This document provides a summary of a study material presentation on lipid metabolism. It discusses (1) the beta-oxidation of saturated fatty acids like palmitic acid, (2) the formation and utilization of ketone bodies and ketoacidosis, and (3) disorders of lipid metabolism including hypercholesterolemia, atherosclerosis, fatty liver and obesity. The presentation covers the stages of fatty acid oxidation, the breakdown of fatty acids into acetyl-CoA, and the major pathways of ketone body utilization. It also examines the causes and consequences of hypercholesterolemia, obesity, and fatty liver disease.
Formation and utilization of ketone bodies; ketoacidosisJinal Tandel
Formation and utilization of ketone bodies is part of lipid metabolism. After completion of this topic one can understand about Ketogenesis, utilization of Ketone bodies and ketoacidosis
explains the palmitate synthesis- which is most common FA stored in Adipose tissue , elongation system and Desaturation system, compares oxidation with synthesis.
Formation and utilization of ketone bodies; ketoacidosisJinal Tandel
Formation and utilization of ketone bodies is part of lipid metabolism. After completion of this topic one can understand about Ketogenesis, utilization of Ketone bodies and ketoacidosis
explains the palmitate synthesis- which is most common FA stored in Adipose tissue , elongation system and Desaturation system, compares oxidation with synthesis.
De novo synthesis of fatty acids (Biosynthesis of fatty acids)Ashok Katta
Synthesis of fatty acids in the body. Detailed pathway for de novo synthesis of fatty acids in the body including its energetic and regulation. also cover Multienzyme complex
Lipid metabolism is the synthesis and degradation of lipids in cells.
It involves the breakdown or storage of fats for energy and the synthesis of structural and functional lipids, such as those involved in the construction of cell membranes.
In animals, these fats are obtained from food or synthesized by the liver.
Disorders of lipid metabolism | Hypercholesterolemia | Atherosclerosis | Fatt...kiransharma204
This ppt contains details on Disorders of lipid metabolism, Hypercholesterolemia, Atherosclerosis, Fatty liver & Obesity.
Book referred: https://www.amazon.in/Biochemistry-2019-Satyanarayana-Satyanarayana-Author/dp/B07WGHCTKZ/ref=sr_1_1?dchild=1&qid=1591592368&refinements=p_27%3AU+Satyanarayana&s=books&sr=1-1
De novo synthesis of fatty acids (Biosynthesis of fatty acids)Ashok Katta
Synthesis of fatty acids in the body. Detailed pathway for de novo synthesis of fatty acids in the body including its energetic and regulation. also cover Multienzyme complex
Lipid metabolism is the synthesis and degradation of lipids in cells.
It involves the breakdown or storage of fats for energy and the synthesis of structural and functional lipids, such as those involved in the construction of cell membranes.
In animals, these fats are obtained from food or synthesized by the liver.
Disorders of lipid metabolism | Hypercholesterolemia | Atherosclerosis | Fatt...kiransharma204
This ppt contains details on Disorders of lipid metabolism, Hypercholesterolemia, Atherosclerosis, Fatty liver & Obesity.
Book referred: https://www.amazon.in/Biochemistry-2019-Satyanarayana-Satyanarayana-Author/dp/B07WGHCTKZ/ref=sr_1_1?dchild=1&qid=1591592368&refinements=p_27%3AU+Satyanarayana&s=books&sr=1-1
KETONE BODY METABOLISM. FOR MBBS, BDS, LABORATORY MEDICINE pptxRajendra Dev Bhatt
Ketone bodies are produced from acetyl-CoA, mainly in the mitochondrial matrix of liver cells when carbohydrates are so scarce that energy must be obtained from breaking down of fatty acids.
Ketone bodies, or simply ketones are substances produced by the liver during gluconeogenesis, a process which creates glucose in times of fasting and starvation. There are three ketone bodies produced by the liver. They are acetoacetate, beta-hydroxybutyrate, and acetone. These compounds are used in healthy individuals to provide energy to the cells of the body when glucose is low or absent in the diet.
Fatty Acids are Aliphatic carboxylic acids and each animal species will have characteristic pattern of fatty acid composition. Thus, human body fat contains 50% oleic acid, 25% palmitic acid, 10% linoleic acid and 5% stearic acid.
UNIT 1_QUALITY ASSURANCE_QC,QA,GMP,TQM and NABLSayali Powar
UNIT – I
Quality Assurance and Quality Management concepts: Definition and concept of Qualitycontrol, Quality assurance and GMP
Total Quality Management (TQM), NABL
UNIT 1 QUALITY ASSURANCE B. PHARMACY PART 2Sayali Powar
Quality Assurance and Quality Management concepts: Definition and concept of Quality control, Quality assurance and GMP
Total Quality Management (TQM): Definition, elements, philosophies
ICH Guidelines: purpose, participants, process of harmonization, Brief overview of QSEM, with special emphasis on Q-series guidelines, ICH stability testing guidelines
Quality by design (QbD): Definition, overview, elements of QbD program, tools
ISO 9000 & ISO14000: Overview, Benefits, Elements, steps for registration
NABL accreditation : Principles and procedures
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
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1. Study Material
on
Lipid Metabolism
Presented By:
Ms. Sayali Dilip Powar
(M. Pharm )
Department of Pharmaceutical Chemistry,
@ Tatyasaheb Kore College of Pharmacy, Warananagar
26/03/2020
1
2. Content
• β-Oxidation of saturated fatty acid (Palmitic
acid)
• Formation and utilization of ketone bodies;
ketoacidosis
• Disorders of lipid metabolism:
Hypercholesterolemia, atherosclerosis, fatty
liver and obesity
26/03/2020 2
3. β-Oxidation of saturated fatty acid
• The fatty acids in the body are mostly oxidized
by BETA oxidation.
