Jane Cooper, Senior Applications Scientist, Waters Corporation.
Method development
Aim: One peak = one compound
Detect coelutions and peaks missed by optical detection
Track peaks more effectively
Sample profiling
Aim: Identify components and quantify
Process complex matrices and low level target compounds
Improved selectivity, more sensitivity
Synthetic chemistry
Aim: Confirm product identity
Improve turnaround of results
Improve information available on impurities
Purification
Aim: Isolate pure compound
Collect fewer fractions with increased confidence
Jane Cooper, Senior Applications Scientist
Separation by UPC2 is an ideal alternative to both HPLC and GC analysis
- Ability to run LC and GC amenable compounds in single analysis
-Fast 7 minute analysis of the 24 regulated allergens and 6 additional compounds containing:
– Different classes of compounds
– Different polarities
- UC2 with MS detection offers an orthogonal technique, which enables greater selectivity and specificity compared to either HPLC or GC analysis alon
- The developed 7 minute UPC2 method, is greater than 6 times faster than existing HPLC and GC
This presentation will provide an introduction to the technology and benefits of Waters ACQUITY Ultra Performance Convergence Chromatography system (UPC2) and illustrate how it can impact the analysis of chemicals and polymers.
Learn about Waters technologies for analyzing oligonucleotides with LC-MS. We offer solutions for both oligo characterization and QC monitoring. Learn more: http://www.waters.com/oligos
Monitoring Released N-Glycans in Biopharma Development/QC with Fluorescence &...Waters Corporation
Learn how new technologies from Waters, the RapiFluor-MS Labeling Reagent and the ACQUITY QDa Mass Detector, enable biopharmaceutical development and QC labs to monitor released N-glycans with complementary fluorescence and mass detection. http://www.waters.com/glycans
From WCBP 2015: GlycoWorks RapiFluor-MS for Glycan ProfilingWaters Corporation
In this vendor presentation given at WCBP, we introduce a new glycan fluorescent label, RapiFluor-MS, which is used to label N-linked glycans. This innovative label improves FLR and mass spectrometry signals for glycan characterization and profiling analysis. Plus - our GlycoWorks RapiFluor-MS N-Glycan Kit now allows you to finish glycan deglycosylation, labeling and cleanup in 3 steps and just 30 minutes.
Learn more about this novel technology and its applications for glycosylated proteins:
http://www.waters.com/glycans
See more of Waters' solutions for biopharmaceutical laboratories:
http://www.waters.com/biopharmaceutical
Playback a full video of this talk, recorded Jan. 27, 2015 at WCBP:
http://www.waters.com/waters/library.htm?cid=10116552&lid=134833758
Food fraud has become a major concern in recent years. Fruit juice is commonly adulterated with cheaper alternatives. High resolution MS in combination with 'omics data analysis approaches can identify markers of adulteration.
The ACQUITY Advanced Polymer Chromatography (APC™) System is a breakthrough technology that defines the ultimate in size-based chromatographic separations, delivering more information about your polymers faster than ever before. This means better characterization, improved asset utilization and a superior solution for achieving corporate innovation and sustainability goals.
An overview of Pine Lake Laboratories capabilities involving oligonucleotides. Includes challenges, examples, method development, validation, and stability!
Jane Cooper, Senior Applications Scientist
Separation by UPC2 is an ideal alternative to both HPLC and GC analysis
- Ability to run LC and GC amenable compounds in single analysis
-Fast 7 minute analysis of the 24 regulated allergens and 6 additional compounds containing:
– Different classes of compounds
– Different polarities
- UC2 with MS detection offers an orthogonal technique, which enables greater selectivity and specificity compared to either HPLC or GC analysis alon
- The developed 7 minute UPC2 method, is greater than 6 times faster than existing HPLC and GC
This presentation will provide an introduction to the technology and benefits of Waters ACQUITY Ultra Performance Convergence Chromatography system (UPC2) and illustrate how it can impact the analysis of chemicals and polymers.
Learn about Waters technologies for analyzing oligonucleotides with LC-MS. We offer solutions for both oligo characterization and QC monitoring. Learn more: http://www.waters.com/oligos
Monitoring Released N-Glycans in Biopharma Development/QC with Fluorescence &...Waters Corporation
Learn how new technologies from Waters, the RapiFluor-MS Labeling Reagent and the ACQUITY QDa Mass Detector, enable biopharmaceutical development and QC labs to monitor released N-glycans with complementary fluorescence and mass detection. http://www.waters.com/glycans
From WCBP 2015: GlycoWorks RapiFluor-MS for Glycan ProfilingWaters Corporation
In this vendor presentation given at WCBP, we introduce a new glycan fluorescent label, RapiFluor-MS, which is used to label N-linked glycans. This innovative label improves FLR and mass spectrometry signals for glycan characterization and profiling analysis. Plus - our GlycoWorks RapiFluor-MS N-Glycan Kit now allows you to finish glycan deglycosylation, labeling and cleanup in 3 steps and just 30 minutes.
