size analysis. The presentation will explain what makes laser diffraction a “modern technique.” Both wet and dry case studies will be shown along with brief demonstration videos.
In this webinar, you will learn:
- Method development
- Choosing an appropriate refractive index
- Understanding the analysis results
View recorded webinars:
http://bit.ly/particlewebinars
Particle Classroom Series VI: Method DevelopmentHORIBA Particle
Great results need a great method. In order to compare different lots of material or different manufacturing approaches, variation due to sample preparation should be minimized. Should the sample be run in suspension or as a dry powder? What salts or surfactants are needed for the suspension? How much energy should be applied and how? Systematically determining the answers to these questions is method development.
View recorded webinars:
http://bit.ly/particlewebinars
Particle Classroom Series V: Sampling and DispersionHORIBA Particle
The goal of a particle analysis is to understand the properties of a material, whether it is the size distribution of particles that are manufactured today or the size distribution of particles in the truck that just arrived. Naturally, a particle analyzer only encounters a tiny fraction of that material, the sample.
In addition, particles can be bound together to form agglomerates that do not represent the underlying materials. The instrument will then measure the agglomerates, not its constituent particles. In this webinar, Jeff discusses how to improve data quality by obtaining a representative sample and effectively disperse the sample to remove or prevent agglomerates.
View recorded webinars:
http://bit.ly/particlewebinars
Concentration and Size of Viruses and Virus-like ParticlesHORIBA Particle
Accurate concentration for virus and virus-like particles can be determined by multi-laser nanoparticle tracking analysis due to the fact they are nanoparticles. Other biologically relevant materials will have sizes that are close to those of viruses, whether they are protein aggregates that provoke an unwanted immune response or exosomes with a similar size and do not provoke an immune response.
In this webinar, Dr. Jeff Bodycomb will discuss the use of multi-laser nanoparticle tracking analysis (NTA) to determine the size distribution and concentration of these species, the latter which is correlated to viral infectivity.
Learn more about:
-How NTA determines concentration and size distribution
-Advantages and limits of the multi-laser technique
-Example measurement results
View recorded webinars:
http://bit.ly/particlewebinars
Particle Size Analysis for Pharmaceutical Homogenization Process DevelopmentHORIBA Particle
Guest speaker Dr. Daniel Huang of Novartis joins HORIBA Scientific (http://www.horiba.com/particle) to speak about homogenization process development.
High-pressure homogenization has been used to prepare emulsions in a broad range of industries. Particle size distribution and emulsion stability are two key properties of the system essential to a successful downstream application. In this study, Daniel and his colleagues have investigated the effects of process conditions on droplet size and coalescence rate of the emulsion systems.
Selecting the Best Particle Size Analyzer for your ApplicationHORIBA Particle
Mark Bumiller from HORIBA Particle discusses the benefits and limitations of modern particle size analyzers and ideas on how to approach the choice of a new measurement technique or instrument.
This presentation is archived with the original webinar video in the Download Center at www.horiba.com/us/particle.
Modern Particle Characterization Techniques Series I: IntroductionHORIBA Particle
Particle characterization is a rich field that touches industries from mining to pharmaceutical production. There are a number of characterization techniques available to the modern analyst. Understanding them is key to selecting the right technique as well as gaining deeper insight into the meaning of measurement results.
This webinar is the beginning of a new series reviewing a number of modern measurement techniques. Dr. Michael Pohl, Vice President of HORIBA Scientific, will describe some common ideas in particle characterization along with common questions to ask when selecting a technique. Mike will also give a very brief overview of some modern techniques before subsequent webinars go into detail.
View recorded webinars:
http://bit.ly/particlewebinars
How and Why to Analyze Ceramic Powder ParticlesHORIBA Particle
Packing density, mechanical strength, and processing of ceramics are all affected by the size distribution of the powders. Therefore, particle size analysis is an important quality control step. Due to its wide size range and flexibility, laser diffraction is often the preferred method of analysis. Laser diffraction can be used for particles with sizes from 10’s of nanometers to millimeters. In this webinar, Dr. Jeff Bodycomb of HORIBA Scientific discusses particle analysis of ceramic particles, including electronic materials and common oxides. He will cover the basic principles of analysis, practical methods for obtaining good data, and example data.
View recorded webinars:
http://bit.ly/particlewebinars
Modern Particle Characterization Techniques Series: Laser DiffractionHORIBA Particle
This part two of the webinar series will introduce participants to basic experimental considerations when choosing laser diffraction for particle size analysis. The presentation will explain what makes laser diffraction a “modern technique.” Both wet and dry case studies will be shown along with brief demonstration videos.
In this webinar, you will learn:
- Method development
- Choosing an appropriate refractive index
- Understanding the analysis results
View recorded webinars:
http://bit.ly/particlewebinars
Particle Classroom Series VI: Method DevelopmentHORIBA Particle
Great results need a great method. In order to compare different lots of material or different manufacturing approaches, variation due to sample preparation should be minimized. Should the sample be run in suspension or as a dry powder? What salts or surfactants are needed for the suspension? How much energy should be applied and how? Systematically determining the answers to these questions is method development.