• Oxidation may be defined as the oxidation of
fatty acids on the beta carbon atom.
• This results in the sequential removal of a
two carbon fragment, acetyl CoA.
26/03/2020 3
4. β-Oxidation of saturated fatty acid
• It occurs in many tissues including liver, kidney and heart.
• Fatty acids oxidation doesn't occur in the brain
• o There are several types of fatty acids oxidation.
(1) β- oxidation of fatty acid
(2) α- oxidation of fatty acids
(3) ω- oxidation of fatty acids
26/03/2020 4
5. NOTE
• Fatty acids are oxidized by most of the tissues
in the body. However, brain, erythrocytes and
adrenal medulla cannot utilize fatty acids for
energy requirement.
26/03/2020 5
6. Fatty acid oxidation-
Stages and tissues
• The beta oxidation of fatty acids involves three
stages
• I. Activation of fatty acids occurring in the
cytosol
• II. Transport of fatty acids into mitochondria
• III.beta-Oxidation proper in the mitochondrial
matrix.
26/03/2020 6
8. β-oxidation of fatty acid
• β-oxidation of fatty acid- The break down of a
fatty acid to acetyl-CoA.
• Occurs in the mitochondria
• Process is strictly aerobic
• After production Acetyl-CoA is fed directly into the
Krebs cycle
26/03/2020 8
11. Formation and utilization of ketone
bodies; ketoacidosis
• Ketone bodies, or simply ketones are substances
produced by the liver during gluconeogenesis a process
which creates glucose in times of fasting and
starvation.
• There are three ketone bodies produced by the liver.
• They are acetoacetate, beta-hydroxybutyrate,
and acetone.
• These compounds are used in healthy individuals to
provide energy to the cells of the body when glucose is
low or absent in the diet.
• In a normal man, concentration of ketone bodies in the
blood is usually less than 3 mg/100ml
26/03/2020 11
12. Acetoacetate, acetone and β- hydroxybutyrate are
collectively known as ketonebodies
Formation and utilization of ketone
bodies; ketoacidosis
26/03/2020 12
13. • Ketone bodies are the water-soluble
molecules containing the ketone group that
are produced by the liver from fatty acids
during periods of low food intake,
carbohydrate restrictive diets, starvation,
prolonged intense exercise, alcoholism, or in
untreated type 1 diabetes mellitus.
Formation of ketone bodies
26/03/2020 13
14. The major pathway of ketone bodies utilization is Transacylase pathway.
1.Formation of acetoacetate from β-hydroxybutyrate
• β-hydroxybutyrate is converted to acetoacetate by β-hydroxybutyrate
dehydrogenase.
2. Formation of acetoacetyl CoA
• Acetoacetate is activated to form acetoacetyl CoA by the transfer of
CoA molecule from succinyl CoA.
• The reaction is catalyzed by succinyl CoA:Acetoacetate CoA
transferase
3. Formation of acetyl CoA
• Acetoacetyl CoA is cleaved to form acetyl CoA and acetyl CoA in a
reaction catalyzed by thiolase
Utilization of ketone bodies
26/03/2020 14
23. CONTROL OF HIGH CHOLESTEROL
1. Consumption of PUFA
2. Dietary cholesterol
3. Dietary fiber
4. Lifestyle
5. Use of drugs
26/03/2020 23
24. OBESITY
• Obesity is essentially an excessive
accumulation of triacylglycerols in fatty tissue
• A triglyceride (TG, triacylglycerol, TAG, or
triacylglyceride) is an ester derived from
glycerol and three fatty acids (from tri- and
glyceride).
• Triglycerides are the main constituents of
body fat in humans and other vertebrates, as
well as vegetable fat.
26/03/2020 24
29. What is fatty liver disease?
• Liver is the largest organ inside body.
• It helps your body digest food, store energy,
and remove poisons.
• Fatty liver disease is a condition in which fat
builds up in your liver.
26/03/2020 29
30. Types
• There are two main types:
1. Nonalcoholic fatty liver disease (NAFLD)
2. Alcoholic fatty liver disease
26/03/2020 30
31. What is nonalcoholic fatty liver
disease (NAFLD)?
• Fatty liver disease that is not related
to heavy alcohol use.
• There are two kinds:
• Simple fatty liver, in which you have fat in your
liver but little or no inflammation or liver cell
damage.
• Nonalcoholic steatohepatitis (NASH), in which
you have inflammation and liver cell damage, as
well as fat in your liver. Inflammation and liver
cell damage can cause fibrosis, or scarring, of the
liver. NASH may lead to cirrhosis or liver cancer.
26/03/2020 31