This document discusses lead poisoning, its sources, uses, health effects, diagnosis, and treatment. It provides information on:
1. Common sources of lead exposure including paint, petrol, household dust, batteries, ceramics, etc.
2. Compounds containing lead like lead acetate, lead tetraoxide, and their uses.
3. How lead is absorbed in the body, stored in bones and tissues, and its toxic effects on organs like the brain and kidneys.
4. Symptoms of lead poisoning in children and adults.
5. Tests to diagnose lead poisoning through blood, urine, and bone tests.
6. Chelation therapies used to treat lead poisoning by removing
It is heavy metal and bright silvery in appearance.It is liquid and is non poisonous if swallowed. However, it volatilizes at room temp and inhalation of vapors is toxic. It gets widely distributed throughout the body and causes toxic damage to brain, kidney, peripheral nervous system, mucous membranes etc
It is heavy metal and bright silvery in appearance.It is liquid and is non poisonous if swallowed. However, it volatilizes at room temp and inhalation of vapors is toxic. It gets widely distributed throughout the body and causes toxic damage to brain, kidney, peripheral nervous system, mucous membranes etc
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COPPER POISONING
Appear within 15-30 min
Metallic taste
Increased salivation
Burning pain in stomach
Nausea, vomiting (vomited matter : blue / green colour)
Diarrhoea with much straining (motions are liquid and brown)
Oliguria, haematuria, albuminuria, acidosis, uraemia
In severe cases, haemolysis, jaundice, pancreatitis, convulsions, spasm of legs
Breathing difficulty, cold perception, severe head ache
Death due to HEPATIC or RENAL failure or both
This lecture includes Introduction to Poisons, Different Types of Classification of Poisons, Analysis of Poisons (Volatile, Nonvolatile) (Acidic, Basic, Neutral).
Sulphuric acid as a corrosive poison. the characteristics, fatal dose, fatal time, sign and symptoms, post-mortem appearance and medicolegal importance are discussed
Various pests, fungi, weeds and rodents cause much harm to the production and storage of food grains
A large number of pesticides including insecticides, rodenticides, herbicides and fungicides are available in the market.
A POWER POINT PRESENTATION BY DR. SANGEETA CHOWDHRY AND DR. SUNIL SHARMA, DEPARTMENT OF FORENSIC MEDICINE AND TOXICOLOGY, GOVT. MEDICAL COLLEGE, JAMMU (JAMMU AND KASHMIR)
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COPPER POISONING
Appear within 15-30 min
Metallic taste
Increased salivation
Burning pain in stomach
Nausea, vomiting (vomited matter : blue / green colour)
Diarrhoea with much straining (motions are liquid and brown)
Oliguria, haematuria, albuminuria, acidosis, uraemia
In severe cases, haemolysis, jaundice, pancreatitis, convulsions, spasm of legs
Breathing difficulty, cold perception, severe head ache
Death due to HEPATIC or RENAL failure or both
This lecture includes Introduction to Poisons, Different Types of Classification of Poisons, Analysis of Poisons (Volatile, Nonvolatile) (Acidic, Basic, Neutral).
Sulphuric acid as a corrosive poison. the characteristics, fatal dose, fatal time, sign and symptoms, post-mortem appearance and medicolegal importance are discussed
Various pests, fungi, weeds and rodents cause much harm to the production and storage of food grains
A large number of pesticides including insecticides, rodenticides, herbicides and fungicides are available in the market.
A POWER POINT PRESENTATION BY DR. SANGEETA CHOWDHRY AND DR. SUNIL SHARMA, DEPARTMENT OF FORENSIC MEDICINE AND TOXICOLOGY, GOVT. MEDICAL COLLEGE, JAMMU (JAMMU AND KASHMIR)
"whenever any medico-legal case comes to the hospital, the medical officer on duty should inform the Duty Constable, giving the name, age, sex of the patient and the place of occurrence of the incident and should start the treatment of the patient.
It will be the duty of the said Constable to inform the nearest concerned police station or higher police functionaries for further action.
Role of Forensic Pathologists in Mass Aviation Disasters[1].pptxDr. Mohd Kaleem Khan
The forensic pathologist has always had a central role in the identification of the dead in every day practice, in accidents, and in disasters involving hundreds or thousands of victims.
Medico Legal Responsibilities of Doctors
Registered medical practitioner (RMP) i.e. Emergency Medical Officer (EMO)/ Assistant Emergency Medical Officer (Asst. EMO) at Emergency should decide whether the case is to be registered as MLC or not.
Consent of family members NOT required for registration of a case as MLC.
Opinion Should be Crisp and to the Point. Articles Preserved and Should be Enumerated.Prepare Three Copies of The Document, One Copy is Kept at Emergency Room, other as Hospital Record.Original is Given to The Police.
If a MLC, recorded elsewhere (in other hospital) is referred, it should be treated as MLC but NO NEW MLC number should be issued. Treatment should continue in old MLC number. Neither a new MLR should be prepared nor is it needed to inform the police.
If a case is brought several days after the incident, it should be reported and findings to be noted regarding the present condition of the patient.
MLC can be written and signed by (EMO)/Asst. EMO /Faculty. Wherever possible, Faculty member should sign along with SR/JR if the report is prepared by them.