Learn more about this novel technology and its applications for glycosylated proteins:
http://www.waters.com/glycans
See more of Waters' solutions for biopharmaceutical laboratories:
http://www.waters.com/biopharmaceutical
Playback a full video of this talk, recorded Jan. 27, 2015 at WCBP:
http://www.waters.com/waters/library.htm?cid=10116552&lid=134833758
Food fraud has become a major concern in recent years. Fruit juice is commonly adulterated with cheaper alternatives. High resolution MS in combination with 'omics data analysis approaches can identify markers of adulteration.
The ACQUITY Advanced Polymer Chromatography (APC™) System is a breakthrough technology that defines the ultimate in size-based chromatographic separations, delivering more information about your polymers faster than ever before. This means better characterization, improved asset utilization and a superior solution for achieving corporate innovation and sustainability goals.
An overview of Pine Lake Laboratories capabilities involving oligonucleotides. Includes challenges, examples, method development, validation, and stability!
Particle Size Analysis for Pharmaceutical Homogenization Process DevelopmentHORIBA Particle
Guest speaker Dr. Daniel Huang of Novartis joins HORIBA Scientific (http://www.horiba.com/particle) to speak about homogenization process development.
High-pressure homogenization has been used to prepare emulsions in a broad range of industries. Particle size distribution and emulsion stability are two key properties of the system essential to a successful downstream application. In this study, Daniel and his colleagues have investigated the effects of process conditions on droplet size and coalescence rate of the emulsion systems.
HGA-01 Headspace Gas Analyzer is professionally applicable to the determination of the volumes and proportions of O2 and CO2 of sealing packages. Because of its portable design, the instrument could be used on production lines, at warehouses, or in laboratories, to serve as a guide for production and assure shelf life. Many packages are testable, including the packages for instant food, milk powder, bread, meat, medical products, cheese, coffee, soft drinks, agriculture products and MAP packages, active package, and anticorrosive packages.
Overview of webinar:
Rechargeable, manganese-based, lithium-ion batteries (LiBs) are environmentally friendly, have a good safety record, and can be made at a lower cost than other metal-based LiBs. However, they have a shorter lifetime. Much research has been spent on improving product safety, cycle life, and product performance, yet understanding fundamental processes and degradation mechanism in LiBs remains a challenge. Identifying breakdown products and understanding degradation processes can lead to enhancing battery performance, improvements in product safety, and insight into component failure mechanisms.
Introducing the LA-960 Laser Particle Size AnalyzerHORIBA Particle
HORIBA Instruments proudly announces the latest evolution in the LA series of particle size analyzers, the LA-960. Building on the successful LA-950 platform, this advanced model measures the particle size of suspensions, emulsions, powders, pastes, creams, and gels between 10 nanometers and 5 millimeters. The complex science of particle size analysis is simplified with HORIBA’s refined software and powerful sample handling systems.
Join us on Wednesday, September 17th at 1:30 PM Eastern to learn more about the world’s newest and most advanced laser particle size analyzer. This webinar will be suitable for anyone wishing to learn about the state of the art in laser particle size analysis.
توفر شركة تكنوسيرفيس مجموعة أجهزة الكشف عن المعادن Thermo Scientific ™ Sentinel ™ والتي تتميز بأداء كشف عالي الحساسية لجودة منتجك ومدي احتمالية العثور على ملوثات معادن حديدية وغير حديدية وأي ملوثات في الأطعمة والمشروبات وغيرها من المنتجات.
باستخدام تقنيات مبتكرة مثل Multiscan ™ و Selectscan ™ ، تساعد أجهزة الكشف عن المعادن Sentinel الشركات المصنعة على زيادة سلامة وصحة العملاء وتحسين جودة المنتج وزيادة كفاءة الإنتاج.
اكتشف معنا كيف يمكن لمجموعة منتجات Sentinel تلبية احتياجات تطبيقاتك.
أهمية وجود أجهزة الكشف المعادن في خط إنتاجك ؟
1️⃣ أصبح الآن من الشروط الأساسية لدي منظمة الصحة والأغذية لحمايه المستهلك.
