the following document contains various diagnostic test for screening liver function. and interpretation of results, which may confirm the presence of a disease or disorder
ALT is an enzyme present in liver, heart skeletal muscles, highest concentration is present in Liver. it value increases when there is abnormality in liver, ALT is an amino transferase which transfer one amino group from an amino acid and transfer to another substance for production of non essential amino acid
The liver is the largest organ in the body
It is located below the diaphragm in the right upper quadrant of the abdominal cavity and extended approximately from the right 5th rib to the lower border of the rib cage.
Renal function tests are very useful for effective clinical evaluation of renal failure for effective management. So it is useful for medical and allied professional students and clinical practitioners.
Biochemical kidney function tests with their clinical applicationsrohini sane
An illustrative presentation on Biochemical kidney function tests with their clinical applications for medical ,dental, pharmacology and biotechnology student to facilitate easy-learning.
Liver function tests and interpretation is a very important topic for students of medical and allied fields. It is essential for efficient practice of clinical and laboratory medicine.
these clearance test plays an very important role in determining the functioning capacity and working status of kidney.
and we estimate how amount of compund is excreted in the urine and absorption too.
and i also attached the mathematical caluculation to identify the metabolic valuve of urea, creatinine, inulin clearance by kidney.
Importance of enzymes : The two aminotransferases that are checked are the alanine aminotransferase (ALT or SGPT) and aspartate aminotransferase (AST or SGOT). These liver enzymes form a major constituent of the liver cells. They are present in lesser concentration in the muscle cells.
ALT is an enzyme present in liver, heart skeletal muscles, highest concentration is present in Liver. it value increases when there is abnormality in liver, ALT is an amino transferase which transfer one amino group from an amino acid and transfer to another substance for production of non essential amino acid
The liver is the largest organ in the body
It is located below the diaphragm in the right upper quadrant of the abdominal cavity and extended approximately from the right 5th rib to the lower border of the rib cage.
Renal function tests are very useful for effective clinical evaluation of renal failure for effective management. So it is useful for medical and allied professional students and clinical practitioners.
Biochemical kidney function tests with their clinical applicationsrohini sane
An illustrative presentation on Biochemical kidney function tests with their clinical applications for medical ,dental, pharmacology and biotechnology student to facilitate easy-learning.
Liver function tests and interpretation is a very important topic for students of medical and allied fields. It is essential for efficient practice of clinical and laboratory medicine.
these clearance test plays an very important role in determining the functioning capacity and working status of kidney.
and we estimate how amount of compund is excreted in the urine and absorption too.
and i also attached the mathematical caluculation to identify the metabolic valuve of urea, creatinine, inulin clearance by kidney.
Importance of enzymes : The two aminotransferases that are checked are the alanine aminotransferase (ALT or SGPT) and aspartate aminotransferase (AST or SGOT). These liver enzymes form a major constituent of the liver cells. They are present in lesser concentration in the muscle cells.
1.Detect presence of liver disease.
2.Distinguish among different types of liver diseases.
3.Estimate the extent of known liver damage.
4.Follow the response of treatment
LFT tests is also called hepatic panel.
Noninvasive methods for screening of liver dysfunction.
They reflect the synthetic function and evidence of liver damage.
These tests provide insights into several aspects of liver health,
Its ability to synthesize enzymes and protein.
Its ability to process bilirubin and secrete bile.
And the extent of liver damage.
The liver function tests typically include alanine transaminase (ALT) and aspartate transaminase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), serum bilirubin, prothrombin time (PT), the international normalized ratio (INR), total protein and albumin.
INTERPRETATION OF COMMON BIOCHEMICAL TESTS INCLUDING LFT & RFT.pptxDr Debasish Mohapatra
Biochemical tests are commonly used in day-to-day practices for diagnosis of diseases. Liver function test and renal function tests are common tests done.
Selection of an animal model is one of the most important steps in any of the experimental pharmacological study.
Animal model preferred for the study must be producing similar disease profile as in the human.
Screening models for evaluation of anti ulcer activitySIVASWAROOP YARASI
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Separation is an important asset to purify component of interest from a mixture.
Adulteration is a practice of substituting original crude drug partially or whole with other similar looking substances but the latter is either free from or inferior in chemical and therapeutic properties. Adulteration in simple words is the debasement of an article. OR Adulteration is broadly defined as admixture or substitution of original or genuine article/ drug with inferior, defective or otherwise useless or harmful substances.
