This document provides guidance on managing a neonate with respiratory distress, including defining the severity, identifying the etiology, initial management with oxygen therapy and supportive care, and the various modes of respiratory support including CPAP, NIV, HHHFNC, IMV, and HFOV. The goal of respiratory support is to optimize oxygenation and ventilation while avoiding lung injury through use of the lowest effective pressures and tidal volumes. Clinical assessment and arterial blood gases are important to monitor the adequacy of respiratory support and make adjustments as needed.
Surfactant replacement therapy : RDS & beyondDr-Hasen Mia
This presentation is about Surfactant, its use in Respiratory Distress Syndrome & some other conditions of surfactant deficiency due to inactivation like meconium aspiration syndrome & others
Surfactant replacement therapy : RDS & beyondDr-Hasen Mia
This presentation is about Surfactant, its use in Respiratory Distress Syndrome & some other conditions of surfactant deficiency due to inactivation like meconium aspiration syndrome & others
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it is a term used to refers to several kidney disease (both kidney) characterized by inflammation either of the glomeruli or of the small blood vessels in the kidney. but not all the disease necessarily have an inflammatory component.
It occurs due to repeated episodes of acute nephritic syndrome, nephrosclerosis and hyperlipidemia.
A curriculum Plan is the advance arrangement of learning opportunities for a particular population of learners.
Curriculum guide is a written curriculum.
Curriculum Planning is the process whereby the arrangement of curriculum plans or learning opportunities are created.
Master rotation plan is the overall plan of rotation of all students in a particular educational institution, showing the placement of the students belonging to total programme (4 years in B.Sc.(N) and 3 years in GNM) includes both theory and practice denoting the study block, partial block, placement of student in clinical blocks, team nursing, examinations, vacation, co-curricular activities etc.
Curriculum Evaluation is the process of collecting data on a programme to determine its value or worth with the aim of deciding whether to adopt, reject, or revise the programme.
Indian citizens possessing foreign nursing qualification are examined individually & after examination the syllabi and conformation from concerned foreign authorities, the nurses are granted approval for registration in India with the recommendation of equivalence committee under Section 11(2)(a) INC Act. 1947.
A model is a three-dimensional representation of a person or thing or of a proposed structure, typically on a smaller scale than the original:"a model of St. Paul's Cathedral“
A Model is a pattern of something to be made or reproduced and means of transferring a relationship `or process from its real (actual) setting to one which it can be more conveniently studied.
Curriculum development is a process in which participants at many levels make decisions about the purposes of learning, teaching- learning situation.
It is the process of gathering, setting, selecting, balancing and synthesizing relevant information from many sources in order to design the goals of curriculum.
Let’s examine what happens in each step of the curriculum development/revision cycle. This cycle is a dynamic system that helps each school re-vitalize and replenish what is taught to its students.
Determinants of curriculum are the factors that affect the process of assessing needs, formulating objectives and developing instructional opportunities and evaluations.
The term philosophy is derived from the Greek word Philein meaning to love, to strive after or search for and from the word Sophia which means wisdom.
Therefore, Philosophy is the search for wisdom by philosophers.
Teachers use curricula when trying to see what to teach to students and when, as well as what the rubrics should be, what kind of worksheets and teacher worksheets they should make, among other things.
It is actually up to the teachers themselves how these rubrics should be made, how these worksheets should be made and taught; it's all up to the teachers.
Perception (from the Latin perceptio) is the organization, identification, and interpretation of sensory information in order to represent and understand the presented information, or the environment.
The somatoform disorders are a group of psychological disorders in which a patient experiences physical symptoms that are inconsistent with or cannot be fully explained by any underlying general medical or neurologic condition. Medically unexplained physical symptoms account for as many as 50% of new medical outpatient visits. [1] Physical symptoms or painful complaints of unknown etiology are fairly common in pediatric populations. [2] Many healthy young children express emotional distress in terms of physical pain, such as stomachaches or headaches, but these complaints are usually transient and do not effect the child's overall functioning. The somatoform disorders represent the severe end of a continuum of somatic symptoms.
