paracoccidiodiomycosis- its a acute subacute chronic ,systemic fungal infection
mainly effect respiratory system from there disseminated to various body parts.
Cryptococcosis also called as Torulosis is a subacute or chronic fungal infection caused by Cryptococcus neoformans. It leads to compications such as fatal meningoencephalitis. It is an opportunistic infection in HIV-infected patients. The PPT discuss on the morphology of the fungus, pathogenesis, laboratory diagnosis and treatment.
COLLECTION AND TRANSPORTATION OF CLINICAL SAMPLESNCRIMS, Meerut
Principles of Sample Collection:
Aseptic precautions to minimize chances of
contamination.
Appropriate anatomic sites
Adequate volume
Adequate no. of samples
Appropriate time
Appropriate container with proper labelling
Before initiation of anti-microbials
Adequate information in request form
teaching support for 2nd year medical school students: steps of the laboratory diagnosis of infections caused by bacteria of the genera Staphylococcus and Streptococcus
WHO CME ANTIBIOTC STEWARDSHIP ITALY
• Describe appropriate blood culture specimen collection techniques to reduce opportunities for contamination, which can lead to inappropriate antimicrobial use
• Review framework for appropriate antimicrobial prescribing for
patients with suspected blood stream infections (BSI).
• Demonstrate opportunities for collaboration between clinicians and microbiologist to achieve the dual goals of antimicrobial and
diagnostic stewardship
As the channel name suggests, our channel will be a perfect lounge for the malayali medicos..we wil be covering videos which will be like lecture classes related to the subjects biochemistry and microbiology in which we are specialised.. It will be a better learning experience for the students especially for those who are not able to understand and follow the normal classes in college..we assure the students that you will get a basic idea regarding the topic and extra reading can be done from the reference textbooks..
Qalification
AHLAD T O
MSc MLT (Biochemistry)
Assistant Professor
Baby memorial college of allied Health science
Kozhikode
Maneesha M Joseph
MSc MLT (Microbiology)
Assistant Professor
Baby memorial college of allied Health science
Kozhikode
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paracoccidiodiomycosis- its a acute subacute chronic ,systemic fungal infection
mainly effect respiratory system from there disseminated to various body parts.
Cryptococcosis also called as Torulosis is a subacute or chronic fungal infection caused by Cryptococcus neoformans. It leads to compications such as fatal meningoencephalitis. It is an opportunistic infection in HIV-infected patients. The PPT discuss on the morphology of the fungus, pathogenesis, laboratory diagnosis and treatment.
COLLECTION AND TRANSPORTATION OF CLINICAL SAMPLESNCRIMS, Meerut
Principles of Sample Collection:
Aseptic precautions to minimize chances of
contamination.
Appropriate anatomic sites
Adequate volume
Adequate no. of samples
Appropriate time
Appropriate container with proper labelling
Before initiation of anti-microbials
Adequate information in request form
teaching support for 2nd year medical school students: steps of the laboratory diagnosis of infections caused by bacteria of the genera Staphylococcus and Streptococcus
WHO CME ANTIBIOTC STEWARDSHIP ITALY
• Describe appropriate blood culture specimen collection techniques to reduce opportunities for contamination, which can lead to inappropriate antimicrobial use
• Review framework for appropriate antimicrobial prescribing for
patients with suspected blood stream infections (BSI).
• Demonstrate opportunities for collaboration between clinicians and microbiologist to achieve the dual goals of antimicrobial and
diagnostic stewardship
As the channel name suggests, our channel will be a perfect lounge for the malayali medicos..we wil be covering videos which will be like lecture classes related to the subjects biochemistry and microbiology in which we are specialised.. It will be a better learning experience for the students especially for those who are not able to understand and follow the normal classes in college..we assure the students that you will get a basic idea regarding the topic and extra reading can be done from the reference textbooks..
Qalification
AHLAD T O
MSc MLT (Biochemistry)
Assistant Professor
Baby memorial college of allied Health science
Kozhikode
Maneesha M Joseph
MSc MLT (Microbiology)
Assistant Professor
Baby memorial college of allied Health science
Kozhikode
Our Partner Channel
Health & Voyage channel link - https://youtu.be/nzKqRVjlwc0
#Proteus microbiology
#Medical
#Microbiology
#Biochemistry
#Mallu Medicos Lounge
##MalluMedicosLounge
#MLT
#Channel introduction
#HealthAndVoyage
#New Youtube Channel introduction
#Gram-negative
#Enterobactericea
#Weil Felix Test
#PROTEUS - causes, symptoms, diagnosis, treatment, pathology
Infection control in dentistry / /certified fixed orthodontic courses by Indi...Indian dental academy
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this presentation is help to the student for the getting information regarding the sorces, types, & mode of infection spread in the hospital sector, it help firstd year student student gain the information regarding through this ppt
Infection Control In Health Care SettingsSagar Desai
The goal of this report was to assess the current and potential future role of diagnostics in hospital-acquired infection (HAI) control programs. We examined current issues resulting from HAIs and determined which infections needed foremost attention. Then, with input from Prof. Neimz, we selected diagnostics available on the market we could use. The final chapter of the review contains a market analysis with info about costs prevented upon implementation of diagnostic recommendations.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
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Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
2. Page 1
Introduction:
Hospital acquired infections or HAIs are Infections which are acquired from
hospitals are called nosocomial infections. If the organisms come from another
patient it is called cross infections and if the patient himself carries the infection
to some other site then it is autoinfection. Infection may become apparent
during the stay of the patient in the hospital or after his discharge from the
hospital.