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chemical substances which together exert a complex interaction to
meet the needs of the plant. Five groups of plant hormones are well
established; they are the auxins, gibberellins, cytokinins, abscisic acid
and its derivatives, and ethylene. These substances are of wide distribution
and may, in fact, occur in all higher plants. They are specific
in their action, are active in very low concentrations, and regulate cell
enlargement, cell division, cell differentiation, organogenesis, senescence
and dormancy. Their action is probably sequential. Other hormones
concerned with flower formation and reproduction, but as yet
uncharacterized, have also been envisaged. The essential role of these
substances is illustrated by cell and tissue cultures; without the addition
of suitable hormones no development or cell division occurs. The effects of these very active substances on the production of
secondary metabolites, particularly with a view to producing plants
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influence the size of the test plant compared with the controls. For
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for biosynthetic studies yield per plant or per cent fresh weight may be
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this is an act that comes under Indian judiciary. it deals about the cultivation, supply and proper usage of narcotic substances. it has its own committee that regulates the activities according to the act.
liposomes are novel drug delivery dosage systems, where the drug is entrapped in phospholipid bilayered vesicles. the release of drug from the vesicles can be controlled or sustained.
the follwing presentation contain structure, classification and preparation methods, characterization and applications of liposomes.
Autacoids - pharmacological actions and drugs related to them. SIVASWAROOP YARASI
Autacoids or "autocoids" are biological factors which act like local hormones, have a brief duration, and act near the site of synthesis. The word autacoids comes from the Greek "autos" (self) and "acos" (relief, i.e. drug).
it is a method of miscellaneous instrumental analytical technique. it is one of the thermal analytical techniques used. it also has wide applications in the field of pharmacy.
It is instrumental analytical technique. it is one of the major type of chromatography technique. its basic principle is adsorption. it has many applications in various fields
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liver function test
1. LIVER FUNCTION TESTS
Liver is the largest organ in the body. It is located below the diaphragm in the right upper
quadrant of the abdominal cavity and extended approximately from the right 5th
rib to the lower
border of the rib cage. The working cells of the liver are known as hepatocytes.
Major Metabolic Functions of the Liver:
Synthetic Function
o Plasma proteins (albumin, globulins), cholesterol, triglycerides and lipoproteins
Detoxification and excretion
o Ammonia to urea (urea cycle), bilirubin, cholesterol, drug metabolites
Storage Function
o Vitamins A, D, E, K and B12
Production of bile salts
o Helps in digestion.
Liver function tests:
Liver function tests, also known as liver chemistries, help determine the health of your liver
by measuring the levels of proteins, liver enzymes, and bilirubin in your blood.
Noninvasive methods for screening of liver dysfunction.
Help in identifying general types of disorder.
Assess severity and allow prediction of outcome.
Disease and treatment follow up.
Liver function test is often recommended in the following situations:
To check for damage from liver infections, such as hepatitis B and hepatitis C.
To monitor the side effects of certain medications known to affect the liver.
To monitor the disease and how well a treatment is working.
If patient is experiencing the symptoms of a liver disorder.
If patient has certain medical conditions such as high triglycerides, diabetes, high blood
pressure, or anaemia.
If patient is alcoholic.
If patient has gallbladder disease.
LFTs are classified as:
Liver protein test:
o Albumin levels.
o Globulin levels.
o Albumin to globulin ratio.
o Prothrombin time.
Liver enzyme test:
o Alkaline phosphatase (ALP)
o Alanine aminotransferase (ALT)
o Aspartate aminotransferase (AST)
2. o g-glutamyl transferase (GGT)
Bilirubin tests:
o Serum bilirubin.
o Urobilinogen.
Bilirubin tests:
Bilirubin
A by-product of red blood cell breakdown
It is the yellowish pigment observed in jaundice
High bilirubin levels are observed in:
o Gallstones, acute and chronic hepatitis
1. Serum bilirubin levels:
o Normal: 0.2 – 0.8 mg/dL
o Unconjugated (indirect): 0.2 – 0.7 mg/dL
o Conjugated (direct): 0.1 – 0.4 mg/dL
If the plasma bilirubin levels exceed 1mg/dl, the condition is called
hyperbilirubinemia. Levelsbetween 1 & 2 mg/dl are indicative of latentjaundice. When the
bilirubinlevel exceeds 2 mg/dl, it diffuses into tissues producing yellowish discoloration of
sclera, conjunctiva, skin & mucous membrane resulting in jaundice.
