This document discusses hypertrophic pyloric stenosis, a condition where the pylorus (lower part of the stomach) becomes narrowed, preventing food from moving to the intestines. It typically affects infants 2-8 weeks old and is more common in boys. The narrowing is caused by thickening of the pyloric muscles. Symptoms include projectile vomiting and failure to gain weight. Diagnosis involves physical exam, barium X-ray, and blood tests. Treatment is pyloromyotomy surgery to open the tightened muscles. Nursing care focuses on monitoring fluids and electrolytes pre-op and the incision site and bowel function post-op.
Bladder exstrophy is a congenital (present at birth) abnormality of the bladder. It happens when the skin over the lower abdominal wall (bottom part of the tummy) does not form properly, so the bladder is open and exposed on the outside of the abdomen. In epispadias, the urethra does not form properly.
PYLORIC STENOSIS:
Review the anatomy and physiology of digestive system
Review the incidence of pyloric stenosis
Define pyloric stenosis
Explain the causes and risk factors of pyloric stenosis
Describe the pathophysiology of pyloric stenosis
Enumerate clinical features of pyloric stenosis
Enlist the diagnostic evaluation for pyloric stenosis
Explain the management of pyloric stenosis
Enumerate the complications of pyloric stenosis
Hypospadias is a relatively rare congenital condition where the opening of the penis is on the underside of the organ. This condition is more common in infants with a family history of hypospadias.
The penis may curve down in an infant and the baby may spray while urinating.
Bladder exstrophy is a congenital (present at birth) abnormality of the bladder. It happens when the skin over the lower abdominal wall (bottom part of the tummy) does not form properly, so the bladder is open and exposed on the outside of the abdomen. In epispadias, the urethra does not form properly.
PYLORIC STENOSIS:
Review the anatomy and physiology of digestive system
Review the incidence of pyloric stenosis
Define pyloric stenosis
Explain the causes and risk factors of pyloric stenosis
Describe the pathophysiology of pyloric stenosis
Enumerate clinical features of pyloric stenosis
Enlist the diagnostic evaluation for pyloric stenosis
Explain the management of pyloric stenosis
Enumerate the complications of pyloric stenosis
Hypospadias is a relatively rare congenital condition where the opening of the penis is on the underside of the organ. This condition is more common in infants with a family history of hypospadias.
The penis may curve down in an infant and the baby may spray while urinating.
A Tracheoesophageal fistula (TEF) is an abnormal connection (fistula) between the Oesophagus and the trachea. TEF is a common congenital abnormality.
Oesophageal atresia is failure of oesophagus to form a continuous passage from the pharynx to the stomach
TEF is an abnormal connection between the trachea and the oesophagus
PYLORIC STENOSIS
Pyloric stenosis is a medical condition in which the pylorus, the muscular valve between the stomach and the small intestine, becomes abnormally narrowed or obstructed, leading to the obstruction of the gastric outlet. This narrowing of the pylorus prevents the proper passage of food from the stomach to the small intestine.
The exact cause of pyloric stenosis is still unknown, but it is believed to have a multifactorial etiology.
Genetic factors are thought to play a role, as there is a higher incidence of pyloric stenosis among siblings and family members.
Environmental factors may also contribute to the development of the condition, but specific triggers remain unidentified.
The hallmark symptom of pyloric stenosis is projectile vomiting, which occurs shortly after feeding.
Vomitus is often non-bilious and may resemble curdled milk.
Forceful vomiting that may project several feet away from the infant.
Signs of hunger and irritability despite frequent feeding attempts.
Weight loss or poor weight gain.
Dehydration and electrolyte imbalances due to excessive vomiting.
Palpable “olive-shaped” mass in the epigastric region.
Infants appear hungry, irritable, and unsatisfied after feeds.
Physical Examination:
Palpation of the abdomen may reveal a palpable “olive-shaped” mass in the epigastric region, which represents the hypertrophied pylorus.
The “olive” can often be felt when the infant is in a relaxed state and the stomach is empty.
Abdominal Ultrasound:
Abdominal ultrasound is the primary diagnostic tool for confirming pyloric stenosis.
Fluid and Electrolyte Management:
Prior to surgery, infants with pyloric stenosis often require fluid resuscitation and correction of electrolyte imbalances caused by excessive vomiting.
Intravenous hydration and electrolyte replacement may be necessary to restore the infant’s fluid and electrolyte balance.
Atropine Therapy:
In some cases, medical management with intravenous atropine may be attempted as a temporary measure to relieve pyloric spasm and improve the passage of food.
Surgical management of pyloric stenosis involves performing a pyloromyotomy.