Cases wherever attending doctor after taking history and clinical examination of the patient thinks that some investigation by law enforcing agencies are essential so as to fix the responsibility regarding the case in accordance with the law of land.
consent
Indian Contract Act 1872 defines when two or more persons agree upon the same thing and at the same time in the same sense provided the consent has been taken prior to coercion, not under the influence of fraud or misinterpretation and mistake
infanticide are quite common in India because of illiteracy as well as the female child unwanted . Now a days female sexual assault and murder is getting common in north Indian society
Criminal abortion is commonly practiced in India as access to legal abortion and society fear are still great barrier. Approach of the physician and government should favorable.
infections through food contamination and food adulteration often leads poisoning like status. mortality and morbidity decides the nature and severity of poison. awareness needed for common food born infections and common food adulterants.
Analysis of hair and fiber , differentiating it between human and animals. analysis in identification cases of male and female and different places of body origin. Examination in sexual assault cases and extraction of DNA from hair from DNA fingerprinting.
Drowning is an inhalation of liquid in respiratory tract leading to suffocation and death. it can be wet or dry drowning depending upon the water entering in trachea. some times water touching the larynx leading to spasm and complete closure leading to dry drowning.
injury to thorax and abdomen. tension pneumothorax , cardiac tamponade, rupture of kidney, rupture of liver, intestinal perforation, foreign body in rectum
The chief vegetable purgatives are aloes, colocynth, gamboge, jalap,
scammony, seeds of castor-oil plant, croton-oil, elaterium, the
hellebores, and colchicum. All these have, either alone or combined,
proved fatal. The active principle in aloes is aloin; of jalap, jalapin;
of white hellebore, veratria; and of colchicum, colchicin. Morrison's
pills contain aloes and colocynth; aloes is also the chief ingredient in
Holloway's pills
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
2. Uses and Sources of Lead Uses and Sources of Lead
Paint (until 1970)
Petrol (tetraethyl lead)
Household dust
Ceiling dust
Occupational
Solder
Ceramic glazes
Pesticide(Pb arsenate)
Cigarettes
Mines, smelters
TV's, Computer monitors
Batteries, Bullets
Sinkers
Aviation
X-ray shields
Crystal-ware (high levels
in decanters)
Explosives
Non-stick linings of pots
(in the past)
Plastic colouring (wire,
blinds)
Pewter
2
3. S no. Compound Uses
1 Lead acetate Astringent, local sedative
2 Lead tetra oxide Sindoor
3 Tetraethyl lead Antiknock for petrol
4 Lead sulphide Surma
5 Lead carbonate paints
3
4. ◦ Sugar of lead, lead sugar, salt of Saturn
◦ Formula: Pb(C2H3O2)2
◦ White crystalline chemical compound with a sweetish taste
◦ Solubility: Anhydrous and trihydrate are soluble in alcohol,
glycerol
◦ LD50 (median dose): 400 mg/kg (mice, oral)
4
6. Bright Red or Orange Crystalline or Amorphous
Pigment, Chemically, Red Lead
Formula: Pb3O4
6
7. Lead tetraoxide is most often used as a pigment for
primer paints for iron objects.
The combination of minium and linen fibres was also
used for plumbing,.
Currently it is mostly used for manufacture of glass,
especially lead crystal glass.
7
12. Lead goes down iron or calcium absorption pathway in GIT.
Children absorb lead well orally (~50%) cf adults poorly
(~10%). Children also have more hand to mouth activity.
Lead absorption is enhanced if diet is poor in iron or calcium.
Pica is one of the worst risk factors.
Lead can be inhaled.
Tetraethyl lead can be absorbed via skin.
12
16. 95% long bones.
Binds into matrix.
Released during osteolysis.
4% brain,liver, kidneys.
1% blood.
Crosses placenta, foetal BBB is
open
16
18. Pb + essential SH-groups of certain enzymes
Increase in permeability
Potassium leakage
19. INORGANIC Pb
exposure:-
Abd. Colic
obstinate constipation
Loss of appetite
Blue lines on gums
Stippling of red
cells
Anaemia
Wrist drop
Foot drop
19
30. Fatal dose
Lead carbonate:40 g
Lead acetate:20 g.
Fatal period: 1-2 days
30
31. Aim
a)To prevent further absorption
b)To remove lead from soft tissues
c)To prevent recurrence
TREATMENT
Saline purge (remove lead from the gut)
d-penicillamine(promote Pb excretion in urine)
32. In a child with acute lead ingestion, consider placing an orogastric or
nasogastric catheter to enable whole-bowel irrigation (WBI) with
polyethylene glycol
Dimercaprol, also k/a BAL (British antilewisite), IM
CaNa2 EDTA
Succimer
32
33. a)Substitution
Pb compounds should be substituted by less toxic materials.
b)Isolation
Pb dust or fumes should be enclosed and segregated
c)Local exhaust ventillation
To remove dust & fumes
34. d)Personal protection
By approved respirators
e)Good housekeeping
f)In working atmosphere
Pb conc. Should be kept <2mg per 10cu.m of air
g)Periodic medical examination of workers
h)Personal hygiene (Hand washing)
i)Health education