This document discusses creatinine clearance and how it is used to evaluate kidney function. It begins by explaining that creatinine is a waste product produced from muscle metabolism and filtered out by the kidneys. Checking blood creatinine levels provides information about kidney function, as elevated levels indicate impaired function. Creatinine clearance compares the amount of creatinine cleared from the blood by the kidneys over 24 hours to a blood sample, estimating the glomerular filtration rate (GFR) and severity of kidney disease. Creatinine clearance can be directly measured from urine and blood samples over 24 hours or calculated using the Cockcroft-Gault formula incorporating a person's serum creatinine, age, weight, and

1. WHAT IS CREATININE
CLEARANCE?
Dr. Haji Bahadar,PharmD, PhD
Assistant Professor, KMU-IPMS

2. Topics
 What is creatinine?
 Why is it important to check blood creatinine
levels?
 What is creatinine clearance?
 How creatinine clearance can be measured ?

3. What is creatinine?
 Creatinine is a chemical waste molecule that is
generated from muscle metabolism.
 Creatinine is produced from creatine, a
molecule of major importance for energy
production in muscles.
 Creatinine is transported through the
bloodstream to the kidneys. The kidneys filter
out the creatinine.

4. Creatine
 Creatine is a nitrogenous organic acid that
occurs naturally in vertebrates. Its main role is to
facilitate recycling of adenosine
triphosphate (ATP), the energy currency of the
cell, primarily in muscle and brain tissue.
Creatine is not an essential nutrient as it is
naturally produced in the human body from
the amino acids glycine and arginine.
 Creatine, synthesized in the liver and kidney, is
transported through the blood and taken up by
tissues with high energy demands, such as the
brain and skeletal muscle.

7. Why is it important to check blood creatinine
levels?
 The kidneys maintain the blood creatinine in a
normal range ( male: 0.6 to 1.2 milligrams (mg)
per deciliter (dL). Creatinine is a reliable
indicator of kidney function. Elevated
creatinine level show impaired kidney function
or kidney disease.

8. Creatinine Clearance
 Creatinine clearance means to compare the
creatinine level in a 24-hour urine sample with the
creatinine level in your blood. Creatinine
clearance also helps estimate the glomerular
filtration rate (GFR). This test provide information
about the severity of kidney disease.
 The amount of blood the kidneys can make
creatinine-free each minute is called the creatinine
clearance.
 Creatinine clearance in a healthy young person is
about 125 milliliters per minute -- meaning each
minute, that person's kidneys clear 125 mL of
blood free of creatinine.

9. How creatinine clearance can be measured
?
 The creatinine clearance can be calculated by a
formula using serum (blood) creatinine level, patient's
weight, and age.
1. COCKCROFT-GAULT FORMULA (NOT CLINICALLY
USED).
 CCr=(l 40–age) x weight)/(72xSCr)}x 0.85 (if female)
 Abbreviations/ Units
 CCr (creatinine clearance) = mL/minute
 Age = years
 Weight = kg
 SCr (serum creatinine) = mg/dL
 https://www.kidney.org/professionals/KDOQI/gfr_calcu
latorCoc

10.  2. Creatinine clearance can also be more
directly measured by collecting a 24-hour urine
sample and then drawing a blood sample. The
creatinine levels in both urine and blood are
determined and compared using a formula.
Decreased creatinine clearance indicates
decreased glomerular filtration rate (GFR).
This can be due to conditions such as
progressive renal disease.

12. Thank you