This procedure is typically done under general anaesthesia and can be performed as an open surgery or laparoscopically.
Postoperative Nursing Care:
Monitor vital signs, surgical site, and signs of infection, such as fever, redness, swelling, or discharge.
Administer prescribed pain medications and antibiotics.
Observe for complications, such as bleeding or infection, and report any abnormalities to the healthcare team.
Encourage early feeding and monitor for successful feeding tolerance, ensuring the infant is retaining and digesting food properly.
Educate parents about postoperative care, including incision care, feeding techniques, and signs of potential complications, emphasizing the importance of follow-up visits and ongoing care.
A developmental anomaly is a broad term used to define conditions which are present at conception or occur before the end of pregnancy. In the case of cerebral palsy, a small number also occur after birth. this is also a birth defect.
A Tracheoesophageal fistula is a congenital disease. It is a acquired communication between the trachea and esophagus. Most of the patient with TEF are diagnosed immediately following after birth.TEF are often associated with life threatening complications.
Intestinal obstruction, is a mechanical or functional obstruction of the intestines which prevents the normal movement of the products of digestion. Either the small bowel or large bowel may be affected. Signs and symptoms include abdominal pain, vomiting, bloating and not passing gas.
Introduction
• Pyloric stenosis is also known as pylorostenosis or infantile hypertrophic pyloric stenosis. It is the most common cause of intestinal obstruction in infants. It is a form of obstruction in the gastric outlet which means a blockage from stomach to intestine.
• It was First described by Hirschsprung in 1888
• Ramstedt described an operative procedure to alleviate the condition in 1907 – the procedure used to this day to treat pyloric stenosis.
Definition
• Hypertrophic pyloric stenosis is a marked and progressive outgrowth or enlargement of circular muscle fibers of pylorus causing partial or total obstruction of the stomach outlet due to narrowing of lumen.
Anatomy
The stomach sits in the upper abdomen on left side of the body. The top of the stomach connects to a valve called the esophageal sphincter (a muscle at the end of esophagus). The bottom of stomach connects to small intestine.
The stomach is divided into 5 regions:
• The cardia is the top part of the stomach. It contains the cardiac sphincter, which prevents food from traveling back up the esophagus.
• The fundus is a rounded section next to the cardia. It's below the diaphragm (the dome-shaped muscle that helps to breathe).
• The body (corpus) is the largest section of the stomach. In the body, stomach contracts and begins to mix food.
• The antrum lies below the body. It holds food until the stomach is ready to send it to your small intestine.
• The pylorus is the bottom part of the stomach. It includes the pyloric sphincter. This ring of tissue controls when and how stomach contents move to the small intestine.
Incidence
• It is more commonly seen in child with 2-5wks of age.
• 2-9 per 1000 livebirths can be born with this condition.
• Predominant sex: Male > Female (6:1). Males are more prone to get
• Genetic predisposition can be an underlying factor for disease causation.
• Full term babies especially first borne are most commonly affected.
• Death from infantile hypertrophic pyloric stenosis is rare and unexpected; the reported mortality rate is very low and usually results from delays in diagnosis with eventual dehydration and shock.
Etiology
• Idiopathic
• Other factors : *maternal stress especially in third trimester *elevated prostaglandin levels *deficiency of nitric acid *immature pyloric ganglion cells with abnormal muscle innervation.
• In adults, it can occur due to history of peptic ulcer in pylorus region and hypertrophic changes in muscle layer of pylorus.
Risk factors
• Sex. Pyloric stenosis is seen more often in boys — especially firstborn children — than in girls.
• Race. Pyloric stenosis is more common in whites of northern European ancestry, less common in Black people and rare in Asian
A Tracheoesophageal fistula (TEF) is an abnormal connection (fistula) between the Oesophagus and the trachea. TEF is a common congenital abnormality.
Oesophageal atresia is failure of oesophagus to form a continuous passage from the pharynx to the stomach
TEF is an abnormal connection between the trachea and the oesophagus
PYLORIC STENOSIS
Pyloric stenosis is a medical condition in which the pylorus, the muscular valve between the stomach and the small intestine, becomes abnormally narrowed or obstructed, leading to the obstruction of the gastric outlet. This narrowing of the pylorus prevents the proper passage of food from the stomach to the small intestine.
The exact cause of pyloric stenosis is still unknown, but it is believed to have a multifactorial etiology.
Genetic factors are thought to play a role, as there is a higher incidence of pyloric stenosis among siblings and family members.
Environmental factors may also contribute to the development of the condition, but specific triggers remain unidentified.
