This document discusses the use of herbal immunomodulators in poultry to improve immunity and combat antibiotic resistance. It provides background on immunomodulators and how certain herbs like ashwagandha, neem, tinospora cordifolia, and mint can modulate the immune system through effects on cytokines, immune cells, and phagocytosis. Several studies are summarized that show herbs like ashwagandha and tinospora cordifolia can improve performance parameters and immune responses in broiler chickens and quails. The document concludes that herbs have potential immunomodulatory properties through effects on macrophages, cytokines, and immune cells like NK cells.
Phytogenic feed additives as an alternative to antibiotics in poultry dietsDeepak Nelagonda
Use of antibiotics as growth promoters is an age old process but due to many factors thrust for the search of alternative to antibiotics is growing, 'phytogenic feed additives' are one of the possible domains which could address the issue if they could be properly explored.
"عسى ان تكون علما ينتفع به"
Role of trace minerals in poultry nutrition
Difference between organic and inorganic source of trace minerals
Poultry nutrition
Improvement in Poultry Performance through Application of PhytobioticsDr. MAYUR VISPUTE
An attempt to explore the possibilities of future use of Phytogenic feed additives as a green and clean alternative to the conventional feed additives like antibiotic growth promoters in modern poultry production
Antibiotic-free broiler meet production in indiaMilindNande2
Sustainable broiler production not only requires maximum productivity but, also, includes bird and human welfare and environmental protection. It is expected that this can be achieved by upgrading farming practices that are profitable, environmentally sound, good for communities, and antibiotic-free. However, raising animals without antibiotics is a challenge especially, antibiotic-free broiler meat production is a growing challenge.
Antibiotic growth promoter have played a critical role in contributing to the economic effectiveness of animal production as feed supplements at sub-therapeutic doses, to improve growth and feed conversion efficiency, and to prevent infections However, injudicious use of antibiotic growth promoter leads to development of antimicrobial resistance and antibiotic residue posing a potential threat to human health.
Organic acids, probiotics, prebiiotic, enzymes, phytobiotics, bacteriophage etc. are effective antibiotic alternatives to promote animal growth performance in poultry, swine, and beef and dairy production.
The color of the egg yolk and chicken skin is determined by the concentration and type of carotenoid present in the broiler or layer diet. This is important to keep in mind, as different colours are preferred depending on the geographical area.
Find out more about the effect of different types of carotenoids on broiler skin and egg yolk colour. In particular, look closely at effective the CAROPHYLL Red and Yellow products by DSM.
To find out more about DSM's work on poultry visit us at: http://www.dsm.com/markets/anh/en_US/species/species-poultry.html
Or why not talk to the expert on Twitter: @goldenyolk
Phytogenic feed additives as an alternative to antibiotics in poultry dietsDeepak Nelagonda
Use of antibiotics as growth promoters is an age old process but due to many factors thrust for the search of alternative to antibiotics is growing, 'phytogenic feed additives' are one of the possible domains which could address the issue if they could be properly explored.
"عسى ان تكون علما ينتفع به"
Role of trace minerals in poultry nutrition
Difference between organic and inorganic source of trace minerals
Poultry nutrition
Improvement in Poultry Performance through Application of PhytobioticsDr. MAYUR VISPUTE
An attempt to explore the possibilities of future use of Phytogenic feed additives as a green and clean alternative to the conventional feed additives like antibiotic growth promoters in modern poultry production
Antibiotic-free broiler meet production in indiaMilindNande2
Sustainable broiler production not only requires maximum productivity but, also, includes bird and human welfare and environmental protection. It is expected that this can be achieved by upgrading farming practices that are profitable, environmentally sound, good for communities, and antibiotic-free. However, raising animals without antibiotics is a challenge especially, antibiotic-free broiler meat production is a growing challenge.
