Jet ventilation is a form of mechanical ventilation that uses very high respiratory rates and small tidal volumes delivered via a jet of gas. It can be used supraglottically or subglottically for procedures involving the airway. Key indications are subglottic and tracheal stenosis. The jet ventilator provides active insufflation of gas while exhalation is passive. Gas exchange occurs via mechanisms like laminar flow and Taylor dispersion. Precautions must be taken to ensure adequate ventilation and monitoring of end-tidal CO2. Complications can include barotrauma, pneumothorax, or difficulty ventilating.
Intro to Hypoxic pulmonary vasoconstriction Arun Shetty
Hypoxic pulmonary vasoconstriction, a seldom heard phenomenon but very effective physiologic property which helps lungs utilise ventilation to the maximum
Intro to Hypoxic pulmonary vasoconstriction Arun Shetty
Hypoxic pulmonary vasoconstriction, a seldom heard phenomenon but very effective physiologic property which helps lungs utilise ventilation to the maximum
In critical care medicine the invasive life saving techniques are often employed and when all goes well such interventions will be withdrawn to all for normal physiology to resume. Identifying this point for safe withdrawal for the resumption of normal respiratory function is of utmost importance.
In critical care medicine the invasive life saving techniques are often employed and when all goes well such interventions will be withdrawn to all for normal physiology to resume. Identifying this point for safe withdrawal for the resumption of normal respiratory function is of utmost importance.
Basic concepts in neonatal ventilation - Safe ventilation of neonatemohamed osama hussein
Lecture by by dr Muhammad Ezzat Abdel-Shafy MB.BCh, M.Sc Pediatrics Neonatology Sp. , Benha Children Hospital, provided during our Doctors neonatology workshop, 20th of January 2017
Navigating the Health Insurance Market_ Understanding Trends and Options.pdfEnterprise Wired
From navigating policy options to staying informed about industry trends, this comprehensive guide explores everything you need to know about the health insurance market.
Antibiotic Stewardship by Anushri Srivastava.pptxAnushriSrivastav
Stewardship is the act of taking good care of something.
Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials (including antibiotics), improves patient outcomes, reduces microbial resistance, and decreases the spread of infections caused by multidrug-resistant organisms.
WHO launched the Global Antimicrobial Resistance and Use Surveillance System (GLASS) in 2015 to fill knowledge gaps and inform strategies at all levels.
ACCORDING TO apic.org,
Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials (including antibiotics), improves patient outcomes, reduces microbial resistance, and decreases the spread of infections caused by multidrug-resistant organisms.
ACCORDING TO pewtrusts.org,
Antibiotic stewardship refers to efforts in doctors’ offices, hospitals, long term care facilities, and other health care settings to ensure that antibiotics are used only when necessary and appropriate
According to WHO,
Antimicrobial stewardship is a systematic approach to educate and support health care professionals to follow evidence-based guidelines for prescribing and administering antimicrobials
In 1996, John McGowan and Dale Gerding first applied the term antimicrobial stewardship, where they suggested a causal association between antimicrobial agent use and resistance. They also focused on the urgency of large-scale controlled trials of antimicrobial-use regulation employing sophisticated epidemiologic methods, molecular typing, and precise resistance mechanism analysis.
Antimicrobial Stewardship(AMS) refers to the optimal selection, dosing, and duration of antimicrobial treatment resulting in the best clinical outcome with minimal side effects to the patients and minimal impact on subsequent resistance.
According to the 2019 report, in the US, more than 2.8 million antibiotic-resistant infections occur each year, and more than 35000 people die. In addition to this, it also mentioned that 223,900 cases of Clostridoides difficile occurred in 2017, of which 12800 people died. The report did not include viruses or parasites
VISION
Being proactive
Supporting optimal animal and human health
Exploring ways to reduce overall use of antimicrobials
Using the drugs that prevent and treat disease by killing microscopic organisms in a responsible way
GOAL
to prevent the generation and spread of antimicrobial resistance (AMR). Doing so will preserve the effectiveness of these drugs in animals and humans for years to come.
being to preserve human and animal health and the effectiveness of antimicrobial medications.