Van den Bergh test is a specific test for identification of increased serum bilirubin
levels.
2. Urobilinogen (UBG) and bile salts:
Urobilinogenisacolourlessby-productof bilirubinreduction.Itisformedinthe intestinesby
bacterial action on bilirubin.
Most UBG ismetabolizedinthe large intestinebutafractionisexcretedinurine (less
than 4 mg/day)
Normally bile salts are NOT present in urine
Obstruction in the biliary passages causes:
o Leakage of bile salts into circulation
o Excretion in urine
Sensitive indicator of
o hepatocellular dysfunction
o alcoholic liver damage.
Liver protein tests:
1. Serum Albumin:
The most abundant protein synthesized by the liver.
Normal serum levels: 3.5 – 5 g/dL.
Synthesis depends on the extent of functioning liver cell mass.
Longer half-life: 20 days.
Its levels decrease in all chronic liver diseases.
Methods of estimation:
o Dye binding method
o Immunoassay
3. o Chromatography
o Salt -fractionation
3. Serum Globulin:
Normal serum levels: 2.5 – 3.5g/dL
a and b-globulins mainly synthesized by the liver
They constitute immunoglobulins (antibodies)
High serum g-globulins are observed in chronic hepatitis and cirrhosis:
o IgG in autoimmune hepatitis
o IgA in alcoholic liver disease
4. Albumin to globulin (A/G) ratio:
Normal A/G ratio: 1.2/1 – 1.5/1
Globulin levels increase in hypoalbuminemia as a compensation.
5. Prothrombin time:
Prothrombin: synthesized by the liver, a marker of liver function.
Half-life: 6 hrs. (indicates the present function of the liver).
PT is prolonged only when liver loses more than 80% of its reserve capacity. PT is
prolonged in severe parenchymal liver disease due to decreased synthesis of
prothrombin.
VitaminKdeficiencyalsocausesprolongedPT.Intake of vitaminKdoesnotaffectPT
in liver disease.
If PT returns to normal after vitaminKinjectionitindicatesthathepatocyte function
is good.
Liver enzyme tests:
1. Alkaline phosphatase (ALP)
A non-specific marker of liver disease.
A family of Zinc metalloid enzymes, with a serine at the active centre. The release
inorganic phosphate from various organic phosphates.
Inthe liveritisfoundinmicrovilliof bile canaliculiandonthe sinusoidal surfaceof the
hepatocytes.
Normal levels – 41-133 IU/L
Moderate elevation observed in:
o Infective hepatitis, alcoholic hepatitis and hepatocellular carcinoma
High levels are observed in:
o Extrahepaticobstruction(obstructivejaundice) and intrahepatic cholestasis
Very high levels are observed in:
o Bone diseases
2. Alanine aminotransferase (ALT)
ALT or SGPT (serum glutamate pyruvate transaminase)
ALT is a cytoplasmic enzyme.
More liver-specific than AST
Normal range (U/L): 7-56 IU/L.
High serum levels
4. o acute hepatitis (300-1000U/L)
Moderate elevation
o alcoholic hepatitis (100-300U/L)
Minor elevation
o cirrhosis, hepatitis C and non-alcoholic steatohepatitis (NASH) (50-100U/L)
Appears in plasma many days before clinical signs appear.
A normal value does not always indicate absence of liver damage.
Obese but otherwise normal individuals may have elevated ALT levels.
3. Aspartate aminotransferase (AST)
AST or SGOT (serum glutamate oxaloacetate transaminase)
A marker of hepatocellular damage
Normal range: 10-45 U/L.
AST is found in both cytoplasm & mitochondria
AST/SGOTalsoreflectsdamage tothe hepaticcells& islessspecific forliverdisease.
It can also be released with heart, muscle & brain disorders.
AST help diagnose various heart, muscle or brain disorders, such as a myocardial
infarct (heart attack).
High serum levels are observed in:
o Chronic hepatitis, cirrhosis and liver cancer
4. Gamma-glutamyl transferase (GGT)
This is a microsomal enzyme widely distributed in body tissues, including liver.
Used for glutathione synthesis
Measurementof γ - glutamyl transpeptidase (GGT) activityprovidesasensitive index
to assess liver abnormality.
The activityof thisenzyme almostparallelsthatof transaminasesinhepaticdamage.
Moderate elevation observed in:
o Infective hepatitis and prostate cancers
GGT is increased in:
o alcoholics despite normal liver function tests
Highly sensitive to detecting alcohol abuse.