This document discusses microscopy practices for particle identification and USP initiatives for subvisible particles. It covers visual inspection programs that use microscopy to verify inspection standards and characterize defects. Microscopy methods like light, polarized light, electron, and microspectroscopy are used to determine the nature, size, shape, and composition of particles. The document also describes identification schemes for different particle types like fibers, synthetic materials, and biological particles. Finally, it mentions recent USP guidance that categorizes particles as extrinsic, intrinsic, or inherent based on their origin within or external to the product.
Clean And Stable Ds Aldrich Aaps Nbc May 2010 Low RezD Scott Aldrich
This document discusses particle analysis in pharmaceutical products. It outlines compendial requirements for particulate matter limits in injectable and ophthalmic products. It describes various microscopy applications that can be used to investigate particle content, including observations, isolation techniques, and analytical tests performed at increasing levels of magnification and technical complexity. The goal is to determine the nature, source, and stability implications of any particles observed.
Compendial requirements for particle testing 2014D Scott Aldrich
This document discusses particle counting and identification strategies, outlining compendial guidance from the US, EU, and Japan. It defines particulate matter and describes size ranges and categories. Visible and subvisible particles are monitored using techniques like light obscuration and membrane microscopy. Harmonized limits for subvisible particles are outlined in USP <788>. The document stresses that particle investigation requires a holistic approach using various characterization methods.
Visual inspection of parenteral products is conducted to detect defective units and ensure compliance with regulatory requirements that injectable products be free of visible particles. All filled containers undergo 100% visual inspection against black and white backgrounds under controlled lighting. Inspections are usually manual but can also be automated. Post-inspection sampling is required and failures can result in batch rejection. Any particles detected must be characterized to identify the source and ensure appropriate corrective actions. Recalls are sometimes necessary when particles are found, posing a risk to patient safety. Thorough training and documentation are needed to support consistent visual inspection.
This document discusses visual inspection of drug products for defects and container integrity. It summarizes regulations around ensuring container closure systems provide adequate protection and rejecting drug products that fail to meet standards. The document also discusses recalls related to visible particulates and FDA observations around visual inspection issues. It provides an overview of differences between human and automated inspections. A survey found manual inspection is most common and discusses typical inspection conditions and rejection rates. Key aspects of USP <790> on visible particulates in injections are also summarized, including inspection illumination, times, and acceptance criteria. The document concludes that while inspection cannot ensure products are 100% defect free, practical limits and patient risk guide the process.
At present the Company is engaged in the testing of Drugs, Pharmaceuticals, Ayurveda & Sidha Chemicals, Cosmetics, Food & Food products, Oil & Oil Cakes, Poultry Feed, Water, Waste Water, Air Pollution, Noise Monitoring, Building Materials and Material testing etc. Apart from this we are also in the business of Calibration in the field of Mass, Force and Pressure for industry as well as laboratories .We identify & provide solutions of trouble shooting in Quality Control of industries.
Membrane Solutions LLC is a leading global supplier of consumable products for laboratory and industrial applications. It offers a wide range of filtration products including syringe filters, membrane filters, spin columns, capsules filters, and more. The document provides information on Membrane Solutions' product portfolio and capabilities in areas such as sample preparation, life science consumables, and industrial processing. It also includes ordering details and contact information.
This two-page test report from SGS Testing Korea Co., Ltd summarizes the results of testing samples of NEW MDK K INK BASE submitted by SAMYOUNG INK & PAINT MFG CO., LTD. The samples were tested for levels of perfluorooctanoic acid and perfluorooctane sulfonates and found to be not detected above the method detection limit of 1 mg/kg for both substances. The report provides details of the testing performed, samples analyzed, test methods used, and results obtained.
SGS Turkey was founded in 1933 and today operates with over 400 employees across 8 divisions and 11 locations in Turkey. The document focuses on SGS Turkey's Consumer Testing Services division, which has over 200 employees and tests products across many sectors to ensure compliance with contractual or regulatory requirements. Specifically, it provides details on CTS Turkey's accredited food and non-food laboratories and the wide range of chemical and physical tests they perform on softline and hardline products.
Clean And Stable Ds Aldrich Aaps Nbc May 2010 Low RezD Scott Aldrich
This document discusses particle analysis in pharmaceutical products. It outlines compendial requirements for particulate matter limits in injectable and ophthalmic products. It describes various microscopy applications that can be used to investigate particle content, including observations, isolation techniques, and analytical tests performed at increasing levels of magnification and technical complexity. The goal is to determine the nature, source, and stability implications of any particles observed.
Compendial requirements for particle testing 2014D Scott Aldrich
This document discusses particle counting and identification strategies, outlining compendial guidance from the US, EU, and Japan. It defines particulate matter and describes size ranges and categories. Visible and subvisible particles are monitored using techniques like light obscuration and membrane microscopy. Harmonized limits for subvisible particles are outlined in USP <788>. The document stresses that particle investigation requires a holistic approach using various characterization methods.
Visual inspection of parenteral products is conducted to detect defective units and ensure compliance with regulatory requirements that injectable products be free of visible particles. All filled containers undergo 100% visual inspection against black and white backgrounds under controlled lighting. Inspections are usually manual but can also be automated. Post-inspection sampling is required and failures can result in batch rejection. Any particles detected must be characterized to identify the source and ensure appropriate corrective actions. Recalls are sometimes necessary when particles are found, posing a risk to patient safety. Thorough training and documentation are needed to support consistent visual inspection.