Hospital-acquired infections (HAI) are a global problem and a major public
health concern in hospitals throughout the world. Mostly caused by multi drug
resistance (MDR) organisms, HAI significantly contributes to increased
morbidity, mortality, and hospital cost. HAI is also a major global safety
concern for both patients and health-care professionals.
In developed countries, HAI rates of 5% to 15%, sometimes up to 50%, have
been reported among hospitalized patients in the regular wards and intensive
care units (ICUs) respectively. In developing countries, the problem is likely
much higher, and yet, the magnitude of the problem remains underestimated or
even unknown largely because HAI diagnosis is complex and surveillance
activities which requires expertise and resources, are lacking in most of these
countries. Furthermore, infection control practices remain rudimentary as most
hospitals lack effective infection control programs and trained professionals.
Quantification of HAI is needed through an effective surveillance system in
developing countries to understand the burden and help to justify resources
dedicated to infection control.
Hospital mode of infection can be through Direct Contact, e.g. hands, clothing,
etc., or airborne aerosols, contaminated food and water or contaminated hospital
equipment and instruments. (1)
3. Page 2
Commonest types of hospital acquired infections and their main causative
agents (bacteria, fungi or virus) in relation to important Laboratory and
diagnostic methods will be discussed.
There are many types of nosocomial infections such as:
1- UTIs: urinary tract infections or catheter induced infection.
2- Nosocomial pneumonia or ventilators acquired pneumonia.
3- Catheter-related bloodstream infection (CRBSI).
4- Surgical site infections (SSIs).
5- Hospital epidemics of diarrhea and vomiting.
6- Clostridium difficle infection.
7- Sepsis.
8- Hemodialysis viral infection (HIV, HBV, HCV). (2)
Laboratory diagnosis for commonest hospital acquired infections:
In order to reach the diagnosis for these commonest four HAIs. Laboratory
diagnostic tests and methods should be done as follows:
1- UTIs: are very common in the clinical microbiology laboratory. UTIs are
more common in women and girls than men.
Laboratory diagnosis (Urinalysis):-
The presence of WBC in urine sample under microscope absolutely
indicates the presence of infection.
Urine dipstick tests (i.e. nitrate-reductase and leucocyte esterase
detection).
Urine culturing a test to find germs (such as bacteria) in the urine that can
cause an infection. This method is done through prospective steps :
a- Specimen collection: In adults, most urine specimens for laboratory
examination are obtained by the clean catch-voided midstream
technique. This technique is widely accepted and applied because it is
simple, inexpensive and non-invasive and there is no risk of
4. Page 3
complications disadvantage of this technique is that the urine can be
contaminated with commensal bacteria during its passage through the
distal urethra.in young children Supra-pubic aspiration is the best
method to avoid urethral contamination, but it is infrequently used
nowadays because it invasive, uncomfortable and time-consuming.
Other way, straight catheter technique is the next-best technique to
obtain urine specimens with minimal contamination risk. But of course
have some disadvantages.
b- Specimen transportation and storage : inoculation of urine specimens
should be done within 2 h after collection however, it have to be stored
in tubes with preservatives up to 24 h at 2–8 °C to prevent
microorganism death.
c- Result interpretation: a positive result of urinary tract infection should
exclude the genus uropathogenes by sensitivity tests or under
microscope by gram staining.
UTIs causative agents include: Escherichia coli (almost 80-85% of cases)
due to uncomplicated or upper UTIs. Other organisms: Proteus,
Klebsiella, and Enterococcus. (3)
2- Nosocomial pneumonia (ventilators & non ventilators acquired): the
second most common nosocomial infection and accounts for 15–20% of the
total. HAP refers to any pneumonia contracted by a patient in a hospital at
least 48–72 hours after being admitted.