The hallmark symptom of pyloric stenosis is projectile vomiting, which occurs shortly after feeding.
Vomitus is often non-bilious and may resemble curdled milk.
Forceful vomiting that may project several feet away from the infant.
Signs of hunger and irritability despite frequent feeding attempts.
Weight loss or poor weight gain.
Dehydration and electrolyte imbalances due to excessive vomiting.
Palpable “olive-shaped” mass in the epigastric region.
Infants appear hungry, irritable, and unsatisfied after feeds.
Physical Examination:
Palpation of the abdomen may reveal a palpable “olive-shaped” mass in the epigastric region, which represents the hypertrophied pylorus.
The “olive” can often be felt when the infant is in a relaxed state and the stomach is empty.
Abdominal Ultrasound:
Abdominal ultrasound is the primary diagnostic tool for confirming pyloric stenosis.
Fluid and Electrolyte Management:
Prior to surgery, infants with pyloric stenosis often require fluid resuscitation and correction of electrolyte imbalances caused by excessive vomiting.
Intravenous hydration and electrolyte replacement may be necessary to restore the infant’s fluid and electrolyte balance.
Atropine Therapy:
In some cases, medical management with intravenous atropine may be attempted as a temporary measure to relieve pyloric spasm and improve the passage of food.
Surgical management of pyloric stenosis involves performing a pyloromyotomy.
This procedure is typically done under general anaesthesia and can be performed as an open surgery or laparoscopically.
Postoperative Nursing Care:
Monitor vital signs, surgical site, and signs of infection, such as fever, redness, swelling, or discharge.
Administer prescribed pain medications and antibiotics.
Observe for complications, such as bleeding or infection, and report any abnormalities to the healthcare team.
Encourage early feeding and monitor for successful feeding tolerance, ensuring the infant is retaining and digesting food properly.
Educate parents about postoperative care, including incision care, feeding techniques, and signs of potential complications, emphasizing the importance of follow-up visits and ongoing care.
A developmental anomaly is a broad term used to define conditions which are present at conception or occur before the end of pregnancy. In the case of cerebral palsy, a small number also occur after birth. this is also a birth defect.
A Tracheoesophageal fistula is a congenital disease. It is a acquired communication between the trachea and esophagus. Most of the patient with TEF are diagnosed immediately following after birth.TEF are often associated with life threatening complications.
Intestinal obstruction, is a mechanical or functional obstruction of the intestines which prevents the normal movement of the products of digestion. Either the small bowel or large bowel may be affected. Signs and symptoms include abdominal pain, vomiting, bloating and not passing gas.
Introduction
• Pyloric stenosis is also known as pylorostenosis or infantile hypertrophic pyloric stenosis. It is the most common cause of intestinal obstruction in infants. It is a form of obstruction in the gastric outlet which means a blockage from stomach to intestine.
• It was First described by Hirschsprung in 1888
• Ramstedt described an operative procedure to alleviate the condition in 1907 – the procedure used to this day to treat pyloric stenosis.
Definition
• Hypertrophic pyloric stenosis is a marked and progressive outgrowth or enlargement of circular muscle fibers of pylorus causing partial or total obstruction of the stomach outlet due to narrowing of lumen.
Anatomy
The stomach sits in the upper abdomen on left side of the body. The top of the stomach connects to a valve called the esophageal sphincter (a muscle at the end of esophagus). The bottom of stomach connects to small intestine.
The stomach is divided into 5 regions:
• The cardia is the top part of the stomach. It contains the cardiac sphincter, which prevents food from traveling back up the esophagus.
• The fundus is a rounded section next to the cardia. It's below the diaphragm (the dome-shaped muscle that helps to breathe).
• The body (corpus) is the largest section of the stomach. In the body, stomach contracts and begins to mix food.
• The antrum lies below the body. It holds food until the stomach is ready to send it to your small intestine.
• The pylorus is the bottom part of the stomach. It includes the pyloric sphincter. This ring of tissue controls when and how stomach contents move to the small intestine.
Incidence
• It is more commonly seen in child with 2-5wks of age.
• 2-9 per 1000 livebirths can be born with this condition.
• Predominant sex: Male > Female (6:1). Males are more prone to get
• Genetic predisposition can be an underlying factor for disease causation.
• Full term babies especially first borne are most commonly affected.
• Death from infantile hypertrophic pyloric stenosis is rare and unexpected; the reported mortality rate is very low and usually results from delays in diagnosis with eventual dehydration and shock.
Etiology
• Idiopathic
• Other factors : *maternal stress especially in third trimester *elevated prostaglandin levels *deficiency of nitric acid *immature pyloric ganglion cells with abnormal muscle innervation.