2️⃣ ضروري لمنح شهادة الأيزو لمنتجك
3️⃣ ضمان استمرارية البراند الخاص بك في السوق وحصوله علي سمعة طيبة نتيجة ضمان الجودة
تستخدم هذه الاجهزه على خطوط انتاج وتعبئه الاغذيه
(مثل المطاحن و مصانع الالبان والحلويات والبسكويت والشيكولاته والمكرونه والمخللات والخضروات والفواكه المجمده والايس كريم ..وغيرها)
مميزات الجهاز:
◀يمكنه الكشف عن المعادن داخل منتجك خلال مراحل عمليه التصنيع حتى التعبئه وبدقه عاليه
◀ يمكنه رفض كل المنتجات المخالفه لمعايير الجوده وسلامه الغذاء
◀ يتميز الجهاز بالشكل الانسيابي وصغر الحجم
◀الجهاز حاصل على شهاده من هيئه سلامه الغذاء FDA
◀ الجهاز حاصل على IP69K لمقاومه الماء
◀ السير مصنوع من اعلى الخامات جوده والتي تتحمل الاوزان الكبيره
◀ سهل برمجته والتدريب عليه وتوافر قطع الغيار والصيانه
◀ ضمان لمده عام كامل
◀ الجهاز به إنذار صوت وضوء
◀ مهندسين متخصصين للتركيب والتدريب علي الجهاز وحاصلين علي شهادات معتمدة من ThermoFisher
تطبيقات اجهزه الكشف عن المعادن والشوائب :
تستهدف اجهزه الكشف عن المعادن والشوائب (metal detectors وال x-ray) كل شركات ومصانع الاغذيه وقطاع سلامه الغذاء وخطوط الانتاج التي تسعى للحصول على شهادات الايزو والجوده .
تسعى تكنوسيرفيس لخدمه جميع عملائها باحترافيه عن طريق مساعدتهم للوصول للنجاح في جميع المجالات السابقه .
just call us 01116593835
http://technoservice-egypt.com/
Determination of Common Counterions and Impurity Anions in Pharmaceuticals Using a Capillary HPIC System with Suppressed Conductivity and Charge Detection
Recently, identification and quantification of ions in early stage drug development has gained increasing attention, because the APIs maybe contaminated with different counter ions from synthesis steps, and because selecting the counter ion to enhance APIs’ solubility and stability is becoming a key step in formulation development. This presentation demonstrates the identification and quantification of 22 commonly found anions in pharmaceuticals in a single run using a high-pressure capillary IC system (HPIC) with 4-μm particle ion –exchange column, and CD-QD dual detectors.
Selecting the Best Particle Size Analyzer for your ApplicationHORIBA Particle
Mark Bumiller from HORIBA Particle discusses the benefits and limitations of modern particle size analyzers and ideas on how to approach the choice of a new measurement technique or instrument.
This presentation is archived with the original webinar video in the Download Center at www.horiba.com/us/particle.
Particle Classroom Series VI: Method DevelopmentHORIBA Particle
Great results need a great method. In order to compare different lots of material or different manufacturing approaches, variation due to sample preparation should be minimized. Should the sample be run in suspension or as a dry powder? What salts or surfactants are needed for the suspension? How much energy should be applied and how? Systematically determining the answers to these questions is method development.
View recorded webinars:
http://bit.ly/particlewebinars
Modern Particle Characterization Techniques Series: Laser DiffractionHORIBA Particle
This part two of the webinar series will introduce participants to basic experimental considerations when choosing laser diffraction for particle size analysis. The presentation will explain what makes laser diffraction a “modern technique.” Both wet and dry case studies will be shown along with brief demonstration videos.
In this webinar, you will learn:
- Method development
- Choosing an appropriate refractive index
- Understanding the analysis results
View recorded webinars:
http://bit.ly/particlewebinars
Spps and its applications for bioactive peptides(Rajendra Sonawane)Rajendra Sonawane
Bioactive peptides are protein fragments which have a positive impact on the functions and conditions of
living beings. Peptides have shown several useful properties for human health, including antimicrobial, antifungal, antiviral,
and antitumor activities.
Improving Downstream Processing: Application of Excipients in DSPMilliporeSigma
Webinar summary:
This webinar will showcase the beneficial potential of using excipients during downstream processing of monoclonal antibodies.
