Ion-exclusion chromatography is a technique that separates ionic compounds from non-ionic compounds and separates mixtures of acids. It functions using a Donnan exclusion mechanism with an ion exchange resin stationary phase and a liquid mobile phase. Ionic substances pass through the column quickly while non-ionic or partially ionized substances are retained longer. The technique has applications in determining neutral molecules, strong inorganic acids, carboxylic acids, and weakly ionized inorganic acids and bases from samples like wastewater. Conductivity and UV-visible detectors can be used and columns are typically glass, stainless steel, or polymer.