This document discusses visual inspection of drug products for defects and container integrity. It summarizes regulations around ensuring container closure systems provide adequate protection and rejecting drug products that fail to meet standards. The document also discusses recalls related to visible particulates and FDA observations around visual inspection issues. It provides an overview of differences between human and automated inspections. A survey found manual inspection is most common and discusses typical inspection conditions and rejection rates. Key aspects of USP <790> on visible particulates in injections are also summarized, including inspection illumination, times, and acceptance criteria. The document concludes that while inspection cannot ensure products are 100% defect free, practical limits and patient risk guide the process.
At present the Company is engaged in the testing of Drugs, Pharmaceuticals, Ayurveda & Sidha Chemicals, Cosmetics, Food & Food products, Oil & Oil Cakes, Poultry Feed, Water, Waste Water, Air Pollution, Noise Monitoring, Building Materials and Material testing etc. Apart from this we are also in the business of Calibration in the field of Mass, Force and Pressure for industry as well as laboratories .We identify & provide solutions of trouble shooting in Quality Control of industries.
Membrane Solutions LLC is a leading global supplier of consumable products for laboratory and industrial applications. It offers a wide range of filtration products including syringe filters, membrane filters, spin columns, capsules filters, and more. The document provides information on Membrane Solutions' product portfolio and capabilities in areas such as sample preparation, life science consumables, and industrial processing. It also includes ordering details and contact information.
This two-page test report from SGS Testing Korea Co., Ltd summarizes the results of testing samples of NEW MDK K INK BASE submitted by SAMYOUNG INK & PAINT MFG CO., LTD. The samples were tested for levels of perfluorooctanoic acid and perfluorooctane sulfonates and found to be not detected above the method detection limit of 1 mg/kg for both substances. The report provides details of the testing performed, samples analyzed, test methods used, and results obtained.
SGS Turkey was founded in 1933 and today operates with over 400 employees across 8 divisions and 11 locations in Turkey. The document focuses on SGS Turkey's Consumer Testing Services division, which has over 200 employees and tests products across many sectors to ensure compliance with contractual or regulatory requirements. Specifically, it provides details on CTS Turkey's accredited food and non-food laboratories and the wide range of chemical and physical tests they perform on softline and hardline products.
The document provides an overview of non-destructive testing (NDT) methods. It defines NDT as testing materials without destroying them to check for defects. The key NDT methods discussed are visual testing, liquid penetrant testing, magnetic particle testing, ultrasonic testing, radiographic testing, and eddy current testing. For each method, the document outlines their basic principles, typical applications, advantages, and limitations. The overall document serves as an introduction to common NDT techniques for detecting manufacturing and structural defects without harming the test object.
Nanotechnology is an emerging field of science deals with materials in nanoscaled size (0.1 – 100nm).
Nanomaterials have superior properties than bulk substances : Mechanical strength, thermal stability, catalytic activity, electrical conductivity, magnetic and optical properties.
Metal NPs: ZnO, TiO2 , SiO2.
ZnO NPs exhibits antimicrobial properties which depends upon their size and shape.
“Biogenic synthesis” of nanoparticles makes use of environmental friendly, Non-toxic and safe reagents.
1% of reading value effectively ensures the accuracy of test results
2 independent test modes are available, including tensile strength and peeling force to meet the distinct requirements of users
3 kinds of testing data provided for each test i.e. Maximum Value, Minimum Value and Average Value. Group data analysis is also available.
Particle Size Determination and Raman Spectroscopic Evaluation of a Semi-soli...HORIBA Particle
Particle size analysis of pharmaceutical formulations is important. This document describes using light microscopy image analysis and laser diffraction to characterize particle size in semi-solid vaginal gels. Both methods were validated using polystyrene standards and shown to provide accurate size measurements with good precision. Light microscopy allowed visualization of particle morphology while laser diffraction provided faster analysis of a larger sample volume. These techniques can effectively measure drug particle sizes in gels for product quality control.
Concrete Mix Design, Concrete Testing, Testing Concrete Admixtures, Compressive Strength Of Concrete. Sigmatest covers all these testing. Concrete mix design and concrete testing is their specialty.
XLW (PC) Auto Tensile Tester is professionally applicable to the determination of force properties of various flexible packaging materials, with high precision (better than 0.5% of reading accuracy) and multiple test ranges. The instrument is designed with 7independent test modes and could perform tests at seven different test speeds to meet various test conditions. Intelligent software facilitates to operate the instrument and provides data analysis and comparison functions.
The document discusses observations from the analysis of various zeolite samples using techniques like x-ray diffraction, TEM/EDS, and optical microscopy with cross-polarized light and Becke line analysis. It identifies several samples as being mislabeled based on the x-ray diffraction results. It also provides refractive index and elemental composition data for some zeolite samples and discusses the need for further characterization of zeolites using multiple analytical techniques for accurate identification.
1% of reading value effectively ensures the accuracy of test results
7 independent test modes are available, including tensile strength, peeling force, tearing force, heat seal strength and other force properties of flexible packages
Different ranges of load cells and 7 distinct test speeds to meet different test requirements
The instrument is controlled by micro-computer with menu interface, PVC operation panel and large LCD display
Particle Size Analysis for Homogenization Process Development HORIBA Particle
Emulsions and suspensions are commonly used in pharmaceutical, chemical and consumer products. The pharmaceutical industry, in particular, uses emulsions and suspensions to increase drug efficacy by controlling their particle size and size distribution. Among various available preparation methods, high-pressure homogenization is one of the widely employed processes in the field. This webinar discusses ways to develop a robust homogenization process for making pharmaceutical emulsions by evaluating droplet size distribution.
View recorded webinars:
http://bit.ly/particlewebinars
Laboratories of all types, including medical, pharmaceutical, government, and manufacturing frequently use ThomasNet.com to source the materials and equipment they need. Some of the top laboratories listed that use the site are Abbott Laboratories, Johns Hopkins University Applied Physics Laboratory, Merck Research Labs, and Oak Ridge National Laboratory. Sellers also find ThomasNet.com effective for generating qualified sales leads from these laboratories.
