Liquisolid technique is a new and promising method that can change the dissolution rate of drugs. It has been used to enhance dissolution rate of poorly water-soluble drugs. Orally Disintegrating Tablets (ODT) which disintegrates rapidly in saliva, usually within seconds, without need for water. Drug dissolution, absorption, the onset of action and drug bioavailability may be significantly increased better than those obtained from conventional dosage forms. combination of this two techniques is a promising approach for effective drug delivery