Somatization in children consists of the persistent experience and complaints of somatic distress that cannot be fully explained by a medical diagnosis. They can be represented by a wide spectrum of severity, ranging from mild self-limited symptoms, such as stomachache and headache, to chronic disabling symptoms, such as seizures and paralysis. These psychological disorders are often difficult to approach and complex to understand. It is important to note that these symptoms are not intentionally produced or under voluntary control.
In somatoform disorders, somatic symptoms become the focus of children and their families. They generally interfere with school, home life, and peer relationships. These youngsters are more likely to be considered sickly or health impaired by parents and caretakers, to be absent from school, and to perform poorly in academics. Somatization is often associated temporarily with psychosocial stress and can persist even after the acute stressor has resolved, resulting in the belief by the child and his or her family that the correct medical diagnosis has not yet been found. Thus, patients and families may continue to seek repeated medical treatment after being informed that no acute physical illness has been found and that the symptoms cannot be fully explained by a general medical condition. When somatization occurs in the context of a physical illness, it is identified by symptoms that go beyond the expected pathophysiology of the physical illness.
Recurrent complaints often present as diagnostic and treatment dilemmas to the primary care practitioner (PCP) who is trying to make sense of these symptoms. The PCP may feel poorly prepared and/or may have little time to assess or treat the somatic concerns. While the more disabling somatic complaints are more likely to be referred to a mental health professional, these youngsters presenting with these disabling physical symptoms bridge both medical and psychological domains and present a puzzling quandary for professionals from either field if working with them alone. [3] The nature of these symptoms requires an integrated medical and psychiatric treatment approach to successfully decrease the impairment caused by these disorders.
Schizophrenia is a mental disorder that usually appears in late adolescence or early adulthood. Characterized by delusions, hallucinations, and other cognitive difficulties, schizophrenia can often be a lifelong struggle. In this article, we will cover the causes, symptoms, and treatment of schizophrenia
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
3. Defining Respiratory Distress
Presence of 2 of the following
• Tachypnea
• Retractions (intercostal and/or Subcostal)
• Grunt
Ensure baby is quite, normothermic before
counting Respiratory rate ( count RR for 1min)
4. • Respiratory Distress: increase in work of
breathing
• Respiratory Failure: ineffective ventilation or
oxygenation or both. Associated worsening
sensorium, slow or fast breathing
• Respiratory Arrest: No spontaneous breathing,
cyanosis, unresponsiveness
5. Knowing the severity
• Downe’s Score
• Silverman-Anderson Score
• WHO Classification of respiratory distress
10. Etiology Based on Gestation and Age Of Onset
Preterm
RDS
Cong.Pneumonia
TTN
Pneumothorax
Lung
malformations
Cong.Pneumonia
Aspiration Syndromes
PDA
Shock
CHD-duct Dependant
Lung Malformations
Pneumothorax
Acquired Pneumonia
Aspiration Syndromes
PDA
Shock
CHD-Duct Dependant
Lung Malformations
Pneumothorax
Pulmonary
Haemorrhage
< 6 hrs 6-24 hrs > 24 HRS
11. Etiology Based on Gestation and Age Of Onset
Term
TTN
Cong.Pneumonia
Asphyxial Lung
Aspiration Syn
Malformations
Pneumothorax
Rds
Aspiration Syn
Cong.Pneumonia
CHD-duct Dep.
Shock
Lung Malfor.