XLW (EC) Auto Tensile Tester can be used to measure tensile, peeling, deformation, tearing, heat sealing, adhesive, puncture force, opening force and low speed unwrapping force as well as other performance of plastic films, composite materials, soft package materials, plastic flexible tube, adhesives, adhesive tape, label stickers, medical plasters, release paper, protection films, combined caps, aluminum foil, diaphragm, back sheets, non-woven fabrics, rubber, and paper, and etc.
Gunshot residue analysis is used to determine if a firearm was discharged. Gunshot residue particles less than 10 microns containing elements like lead, barium, and antimony are deposited on the hands and clothes of shooters and can be analyzed using scanning electron microscopes. Various instrumental methods like Raman spectroscopy, mass spectrometry, and attenuated total reflectance Fourier-transform infrared spectroscopy are used to analyze gunshot residue particles from crime scenes and determine characteristics that can help identify shooters. Field tests are also used to preliminarily identify gunshot residue on skin and clothing.
F.Sc. Part 1 Chemistry.Ch.02.Test (Malik Xufyan)Malik Xufyan
The document describes test series and publications for chemistry from Malik Xufyan and JIAS Academy. It includes chapter-wise and board paper-wise test series for 9th, 10th, F.Sc part 1 and part 2 chemistry classes, as well as MSc chemistry. It also lists publications on chemistry from Jhang Institute for Advanced Studies. Contact information is provided for Malik Xufyan and the academy. An index at the end lists chapter topics and page numbers for the test series.
Pigment orange 64 cas 72102 84-2 msds, Our products are organic pigments, antioxidants, uv absorber, light stabilizers, optical brighteners. Also are agent of Addivant and Xrite in China, website:https://www.additivesforpolymer.com email:info@additivesforpolymer.com
1% of reading value effectively ensures the accuracy of test results7 independent test modes are available, including tensile strength, peeling force, tearing force, heat seal strength and other force properties of flexible packagesDifferent ranges of load cells and 7 distinct test speeds to meet different test requirements
Extractable and Leachable Testing In Prefilled Syringes Componentsijsrd.com
In prefilled syringes (PFS) two words are namely Leachable and Extractable are becoming a centre for discussion in therapeutic protein produces to patients. So understanding and testing of leachable and extractable of prefilled syringe components is of utmost requirement in parental drug delivery formulation development.
2015 PDA Visual Inspection Forum DS Aldrich PresentationD Scott Aldrich
The document discusses the process of forensic microscopy for particle identification. It describes a three level process: 1) detection and observation of particles, 2) separation, description and categorization of particles, and 3) identification of particles through various analytical techniques. Key techniques mentioned include microscopy, spectroscopy, X-ray diffraction and mass analysis. The goal is to methodically analyze unknown particles through increasing levels of resolution and specificity.
Visual inspection is an important first step in the particle identification process for pharmaceutical liquids and presentations. It provides an overview of product characteristics and defects that can be connected to particle content. Membrane microscopic counting is a key technique for quantifying particulate matter at various size ranges. Proper isolation, characterization, and identification of particles is essential to determine their origin and ensure product quality and stability.
Visual Inspection is one of the most widely used Non-Destructive Testing methods for the detection of discontinuities before they cause major problems, e.g. poor welding, surface defects, corrosion pits, general condition, degradation, blockages and foreign materials.
The document provides an overview of non-destructive testing (NDT) methods. It defines NDT as testing materials without destroying them to check for defects. The key NDT methods discussed are visual testing, liquid penetrant testing, magnetic particle testing, ultrasonic testing, radiographic testing, and eddy current testing. For each method, the document outlines their basic principles, typical applications, advantages, and limitations. The overall document serves as an introduction to common NDT techniques for detecting manufacturing and structural defects without harming the test object.
Nanotechnology is an emerging field of science deals with materials in nanoscaled size (0.1 – 100nm).
Nanomaterials have superior properties than bulk substances : Mechanical strength, thermal stability, catalytic activity, electrical conductivity, magnetic and optical properties.
Metal NPs: ZnO, TiO2 , SiO2.
ZnO NPs exhibits antimicrobial properties which depends upon their size and shape.
“Biogenic synthesis” of nanoparticles makes use of environmental friendly, Non-toxic and safe reagents.
1% of reading value effectively ensures the accuracy of test results
2 independent test modes are available, including tensile strength and peeling force to meet the distinct requirements of users
3 kinds of testing data provided for each test i.e. Maximum Value, Minimum Value and Average Value. Group data analysis is also available.
Particle Size Determination and Raman Spectroscopic Evaluation of a Semi-soli...HORIBA Particle
Particle size analysis of pharmaceutical formulations is important. This document describes using light microscopy image analysis and laser diffraction to characterize particle size in semi-solid vaginal gels. Both methods were validated using polystyrene standards and shown to provide accurate size measurements with good precision. Light microscopy allowed visualization of particle morphology while laser diffraction provided faster analysis of a larger sample volume. These techniques can effectively measure drug particle sizes in gels for product quality control.
Concrete Mix Design, Concrete Testing, Testing Concrete Admixtures, Compressive Strength Of Concrete. Sigmatest covers all these testing. Concrete mix design and concrete testing is their specialty.
XLW (PC) Auto Tensile Tester is professionally applicable to the determination of force properties of various flexible packaging materials, with high precision (better than 0.5% of reading accuracy) and multiple test ranges. The instrument is designed with 7independent test modes and could perform tests at seven different test speeds to meet various test conditions. Intelligent software facilitates to operate the instrument and provides data analysis and comparison functions.