View recorded webinars:
http://bit.ly/particlewebinars
Particle Classroom Series V: Sampling and DispersionHORIBA Particle
The goal of a particle analysis is to understand the properties of a material, whether it is the size distribution of particles that are manufactured today or the size distribution of particles in the truck that just arrived. Naturally, a particle analyzer only encounters a tiny fraction of that material, the sample.
In addition, particles can be bound together to form agglomerates that do not represent the underlying materials. The instrument will then measure the agglomerates, not its constituent particles. In this webinar, Jeff discusses how to improve data quality by obtaining a representative sample and effectively disperse the sample to remove or prevent agglomerates.
View recorded webinars:
http://bit.ly/particlewebinars
Concentration and Size of Viruses and Virus-like ParticlesHORIBA Particle
Accurate concentration for virus and virus-like particles can be determined by multi-laser nanoparticle tracking analysis due to the fact they are nanoparticles. Other biologically relevant materials will have sizes that are close to those of viruses, whether they are protein aggregates that provoke an unwanted immune response or exosomes with a similar size and do not provoke an immune response.
In this webinar, Dr. Jeff Bodycomb will discuss the use of multi-laser nanoparticle tracking analysis (NTA) to determine the size distribution and concentration of these species, the latter which is correlated to viral infectivity.
Learn more about:
-How NTA determines concentration and size distribution
-Advantages and limits of the multi-laser technique
-Example measurement results
View recorded webinars:
http://bit.ly/particlewebinars
Particle Size Analysis for Pharmaceutical Homogenization Process DevelopmentHORIBA Particle
Guest speaker Dr. Daniel Huang of Novartis joins HORIBA Scientific (http://www.horiba.com/particle) to speak about homogenization process development.
High-pressure homogenization has been used to prepare emulsions in a broad range of industries. Particle size distribution and emulsion stability are two key properties of the system essential to a successful downstream application. In this study, Daniel and his colleagues have investigated the effects of process conditions on droplet size and coalescence rate of the emulsion systems.
Selecting the Best Particle Size Analyzer for your ApplicationHORIBA Particle
Mark Bumiller from HORIBA Particle discusses the benefits and limitations of modern particle size analyzers and ideas on how to approach the choice of a new measurement technique or instrument.
This presentation is archived with the original webinar video in the Download Center at www.horiba.com/us/particle.
Introducing the LA-960 Laser Particle Size AnalyzerHORIBA Particle
HORIBA Instruments proudly announces the latest evolution in the LA series of particle size analyzers, the LA-960. Building on the successful LA-950 platform, this advanced model measures the particle size of suspensions, emulsions, powders, pastes, creams, and gels between 10 nanometers and 5 millimeters. The complex science of particle size analysis is simplified with HORIBA’s refined software and powerful sample handling systems.
Join us on Wednesday, September 17th at 1:30 PM Eastern to learn more about the world’s newest and most advanced laser particle size analyzer. This webinar will be suitable for anyone wishing to learn about the state of the art in laser particle size analysis.
Particle Size Analysis for Homogenization Process Development HORIBA Particle
Emulsions and suspensions are commonly used in pharmaceutical, chemical and consumer products. The pharmaceutical industry, in particular, uses emulsions and suspensions to increase drug efficacy by controlling their particle size and size distribution. Among various available preparation methods, high-pressure homogenization is one of the widely employed processes in the field. This webinar discusses ways to develop a robust homogenization process for making pharmaceutical emulsions by evaluating droplet size distribution.
View recorded webinars:
http://bit.ly/particlewebinars
Interpreting Laser Diffraction Results for Non-Spherical ParticlesHORIBA Particle
Particle shape can have a profound impact on particle size distribution (PSD) measurements. In the case of Laser Diffraction, the shape and aspect ratio of particles alter the diffraction pattern used to determine PSD, which is calculated on the basis of equivalent spherical diameter. For instance, it has been established that the reported size of an ellipsoid is always smaller than the physical major dimension of the particle. Furthermore, when non-spherical particles align within a flowing sample, laser diffraction instruments typically report a bi-modal size distribution even in the case of monodisperse samples.
Equipped with only qualitative knowledge of particle shape, the particle analyst can resolve this inherent ambiguity and use laser diffraction to obtain quantitative information (such as aspect ratio) about non-spherical particles. This webinar explains the origin of this effect, describes how to interpret PSD data in such cases, and demonstrates several practical applications for measurements of crystals, bacteria, and clays.
View recorded webinars:
http://bit.ly/particlewebinars
Mark Bumiller of HORIBA Scientific discusses tactics for getting the best possible particle size results for pigments, inks, and paints. These applications tend to be more challenging than most, so the information in this presentation will be valuable for any chemist responsible for these materials.