Main causative agents’ bacterial (90%): Staph.aureus and Pseudomonas
aeruginosa, Streptococcus pneumonia and H. influenza. (5)
Less likely to
be found: klebsiella. Viral (<10%): Respiratory Syncytial Virus and
Influenzae virus. (4)
Laboratory and diagnostic methods are:
a- Chest X-Ray: we can observe respiratory insufficiency, purulent
secretions, newly developed infiltrates.
5. Page 4
b- Blood sample :( red and white blood cell count, differential cell count,
creatinine and urea nitrogen, aminotransferases, sodium, potassium).
c- Arterial blood gas or pulse oximetry determinations (PO2, PCO2).
d- Bronchoscopy (sensitive).
e- Trans-thoracic needle aspiration (TNA): uses a cutting needle to
aspirate a core of tissue with some mucus to develop an accurate
diagnosis but it is recognized as an invasive procedure.
f- Sputum cultures with gram stain: is a test to detect and identify
bacteria, a sample of sputum is collected in a sterile, wide-mouthed,
purulent, leak-proof and break-resistant plastic-specimen. Fresh
morning sample is preferred.
g- Direct immunofluorescence & PCR: for detection of RSV, Influenzae
virus and corona viruses. (5)
3- Surgical site infections(SSIs): an infection that occurs after surgery in the
part of the body where the surgery took place , Wound infections account for
up to 20–30% of nosocomial infections.
The most common pathogens of SSIs are S.aureus, coagulase-negative
staphylococci, and enteric and anaerobic bacteria.
Laboratory diagnosis : depends on the site of infection as follows:
a- Culturing for microbiological purposes summarized in aspiration of the
wound abscess and exudates and prepares it for gram staining in order to
identify the specific invading organism. This method used for superficial
or mild SSIs.
b- Diagnosis of deeper organ-space infections or sub phrenic abscesses
requires a high index of suspicion and the use of CT or MRI. (4)
c- Standard blood test: increase in WBCs rate due to infection and increased
ESR and C-reactive protein (CRP) due to cellulitis.
6. Page 5
4- Catheter-related bloodstream infection (CRBSI): is defined as the
presence of bacteremia originating from an intravenous catheter. It is one of
the most frequent, lethal, and costly complications of central venous
catheterization and nosocomial infections. Clinical manifestations of
infections (i.e., fever, chills, and/or hypotension).
Causative agents: bacteria: S. aureus, Pseudomonas aeruginosa, E. coli,
Klebsiella pneumonia, fungi: Candida albicans spp.
Laboratory diagnostic methods:
a- Standard blood culturing: blood sample obtained from a peripheral vein.
Hint: Simultaneous quantitative paired blood cultures. However, a non-
quantitative blood culture drawn from the CVC that becomes positive at
least 2 hr. earlier than the peripheral blood culture, is a new method for
the diagnosis of CRBSI without removing the catheter. And as shown
figure below.
After that, the culture media are stained by gram or H&E stain. Then
gathered in microscopic studies.
b- Polymerase chain reaction (PCR): is a sensitive test used to detect
pathogen’s DNA.
c- Other methods : CT scan, MRI, FISH, and etc. (6)
7. Page 6
Conclusion:
With increased burden of nosocomial infections and antimicrobial resistance, it
has become difficult for healthcare administrations and infection control
committees to reach the goal for elimination of intervals. However, an efficient
surveillance method guided by WHO can help healthcare institutes to improve
infection control programs. It has provided Proper training to hospital staffs for
biosafety. Sufficient laboratory instruments and devices should present, to reach
to an accurate diagnosis for these types of infections as soon as possible.
References :
(1)Satish Gupte, “The Short Textbook of Medical Microbiology (Including
Parasitology)”, 10th edition, New Delhi, India: Jaypee Brothers Medical
Publishers (P) Ltd, 2010.
(2)Connie R. Mahon, Donald C. Lehman, “Textbook of diagnostic
microbiology”, 6th
edition, St. Louis, Missouri: Elsevier Inc., 2019.
(3) Wilson M, Gaido L, “Laboratory Diagnosis of Urinary Tract Infections
in Adult Patients”. “Clinical Infectious Diseases”, 2004;38(8):
p.1150-1158.Available from:
https://academic.oup.com/cid/article/38/8/1150/441696#32176083
(4)Dennis L. Kasper, Anthony S. Fauci, “HARRISON’S Infectious
Diseases”, 17th
edition, United States: The McGraw-Hill Companies,
2010.
(5)Woodhead M., “Guidelines for the management of adult lower
respiratory tract infections”, “European Respiratory Journal”. 2011;
38(6):p.1250-1251.
(6)Rupam G., Chaitanya N., “Catheter-related bloodstream infections”,
“International Journal of Critical Illness and Injury Science”. 2014; 4(2):
p.162–167.