Learning points:
In this webinar, you will see:
* An innovative excipient screening approach simulating low pH stress conditions during protein A chromatography and virus inactivation
* How the application of excipients in buffer systems can significantly improve protein stability and chromatographic performance
Abstract:
Key aspects during downstream purification of biopharmaceutical drugs are purity and process yield. Therefore, the downstream process needs to be designed in a way that the final product which will eventually end up in the patient entails low levels of product- and process related impurities (e.g. high molecular weight aggregates) as well as process related contaminants (e.g. host cell protein levels). In addition to this, the process must be capable of clearing and inactivating viruses to ensure product safety. In this webinar, we will explore the benefits of adding excipients during downstream processing on protein stability, chromatographic performance and viral inactivation.
Intervento di Petra Scanferla, CVR
Conferenza Finale Progetto GREEN SITE: “Supercritical fluid technologies for river and sea dredge sediment remediation”. LIFE 10 ENV/IT/343.
Venezia, 13 dicembre 2013
Mastering the Processing Methods of Engineered ParticlesHORIBA Particle
This webinar will explain the development process for particles with specific attributes that can cause problems during production. Three case studies will be discussed: Engineered particles that protect omega-3 oil from oxidation using special microencapsulation methods; modified cellulose fibers with high water holding capacity; and engineered particles produced by melt atomization processes with unique attributes. The talk will focus on alternative processing methods, the importance of understanding the materials being used, and what can happen when you do not understand the functional properties that you are designing for.
View recorded webinars:
http://bit.ly/particlewebinars
High-performance anion-exchange chromatography with pulsed amperometric detection is valuable for oligosaccharide analysis with the value derived from the high-resolution separation followed by sensitive detection of native oligosaccharides. In this presentation the application of HPAE-PAD to oligosaccharides released from glycoproteins is demonstrated.
Industrial Laboratories around the world are trying to find ways to minimize sample preparation and enhance productivity. The adaptation of modern mass spectrometry instrumentation is desired due to the high sensitivity and selectivity they provide. This presentation will describe how different sample preparation techniques can be simplified and automated for LC/MS/MS analyses.
Cleaning validation is necessary to establish the quality and safety of pharmaceutical drug products. In cleaning validation protocols, direct sampling is performed with swabs, which are sticks with textiles at one end. The sample on the swab after swabbing the surface of equipment is analyzed with a TOC analyzer and HPLC. Recently, HPLC has been more preferable because of the growing need for the individual analysis of products. Before the HPLC analysis, manual processes such as a sample extraction and a sample condensation are required. Such manual processes may affect to the quality of results. Thus, we evaluated the application of a novel on-line supercritical fluid extraction/chromatography system for the cleaning validation.
For more information, go to ssi.shimadzu.com and follow us on Twitter @ShimdzuSSI
Waters analytical technologies enable laboratories to generate more information, complete analyses more rapidly and reduce overall costs throughout key steps in the agrochemical development workflow - including Synthetic Chemistry, Purification, Formulation, Trace Detection, Metabolite ID.
Particle Size Analysis for Pharmaceutical Homogenization Process DevelopmentHORIBA Particle
Guest speaker Dr. Daniel Huang of Novartis joins HORIBA Scientific (http://www.horiba.com/particle) to speak about homogenization process development.
High-pressure homogenization has been used to prepare emulsions in a broad range of industries. Particle size distribution and emulsion stability are two key properties of the system essential to a successful downstream application. In this study, Daniel and his colleagues have investigated the effects of process conditions on droplet size and coalescence rate of the emulsion systems.
HGA-01 Headspace Gas Analyzer is professionally applicable to the determination of the volumes and proportions of O2 and CO2 of sealing packages. Because of its portable design, the instrument could be used on production lines, at warehouses, or in laboratories, to serve as a guide for production and assure shelf life. Many packages are testable, including the packages for instant food, milk powder, bread, meat, medical products, cheese, coffee, soft drinks, agriculture products and MAP packages, active package, and anticorrosive packages.
Overview of webinar:
Rechargeable, manganese-based, lithium-ion batteries (LiBs) are environmentally friendly, have a good safety record, and can be made at a lower cost than other metal-based LiBs. However, they have a shorter lifetime. Much research has been spent on improving product safety, cycle life, and product performance, yet understanding fundamental processes and degradation mechanism in LiBs remains a challenge. Identifying breakdown products and understanding degradation processes can lead to enhancing battery performance, improvements in product safety, and insight into component failure mechanisms.