The document discusses observations from the analysis of various zeolite samples using techniques like x-ray diffraction, TEM/EDS, and optical microscopy with cross-polarized light and Becke line analysis. It identifies several samples as being mislabeled based on the x-ray diffraction results. It also provides refractive index and elemental composition data for some zeolite samples and discusses the need for further characterization of zeolites using multiple analytical techniques for accurate identification.
1% of reading value effectively ensures the accuracy of test results
7 independent test modes are available, including tensile strength, peeling force, tearing force, heat seal strength and other force properties of flexible packages
Different ranges of load cells and 7 distinct test speeds to meet different test requirements
The instrument is controlled by micro-computer with menu interface, PVC operation panel and large LCD display
Particle Size Analysis for Homogenization Process Development HORIBA Particle
Emulsions and suspensions are commonly used in pharmaceutical, chemical and consumer products. The pharmaceutical industry, in particular, uses emulsions and suspensions to increase drug efficacy by controlling their particle size and size distribution. Among various available preparation methods, high-pressure homogenization is one of the widely employed processes in the field. This webinar discusses ways to develop a robust homogenization process for making pharmaceutical emulsions by evaluating droplet size distribution.
View recorded webinars:
http://bit.ly/particlewebinars
Laboratories of all types, including medical, pharmaceutical, government, and manufacturing frequently use ThomasNet.com to source the materials and equipment they need. Some of the top laboratories listed that use the site are Abbott Laboratories, Johns Hopkins University Applied Physics Laboratory, Merck Research Labs, and Oak Ridge National Laboratory. Sellers also find ThomasNet.com effective for generating qualified sales leads from these laboratories.
XLW (EC) Auto Tensile Tester can be used to measure tensile, peeling, deformation, tearing, heat sealing, adhesive, puncture force, opening force and low speed unwrapping force as well as other performance of plastic films, composite materials, soft package materials, plastic flexible tube, adhesives, adhesive tape, label stickers, medical plasters, release paper, protection films, combined caps, aluminum foil, diaphragm, back sheets, non-woven fabrics, rubber, and paper, and etc.
Gunshot residue analysis is used to determine if a firearm was discharged. Gunshot residue particles less than 10 microns containing elements like lead, barium, and antimony are deposited on the hands and clothes of shooters and can be analyzed using scanning electron microscopes. Various instrumental methods like Raman spectroscopy, mass spectrometry, and attenuated total reflectance Fourier-transform infrared spectroscopy are used to analyze gunshot residue particles from crime scenes and determine characteristics that can help identify shooters. Field tests are also used to preliminarily identify gunshot residue on skin and clothing.
F.Sc. Part 1 Chemistry.Ch.02.Test (Malik Xufyan)Malik Xufyan
The document describes test series and publications for chemistry from Malik Xufyan and JIAS Academy. It includes chapter-wise and board paper-wise test series for 9th, 10th, F.Sc part 1 and part 2 chemistry classes, as well as MSc chemistry. It also lists publications on chemistry from Jhang Institute for Advanced Studies. Contact information is provided for Malik Xufyan and the academy. An index at the end lists chapter topics and page numbers for the test series.
Pigment orange 64 cas 72102 84-2 msds, Our products are organic pigments, antioxidants, uv absorber, light stabilizers, optical brighteners. Also are agent of Addivant and Xrite in China, website:https://www.additivesforpolymer.com email:info@additivesforpolymer.com
1% of reading value effectively ensures the accuracy of test results7 independent test modes are available, including tensile strength, peeling force, tearing force, heat seal strength and other force properties of flexible packagesDifferent ranges of load cells and 7 distinct test speeds to meet different test requirements
Extractable and Leachable Testing In Prefilled Syringes Componentsijsrd.com
In prefilled syringes (PFS) two words are namely Leachable and Extractable are becoming a centre for discussion in therapeutic protein produces to patients. So understanding and testing of leachable and extractable of prefilled syringe components is of utmost requirement in parental drug delivery formulation development.
2015 PDA Visual Inspection Forum DS Aldrich PresentationD Scott Aldrich
The document discusses the process of forensic microscopy for particle identification. It describes a three level process: 1) detection and observation of particles, 2) separation, description and categorization of particles, and 3) identification of particles through various analytical techniques. Key techniques mentioned include microscopy, spectroscopy, X-ray diffraction and mass analysis. The goal is to methodically analyze unknown particles through increasing levels of resolution and specificity.
Visual inspection is an important first step in the particle identification process for pharmaceutical liquids and presentations. It provides an overview of product characteristics and defects that can be connected to particle content. Membrane microscopic counting is a key technique for quantifying particulate matter at various size ranges. Proper isolation, characterization, and identification of particles is essential to determine their origin and ensure product quality and stability.
Visual Inspection is one of the most widely used Non-Destructive Testing methods for the detection of discontinuities before they cause major problems, e.g. poor welding, surface defects, corrosion pits, general condition, degradation, blockages and foreign materials.
QUALITY CONTROL OF PARENTERALS,STERILE PRODUCTMuhammad Arsal
This document discusses quality control testing of sterile products, particularly parenteral products. It begins by defining sterile products as dosage forms free from viable microorganisms, including parenterals, ophthalmics, and irrigating preparations. Parenterals are unique as they are injected directly into the body. The document then discusses various quality control tests performed on parenterals, including leaker testing to detect incomplete seals, clarity testing, pyrogen testing, sterility testing, and content uniformity testing. It provides details on each of these tests and their purposes in ensuring the safety and quality of sterile parenteral products.