Particle Classroom Series II: The Basics of Laser DiffractionHORIBA Particle
Particle size analysis by laser diffraction offers many advantages. The technique is fast, reliable, and can be used for analyzing a wide range of particle sizes. In laser diffraction scattering as a function of angle is measured and the data used to determine the particle size distribution. The technique can be used over a very wide range of particle sizes -- 10's of nm to 100's of microns. In addition it is very fast and reliable. In this webinar, Dr. Jeff Bodycomb will discuss:
Exactly what happens when light strikes a particle
Light intensity and how it effects the measurement
Fraunhofer vs. Mie
Real and imaginary refractive index values
This is a great introduction to someone who wants to understand the science behind the measurement.
View recorded webinars:
http://bit.ly/particlewebinars
Key Points to Achieving Successful Laser Diffraction Method DevelopmentHORIBA Particle
Unlock the secrets to the best measurement for particles. Topics covered include choosing appropriate accessories, selecting the best dispersing medium, assessing the effect of circulation pump speed, and evaluating the impact of using different imaginary refractive index values.
View recorded webinars:
http://bit.ly/particlewebinars
How to Select the Best Refractive Index for Particle Size AnalysisHORIBA Particle
Dr. Jeff Bodycomb discusses the process HORIBA uses to select the best possible refractive index. This information is valuable for anyone using any type of laser diffraction particle size analyzer regardless of manufacturer or model.
This presentation covers the following topics:
* Available resources and current thinking
* Automated RI determination with the Method Expert
* Effect on accuracy of using good, bad, and no refractive index
Particle Classroom Series I: Introduction to Particle AnalysisHORIBA Particle
If you're new to particle characterization, this is a webinar just for you! Dr. Jeff Bodycomb will discuss the basics of particles....why different size definitions will give you different results, various methods used to measure particles and why the method you use matters! This webinar will be the first in a series that will give you the knowledge you'll need to be the particle expert in your lab.
View recorded webinars:
http://bit.ly/particlewebinars
The Importance of Sampling & Dispersion for Particle Size AnalysisHORIBA Particle
Dr. Jeff Bodycomb of HORIBA Scientific discusses why sampling & dispersion are such critical factors in obtaining accurate and reproducible particle size results for every application and analyzer.
Particle Classroom Series IV: System VerificationHORIBA Particle
Confirming the performance of a particle analyzer is a critical step in ensuring and proving data quality. Join Dr. Jeff Bodycomb as he discusses performance expectations, confirming system performance, and recommended practices. This is part four of a six-part classroom series.
View recorded webinars:
http://bit.ly/particlewebinars
How to Present and Compare Data Obtained by Particle Tracking Analysis and Ot...HORIBA Particle
This Webinar is for anyone who wants to understand how experimental data should be presented and compared properly while using histograms.
Dr. Kuba Tatarkiewicz examines methods for particle size distributions as obtained by particle tracking analysis, fluorescence, as well as micro-sedimentation. Choices of binning schemes that users can design themselves will be discussed with examples of how various parameters (like mode and D50) change with different binnings, especially for highly polydisperse colloids. Methods for comparison of particle size distributions will be presented and explained in practical terms.
View recorded webinars:
http://bit.ly/particlewebinars
Modern Laser Diffraction for Particle AnalysisHORIBA Particle
Laser Diffraction is the most popular technique in modern particle sizing. It can be used to rapidly and reliably determine the size and size distribution particles with sizes from 10's of nanometers to a few millimeters.
View recorded webinars:
http://bit.ly/particlewebinars
Particle Classroom Series III: Refractive Index and Laser DiffractionHORIBA Particle
Modern laser diffraction particle analyzers use particle refractive index to accurately model the behavior of light inside of the particle. However, this presents the analyst with the challenge of choosing the correct value. In this Webinar, Dr. Jeff Bodycomb will discuss:
- Why do we need a refractive index value?
- What is refractive index?
- How do we choose refractive index values?
View recorded webinars:
http://bit.ly/particlewebinars
Evaluation of stress resistant sweetpotato varieties and their low cost micro...ILRI
Presented by Emana Getu, Tileye Feyissa and Addisu Nega (Addis Ababa University, College of Natural Sciences) at the First Bio-Innovate Regional Scientific Conference, Addis Ababa, Ethiopia, 25-27 February 2013
Jane Cooper, Senior Applications Scientist
Separation by UPC2 is an ideal alternative to both HPLC and GC analysis
- Ability to run LC and GC amenable compounds in single analysis
-Fast 7 minute analysis of the 24 regulated allergens and 6 additional compounds containing:
– Different classes of compounds
– Different polarities
- UC2 with MS detection offers an orthogonal technique, which enables greater selectivity and specificity compared to either HPLC or GC analysis alon
- The developed 7 minute UPC2 method, is greater than 6 times faster than existing HPLC and GC
Jane Cooper, Senior Applications Scientist, Waters Corporation.