Pneumothorax
Acquired Pneumonia
Shock
Chd-duct Dependant
Lung Malformations
Pneumothorax
Pulmonary Haemorrhage
< 6 hrs 6-24 hrs > 24 hrs
12. Risk factor Based Approach to
Respiratory Distress
Ask for risk factors Suggestive of
Worsening on bag & mask ventilation CDH, Air Leak
Prolonged labor, difficult labor, assisted
delivery, fetal distress, MSAF
Asphyxia Lung disease, MAS, Birth Injury
Elective Caeserian Section TTNB
Maternal Fever, Foul Liquor, prolonged
labour, multiple PV examinationPPROM,
PROM >12hrs, Assisted Delivery
Congenital pneumonia
No antenatal Steroid to mother, infant of
diabetic mother, Rh Issoimmunisation,
Perinatal Asphyxia
RDS
Polyhydramnios CDH, TEF
Oligohydramnios MAS, Pulmonary Hypoplasia
13. Risk factor Based Approach to
Respiratory Distress
Ask for risk factors Suggestive of
Maternal Hypertension, Preeclampsia Asphyxia, MAS
Placenta Previa or abruption Shock
Family h/o unexplained neonatal deaths,
still births
RDS, IDM, CHD, IEM
Post Feed worsening GERD, Isolated Cleft Palate, TEF, IEM
Relationship with Crying Crying worsens cyanosis (CHD)
Crying relieves cyanosis (Choanal atresia)
Chronic course, O2 dependency BPD, CHD (TAPVC), Atypical
Infection(CMV, Fungus, Chlamydia),
Recurrent aspiration (GER, Pharyngeal
incordination, H shaped TOF), Osteopenia
of Prematurity
14. Physical Assessment
• Sensorium
• Color
• Tone, posture
• Response to touch
• Cry
• Gestation
• Weight
• Vital Parameters (Temp,
HR, RR, BP, SPO2)
• Work of Breathing
(Downe’s or silverman
score)
• Perfusion (HR, Color, core-
axillary temp, CRT, urine
output, BP)
• Danger Signs
15. Systematic Evaluation
SGA MAS, Asphyxia, Polycythemia
LGA Birth Trauma, Asphyxia, Polycythemia,
RDS, CHD, Hypoglycemia
Potter Facies Hypoplastic Lungs
Barrel chest MAS
Large caput or bruises Difficult or prolonged Labour
Frothing at Mouth TEF
Meconium staining MAS
Pallor Anemia, Shock
Plethora Polycythemia
Cyanosis CHD, Severe Luung disease, Shunt,
abnormal Hb, Air Leak
18. Respiratory vs Cardiac cause
Resp System CVS System
Breathing Retractions Tachypnea
Cardiac evaluation Normal Gallop, weak pulses,
hepatomegaly, absent
femorals
Second Heart Sound Split Single
X ray Chest Parenchymal lesion Abnormal shape, size of
heart
Abnormal pulmonary
vasculature
pCO2 High Low
Pulse Oxymeter Improvement with O2 Not much improvement
with O2, differential
cyanosis
Hyperoxia Test PaO2 >300mmHg rules out
cardiac disease
PaO2 does not rise
19. Clues to congenital Heart Disease
• Cyanosis disproportionate to clinical status
• Differential cyanosis (UL > LL saturation)
• Single S2
• Murmur
• Isolated Hepatomegaly
• Sudden deterioration
• Lack of response to O2
• Cardiomegaly
22. Indicators of Gas Exchange
Alveolar-arterial O2 gradient(A-aDO2)
• PAO2-PaO2 = FIO2 (PBAR – PH2O) – PACO2/RQ-PaO2
• normal range in newborn-5-15
• abnormal -15-40
• Definitely abnormal >40
a/A ratio (Ratio of PaO2 to PAO2)
• >0.8 is normal
• <0.6 –Needs Oxygen Therapy
• <0.15-severe Hypoxemia
Oxygen Index (OI)=(MAP X FiO2)/PaO2
• 25-45-severe Respiratory Failure, mortality risk 50-60%
• >40-mortality risk>80%