Visual inspection is commonly used for quality control and can be manual or automated using machine vision. Manual inspection relies on human vision using light and the eyes to examine products for defects. It is applicable to many materials and can check for dimensional accuracy, discontinuities, fit and wear. Automated inspection uses machine vision systems for rapid, consistent inspection of specific component details in production applications. Both methods are affected by lighting, detector quality, data processing ability, and training level.
This document discusses various methods for identifying textile fibers, including non-technical and technical tests. Non-technical tests include feeling, burning, and microscopic analysis. The burning test observes each fiber's reaction to heat, including flame characteristics, odor, and ash properties. Technical tests like microscopic examination and chemical analysis require specialized equipment and knowledge but can more precisely identify fiber blends and properties. Microscopy reveals unique structures of natural and man-made fibers. Chemical tests use solvents and reagents to distinguish fibers based on their different solubility properties.
Fibre: types, collection and preservation; Identification and comparison of fibres: Microscopic examination, dye composition, chemical composition, significance of match, floatation, solubility and flame test; Analytical techniques in fibre examination
This document discusses the key steps and principles of histotechniques, which is the process of preparing tissue for microscopic examination. The main steps described are:
1. Tissue procurement and preparation, which involves obtaining tissue samples while following legal and ethical guidelines.
2. Fixation, which uses chemicals to preserve tissue structure. Common fixatives discussed include formaldehyde, mercuric chloride, and glutaraldehyde.
3. Further processing steps like dehydration, clearing, and embedding prepare the tissue for microscopic examination by changing the tissue properties.
The document emphasizes best practices for fixation like using the proper fixative concentration and duration tailored to the specific tissue type and intended analysis. Artifacts from improper
The slides describe morphology, ultra structure, growth curve and growth measurement, physical requirements, nutritional requirements and biochemical testes used for identification of bacteria.
This document provides information on sterilization and disinfection methods. It defines sterilization as removing all microorganisms including bacterial spores and viruses, while disinfection removes some or all microorganisms but not necessarily spores. Various sterilization methods are discussed including heat (dry and moist), filtration, radiation, and sterilant gases. Specific processes within each method like autoclaving, flaming, and membrane filtration are described. Categories of disinfectants like alcohols, aldehydes, halogens, and phenolics are also outlined. Tests for evaluating disinfectant efficacy are briefly mentioned.
This document provides information on laboratory diagnosis of fungal infections. It begins with an introduction to mycology and classification of fungi. It then discusses various diagnostic methods for different types of fungal infections, including microscopic examination, culture techniques, biochemical methods, and molecular identification. Specific techniques are described for diagnosing candidiasis, including microscopic morphology, culture characteristics on different media, biochemical profiles, commercially available identification systems, and molecular methods. Sample collection and processing methods are also summarized.
This is a presentation covering all techniques in histopathology. Comprehensive coverage of all related aspects.. Useful for postgraduate Pathology students and practitioners.
Mastering the Processing Methods of Engineered ParticlesHORIBA Particle
This document summarizes AVEKA's expertise in processing engineered particles through various methods. It discusses AVEKA's facilities and capabilities, an overview of engineered particles, and challenges in particle processing. It then provides examples of AVEKA applying methods like spray drying, coating, and prilling to address needs like separating cellulose fibers, encapsulating omega-3 oils, and producing monodisperse wax beads. While results were promising, further refinement was sometimes needed, highlighting the importance of testing and understanding materials at multiple scales.
The Power Point Presentation includes The Size Exclusion Chromatography and Its Method. These Slides may be helpful for master of science students. The Syllabus for the slides was prepared by following as KSV, Gandhinagar. Paper Code is CH-AC-302, Unit-01
This document provides an overview of tissue fixation. It begins with an introduction to fixation and its importance in histology. The main functions of fixatives are to prevent autolysis and putrefaction of tissue. Various fixation methods and types of fixatives are described, including aldehydes, metallic salts, picric acid, alcohols, chromates, and osmium tetroxide. The document discusses the reactions of fixatives with proteins, nucleic acids, lipids, and carbohydrates. Common fixatives like formaldehyde and glutaraldehyde are compared. Factors affecting fixation and the effects of fixation are also summarized.
The document discusses polymers and their properties. It begins by describing how ubiquitous plastics are in modern society and lists many common plastic items. It then discusses properties of polymers like being lightweight, corrosion resistant, and inexpensive to produce. The document outlines that ancient polymers like wood, rubber and silk have been used for centuries. It describes the hydrocarbon and monomer building blocks of polymers and different polymer classifications. The remainder of the document delves into technical details of polymer synthesis, molecular structures, properties related to molecular weight and chain length, and molecular configurations.
Chemical spinning is the process of converting a fiber-forming substance into a viscous fluid that is extruded through spinneret holes and then solidified. The most widely used chemical spinning method is melt spinning, which is used for polymers that can be melted safely. A spinneret must have corrosion-resistant holes of controlled dimensions to produce uniform fibers and withstand high pressures. Melt spinning is the fastest chemical spinning method. Dry spinning fibers often have deformed cross-sectional shapes due to uneven solidification from the exterior to interior layers. Solvent recovery is essential for dry spinning to minimize environmental and economic costs. Wet spinning poses the highest pollution risks of the three methods discussed.
This document discusses rearing operations for silkworms, including disinfection, brushing, maintaining optimal temperature and humidity, care during moulting, mounting, and harvesting. It provides details on various physical and chemical disinfection methods. It also describes maintaining optimal temperature and humidity conditions for different stages of growth. Feeding schedules and quality of leaves fed to silkworms is addressed. Methods for mounting silkworms, collecting cocoons, and marketing cocoons are summarized. Metrics for evaluating cocoon quality like color, shape, size, compactness, and filament characteristics are outlined.