Method development
Aim: One peak = one compound
Detect coelutions and peaks missed by optical detection
Track peaks more effectively
Sample profiling
Aim: Identify components and quantify
Process complex matrices and low level target compounds
Improved selectivity, more sensitivity
Synthetic chemistry
Aim: Confirm product identity
Improve turnaround of results
Improve information available on impurities
Purification
Aim: Isolate pure compound
Collect fewer fractions with increased confidence
AGC FluoroCompounds Group is the largest long-standing custom fluoropolymer compounder in the world. Drawing from an extensive global supply chain of resins and fillers, we can produce any filled PTFE or melt processable fluoropolymer compound.
The Aveka Group's Particle Processing TechnologiesHORIBA Particle
Willie Hendrickson, President of Aveka, discusses how their particle technology expertise can solve any contract manufacturing or R&D challenge. A case study about milling techniques to achieve a tight particle distribution as well as a case study about fast scale-up & expansion execution will be presented. HORIBA is proud to partner with Aveka as they share their experience in the wider world of particle technology.
Introducing the LA-960 Laser Particle Size AnalyzerHORIBA Particle
HORIBA Instruments proudly announces the latest evolution in the LA series of particle size analyzers, the LA-960. Building on the successful LA-950 platform, this advanced model measures the particle size of suspensions, emulsions, powders, pastes, creams, and gels between 10 nanometers and 5 millimeters. The complex science of particle size analysis is simplified with HORIBA’s refined software and powerful sample handling systems.
Join us on Wednesday, September 17th at 1:30 PM Eastern to learn more about the world’s newest and most advanced laser particle size analyzer. This webinar will be suitable for anyone wishing to learn about the state of the art in laser particle size analysis.
Particle Size Analysis for Homogenization Process Development HORIBA Particle
Emulsions and suspensions are commonly used in pharmaceutical, chemical and consumer products. The pharmaceutical industry, in particular, uses emulsions and suspensions to increase drug efficacy by controlling their particle size and size distribution. Among various available preparation methods, high-pressure homogenization is one of the widely employed processes in the field. This webinar discusses ways to develop a robust homogenization process for making pharmaceutical emulsions by evaluating droplet size distribution.
View recorded webinars:
http://bit.ly/particlewebinars
Interpreting Laser Diffraction Results for Non-Spherical ParticlesHORIBA Particle
Particle shape can have a profound impact on particle size distribution (PSD) measurements. In the case of Laser Diffraction, the shape and aspect ratio of particles alter the diffraction pattern used to determine PSD, which is calculated on the basis of equivalent spherical diameter. For instance, it has been established that the reported size of an ellipsoid is always smaller than the physical major dimension of the particle. Furthermore, when non-spherical particles align within a flowing sample, laser diffraction instruments typically report a bi-modal size distribution even in the case of monodisperse samples.
Equipped with only qualitative knowledge of particle shape, the particle analyst can resolve this inherent ambiguity and use laser diffraction to obtain quantitative information (such as aspect ratio) about non-spherical particles. This webinar explains the origin of this effect, describes how to interpret PSD data in such cases, and demonstrates several practical applications for measurements of crystals, bacteria, and clays.
View recorded webinars:
http://bit.ly/particlewebinars
Mark Bumiller of HORIBA Scientific discusses tactics for getting the best possible particle size results for pigments, inks, and paints. These applications tend to be more challenging than most, so the information in this presentation will be valuable for any chemist responsible for these materials.
Particle Classroom Series II: The Basics of Laser DiffractionHORIBA Particle
Particle size analysis by laser diffraction offers many advantages. The technique is fast, reliable, and can be used for analyzing a wide range of particle sizes. In laser diffraction scattering as a function of angle is measured and the data used to determine the particle size distribution. The technique can be used over a very wide range of particle sizes -- 10's of nm to 100's of microns. In addition it is very fast and reliable. In this webinar, Dr. Jeff Bodycomb will discuss:
Exactly what happens when light strikes a particle
Light intensity and how it effects the measurement
Fraunhofer vs. Mie
Real and imaginary refractive index values
This is a great introduction to someone who wants to understand the science behind the measurement.
View recorded webinars:
http://bit.ly/particlewebinars
Key Points to Achieving Successful Laser Diffraction Method DevelopmentHORIBA Particle
Unlock the secrets to the best measurement for particles. Topics covered include choosing appropriate accessories, selecting the best dispersing medium, assessing the effect of circulation pump speed, and evaluating the impact of using different imaginary refractive index values.
View recorded webinars:
http://bit.ly/particlewebinars
How to Select the Best Refractive Index for Particle Size AnalysisHORIBA Particle
Dr. Jeff Bodycomb discusses the process HORIBA uses to select the best possible refractive index. This information is valuable for anyone using any type of laser diffraction particle size analyzer regardless of manufacturer or model.