to implement a multidisciplinary approach in assembling a stewardship team to include an infectious disease physician, a clinical pharmacist with infectious diseases training, infection preventionist, and a close collaboration with the staff in the clinical microbiology laboratory
to prevent antimicrobial overuse, misuse and abuse.
to minimize the developme
India Clinical Trials Market: Industry Size and Growth Trends [2030] Analyzed...Kumar Satyam
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Growing Prevalence of Lifestyle Diseases
The rising incidence of lifestyle diseases such as diabetes, cardiovascular diseases, and cancer is a major trend driving the clinical trials market in India. These conditions necessitate the development and testing of new treatment methods, creating a robust demand for clinical trials. The increasing burden of these diseases highlights the need for innovative therapies and underscores the importance of India as a key player in global clinical research.
Defecation
Normal defecation begins with movement in the left colon, moving stool toward the anus. When stool reaches the rectum, the distention causes relaxation of the internal sphincter and an awareness of the need to defecate. At the time of defecation, the external sphincter relaxes, and abdominal muscles contract, increasing intrarectal pressure and forcing the stool out
The Valsalva maneuver exerts pressure to expel faeces through a voluntary contraction of the abdominal muscles while maintaining forced expiration against a closed airway. Patients with cardiovascular disease, glaucoma, increased intracranial pressure, or a new surgical wound are at greater risk for cardiac dysrhythmias and elevated blood pressure with the Valsalva maneuver and need to avoid straining to pass the stool.
Normal defecation is painless, resulting in passage of soft, formed stool
CONSTIPATION
Constipation is a symptom, not a disease. Improper diet, reduced fluid intake, lack of exercise, and certain medications can cause constipation. For example, patients receiving opiates for pain after surgery often require a stool softener or laxative to prevent constipation. The signs of constipation include infrequent bowel movements (less than every 3 days), difficulty passing stools, excessive straining, inability to defecate at will, and hard feaces
IMPACTION
Fecal impaction results from unrelieved constipation. It is a collection of hardened feces wedged in the rectum that a person cannot expel. In cases of severe impaction the mass extends up into the sigmoid colon.
DIARRHEA
Diarrhea is an increase in the number of stools and the passage of liquid, unformed feces. It is associated with disorders affecting digestion, absorption, and secretion in the GI tract. Intestinal contents pass through the small and large intestine too quickly to allow for the usual absorption of fluid and nutrients. Irritation within the colon results in increased mucus secretion. As a result, feces become watery, and the patient is unable to control the urge to defecate. Normally an anal bag is safe and effective in long-term treatment of patients with fecal incontinence at home, in hospice, or in the hospital. Fecal incontinence is expensive and a potentially dangerous condition in terms of contamination and risk of skin ulceration
HEMORRHOIDS
Hemorrhoids are dilated, engorged veins in the lining of the rectum. They are either external or internal.
FLATULENCE
As gas accumulates in the lumen of the intestines, the bowel wall stretches and distends (flatulence). It is a common cause of abdominal fullness, pain, and cramping. Normally intestinal gas escapes through the mouth (belching) or the anus (passing of flatus)
FECAL INCONTINENCE
Fecal incontinence is the inability to control passage of feces and gas from the anus. Incontinence harms a patient’s body image
PREPARATION AND GIVING OF LAXATIVESACCORDING TO POTTER AND PERRY,
An enema is the instillation of a solution into the rectum and sig
Telehealth Psychology Building Trust with Clients.pptxThe Harvest Clinic
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One of the most developed cities of India, the city of Chennai is the capital of Tamilnadu and many people from different parts of India come here to earn their bread and butter. Being a metropolitan, the city is filled with towering building and beaches but the sad part as with almost every Indian city
1. Jet ventilation in the operating
room
HELGA KOMEN, MD
DEPARTMENT OF ANESTHESIOLOGY, WASHINGTON UNIVERSITY IN ST LOUIS
2. Jet ventilation - definition
◦ High frequency jet ventilation (HFJV) is a form of mechanical ventilation that
combines very high respiratory rates (>60 breaths per minute, i.e. > 1 Hz (1 Hz = 1 cycle/sec.))
with tidal volumes that are smaller than the volume of total dead space, anatomic +
equipment (<1mL/kg), using a jet of gas [Standiford TJ et al. Chest 1989.].