Introducing the LA-960 Laser Particle Size AnalyzerHORIBA Particle
HORIBA Instruments proudly announces the latest evolution in the LA series of particle size analyzers, the LA-960. Building on the successful LA-950 platform, this advanced model measures the particle size of suspensions, emulsions, powders, pastes, creams, and gels between 10 nanometers and 5 millimeters. The complex science of particle size analysis is simplified with HORIBA’s refined software and powerful sample handling systems.
Join us on Wednesday, September 17th at 1:30 PM Eastern to learn more about the world’s newest and most advanced laser particle size analyzer. This webinar will be suitable for anyone wishing to learn about the state of the art in laser particle size analysis.
توفر شركة تكنوسيرفيس مجموعة أجهزة الكشف عن المعادن Thermo Scientific ™ Sentinel ™ والتي تتميز بأداء كشف عالي الحساسية لجودة منتجك ومدي احتمالية العثور على ملوثات معادن حديدية وغير حديدية وأي ملوثات في الأطعمة والمشروبات وغيرها من المنتجات.
باستخدام تقنيات مبتكرة مثل Multiscan ™ و Selectscan ™ ، تساعد أجهزة الكشف عن المعادن Sentinel الشركات المصنعة على زيادة سلامة وصحة العملاء وتحسين جودة المنتج وزيادة كفاءة الإنتاج.
اكتشف معنا كيف يمكن لمجموعة منتجات Sentinel تلبية احتياجات تطبيقاتك.
أهمية وجود أجهزة الكشف المعادن في خط إنتاجك ؟
1️⃣ أصبح الآن من الشروط الأساسية لدي منظمة الصحة والأغذية لحمايه المستهلك.
2️⃣ ضروري لمنح شهادة الأيزو لمنتجك
3️⃣ ضمان استمرارية البراند الخاص بك في السوق وحصوله علي سمعة طيبة نتيجة ضمان الجودة
تستخدم هذه الاجهزه على خطوط انتاج وتعبئه الاغذيه
(مثل المطاحن و مصانع الالبان والحلويات والبسكويت والشيكولاته والمكرونه والمخللات والخضروات والفواكه المجمده والايس كريم ..وغيرها)
مميزات الجهاز:
◀يمكنه الكشف عن المعادن داخل منتجك خلال مراحل عمليه التصنيع حتى التعبئه وبدقه عاليه
◀ يمكنه رفض كل المنتجات المخالفه لمعايير الجوده وسلامه الغذاء
◀ يتميز الجهاز بالشكل الانسيابي وصغر الحجم
◀الجهاز حاصل على شهاده من هيئه سلامه الغذاء FDA
◀ الجهاز حاصل على IP69K لمقاومه الماء
◀ السير مصنوع من اعلى الخامات جوده والتي تتحمل الاوزان الكبيره
◀ سهل برمجته والتدريب عليه وتوافر قطع الغيار والصيانه
◀ ضمان لمده عام كامل
◀ الجهاز به إنذار صوت وضوء
◀ مهندسين متخصصين للتركيب والتدريب علي الجهاز وحاصلين علي شهادات معتمدة من ThermoFisher
تطبيقات اجهزه الكشف عن المعادن والشوائب :
تستهدف اجهزه الكشف عن المعادن والشوائب (metal detectors وال x-ray) كل شركات ومصانع الاغذيه وقطاع سلامه الغذاء وخطوط الانتاج التي تسعى للحصول على شهادات الايزو والجوده .
تسعى تكنوسيرفيس لخدمه جميع عملائها باحترافيه عن طريق مساعدتهم للوصول للنجاح في جميع المجالات السابقه .
just call us 01116593835
http://technoservice-egypt.com/
Determination of Common Counterions and Impurity Anions in Pharmaceuticals Using a Capillary HPIC System with Suppressed Conductivity and Charge Detection
Recently, identification and quantification of ions in early stage drug development has gained increasing attention, because the APIs maybe contaminated with different counter ions from synthesis steps, and because selecting the counter ion to enhance APIs’ solubility and stability is becoming a key step in formulation development. This presentation demonstrates the identification and quantification of 22 commonly found anions in pharmaceuticals in a single run using a high-pressure capillary IC system (HPIC) with 4-μm particle ion –exchange column, and CD-QD dual detectors.
Selecting the Best Particle Size Analyzer for your ApplicationHORIBA Particle
Mark Bumiller from HORIBA Particle discusses the benefits and limitations of modern particle size analyzers and ideas on how to approach the choice of a new measurement technique or instrument.
This presentation is archived with the original webinar video in the Download Center at www.horiba.com/us/particle.