This presentation covers the following topics:
* Available resources and current thinking
* Automated RI determination with the Method Expert
* Effect on accuracy of using good, bad, and no refractive index
Particle Classroom Series I: Introduction to Particle AnalysisHORIBA Particle
If you're new to particle characterization, this is a webinar just for you! Dr. Jeff Bodycomb will discuss the basics of particles....why different size definitions will give you different results, various methods used to measure particles and why the method you use matters! This webinar will be the first in a series that will give you the knowledge you'll need to be the particle expert in your lab.
View recorded webinars:
http://bit.ly/particlewebinars
The Importance of Sampling & Dispersion for Particle Size AnalysisHORIBA Particle
Dr. Jeff Bodycomb of HORIBA Scientific discusses why sampling & dispersion are such critical factors in obtaining accurate and reproducible particle size results for every application and analyzer.
Particle Classroom Series IV: System VerificationHORIBA Particle
Confirming the performance of a particle analyzer is a critical step in ensuring and proving data quality. Join Dr. Jeff Bodycomb as he discusses performance expectations, confirming system performance, and recommended practices. This is part four of a six-part classroom series.
View recorded webinars:
http://bit.ly/particlewebinars
How to Present and Compare Data Obtained by Particle Tracking Analysis and Ot...HORIBA Particle
This Webinar is for anyone who wants to understand how experimental data should be presented and compared properly while using histograms.
Dr. Kuba Tatarkiewicz examines methods for particle size distributions as obtained by particle tracking analysis, fluorescence, as well as micro-sedimentation. Choices of binning schemes that users can design themselves will be discussed with examples of how various parameters (like mode and D50) change with different binnings, especially for highly polydisperse colloids. Methods for comparison of particle size distributions will be presented and explained in practical terms.
View recorded webinars:
http://bit.ly/particlewebinars
Modern Laser Diffraction for Particle AnalysisHORIBA Particle
Laser Diffraction is the most popular technique in modern particle sizing. It can be used to rapidly and reliably determine the size and size distribution particles with sizes from 10's of nanometers to a few millimeters.
View recorded webinars:
http://bit.ly/particlewebinars
Particle Classroom Series III: Refractive Index and Laser DiffractionHORIBA Particle
Modern laser diffraction particle analyzers use particle refractive index to accurately model the behavior of light inside of the particle. However, this presents the analyst with the challenge of choosing the correct value. In this Webinar, Dr. Jeff Bodycomb will discuss:
- Why do we need a refractive index value?
- What is refractive index?
- How do we choose refractive index values?
View recorded webinars:
http://bit.ly/particlewebinars
Evaluation of stress resistant sweetpotato varieties and their low cost micro...ILRI
Presented by Emana Getu, Tileye Feyissa and Addisu Nega (Addis Ababa University, College of Natural Sciences) at the First Bio-Innovate Regional Scientific Conference, Addis Ababa, Ethiopia, 25-27 February 2013
Jane Cooper, Senior Applications Scientist
Separation by UPC2 is an ideal alternative to both HPLC and GC analysis
- Ability to run LC and GC amenable compounds in single analysis
-Fast 7 minute analysis of the 24 regulated allergens and 6 additional compounds containing:
– Different classes of compounds
– Different polarities
- UC2 with MS detection offers an orthogonal technique, which enables greater selectivity and specificity compared to either HPLC or GC analysis alon
- The developed 7 minute UPC2 method, is greater than 6 times faster than existing HPLC and GC
Jane Cooper, Senior Applications Scientist, Waters Corporation.
Method development
Aim: One peak = one compound
Detect coelutions and peaks missed by optical detection
Track peaks more effectively
Sample profiling
Aim: Identify components and quantify
Process complex matrices and low level target compounds
Improved selectivity, more sensitivity
Synthetic chemistry
Aim: Confirm product identity
Improve turnaround of results
Improve information available on impurities
Purification
Aim: Isolate pure compound
Collect fewer fractions with increased confidence
AGC FluoroCompounds Group is the largest long-standing custom fluoropolymer compounder in the world. Drawing from an extensive global supply chain of resins and fillers, we can produce any filled PTFE or melt processable fluoropolymer compound.
The Aveka Group's Particle Processing TechnologiesHORIBA Particle
Willie Hendrickson, President of Aveka, discusses how their particle technology expertise can solve any contract manufacturing or R&D challenge. A case study about milling techniques to achieve a tight particle distribution as well as a case study about fast scale-up & expansion execution will be presented. HORIBA is proud to partner with Aveka as they share their experience in the wider world of particle technology.
Durability for Carbon Fiber Reinforced Polymers on Timber StructuresJBercot
A thesis presentation submitted in partial fulfilment of the requirements of the subject BEB801 – Project 1 in the Bachelor of Engineering Degree.