23. Initial Management Of A Neonate with Respiratory Distress
Administer O2,attach To Pulse Ox
Maintain Airway In Sniffing Position
,Clear Secretions
Examine For Features Of Respiratory
Distress
Assess Circulation
{skin Color,perfusion,pulses,crt}
PLACE VASCULAR
ACESS,ABG
LOCATE THE
PATHOLOGY,SCORE,
SEND CALL FOR CXR
APPLY SUCTION
TITRATE FIO2 TO
SAO2
SUPPORTIVE MEASURES LIKE
TEMP,SUGAR,FLUID AND ELECTROLYTE
24. Supportive Measures
• Thermal care
• Nursing
• IV Fluids
• Nutrition
• Antibiotics
• Inotropes
• Infection control
• Pain reducing Measures
• Monitoring
25. Preterm <34wks Near Term/Term
EARLY CPAP
IF RDS
SUSPECTED,EARLY
SURFACTANT
CONSIDER SENDING
BLOOD CULTURE
AND START
ANTIBIOTICS
Poor Respiratory Efforts
Worsening Shock
PPHN
Massive Pulmonary
Haemorrhage
Malformations(CDH}
Collapse With Apnea And
Failure To Respond To Bag
And Mask Ventilation
MECHANICAL
VENTILATION
START CPAP
(5-7cm H2O)
• worsening resp
distress
•metaolic
acidosis{ph,7.2
with BE>-10}
•respiratory
acidosis or
worsening ABG
FAILURE OF
CPAP
No
Yes
26. Oxygen therapy
• Judicious use of O2
• Administer appropriate O2 conc by using air-O2
blender or indigenous air-O2 mixing
• Target O2 saturations 90-95%
• Avoid Hypo or Hyperoxia
• Use O2 analyser to check FiO2 when O2 is given
• Set Pulse Oximeter alarms
• Use prewarmed & humidified Oxygen specially at
flow rate >2l/min
• Through nasal canula, nasal prongs,
nasopharyngeal prongs, O2 hoods
27. O2 Delivery Systems
Type Landmark for
depth of
insertion
Recommended
flow
rate(L/min)
FiO2 at
an avg
RFR
Complications Remarks
Nasal
Canula
Nares to inner
margin of eye
brow
1-2 25-45 Crausting,
nasal trauma,
erosion,
inadvertent
PEEP
Alternate between
nares every 12hrs
Nasop
haryng
eal
Canula
Alae nasi to
Tragus
1-2 45-60 Crausting,
nasal trauma,
erosion,
inadvertent
PEEP
Alternate between
nares every 12hrs
Nasal
Prong
1-2 25-45 Crusting,
erosion
Short binasal prongs
recommended
O2
Hood
4 30-70 RFR should be at least
4 times that of minute
vol. Lesser flow rate
risk of CO2 retention
29. Julius Comroe (1945)
“The clinician must bear in
mind that oxygen is a drug
and must be used in
accordance with well
recognized pharmacologic
principles; i.e., since it has
certain toxic effects and is
not completely harmless (as
widely believed in clinical
circles) it should be given
only in the lowest dosage or
concentration required by
the particular patient.”
30. • In preterm baby receiving O2, the saturation
target should be 90-94%
• To achieve this, suggested alarm limits should
be 89-95%
31. Respiratory Support General Principles
A. The aims of respiratory support are to maintain
adequate oxygenation and ventilation, to reduce
respiratory work and to prevent lung injury.
B. With mechanical ventilation, use small or normal tidal
volumes and the lowest effective ventilator pressures.
Both large tidal volumes and high pressures cause
lung injury and inflammation, especially in preterm
infants.
C. PEEP is critical for maintenance of FRC. PEEP is the
main factor that influences PAW, a major determinant
of oxygenation.