◦ That is what we use in the OR
◦ First described by Klain and Smith!
◦ Klain M, Smith RB: High frequency percutaneous transtracheal jet ventilation. Crit Care Med 1977;
5: 280-7
JET VENTILATION IN THE OPERATING ROOM
3. Jet ventilation – available only in Europe (not FDA approved!)
◦ Superimposed jet ventilation (SHFJV®) - jet ventilation of normal frequency (<1Hz)
and high frequency (>1Hz) conducted simultaneously, permits ventilation at two different
pressure plateaus. Thus, oxygenation as well as CO2 elimination can be regulated efficiently.
(e.g. Twinstream™).
◦ We don`t have it
◦ This technique cannot be applied through an infraglottic or transtracheal catheter.
◦ First described in 1990s
◦ Aloy A, Schachner M, Spiss CK, Cancura W: [Tube-free translaryngeal superposed jet ventilation].
Anaesthesist 1990; 39: 493-8 26.
◦ Kull M, Samarütel J, Nurm V: Double frequency jet ventilation for endolaryngeal laser surgery. Lasers
in medical science 1993; 8: 141- 146
JET VENTILATION IN THE OPERATING ROOM
7. HFJV - principles
-The insufflation of gas through the jet nozzle is an active process, whereas
the exhalation happens outside the jet nozzle and is passive (picture!)
- Tidal volumes utilized are smaller than the total dead space (anatomical +
equipment), therefore gas exchange must occur via *alternative means (next
slide!) in addition to the standard bulk flow (convective) ventilation that occurs
during a normal inspiratory-expiratory cycle.
- Expired gas flows out passively during HFJV, seeking its path of least resistance in
the annular or “unused” spaces around the highly accelerated inspired gas. By
moving out along the airway walls, expired gas facilitates mucociliary clearance.
JET VENTILATION IN THE OPERATING ROOM
8. *Alternative means of gas exchange:
•Laminar flow (non-turbulent, low Reynolds number) in small airways produces a scenario where the high-
pressure of the delivered breath flows down the middle of the airway and the margins of the airway contain gas
moving in the opposite direction.
•The Pedulluft effect describes the movement of inspired gas from those alveoli that fill the fastest to those that
are slower to fill. This is based on the fact that there is variability between alveoli in both resistance and
compliance.
•Taylor dispersion (convective streaming) is the diffusion of the high velocity central gases to the margins of the
airway. This phenomenon primarily occurs in the smaller airways and further enhances gas mixing and hence
exchange.
•Cardiogenic mixing also contributes to gas exchange during jet ventilation, albeit likely to a lesser extent than
those mentioned previously. It occurs as a result of the rhythmic, pulsatile nature of the heart conferring a mixing
of gases
- It is important to maintain an adequate portion of the upper airway open to the atmosphere, to allow exhalation
and thus avoiding overdistention of the distal airways (inadvertent PEEP increases).
JET VENTILATION IN THE OPERATING ROOM
HFJV - principles
9. (Relative) Contraindications for HFJV
- Airway stenosis >50% preventing air egress of gas following insufflation - no catheter should be
introduced through an airway narrowing when the remaining cross section for exhalation is less
than 50% of normal. Supraglottic jet ventilation advised!
- Morbid obesity preventing ventilation with patient relaxed (airway collapse, difficulty
visualizing chest rise and fall)