School of Civil Engineering & Built Environment,
Queensland University of Technology, June 2016
Agricultural Commodity Analysis and Trade Issues for ShippingMathew Conoulty
David Conoulty of Commodity Inspection Services outlines the various factors involved with testing for the quality of agricultural commodities during the shipping process. The presentation covers the analysis process, the reliability of results, analytical methods and the improved equipment used to perform quality laboratory analysis.
This research mainly focus on developing an efficient product that will be effective for remediation during groundwater treatment.
It gives in-depth analysis on in-situ oxidation techniques for groundwater remediation.
The Iron Ore Conference presents Damian Connelly as he discusses the future for magnetite projects in Australia and the challenges of new projects. Some case studies are covered including Savage River, Project Magnetite, Sino Iron and Karara project
Learn how to have a lining project that is done safely, correctly and environmentally compliant. This presentations explains how planning can help you stay on schedule within budget and accrue no extras costs while meeting the expectations of your team. We share failure prevention engineering steps and identify components for a successful linings project, lining selection criteria, comparison of generic product type vs performance, and why choosing International Paint as your linings solution provider is the right choice.
Exosomes: Exploiting the Diagnostic and Therapeutic Potential of Nature’s Bio...HORIBA Particle
Research on exosomes and other forms of extracellular vesicles (EVs) have rapidly expanded over the last two decades. These lipid-enclosed, nanoscale messengers are released from cells packed with diverse cargo and can travel long distances to modify the function of target cells. Found in abundant quantities in biological fluids like blood, there is great clinical interest in using EVs as diagnostic markers or altering their properties for therapeutic delivery. Tune in to find out more about what exosomes are, how researchers study them, and what challenges remain. This talk will highlight multi-laser nanoparticle tracking analysis (NTA) with the ViewSizer 3000 and what it offers in exosome research.
View recorded webinars:
http://bit.ly/particlewebinars
The Value of Real-time Imaging: Integrating Particle Size Analysis onto Fluid...HORIBA Particle
The capability to measure critical quality attributes (CQA) such as particle size in real time reveals their functional relationships with the critical process parameters (CPP). The Eyecon2™ offers a true non-product contact, a real-time imaging system that can be used with dry and wet bulk solid processing equipment affording a digital maturity competitive edge. We will dive into how the imaging technology works, the basic principles of analysis for particle size detection, the methods of integration onto process equipment such as Fluid Beds, Twin Screw Granulators and Roller Compactor and discuss key applications where the value of real-time in-line particle size results archetype how the Eyecon2 enables transparency, agility and productivity that aligns with the Factory of the Future and Pharma 4.0.
View recorded webinars:
http://bit.ly/particlewebinars
Particle Size Analyses of Polydisperse Liposome Formulations with Multispectr...HORIBA Particle
During this webinar, Dr. Singh will discuss the significance of liposome size characteristics in medicine. He will discuss the challenges present in particle size measurement for heterogeneous size containing formulation (polydisperse). He will also discuss his recently published results on polydisperse bead and liposome formulations using DLS, conventional NTA, laser diffraction and a novel multispectral NTA measurement techniques.
View recorded webinars:
http://bit.ly/particlewebinars
Principio, Optimización y Aplicaciones del Análisis de seguimiento de Nanopar...HORIBA Particle
Este webinar tiene como objetivo presentar los fundamentos teóricos del análisis de seguimiento de nanopartículas (NTA), su optimización y su aplicaciones más recientes en la industria e investigación.
- Principio de la Técnica de Rastreo de Nanopartículas (NTA)
- Información que nos proporciona la técnica NTA
- Limitaciones de la técnica NTA
- Optimización
- Aplicaciones más recientes
View recorded webinars:
http://bit.ly/particlewebinars
Surface area is an important physical property that influences the reactivity, dissolution, catalysis, and separation of materials. The surface area often must be carefully engineered and measured to optimize specific functions. In this Webinar, our applications lab will explain with real-world examples:
- Physical adsorption technique - BET theory
- Sample preparation – the start of a good measurement
- Calculating specific surface area from gas adsorption on solid surfaces
- Troubleshooting – what happens when things go wrong?
View recorded webinars:
http://bit.ly/particlewebinars
Why the University of Washington chose the HORIBA Laser Scattering Particle S...HORIBA Particle
Join our users at the University of Washington (UW) as they discuss how the HORIBA particle size analyzer is used in their undergraduate courses and how the instrument manages to support a wide range of applications. Some examples include polymers spheres, ceramic powders, soil, and rocks. In this Webinar, Materials Science and Engineering (MSE) graduate students, Michelle Katz and Tiffany Tang will demonstrate with case studies how other orthogonal methods such as optical microscopy, scanning electron microscopy and x-ray diffraction help them cross-validate their particle size and size distribution. You will also learn in their own words, why the UW MSE program chose the HORIBA particle size analyzer over other options for their undergraduate environment.