• In adults, it can occur due to history of peptic ulcer in pylorus region and hypertrophic changes in muscle layer of pylorus.
Risk factors
• Sex. Pyloric stenosis is seen more often in boys — especially firstborn children — than in girls.
• Race. Pyloric stenosis is more common in whites of northern European ancestry, less common in Black people and rare in Asian
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Stewardship is the act of taking good care of something.
Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials (including antibiotics), improves patient outcomes, reduces microbial resistance, and decreases the spread of infections caused by multidrug-resistant organisms.
WHO launched the Global Antimicrobial Resistance and Use Surveillance System (GLASS) in 2015 to fill knowledge gaps and inform strategies at all levels.
ACCORDING TO apic.org,
Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials (including antibiotics), improves patient outcomes, reduces microbial resistance, and decreases the spread of infections caused by multidrug-resistant organisms.
ACCORDING TO pewtrusts.org,
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VISION
Being proactive
Supporting optimal animal and human health
Exploring ways to reduce overall use of antimicrobials
Using the drugs that prevent and treat disease by killing microscopic organisms in a responsible way
GOAL
to prevent the generation and spread of antimicrobial resistance (AMR). Doing so will preserve the effectiveness of these drugs in animals and humans for years to come.
being to preserve human and animal health and the effectiveness of antimicrobial medications.
to implement a multidisciplinary approach in assembling a stewardship team to include an infectious disease physician, a clinical pharmacist with infectious diseases training, infection preventionist, and a close collaboration with the staff in the clinical microbiology laboratory
to prevent antimicrobial overuse, misuse and abuse.
to minimize the developme
2. DEFINITION
• Narrowing and obstruction of the lower portion
of stomach (pylorus) that prevents food from
moving from the stomach of the intestine.
• It is caused due to hypertrophy and hyperplasia
of the muscles of stomach.
3. INCIDENCE
• Typically occurs in infants between 2 – 8 weeks of age.
• Affects 1 out of every 500 to 1000 live births.
• More common in boys than girls.
4. Hypertrophy and hyperplasia of smooth muscles of
pyloric sphincter
Narrowing of pylorus (partial to complete obstruction)
Stomach content cannot flow easily through
constricted pylorus
Vigorous peristalsis
Vomiting and dilated stomach musculature
PATHOPHYSIOLOGY
5. CLINICAL MANIFESTATIONS
• Regurgitation and non – bilious vomiting during or after feeding (in
initial stage).
• Projectile vomiting (later stages).
• Weight loss or failure to gain weight.
• Dehydration.
• Reduced frequency and amount of stool.
6. DIAGNOSTIC EVALUATION
• Physical examination reveals a firm, olive sized mass in the epigastrium
to the right of midline.
• In severely malnourished infants, epigastric distension and peristaltic
waves may be seen during and after feeding.
7. • Barium meal X- ray reveals delayed emptying of
gastric contents as well as narrowing of pylorus.
• Blood investigations reveals low Na, K and Cl
with increased pH.
• Urine examination shows concentrated urine
with increased specific gravity.
DIAGNOSTIC EVALUATION
9. SURGICAL MANAGEMENT
• Initially IV fluids are given to treat dehydration and
restore the body’s normal chemistry.
• After that pyloromyotomy surgery is performed.
• It involves opening of tight circular muscles of pylorus
that had caused narrowing.
• Can be performed using either an open or laproscopic
surgical approach.
11. PRE OPERATIVE MANAGEMENT
• Monitor vital signs to detect alkalosis and fluid / electrolyte
imbalance.
• Note and record the amount and characteristic of vomitus and
stool.
• Stop oral feeding
• Administer IV fluids
• In partial obstruction, feed the infant in semi upright position.
12. • Weigh infant daily
• Maintain strict intake and output chart.
• Gastric lavage with normal saline before surgery.
• Correct fluid and electrolyte imbalance.
PRE OPERATIVE MANAGEMENT
13. POST OPERATIVE MANAGEMENT
• Observe the incision site for drainage, signs of infection.
• Keep the incision site clean and dry.
• Use aseptic techniques while dressing.
• Monitor abdominal girth to detect abdominal distension.
• Provide calm and restful environment.
• Administer IV fluids.
• Assess for return of bowel sounds.
Editor's Notes
Hypochloremic, hypokalemic metabolic alkalosis is the classic electrolyte and acid-base imbalance of pyloric stenosis. Persistent emesis causes progressive loss of fluids rich in hydrochloric acid, which causes the kidneys to retain hydrogen ions in favor of potassium.