32. Adequacy of Respiratory Support
• Comfortable baby
• Minimal retraction, no grunt
• Normal capillary refill, BP
• Normal saturations: 87% - 93%
• Normal ABG
(PaO2 60-80, PaCO2 40-60, pH 7.35-7.45, BE±2)
33. Modes of Respiratory Support
Non Invasive
• CPAP
• NIV
• HHHFNC
Invasive
• IMV/SIMV
• HFOV
35. What’s the Target of Respiratory
Support
• Optimise Oxygenation and Ventilation
• Correct V/Q mismatch
• Comfortable Baby
• Lung Recruitment
• Avoid Lung Hyperinflation & Lung Injury
36. Evidences of hyperinflation
• Lung expansion > 6 ribs anteriorly or > 8 ribs
posteriorly
• Flattening of diaphragms
• Increased lucency of lungs
• Air under the heart or herniation of lung to
other side
• Ribs more horizontal
40. Abnormal Gas Exchange
• Hypoxemia can be
due to:
– hypoventilation
– V/Q mismatch
– shunt
– diffusion
impairments
• Hypercarbia can be
due to:
– hypoventilation
– V/Q mismatch
41. CO2 elimination is determined by
Recruit maximal alveoli
Minimize alveolar dead space
No collapse / over-distension
Minimize external dead space
Tidal volume
Reduce resistance & obstruction of airways
Expiratory time and rates
42. • High CO2 - Cerebral Vasodilation---------------
risk of IVH
• Low CO2 –Cerebral Vasoconstriction----------
risk of PVL
47. Indications of CPAP
• Respiratory distress syndrome
• Transient tachypnoea of
newborn
• Post Extubation
• Apnea of prematurity
• MAS
• Pneumonia
• Laryngo/ Tracheo/Broncho
malacia
• Spontaneously breathing
• Haemodynamically stable
• No upper airway
anomalies
• Not in severe respiratory
failure
48. • CPAP from birth in all babies at risk of RDS
• System delivering CPAP is of little importance,
however the interface should be short binasal
prongs
• CPAP start at 5-6cm H2O and then
individualise depending on clinical condition,
oxygenation and perfusion
49. Contraindications of CPAP
• Progressive respiratory failure and unable to maintain
oxygenation, PaCO2 >60 mm Hg and/or pH 7.25 or less
• Congenital malformations: congenital diaphragmatic
hernia, tracheoesophageal fistula, choanal atresia, cleft
palate, gastroschisis
• Infants with severe cardiovascular instability
(hypotension, poor ventricular function)
• Neonates with poor or unstable respiratory drive
(frequent apnea, bradycardia, and/or oxygenation
desaturation) that is not improved by CPAP
50.
51. DEVICE ADVANTAGE DISADVANTAGE
Ventilator
CPAP
• No need of a separate equipment
•Can be easily switched over to
Mechanical ventilation, if CPAP fails
• Expensive
• Standard flow of 5-8L/ min may be
insufficient in the presence of high
leak
• Difficult to know if the set flow is
sufficient or not (insufficient flow can
lead to increased WOB)
Bubble CPAP • Simple and inexpensive
• Oscillations produced by
continuous bubbling might
contribute to gas exchange (akin to
HFV)
• Can identify large leaks at the
nares
(bubbling stops)
• Flow has to be altered to ensure
proper
bubbling
• It is difficult to detect high flow
which can ead to over distension of
the lungs
Variable Flow
Device
• Maintains more uniform pressure
•Might decrease the WOB
• Recruits lung volume more
effectively
• Expensive
• Requires more technical expertise
52. Flow, PEEP and FiO2• PEEP
– 5 cms
– Chest recessions, air entry, CXR
• FiO2 50%
• Flow
– 2 to 5 liters
– Minimum to ensure continuous bubbling
– High flow- check for leaks (open mouth)
Rule of 5
53. How do we know when to change CPAP
pressure?