View recorded webinars:
http://bit.ly/particlewebinars
Improved Visualization, Counting and Sizing of Polydisperse Nanoparticle Coll...HORIBA Particle
The ViewSizer® 3000 offers the ability to visualize nanoparticle colloids without requiring calibration standards or knowledge of any particle material properties, such as refractive index. It was developed by MANTA – the Most Advanced Nanoparticle Tracking Analysis – and offers the user an unprecedented ability to count and size highly polydispersed samples, such as milk, sea water, or blood plasma.
View recorded webinars:
http://bit.ly/particlewebinars
Accurately Measure Concentration of Nanoparticles in ColloidsHORIBA Particle
In this presentation, Dr. Jan "Kuba" Tatarkiewicz discusses the influence of various experimental parameters determined by different methods to measure the concentration of particles in colloids, especially in poly-dispersed and poly-material samples. Dr. Tatarkiewicz compares the principles of measurements for established technologies such as transmission electron microscopy (TEM), flow cytometry (FC), resistive pulse sensing (Coulter), nanoparticle tracking analysis (NTA) as well as improvements introduced to the latter by multispectral advanced nanoparticle tracking analysis (MANTA). Dr. Tatarkiewicz will present experimental results obtained for standardized samples and colloids encountered in research studies in diverse fields of interest.
View recorded webinars:
http://bit.ly/particlewebinars
Introdução às Principais Técnicas para Caracterização de Partículas e suas Ap...HORIBA Particle
Esse webinar tem por finalidade apresentar os conceitos das principais técnicas atuais para a análise de distribuição de tamanho de partículas (Difração de Laser, Espalhamento Dinâmico de Luz – DLS, Imagem Dinâmica, e Rastreamento de Partículas - PTA) a fim de ajuda-los a determinar qual a melhor técnica para atender as suas necessidades.
Ver webinars:
http://bit.ly/particlewebinars
River Sediment Transport Measurement of a River ColumnHORIBA Particle
Dr. Yogi Agrawal discusses how the transport of sediments by rivers affects the environment in many ways, forming and deforming bedforms, eroding banks, and transporting pollutants to name a few.
Emerging food trends, Plant Based Proteins, Healthy Fat and SugarHORIBA Particle
This presentation by Julie Nguyen of HORIBA Scientific discusses some of the growing trends toward a healthier diet and new FDA guidelines. From a webinar presented in July, 2016.
Kiwan Park of HORIBA Scientific, presents an overview of Piezo Particles beginning with the discover by Jacques and Pierre Curie and stepping through some of today's applications from Igniters to Ultrasounds.
Soil Particle Size Analysis and Clay Fraction ExtractionHORIBA Particle
Dr. Scott Werts, Assistant Geology Professor at Winthrop University, discusses how he and his graduate students use particle size analysis in their research. He presented a webinar on behalf of HORIBA Scientific in October 2016.
Dr. Jeff Bodycomb shares the core principle behind laser diffraction and two laser diffraction models (Fraunhofer and Mie) that are the backbone of laser diffraction theory.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Mastering the Processing Methods of Engineered Particles
1. AVEKAGroup
MASTERING THE PROCESSING
METHODS OF ENGINEERED PARTICLES
MAY 13, 2020
PA RT I C L E P RO C ES S I N G S E RV I C ES
TO L L M A N U FAC T U R I N G
R ES EA RC H & D E V E LO P M E N T
I N N O VAT I V E S O LU T I O N S
AVEKA
PRESENTED BY: WILLIE HENDRICKSON, CEO & FOUNDER
2. Presentation
Outline
Overview of AVEKA
What are engineered particles?
How do you approach making engineered particles?
General processing methods to consider
Practical challenges
Separation example
Coating example
Atomization example
Conclusions
3. AVEKAGroup
Overview
• Particle technology company focused on
contract manufacturing
• Spin-off of 3M in 1994
• Comprised of 5 separate companies
• ISO certifications / food-grade
certifications
• Currently 290 employees
4. AVEKA’s
Vision
AVEKA
AVEKA’sVision
Building the legacy of leadership and innovation in
manufacturing solutions for particle technology
AVEKA’s Mission
Our team of employee owners will deliver custom
solutions, quality manufacturing, and excellent
customer service for the benefit of our customers,
employees and communities.
