The lectin pathway is part of the complement system, which is part of the innate immune system. It acts as the first line of defense against microbes entering the body. In the lectin pathway, MBL attaches to mannose on microbes. This activates the complement system by breaking down C4 and C2 proteins to form a C3 convertase, which then breaks down C3 into C3b and C3a. C3b opsonizes the microbe while C3a causes inflammation. C3b then binds to the microbe and C3 convertase to form a C5 convertase, continuing the complement cascade and ultimately forming a membrane attack complex that causes cell lysis of the micro