At IDLIFE, we understand that no two people are alike. That's why we developed IDNutrition. You simple take a FREE, thorough, confidential online assessment based on your diet, lifestyle, body type, physical condition, health issues and medications. You then receive a personalized supplement recommendation. Our proprietary formula uses the science of Chronobiology which assures that nutrients are delivered to the body system when they are needed. You receive a personalized nutritional program delivered in easy, convenient, portable AM/PM packs that deliver exactly the right nutrients your body needs at the right time.
At IDLIFE, we understand that no two people are alike. That's why we developed IDNutrition. You simple take a FREE, thorough, confidential online assessment based on your diet, lifestyle, body type, physical condition, health issues and medications. You then receive a personalized supplement recommendation. Our proprietary formula uses the science of Chronobiology which assures that nutrients are delivered to the body system when they are needed. You receive a personalized nutritional program delivered in easy, convenient, portable AM/PM packs that deliver exactly the right nutrients your body needs at the right time.
Covers information on soil formation, soil characteristics, soil food webs, globals soil maps, and ESTAR satellite data and a link to NCRS GIS soil database
At the completion of this unit, learners will be able to: 1. Define the term joint. 2. List three types of joints I.e. Fibrous Cartilaginous Synovial 3. Describe the common characteristic features of a synovial joint. 4. List the types of synovial joints. 5. Discuss the types of movements possible at synovial joints.
A joint is an articulation between two bones in the body and are broadly classified by the tissue which connects the bones. The three main types of joints are: synovial, cartilaginous and fibrous.
Joints, function and types of joints.pptx10khan113ii
Joints, or articulations, are the structures where two or more bones meet, allowing for movement and providing mechanical support. They are essential for a wide range of motions and functions in the human body. Here's a detailed description of joints:
### Types of Joints Based on Structure:
1. **Fibrous Joints**:
- **Description**: Connected by dense connective tissue rich in collagen.
- **Movement**: Generally immovable (synarthrotic).
- **Examples**: Sutures in the skull, syndesmoses between long bones like the tibia and fibula.
2. **Cartilaginous Joints**:
- **Description**: Bones connected entirely by cartilage (either hyaline or fibrocartilage).
- **Movement**: Allow limited movement (amphiarthrotic).
- **Examples**: Intervertebral discs, pubic symphysis.
3. **Synovial Joints**:
- **Description**: Characterized by a fluid-filled synovial cavity that separates the articulating bones.
- **Movement**: Freely movable (diarthrotic), with various degrees and types of movement depending on the specific joint type.
- **Examples and Subtypes**:
- **Hinge Joints**: Permit flexion and extension (e.g., elbow, knee).
- **Ball-and-Socket Joints**: Allow rotational movement and a wide range of motion (e.g., shoulder, hip).
- **Pivot Joints**: Enable rotational movement around a single axis (e.g., atlantoaxial joint in the neck).
- **Gliding Joints**: Allow sliding or gliding movements (e.g., intercarpal joints in the wrist).
- **Saddle Joints**: Permit movement along two planes (e.g., thumb joint).
- **Condyloid Joints**: Allow movement but no rotation (e.g., wrist joint between the radius and carpal bones).
### Types of Joints Based on Function:
1. **Synarthroses**:
- **Description**: Immovable joints providing strong, stable connections.
- **Examples**: Skull sutures.
2. **Amphiarthroses**:
- **Description**: Slightly movable joints.
- **Examples**: Intervertebral discs, pubic symphysis.
3. **Diarthroses**:
- **Description**: Freely movable joints, synonymous with synovial joints.
- **Examples**: Most limb joints like the knee, hip, shoulder.
### Joint Anatomy:
- **Cartilage**: Covers the ends of bones, providing a smooth surface for movement and cushioning.
- **Synovial Membrane**: Lines the joint capsule and secretes synovial fluid for lubrication.
- **Ligaments**: Strong bands of connective tissue that connect bones and stabilize the joint.
- **Tendons**: Connect muscle to bone, aiding in joint movement.
- **Bursae**: Fluid-filled sacs that reduce friction between moving structures within the joint.
### Functions of Joints:
- **Movement**: Facilitate a range of bodily movements, from gross motor functions like walking and lifting to fine motor skills like writing and typing.
- **Support**: Maintain the body's structure and posture.
- **Protection**: Protect internal structures by providing cushioning and absorbing impact.