• Clinical signs only – little research
1. Observe grunting / chest wall retraction
– If obvious ? need more pressure
2. How much oxygen?
– - high FiO2 ? Need more pressure
3. Observe the chest x-ray
• - very granular ? Need more pressure
– May need pressures > 5 cm H2O
54. Methods of weaning preterm babies <30 weeks gestation off CPAP:
a multicentre randomized controlled trial
Stability criteria( all 8 criteria for > 12hrs) Criteria for failed Trial Off (at least 2 of
Following)• CPAP 4-6cm H2O
• O2 requirement < 25% and not
increasing
• RR < 60
• No significant chest recession
( sternal/diaphragmatic)
• <3 episodes of self reverting
apneas/bradycardia/desaturation
s in 1hr for previous 6hrs
• Avg SpO2 > 86% most of time or
PaO2/TcPO2 >45mm Hg
• Not currently treated for
PDA/Sepsis
• Tolerated time off CPAP during
cares up to 15min
• Increase work of breathing
with RR> 75
• Increased
apnoea/bradycardia/desaturat
ions > 2 in 1 hr for previous
6hr period
• Increase O2 requirement >
25% to maintain SpO2 >86%
and/or PaO2/TcPO2 >45mm
Hg
• PH < 7.2
• PaCO2/ Tc PcO2 > 65 mm Hg
• Major apnea/ bradycardia
requiring Resuscitation
Arch Dis Child Fetal Neonatal Ed July 2012 Vol 97 No 4
55. When has CPAP failed?
• Apnoea
• Respiratory failure =
PaCO2 rising >60 mmHg
(pH<7.20)
• Or FiO2 is rising above
??? 60%
• Worsening of respiratory
distress
• Agitation not relieved by
simple measures
But only after you have
checked
– The prongs are in the nose
– They are the right size
– The nose has been cleared
– Place baby prone
– The mouth is closed
– The neck slightly extended
– You have tried higher
pressures (?? ~ 10 cm H2O
or more.)
57. HHHFNC oxygen therapy: definition
Optimally warmed and humidified respiratory gases
delivered by nasal cannula at flow rates between 2
and 8 L/min.
58. Mechanism of action
• Reduce dead space
making minute
ventilation more
efficient.
Dead space
washout
• Exceeds inspiratory
flow thus
eliminating nasal
resistance.
Reduce
inspiratory work
of breathing
• Warmed,
humidified gas has
been shown to
improve lung
compliance.
Improved lung
mechanics
• Attenuates the
energy and water
loss associated with
conditioning
inspiratory gas.
Decreases
metabolic work
• Flow generates
some positive
distending pressure,
It can be helpful in
lung recruitment.
Provision of mild
distending
pressure
• Ideal humidification
of the inspired gas
has been shown to
restore mucocilliary
function.
Improve
secretion
mobilization
59. Clinical use of HHHFNC
As a mode of
weaning from
ventilation/NCPAP
support
Alternative to
NCPAP in
mild/moderate
respiratory distress
Treatment or
prevention of
apnoea of
prematurity
Babies with nasal
trauma from
NCPAP
Infants with
Chronic Lung
Disease
Supportive growth
optimisation???
61. Recommended Guidelines for Intubation From Optimized
Noninvasive Respiratory Support with nCPAP or HHFNC
Support
Apnea
• Apnea despite 30 seconds of PPV
• Heart rate ,100 beats per minute and not increasing
despite 30 seconds of PPV
• Frequent or severe apnea and bradycardia
• More than 1 apnea event per 12-hour period requiring
PPV
Cardiovascular collapse
• Heart rate <60 beats per minute
• Shock
Pediatrics 2013;131:e1482–e1490
62. Recommended Guidelines for Intubation From Optimized
Noninvasive Respiratory Support with nCPAP or HHFNC Support
Marked respiratory distress
• Persistent marked/severe retractions
• Suspected airway obstruction (despite adequate suctioning)
High O2 requirement
• FIO2 .0.6 to maintain SpO2 >88%
ABG
• Severe metabolic acidosis (arterial base deficit > -10)
• Severe respiratory acidosis (arterial pCO2 >65 mm Hg)
Pediatrics 2013;131:e1482–e1490
63. Invasive Ventilation
Disease PIP PEEP Ti Frequency Flow
RDS 16-18 5-6 0.3-0.35 60 7-8
Pneumonia 14-16 3-4 0.35-0.4 50-60 6-8
MAS 14-16 3-4 0.35-0.4 40-50 5-7
Apnea 12-14 3 0.35 20-30 5-6
Air leak 14-16 3 0.3-0.35 60 5-6
BPD 15-20 4-5 0.4-0.7 20-40 5-6
65. Weaning from Invasive Ventilation
• Clinically & Hemodynamically stable
• Effective respiratory efforts
• Basic Lung pathology/disease improving
• Associated illnesses (active Sepsis, PDA)
improving
• Optimum blood gases
• Principle of weaning ( decrease the most harmful
parameter first, limit change to one parameter at
a time, avoid changes of a large magnitude)
66. High Frequency Ventilation
• Indications
• Failure of conventional ventilation (high PIP
requirement 22-25 in preterm, 25-28 in term
to maintain normal blood gases in conditions
including HMD, Pneumonia, MAS, Pulmonary
Hypoplasia)
• Air Leak
• PPHN not responding to conventional
ventilation
67. Surfactant therapy
• Prophylactic therapy
a. Neonates with gestation less than 30 weeks of gestation
b. Surfactant given within 15 minutes of birth before a
diagnosis of RDS is made
• Early Rescue therapy
a. Neonate with RDS (confirmed clinically ,radiologically).
