This document provides a summary of the management protocol for carbon monoxide intoxication. It begins by noting that CO is odorless, colorless, and tasteless, requiring a high index of suspicion for diagnosis. Presentation is often nonspecific, but history can reveal circumstances of exposure. Clinical manifestations include headache, nausea, shortness of breath, and altered mental status. Diagnosis requires considering CO exposure in the differential. Management involves high-flow oxygen, supportive care, monitoring for complications, and potentially hyperbaric oxygen therapy. Untreated, CO poisoning can cause neurological sequalae.