This document discusses the isolation, screening, and production of keratinolytic bacteria and enzymes from feather waste. The objectives are to isolate keratinolytic bacteria from soil and feather samples, produce keratinase enzymes through bacterial fermentation, partially purify the enzymes, and test the enzymes' ability to break down keratin substrates. The methodology involves isolating bacteria using heat treatment and growth on selective media, identifying the isolates, producing enzymes through shaking flask fermentation, precipitating enzymes from culture broth, and evaluating enzymatic activity on keratin substrates. Potential applications of the keratinolytic bacteria and enzymes include solid waste management, fertilizer production, animal feed supplementation, and treatment of prion diseases.
This document summarizes methods for identifying chemicals that migrate from food packaging materials into food. It discusses factors that affect migration, such as the nature of the packaging material, migrating substances, food-packaging contact, and food type. It also outlines European Union legislation and protocols for testing migration into food simulants and foods to ensure packaging safety.
This document provides an overview of polymers including their definition, history, types, nomenclature, molecular structure, and polymerization mechanisms. Key points include:
- Polymers are high molecular weight materials formed by combining many small monomer units through covalent bonds.
- They can be classified as addition or condensation polymers depending on their polymerization mechanism.
- Common polymerization mechanisms include free radical, cationic, anionic, and step-growth polymerization.
- Polymer properties depend on factors like molecular structure, morphology, and configuration.
This document summarizes the facilities and testing capabilities of three laboratories - a water laboratory, microbiology laboratory, and food analysis laboratory. It describes the various tests and equipment used in each laboratory to test water quality, detect microbes, and analyze food properties like moisture, pH, ash content, and soluble solids. Tables of sample results are provided for tests like moisture content, ash content, pH, conductivity, and alkalinity. The document concludes by stating the knowledge, confidence, time management skills, and experience gained from working in the laboratories.
This document summarizes various methods used in forensic investigation and analysis of biological evidence from crime scenes. It discusses principles like Locard's exchange principle and provides details on presumptive and confirmatory tests for blood, semen, saliva and other bodily fluids. It also describes techniques like DNA fingerprinting that can be used to identify suspects by matching biological samples left at the crime scene.
This presentation by OECD, OECD Secretariat, was made during the discussion “Competition and Regulation in Professions and Occupations” held at the 77th meeting of the OECD Working Party No. 2 on Competition and Regulation on 10 June 2024. More papers and presentations on the topic can be found at oe.cd/crps.
This presentation was uploaded with the author’s consent.
This presentation by Yong Lim, Professor of Economic Law at Seoul National University School of Law, was made during the discussion “Artificial Intelligence, Data and Competition” held at the 143rd meeting of the OECD Competition Committee on 12 June 2024. More papers and presentations on the topic can be found at oe.cd/aicomp.
This presentation was uploaded with the author’s consent.
This presentation by OECD, OECD Secretariat, was made during the discussion “Pro-competitive Industrial Policy” held at the 143rd meeting of the OECD Competition Committee on 12 June 2024. More papers and presentations on the topic can be found at oe.cd/pcip.
This presentation was uploaded with the author’s consent.
Carrer goals.pptx and their importance in real lifeartemacademy2
Career goals serve as a roadmap for individuals, guiding them toward achieving long-term professional aspirations and personal fulfillment. Establishing clear career goals enables professionals to focus their efforts on developing specific skills, gaining relevant experience, and making strategic decisions that align with their desired career trajectory. By setting both short-term and long-term objectives, individuals can systematically track their progress, make necessary adjustments, and stay motivated. Short-term goals often include acquiring new qualifications, mastering particular competencies, or securing a specific role, while long-term goals might encompass reaching executive positions, becoming industry experts, or launching entrepreneurial ventures.
Moreover, having well-defined career goals fosters a sense of purpose and direction, enhancing job satisfaction and overall productivity. It encourages continuous learning and adaptation, as professionals remain attuned to industry trends and evolving job market demands. Career goals also facilitate better time management and resource allocation, as individuals prioritize tasks and opportunities that advance their professional growth. In addition, articulating career goals can aid in networking and mentorship, as it allows individuals to communicate their aspirations clearly to potential mentors, colleagues, and employers, thereby opening doors to valuable guidance and support. Ultimately, career goals are integral to personal and professional development, driving individuals toward sustained success and fulfillment in their chosen fields.
This presentation by Juraj Čorba, Chair of OECD Working Party on Artificial Intelligence Governance (AIGO), was made during the discussion “Artificial Intelligence, Data and Competition” held at the 143rd meeting of the OECD Competition Committee on 12 June 2024. More papers and presentations on the topic can be found at oe.cd/aicomp.
This presentation was uploaded with the author’s consent.
This presentation by Thibault Schrepel, Associate Professor of Law at Vrije Universiteit Amsterdam University, was made during the discussion “Artificial Intelligence, Data and Competition” held at the 143rd meeting of the OECD Competition Committee on 12 June 2024. More papers and presentations on the topic can be found at oe.cd/aicomp.
This presentation was uploaded with the author’s consent.
Collapsing Narratives: Exploring Non-Linearity • a micro report by Rosie WellsRosie Wells
Insight: In a landscape where traditional narrative structures are giving way to fragmented and non-linear forms of storytelling, there lies immense potential for creativity and exploration.
'Collapsing Narratives: Exploring Non-Linearity' is a micro report from Rosie Wells.
Rosie Wells is an Arts & Cultural Strategist uniquely positioned at the intersection of grassroots and mainstream storytelling.
Their work is focused on developing meaningful and lasting connections that can drive social change.
Please download this presentation to enjoy the hyperlinks!