Particle Classroom Series VI: Method DevelopmentHORIBA Particle
Great results need a great method. In order to compare different lots of material or different manufacturing approaches, variation due to sample preparation should be minimized. Should the sample be run in suspension or as a dry powder? What salts or surfactants are needed for the suspension? How much energy should be applied and how? Systematically determining the answers to these questions is method development.
View recorded webinars:
http://bit.ly/particlewebinars
Modern Particle Characterization Techniques Series: Laser DiffractionHORIBA Particle
This part two of the webinar series will introduce participants to basic experimental considerations when choosing laser diffraction for particle size analysis. The presentation will explain what makes laser diffraction a “modern technique.” Both wet and dry case studies will be shown along with brief demonstration videos.
In this webinar, you will learn:
- Method development
- Choosing an appropriate refractive index
- Understanding the analysis results
View recorded webinars:
http://bit.ly/particlewebinars
Spps and its applications for bioactive peptides(Rajendra Sonawane)Rajendra Sonawane
Bioactive peptides are protein fragments which have a positive impact on the functions and conditions of
living beings. Peptides have shown several useful properties for human health, including antimicrobial, antifungal, antiviral,
and antitumor activities.
Improving Downstream Processing: Application of Excipients in DSPMilliporeSigma
Webinar summary:
This webinar will showcase the beneficial potential of using excipients during downstream processing of monoclonal antibodies.
Learning points:
In this webinar, you will see:
* An innovative excipient screening approach simulating low pH stress conditions during protein A chromatography and virus inactivation
* How the application of excipients in buffer systems can significantly improve protein stability and chromatographic performance
Abstract:
Key aspects during downstream purification of biopharmaceutical drugs are purity and process yield. Therefore, the downstream process needs to be designed in a way that the final product which will eventually end up in the patient entails low levels of product- and process related impurities (e.g. high molecular weight aggregates) as well as process related contaminants (e.g. host cell protein levels). In addition to this, the process must be capable of clearing and inactivating viruses to ensure product safety. In this webinar, we will explore the benefits of adding excipients during downstream processing on protein stability, chromatographic performance and viral inactivation.
Intervento di Petra Scanferla, CVR
Conferenza Finale Progetto GREEN SITE: “Supercritical fluid technologies for river and sea dredge sediment remediation”. LIFE 10 ENV/IT/343.
Venezia, 13 dicembre 2013
Mastering the Processing Methods of Engineered ParticlesHORIBA Particle
This webinar will explain the development process for particles with specific attributes that can cause problems during production. Three case studies will be discussed: Engineered particles that protect omega-3 oil from oxidation using special microencapsulation methods; modified cellulose fibers with high water holding capacity; and engineered particles produced by melt atomization processes with unique attributes. The talk will focus on alternative processing methods, the importance of understanding the materials being used, and what can happen when you do not understand the functional properties that you are designing for.
View recorded webinars:
http://bit.ly/particlewebinars
High-performance anion-exchange chromatography with pulsed amperometric detection is valuable for oligosaccharide analysis with the value derived from the high-resolution separation followed by sensitive detection of native oligosaccharides. In this presentation the application of HPAE-PAD to oligosaccharides released from glycoproteins is demonstrated.
Industrial Laboratories around the world are trying to find ways to minimize sample preparation and enhance productivity. The adaptation of modern mass spectrometry instrumentation is desired due to the high sensitivity and selectivity they provide. This presentation will describe how different sample preparation techniques can be simplified and automated for LC/MS/MS analyses.
Cleaning validation is necessary to establish the quality and safety of pharmaceutical drug products. In cleaning validation protocols, direct sampling is performed with swabs, which are sticks with textiles at one end. The sample on the swab after swabbing the surface of equipment is analyzed with a TOC analyzer and HPLC. Recently, HPLC has been more preferable because of the growing need for the individual analysis of products. Before the HPLC analysis, manual processes such as a sample extraction and a sample condensation are required. Such manual processes may affect to the quality of results. Thus, we evaluated the application of a novel on-line supercritical fluid extraction/chromatography system for the cleaning validation.
For more information, go to ssi.shimadzu.com and follow us on Twitter @ShimdzuSSI
Waters analytical technologies enable laboratories to generate more information, complete analyses more rapidly and reduce overall costs throughout key steps in the agrochemical development workflow - including Synthetic Chemistry, Purification, Formulation, Trace Detection, Metabolite ID.
Stylish mobile cases & cover in sony xperiamobilecases
The Protective Case is designed with the appropriate cutouts for the speaker, camera and other openings to provide the best performance both in functionality and safety. Slim polycarbonate back cover protects from bumps & drops or damages to the phone.