All human joints including axial and appendicular skeleton will clear all the concepts and doubts of learner related to joints and different classification of joints with detail. Also, help student, learner, reader to communicate.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
2. A joint or place of articulation
and is formed where 2 or more
bones come in close contact in
the body and are attached to
each other by ligaments or
cartilage.
Tanveer Saeed
4. There are three types of joints
classified by the amount of
movement they allow:
Fibrous or Immovable----
synarthrosis
Cartilaginous or slightly movable---
Amphiarthrosis
Synovial or freely movable----
diathrosis
Tanveer Saeed
6. Amphiarthrosis or Cartilaginous Joints
This type of joint is characterized by bones
that are connected by hyaline cartilage (fibro
cartilage) and ligaments which allow only
a limited degree of movement.
Examples are
the vertebrae
cartilage in the symphysis which binds the
pubic bones together
cartilage in the joint between the sacrum
and the hip bone.
The ribs that connect to the sternum.
Tanveer Saeed
8. Most of the joints in the adult human
body are freely movable joints.
There are six types of diarthroses joints:
Ball-and-Socket
Condyloid
Saddle
Pivot
Hinge
Gliding
Tanveer Saeed
11. The capsular ligament is lined with
a synovial membrane.
This membrane secretes synovial fluid into
the synovial cavity
acts as a seal, waterproofing the
joint,lubricates the joint.
In addition to the capsule, the bones are
also attached and held together by strong,
tough ligaments made of dense connective
tissue. These ligaments prevent
dislocation during normal movement.
Tanveer Saeed
12. Synovial joints can be subdivided into the
following groups according to the type of
movement they carry out.
All combinations of movements, including
circumduction and rotationcan be
performed.
Tanveer Saeed
13. Tanveer Saeed+
Directions of movement ( ROM)
Flexion - brings a body part forward.
Extension - moves a body part to the rear.
Abduction - moves an appendage laterally from
the midline.
Adduction - moves an appendage toward the
midline.
Circumduction - movement of an appendage in a
circle around a joint.
Pronation - rotating the palm of the hand
downward.
Supination - rotating the palm of the hand
upward.
Inversion - turning the toes of the foot inward.
Eversion - turning the toes of the foot outward.
14. Tanveer Saeed
These joints are formed
where the rounded
head of one bone fits into
the hollow, cup-shaped
socket of another bone
such as the shoulder
joint and the hip joint.
Such joints
allow freedom of
movement in all
directions.
Ball-and-Socket
The Hip Joint - ball-and-socket joint.
15. . These joints occur where the convex
surface of one bone fits into the concave
surface of another bone, so making
movement possible in one plane only e.g.
flexion and extension as in the elbow and
knee joints.
Examples of these joints are the :
knee ,ankle and the elbow joints.
Hinge joints have ligaments mainly at the
sides of the joints.
Tanveer Saeed
18. Oval shaped condyle fits into oval cup
shaped end of another bone allowing
angular motion but not rotation.
Flexion,extension,adduction,abduction
and circumduction but no axial rotation.
Examples include:
wrist joint
Metacarpophalangeal joints(Knuckles)
Meta tarsophalangeal joints (toes)
Tanveer Saeed
19. This type of joint occurs when the
touching surfaces of two bones have
both concave and convex regions
allowing rotation in two directions.
The only saddle joint in the body is in
the thumb.
Tanveer Saeed
20. This type of joint allows for gliding
movements between flat surfaces as the
surfaces slide over one another. Only
a limited amount of movement is allowed
such as the joints between,
clavicles and the sternum
the carpal bones
the joints between the tarsal bones
Tanveer Saeed
22. These joints occur where:
◦ a bony ring rotates round the
pivot (axis) of another bone such
as the ring-like atlas rotating
around the odontoid process of
the axis, allowing the head to
turn from side to side.
◦ the end of one
bone rotates round the axis of
another bone such as the end of
the radius rotating around the
ulna as the palm of the hand isTanveer Saeed
23. A pivot joint between the radius
and ulna
Tanveer Saeed
24. Tanveer Saeed
Self quiz to check what you have learned.
1.A point where one or two bones meet is__________.
2. Ball and socket, hinge, gliding and pivot joints are
example of _______.
3. Elbows, knees and fingers use what type of
joints________.
4. What type of joint can be found between
vertebrae________.
5. What type of movement is possible at Joint between
atlas and axis___________.
6. What type of joints are present in below mentioned
diagram___________.