XP 2024 presentation: A New Look to Leadershipsamililja
Presentation slides from XP2024 conference, Bolzano IT. The slides describe a new view to leadership and combines it with anthro-complexity (aka cynefin).
Mastering the Concepts Tested in the Databricks Certified Data Engineer Assoc...SkillCertProExams
• For a full set of 760+ questions. Go to
https://skillcertpro.com/product/databricks-certified-data-engineer-associate-exam-questions/
• SkillCertPro offers detailed explanations to each question which helps to understand the concepts better.
• It is recommended to score above 85% in SkillCertPro exams before attempting a real exam.
• SkillCertPro updates exam questions every 2 weeks.
• You will get life time access and life time free updates
• SkillCertPro assures 100% pass guarantee in first attempt.
This presentation by Nathaniel Lane, Associate Professor in Economics at Oxford University, was made during the discussion “Pro-competitive Industrial Policy” held at the 143rd meeting of the OECD Competition Committee on 12 June 2024. More papers and presentations on the topic can be found at oe.cd/pcip.
This presentation was uploaded with the author’s consent.
Suzanne Lagerweij - Influence Without Power - Why Empathy is Your Best Friend...Suzanne Lagerweij
This is a workshop about communication and collaboration. We will experience how we can analyze the reasons for resistance to change (exercise 1) and practice how to improve our conversation style and be more in control and effective in the way we communicate (exercise 2).
This session will use Dave Gray’s Empathy Mapping, Argyris’ Ladder of Inference and The Four Rs from Agile Conversations (Squirrel and Fredrick).
Abstract:
Let’s talk about powerful conversations! We all know how to lead a constructive conversation, right? Then why is it so difficult to have those conversations with people at work, especially those in powerful positions that show resistance to change?
Learning to control and direct conversations takes understanding and practice.
We can combine our innate empathy with our analytical skills to gain a deeper understanding of complex situations at work. Join this session to learn how to prepare for difficult conversations and how to improve our agile conversations in order to be more influential without power. We will use Dave Gray’s Empathy Mapping, Argyris’ Ladder of Inference and The Four Rs from Agile Conversations (Squirrel and Fredrick).
In the session you will experience how preparing and reflecting on your conversation can help you be more influential at work. You will learn how to communicate more effectively with the people needed to achieve positive change. You will leave with a self-revised version of a difficult conversation and a practical model to use when you get back to work.
Come learn more on how to become a real influencer!
1. PDA: A Global Association
Microscopy Practices in Visible Particle Identification and USP Initiatives for Subvisibles
2. Outline
•
Visual Inspection is a Program
•
Microscopy Support is a Key Program Component of Inspection Practices
–
Verification of Standards
–
Verification of Rejects
–
Defect Charaterization
–
Sourcing
•
The Microscopical Path is Essential for Full ID
•
Identification Scemes
•
USP Initiatives
2
3. Visual Inspection Program
3
Inspector Selection
Knapp Studies
Procedural Selection
and Refinement
Testing Inspectors
With Standards
Inspector Familiarization
with Typical Defects
Inspector Training
Defect Investigation
Product Inspection & Release
Qualified Inspector
22. Thermal Behavior of Common Fibrous Materials
22
Dupont and McCrone
Fiber Type
Flame/residue
m.p.
Acetate
Burns with melting/brittle bead
230°C and Acel™ 260°C Arnel™288°C-302°C
Acrylic
Modacrylic
Fuses away, burn-melt/ hard irregular black bead
Orlon™ = Indeterminate
Dynel™ ~188°C
Verel™ ~210°C
Aramid
Carbonizes above 800°F
Nonmelting
Modacrylic
210°C
Naturals:
Cotton
Flax
Silk
hair
Does not fuse or shrink, burns
Does not fuse or shrink, burns
Fuses away, burn-melt/soft ash
Fuses away, burns slowly, some melt/soft black ash
Nonmelting
Nonmelting
Nonmelting
Nonmelting
Nylon
Fuses, shrinks/hard gray bead
“6” 213°C
“6-6” 250°C
Nytril
Darvan™ ~218°C
Olefin:
Fuses, shrinks/hard tan bead
Polyethylene 135°C
Polypropylene 170°C
Polyester (polyethylene terphthalate)
Fuses, shrinks/hard black bead
Dacron™ 250°C
Kodel™ 282°C
Vycron™ 232°C
Rayon
No shrinkage/burns/no bead
Nonmelting
Saran
Fuses, shrinks/hard irregular black bead
168-177°C
Spandex: Lycra™, Vyrene™
Fuses, No shrinkage, burns-melts/soft ash
~230°C
Vinyon
140°C
23. Stains for Common Materials
–
Herzberg no. 1, 2, 3 or Wilson Stain for Processed Celluloses
–
Universal Reagent for common yet complex biological compounds [Stahl]
1.
Prepare 5mL of a lactic acid solution saturated with Sudan Red III or Sudan Red G and dilute to 30mL with lactic acid.
2.
Add 0.55gm aniline sulfate to 35mL water
3.
Add 0.55gm KI and 0.05gm iodine to 5mL water, add 5mL 96% ethanol
•
Combine 1-2-3 and add 2.5mL 37% HCl with stirring. Do not filter.
•
Add Rg drops, heat specimen:
–
Yellow = lignin
–
Red = lipids
–
Red-brown = cork
–
Blue-violet = starch
23
24. Herzberg Reagent varieties
24
No. 1: 100mL water + 22g KI + 2g crystalline I2
No. 2: 100mL water + 6g KI + 1.5g crystalline I2
No. 3:
solution A: 20g ZnCl2 in 10mL water
solution B: 2.1g KI + 0.1g I2 in 5mL water
Combine A + B, let stand 24 hr (to clearness) decant to amber airtight bottle, add a leaf of I2.