Professor Cristina Nerin. Professor of Analytical Chemistry. University of Zaragoza, Spain discusses the benefits of Collisional Cross Section measurements in Ion Mobility for the confirmation of food contaminant in packaging.
Environmental analysis can be extremely challenging due to the low detection levels for toxic contaminants specified by legislation, particularly in drinking water, and the complexity of matrices encountered. Consequently highly selective and sensitive detection methods are required. This presentation provides an introduction to tandem quadrupole mass spectrometry and describes the use of high sensitivity tandem quadrupole mass spectrometry for the analysis of various environmental contaminants including pesticides, endocrine disruptors and polyfluorinated compounds such as PFOS.
This presentation describes a new food testing solution that allows mass detection to be accessible for many of the routine analyses found within a food testing lab. The ACQUITY UPLC, QDa detector in combination with the Empower software solution is fit for purpose and is easy to use. You simply power on and you are ready to go
With the ACQUITY QDa detector many of the normal processes that are required for mass spectrometers (such as mass calibration and optimisation and manual adjustments that need to be made) have all been fully automated.
Food fraud is on the increase globally and checking for the authenticity of foodstuffs is a major challenge. Typical of food fraud is the substitution of a low value product for a higher value one to increase profit to the trader. For years, traders have been passing off a lesser quality rice, CSR 30, as the world's finest long-grained, aromatic rice, Basmati, in key markets like the US, Canada and the EU. In the process, the rice exports enjoy the duty exemption accorded to pure Basmati in the EU and thousands of consumers get duped. This presentation describes the use of Atmospheric Pressure Gas Chromatography coupled to high resolution MS to differentiate between types of rice and to identify marker compounds using statistical analysis software.
Agricultural Commodity Analysis and Trade Issues for ShippingMathew Conoulty
David Conoulty of Commodity Inspection Services outlines the various factors involved with testing for the quality of agricultural commodities during the shipping process. The presentation covers the analysis process, the reliability of results, analytical methods and the improved equipment used to perform quality laboratory analysis.
Join the experts as they discuss the use of accelerated solvent extraction and QuEChERS techniques for the extraction of pesticide residues from a diverse range of food samples. Tips and tricks for improving the extraction efficiency will be covered, along with selection criteria for each technique by sample type, assisting analysts in modifying existing methods or developing new methods to tackle their analytical challenges
This presentation compares wo methods for the detection of low-level pesticide residues in fruit juice. One involves the use of QuEChERS sample preparation and the other a 'dliute and shoot' approach. Sample preparation is utilised to remove the matrix effects associated with mass spectrometry (MS), using a 'dilute and shoot' approach requires the use of highly sensitive MS detection. It can be seen from the results shown that the 'dilute and shoot' approach can be used in many cases.
Clean-in-place: how to ensure food safety while maintaining equipment effecti...Design World
Negative PR from food safety violations has never been more prevalent than in today’s interconnected world. Manufacturers are in a constant battle to provide maximum food safety while maintaining throughput.
This webinar will focus on ways to ease these seemingly conflicting goals and introduce Baumer’s broad portfolio to aid with Clean-in-place solutions.
Watch webinar here: http://www.designworldonline.com/clean-in-place-h…nt-effectiveness/
Practical Implementation of the New Elemental Impurities Guidelines May 2015SGS
The International Conference on Harmonization (ICH) released its Q3D Guideline for Elemental Impurities in December 2014, initiating reviews and changes in quality testing programs in bio/pharmaceutical companies around the world. In advance of the implementation dates, companies need to assess the risks of potential elemental impurities in their process and materials streams.
In this presentation, experts will review the requirements of elemental impurities guidelines from ICH, the European Pharmacopeia, and United States Pharmacopeia, outline practical recommendations to address implementation challenges, and discuss key considerations for analytical testing programs.
Fast, selective, and sensitive methods can be developed for the analysis of impurities
Offering many business benefits using UPLC and UPC2
Increase in sample throughput
Reduction in toxic solvent usage
Using mass spectral detection over UV detection provides
Improvement in sensitivity and selectivity
Reduced matrix effects
PDA and mass detection provide complementary information for peak assignment and structural confirmation of impurities
Sistema de control online de calidad de pellets de maderaAVEBIOM
Presentación realizada por Martin Englisch, CEO de BEA Institut für Bioenergie, en el 11 Congreso Internacional de Bioenergía "Bioenergía 4.0: Retos y Oportunidades" www.congresobioenergia.org
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Carlos Afonso, Université de Rouen, Laboratoire COBRA, Plateau technique C2iorga
In this presentation, Carlos Afonso describes the analysis of polymers and petroleum by ion mobility mass spectrometry and utilises novel sample introduction techniques such as the Atmospheric Solids Analysis Probe (ASAP).