b. Surfactant given within first 2 hours of life
• Late Rescue therapy
a. Neonate with RDS and requiring ventilation with a MAP
of at least 8cms of water and/or an FiO2 > 30% or
(a/A ratio < 0.22)
b. Surfactant given after 2 hours of birth
69. Surfactant use
1. Prophylactic therapy
a. Neonates with gestation less than 30 weeks of gestation
b. Surfactant given within 15 minutes of birth before a
diagnosis of RDS is made
2. Early Rescue therapy
a. Neonate with RDS (confirmed clinically ,radiologically).
b. Surfactant given within first 2 hours of life
3. Late Rescue therapy
a. Neonate with RDS and requiring ventilation with a MAP of
at least 8cms of water and/or an FiO2 > 30% or (a/A ratio <
0.22)
b. Surfactant given after 2 hours of birth
70. Exogenous Surfactants in use Worldwide
I. Organic solvent extracts of Minced animal lung tissue:
Bovine: Surfactant-TA, Survanta
Porcine: Curosurf, HL-10
Goat surfactant
II. Organic solvent extracts of Lavaged animal lung surf:
Alveofact (SF-R1-1), BLES, Infasurf
III. Synthetic (protein-free):
ALEC, Exosurf
IV. Peptide-containing synthetic:
Surfaxin (KL-4)
V. Surfactant with Recombinant apoproteins:
Recombinant SP-C surfactant (Venticute)
71. Types of natural surfactant
name source Phospholipid
(mg/ml)
protein Dose
(mg/kg)
Dose
vol(ml/kg)
Survanta
(beractant)
bovine 25 (DPPC50%) SP B,SP C 100 4
Infasurf
(calfactant)
bovine 35 (DPPC74%) SP B,SP C 100 3
Curosurf
(poractant
alfa)
Porcine 80
(DPPC70%)
SP B,SP C 100-200 1.25-2.5
Alveofact
(bovactant)
bovine 50 SP B,SP C 50-100 1-2
BLES
(bovine lipid
extract
surfactant)
NEOSURF
bovine 27 SP B,SP C 135 5
72. Types of synthetic surfactant
Trade name preparation protein Phosphplipid
conc mg/ml
Dose ml/kg
Exosurf DPPC 9%
hexadecanol,6
% tyloxapol
no 13.5 5
Surfact DPPC no 13.5 5
pumactant DPPC,PG no 40 1.2
surfaxin
Trade name preparation protein Phosphplipid
conc mg/ml
Dose ml/kg
Exosurf DPPC 9%
hexadecanol,6
% tyloxapol
no 13.5 5
Surfact DPPC no 13.5 5
pumactant DPPC,PG no 40 1.2
Surfaxin
(lucinactant)
DPPC,POPG Kl 4 peptide as
SP B
(sinapultide)
30 5.8
venticute DPPC,POPG r SP C 50 Not studied in
neonates