Hyperbaric oxygen therapy (HBOT) utilizes 100% oxygen at pressures greater than atmospheric pressure to treat various medical conditions, with historical uses dating back to 1662. The therapy is based on principles such as increased oxygen solubility, mechanical effects, and stimulation of healing processes, with 14 approved medical indications ranging from decompression sickness to carbon monoxide poisoning. Different types of chambers, including portable, monoplace, and multiplace models, are used to administer the therapy, which is also utilized off-label for various neurological and orthopedic conditions.