Vlad Lobodin, National High Magnetic Field Laboratory & Future Fuels Institute, Florida State University, Tallahassee, Florida - discusses advanced mass spectrometry techniques for the characterization of crude oil.
Horning’s group in the 1970’s developed atmospheric pressure ionization (API) mass spectrometry (MS), but it was electrospray ionization that drove the commercialization of API-MS as a liquid introduction technology. The utility of gaseous introduction of volatile compounds into an API source and new developments in GC-API/MS and ASAP-MS will be discussed along with the newly discovered matrix-assisted ionization technology that allows ionization of low and high mass compounds on API instruments without use of a laser, high voltage, or even heat.
Ion mobility- mass spectrometry can help to offer an additional orthogonal dimension of separation, and can help to deconvolute isomeric species in the ion mobility dimension, which, in turn, helps to simplify the analysis of these highly complex samples, and map the compositional space of petroleum samples, and can also characterise the shapes and sizes, or collisional cross sections, of molecules of interest.
The most important component of this work was the development of novel software that helps the user to visualise, interact with, and process ion mobility data – so, for the first time, we are able to utilise the ion mobility dimension in comprehensive petroleomics analyses.
Convergence Chromatography (CC) is a separation technique that uses carbon dioxide as the primary mobile phase, with a co-solvent such as acetonitrile to give similar selectivity as normal phase LC.
Various detection methods can be used with CC including UV and Evaporative Light Scattering Detection (ELSD), but there is also the option of easily and quickly interfacing Convergence Chromatography with Mass Spectrometry (MS) detection.
The additional option to add a solvent via a makeup pump to the flow prior to MS detection can be used to provide greater solvating powers, to enhance the selectivity and sensitivity of MS detection, and also to influence ionization. When using electrospray ionization (ESI) the addition of a protonation source such as formic acid to the makeup solvent can be used to enhance ionization and increase sensitivity. In atmospheric pressure photo ionization (APPI), the addition of a dopant such as toluene to the makeup solvent can enable and enhance ionization. Whereas when using atmospheric pressure chemical ionization (APCI), the solvent present, from both the co-solvent and the makeup solvents, acts as chemical ionization reagent gas in order to ionize the sample.
APGC is a soft ionization technique which produces lower levels of fragmentation compared to traditional EI. Working in dry conditions, APGC typically produces spectra with strong radical cation molecular ions that facilitates the direct comparison of historic, archival EI data from many different sources. The abundant nature of these ions makes it possible to generate specific and sensitive MRM transitions for petroleum biomarkers which provide information on the biological source of the oil, the environment in which the parent organic matter was deposited, and the thermal history of the buried organic matter. Knowledge of these properties is especially useful in upstream applications and is ultimately linked to the economic productivity from a particular geological location.
The universal ionization source offered on all Waters instrumentation facilitates the quick and simple coupling of APGC, UPLC or UPC2 on a single MS platform. Coupled with Xevo TQ-S, APGC enables low-level quantification of petroleum biomarkers that have proved challenging to analyze using GC-MS systems, allowing unambiguous confirmation of the deposition environment from which the oil originates.
This presentation discusses the history of size exclusion chromatography from gel permeation to modern day columns, and introduces the next evolution in polymer chromatography, the ACQUITY Advanced Polymer Chromatography system.
Classifying Petroleum Samples with Waters SYNAPT HDMS and Omics LLC PetroOrg Petroleomics Software
Combines the value of Ion Mobility Mass Spectrometry (IM-MS) and accurate mass information with petroleomics data processing to easily characterize petroleum chemical composition.
http://www.waters.com/waters/en_US/Petroleomics-Analysis-Solution/nav.htm?cid=134802174&bcid=134528340
Waters’ SYNAPT G2-Si HDMS instrument, with its quadrupole – ion mobility-ToF geometry, is an unrivalled tool for the characterisation of complex materials
The orthogonal separation offered by ion mobility enables powerful structural elucidation workflows
Collisional Cross Section (CCS) measurements provide valuable confirmatory data points
Ion mobility-specific software allows interactive data evaluation and processing
Partnering and collaborating with key thought leaders has resulted in the development of unique petroleum industry-specific data processing software
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