5. TheAVEKA
Group
• 75 people
• Corporate Headquarters
• R&D, Manufacturing, Specialty Process Suites
AVEKA Inc
• 96 people – Fredericksburg, Iowa
• Large scale manufacturing
• Spray Drying, Hammer Milling, Fluid Bed Drying, Tumble Coating,
Agglomeration
AVEKA Manufacturing
• 50 people – Cresco, Iowa
• Food Processing
• Spray Drying, Prilling, Drum Drying, Extraction, Wet Blending
Cresco Food Technologies
• 40 people – Waukon Iowa
• Value Added Food Processing
• Spray Drying, Roll Drying, Microfiltration/Nanofiltration, Specialty Separations
AVEKA Nutra Processing
• 15 People – Cottage Grove, Minnesota
• Industrial Materials, Abrasives, Ceramics, Minerals
• Jet Milling and Classification
AVEKA CCE Technologies
6. AVEKA
ParticleCharacterization
Particle size analysis
◦ Particles 1 nm to 2+ mm
◦ Particle size distribution (PSD)
◦ Sonic sieving
◦ Rototap
Imaging
◦ Optical microscopy
◦ Scanning electron microscopy (SEM) with EDS
Surface area analysis
True density analysis
◦ Helium pycnometry
Formulation analysis
◦ High performance liquid chromatography
(HPLC)
◦ Thermogravimetric analysis (TGA)
◦ Spectrophotometer
◦ Differential scanning calorimetry (DSC)
Flow characteristics
◦ Freeman FT4
◦ Zeta potential analysis (ZP)
◦ Rheological analysis
◦ Moisture and solids analysis (MSA)
◦ Karl Fisher
7. What are
Engineered
Particles?
• Size controlled
• Multicomponent
• Tightly adjusted composition
• Complex structure or shape
• Functional property
• Chemically or biologically active
• Controlled release
11. What DoYou
Need to
Know?
Chemistry
Properties
M.p., b.p., solubility,
pH, density
Functional
Properties
Particle size,
viscosity, powder
flow
Financial
Considerations
Cost, volumes,
profitability
What equipment do you have
available?
14. The Examples…. Finally
Cellulose Fiber Separation
◦ Water holding enhancement
Encapsulation of Omega-3 Oils
◦ Reduced oxidation and odor
Monodisperse Particles
◦ Medical device testing
❖Statement of need
❖How we approached the problem
❖What went right
❖What went wrong
AVEKA
15. Preparation
ofCellulose
Fiber from
Corn Bran
The Solution
• Starch:1-10%
• Protein: 1-8%
• Oils: 0-2%
• Ash: 1-6%
• Water: 1-10%
• Fiber: 80-90%
• Cellulose: 25-30%
• Hemicellulose: 60-70%
• Lignin: 1-6%
Statement of challenge
• Scale-up proven
process
• Produce high
concentration of
cellulose fiber with
high water holding
property
AVEKA
Corn Bran Starting Material Composition
Starch 1-10%
Protein 1-8%
Oils 0-2%
Ash 1-6%
Water 1-10%
Fiber 80-90%
• Cellulose 25-30%
• Hemicellulose 60-70%
• Lignin 1-6%
16. Process andCellulose
Images
▪Slurry in Water
▪Remove digested starch and fats
▪Add caustic to solubilize hemicellulose and lignin
▪Centrifuge and dry
AVEKA
17. WHATWENT
WRONG?
• Yields were poor
• Process incredible
inconsistent
• Water holding results
were inconsistent
THE
SOLUTION
• Analyze
• Understand
AVEKA
22. WHATWENT
WRONG?
• Multilayer structure
was made using
atomization and spray
drying methods
followed by coating
process
• Results were as good as
industry standards –
not better
THE
SOLUTION
• Change materials
• Improve on oleosin
usage
AVEKA
23. Preparation of
Monodisperse
Wax Beads
Statement of challenge
• 4mm monodisperse
beads needed for bio
assay end use
• Need to be sterile
• Need to be tight size
and weight
• Minimal waste of raw
material
The Solution
• Prilling process
• Underwater formation and cooling
• New atomization method needed
25. Microencapsulation
via Prilling
▪ Process Parameters
▪ Melts not solutions(50-
200 °C)
▪ Melt viscosities < 300 cps
▪ Atomizers
▪ Drip
▪ Spinning disk
▪ Two-fluid
▪ Single fluid
▪ Chamber temperature
▪ Throughput (1-5000 kg/hr)
▪ Product Parameters
▪ Particle size (10-5000 µm)
▪ Matrix particle with 5-50%
active inclusions
AVEKA
26. Cold water
Melted
wax
Wax beads cool and
forms spheres when
floating up in the water
(~lava lamp) since they are
less dense than the water
Large nozzle to make
4 mm beads
Collect from
top
Underwater
Prilling
AVEKA
29. WHATWENT
WRONG?
• Under water prilling
process produced
beads in the correct
size and consistency
• Water inclusion (holes)
were not expected
THE
SOLUTION
• Vacuum drying worked
• Customer went to
another technology
due to timing
AVEKA
30. AVEKA
Summary
•Knowing the tricks and applying
them are Critical
•Multiple methods should be
considered for every problem
•It is hard to analyze and know too
much
R&D / Lab-Scale
Testing
PilotTesting
Full Scale
Manufacturing
Value Added
Product
Partnerships
• Contact Information:
• Willie Hendrickson
• whendrickson@aveka.com
• 651-730-1729