Typical Herzberg color reactions:
Cellulose Type Color
Linen (flax), cotton, hemp Light to dark claret/purple
Esparto Blue to claret/purple
Straw Blue to violet
Chemical wood pulps Blue
Manila Olive green
Groundwood, Unbleached jute or straw Yellow to colorless
25. Wilson Fiber stain
180mL water + 15mL 37% formaldehyde, add 140g Ca(NO3)2 – 4H2 40g CaCl2 – 2.5 H2O. Mix together, store in an amber airtight bottle
Typical Wilson color reactions:
Paper Process or Cellulose Type Color
Soda Dark claret/purple
Groundwood Bright yellow
Bleached sulfite Pale grey lavender
Sulfite Colorless
Raw Kraft Brown
Well-cooked Kraft Grey
Bleached Kraft Pale Blue
Raw straw Green
Well-cooked straw Blue
Cotton Red
Linen (flax) Pink
32. 32
Particulate Matter Categories
Extrinsic
Intrinsic
Inherent
Wild, Outside the System
Inside the System
Is the System:
Solution
Micelles
Emulsion
Colloid
Protein Assembly
Extremes are “Filth”
Product-contact
n/a
Microbial Vector
May have Microbial Content
Formulation-Relevant
Uncontrolled
Unplanned
Controlled, Expected
Additive
Additive or Changing
Stable
Same TOR as EOS
Single to Many Particles
Various Physical States
Defined active ingredient
May be Considered Most Objectionable
Needs Planning & Control
Most Acceptable, Known
34. •
Traditional <788> is Harmonized with Ph.Eur. and JP through the Pharmacopeal Discussion Group
–
Exploring addition of Flow Imaging Technique
•
New <787> – improved <788> for protein formulae
•
New <771> – Ophthalmic Products
•
Particle Characterization
–
New <1787> – Array of Particle Characterization Techniques for 2-100μm Particles
–
Current <776> Optical Microscopy
–
Current IR <197>
–
Current Raman <1120>
–
Updated Scanning Electron Microscopy <1181>
34
USP Chapters Update
35. 35
More Detail…
•
787
–
De-aeration by vacuum
–
≥10μm and ≥25μm limits
–
Individual containers, all volumes, allowed
–
No limits for sub-10μm
–
Total load at 6000/600 – 3000/300 and 25/3 – 12/2 for all volumes
•
1787
–
Particle Source definitions
–
Silicone oil discussion
–
Discussion regarding the sub-10μm population
–
Technique Sections
•
Size and Distribution
•
Size and Morphology
•
Characterization
38. Review
•
Compendial guidance provides the minimum benchmarks for visible and subvisible particle content
•
Visual inspection is based upon Human Manual
•
However, inspection is not just manual, semiautomatic or automatic processing – it consists of a comprehensive system of detection
•
Subvisible determination methods are part of a system of particle content monitoring and investigation
40. 40
Bibliography
•
Aldrich, D.S. and Smith, M.A. Chapter 9 - Pharmaceutical Applications of Infrared Microspectroscopy, in Practical Guide to Infrared Microspectroscopy, Howard Humecki, Editor, Marcel Dekker 1995; New York, NY, 323-375.
•
Aldrich D.S. Chapter 5 - Particulate Matter: Subvisible, in Pharmaceutical Dosage Forms: Parenteral Medications, Nema S and Ludwig JD, eds. Third ed. Volume 2, Informa Healthcare, New York, pps. 114-145, (2010).
•
Barber, T.A. (1993). Pharmaceutical Particulate Matter - Analysis and Control, InterPharm Press, Buffalo Grove, IL.
•
Borchert, S.J., Maxwell, R.J. Davison, R.L. and Aldrich, D.S. Standard Particulate Sets for Visual Inspection Systems: Their Preparation, Evaluation and Applications. Pharm Sci and Tech., 1986, 265-276.
•
Groves, M.J. Parenteral Products, the preparation and quality control of products for injection, Wm. Heinemann Medical Books, Ltd., London 1973.
•
Knapp, J.Z., Kushner, H.K. and Abramson, L.R. Particulate Inspection of Parenteral Products: an Assessment. J. Parent. Sci. Tech. 1981; 35, 176.
•
Knapp, J. Z., “Absolute” Sterility and “Absolute” Freedom from Particle Contamination, PDA J. Pharm Sci. Technol. 1997, 52, 4, 173-181.
•
Langille, S.E. Particulate Matter in Injectable Drug Products. PDA J Pharm Sci and Tech 2013, 67, 186-200.
•
Madsen R.E, Cherris R.T., Shabushnig J.G. and Hunt D.G. Visible Particulates in Injections – A History and a Proposal to Revise USP General Chapter Injections <1>, Phar. Forum 35(5), pg 1383-1387, 2009.
•
McCrone, W.C. and Delly, J.G. (1973). The Particle Atlas, Volumes I-IV, Ann Arbor Science Publishers, Ann Arbor, MI.
•
Melchore, J.A. and Berdovich, D. Considerations for Design and Use of Container Challenge Sets for Qualification and Validation of Visible Particulate Inspection, PDA J Pharm Sci and Tech 2012, 66, 273-284.
•
Nath N, McNeal E, Obenhuber D, et al. Particulate contaminants of intravenous medication and the limits set by USP General Chapter <788>. Pharm. Forum 30(6), 2004.
•
Stahl, E. (Editor) (1973). Drug Analysis by Chromatography and Microscopy, A Practical Supplement to Pharmacopoeias, Ann Arbor Science Publishers, Ann Arbor, MI.
•
Teetsov, A.S. (1977). Techniques of Small Particle Manipulation, Microscope, 25: 103.