JET VENTILATION IN THE OPERATING ROOM
10. Picture of jet vent machine (take it!)
JET VENTILATION IN THE OPERATING ROOM
11. HFJV in the operating room - equipment
- Monsoon jet ventilator (POD5 (East pavillion supply room)
one and POD3 one)
- CO2 transcutaneous monitor
- Rigid laryngoscope (inserted by surgeon)
- Jet cannula
JET VENTILATION IN THE OPERATING ROOM
12. - Supraglottic
jet cannula
- Subglottic - Hunsaker tube, LaserJet catheter
HFJV in the operating room - delivery
JET VENTILATION IN THE OPERATING ROOM
13. -Make sure patient received good preoxygenation
-All the equipment (surgeon, jet vent) has to be ready/checked before induction
-After induction of anesthesia (fentanil/propofol/succinylcholine) direct laryngoscopy is
performed by the surgeon. Jet cannula is attached to the rigid laryngoscope
-Jet Ventilation is started
- typical settings – driving pressure (DP) 20-30 psi, frequency (f) 120/cpm, FjetO2 100%
- Make sure you see “rise and fall” of the chest wall (smaller amplitude than during ventilation
through OT tube)
- If laser is used, press option `laser` on jet ventilator (lowers FjetO2 to 30%)
JET VENTILATION IN THE OPERATING ROOM
HFJV - Induction of Anestheshia
14. HFJV - Maintenance of Anesthesia
- TIVA – remifentanil + propofol infusion
- Transcutaneous CO2 monitoring - PtcCO2
• latency period of approximately 1 minute
• transcutaneous measurement is local only (it does not represent a global value of the whole organism,
but it yields a fair trend of the global CO2 course)
• an increase of PaCO2 to the extent of 1.5 times baseline can be tolerated at the end of surgery
• If PtcCO2 high, try increasing DP (max 40psi)
-BIS monitoring- preferable
-Muscle relaxation – usually, procedure is one hour long. You may choose to use rocuronium
(Sugammadex?!)
JET VENTILATION IN THE OPERATING ROOM
15. - HFJV does NOT allow: setting specific tidal volume, sampling EtCO2
Inspiratory time (IT)%: 35% (about 1/3 of the respiratory cycle)
DP: 20-40 psi (pound-force per square inch)
f: 120/cpm (above 100/cpm ventilator safety features work best)
Humidifier: As Needed (not required for cases <30mins, in ICU mandatory due to prolonged
ventilation), <50% humidity
PP: 24 cmH2O (may increase as needed – consider as mean airway pressure; measure through
same port/tube used for jet ventilation (BLUE line))
PIP: 28 cmH2O (measured through separate port/tube than used for jet ventilation (RED line),
e.g. when we use Hunsaker tube it can be attached to side port)
Laser FiO2% = 30%
-IT and f improve oxygenation (by increasing "auto-PEEP" or pause pressure), while an increase
in DP and a decrease in f, improve ventilation (CO2 exchange).
Jet ventilator settings
JET VENTILATION IN THE OPERATING ROOM
16. • Optimum frequency for the broadest range of lung pathologies (approx. 90 – 93%) ranges between f =
110 – 140/cpm in patients weighing more than 12 kg.
• The lowest peak pressure in airways with a tolerable inadvertent PEEP occurs at a frequency of 120
c/min.
• Pawmax increases at frequencies under 100 c/min and inadvertent PEEP increases at frequencies over
150 c/min.
• For this reason the recommended golden standard is a frequency of = 120 cpm.
• An increase in DP results in higher TV and MV; however, this relationship is not linear
because of the complex interaction of multiple factors.
Jet ventilator settings – frequency
JET VENTILATION IN THE OPERATING ROOM
17. -Difficulty ventilating
-CO2 retention (transcutaneous monitoring available!) - Degree of gas exchange is uknown until
end tital capnography or ABG obtained, i.e. limited conditions for monitoring gas exchange and
mechanics of ventilation in contrast to conventional ventilation
-Hypoxia
-Barotrauma - observation of chest rising during inspiratory phase and falling during expiratory
phase remains the main safety feature to prevent BAROTRAUMA.
- Pneumothorax
- Mediastinal emphysema, Subcutaneous emphysema (more frequent with transtracheal ventilation )
-Gastric distension
-Distal seeding of virus if used for papilloma surgery (N95 mask mandatory)
JET VENTILATION IN THE OPERATING ROOM
Jet ventilation complications
- postoperative CXR indicated after each case!
18. Manual jet ventilation
• Emergency ventilation situations – post-cricothyrotomy trans-tracheal ventilation
• Equipment
• High-pressure non-collapsible oxygen tubing
• Oxygen source with a flow at 10-15 L/min or higher
• Manual jet ventilator/insufflator device - hand held
• Pressure regulator (less than 50 psi)
- Start with low-frequency JV with approximately 20 cpm, DP 10psi
Increase DP by 5 psi at a time if SpO2 not satisfying.
- We have 3 Manual jet ventilators on POD5 (two in airway carts between ORs
218 and 219, and one in the supply room West pavillion)
JET VENTILATION IN THE OPERATING ROOM