Antibiotic growth promoter have played a critical role in contributing to the economic effectiveness of animal production as feed supplements at sub-therapeutic doses, to improve growth and feed conversion efficiency, and to prevent infections However, injudicious use of antibiotic growth promoter leads to development of antimicrobial resistance and antibiotic residue posing a potential threat to human health.
Organic acids, probiotics, prebiiotic, enzymes, phytobiotics, bacteriophage etc. are effective antibiotic alternatives to promote animal growth performance in poultry, swine, and beef and dairy production.
The color of the egg yolk and chicken skin is determined by the concentration and type of carotenoid present in the broiler or layer diet. This is important to keep in mind, as different colours are preferred depending on the geographical area.
Find out more about the effect of different types of carotenoids on broiler skin and egg yolk colour. In particular, look closely at effective the CAROPHYLL Red and Yellow products by DSM.
To find out more about DSM's work on poultry visit us at: http://www.dsm.com/markets/anh/en_US/species/species-poultry.html
Or why not talk to the expert on Twitter: @goldenyolk
Probiotics- unfolding their potential in boosting poultry industryX S
Definition:
“Living microorganisms when conferred in sufficient amount on the host, will render beneficial effects on health.”(FAO/WHO)
Lactobacillus, Candida, Streptococcus, Enterococcus, Bifidobacterium, Aspergillus, and Saccharomyces spp.
History
Élie Metchnikoff (20th century)
Werner Kolath(1953)
Probiotics for poultry
Need of Probiotics?
Selection criteria
Probiotics in poultry industry
First decisive incident
Commercial vs. wild chicken
Selection criteria
Probiotic requirement in poultry (concept)
How probiotics act?
Maintain normal intestinal microflora
competitive exclusion and resistance
Change metabolism
speeding digestive enzyme activity
Perk up feed intake and digestion
Diminish bacterial enzyme activity and ammonia production
Stimulate the immune system
Evaluation of probiotics on poultry
Growth performance
Intestinal microbiota and morphology
Immune response
Meat quality/chicken caracass
Side effects(toxicity of ingredients)
Growth performance
broilers fed with two probiotic species put on more weight(Lan et al.,2003 )
weight gain significantly higher in probiotic fed birds(Kabir et al.,2004) .
inactivated probiotics have constructive actions on the production achievement (Huang et al.,2004).
Cont’d
values of giblets and dressing percentage elevated for probiotic fed broilers (Mahanjan et al.,1999)
Intestinal microbiota and morphology
Probiotics inhibited pathogens by dwelling on intestinal wall space(Kabir et al.,2005 )
Birds fed dietary B. subtilis for 28 days displayed better growth and prominent intestinal histologies. (Samanya and Yamauchi.,2002)
Chicks given Lactobacillus strains had less amount of coliforms in cecal grindings(Watkins and Kratzer.,1983 ).
Cont’d
L. salivarius 3d strain decreased the number of Clostridium perfringens and Salmonella enteritidis (Kizerwetter-Swida and Binek., 2009).
Probiotic species have an implicit action on regulation of intestinal microflora and pathogen occlusion (Higgins et al., 2007)
Immune response
Higher amount of antibody production(Kabir et al.,2005 )
Improved serum and intestinal antibodies to a foreign antigens in chickens (Haghighi et al.,2005)
Probiotics protected broilers against Eimeria acervulina infection even with a moderate dose (Dalloul et al.,2003)
Cont’d
Better local immune defenses against coccidiosis.
Splenocytes and cecal tonsil cells, STAT2 and STAT4 genes were greatly stimulated and the expression of STAT2, STAT4, IL-18, IFN-alpha, and IFN-gamma genes in cecal tonsil cells were up-regulated after treating with L. acidophilus DNA.
Additive probiotic supplements were ineffective on systemic IgG (Midilli et al.,2008 ).
>Since the ban of antibiotic growth promoters (AGPs) in the European Union, the industry has been looking for valid alternatives to improve health, immune status and performance in animal agriculture.
>The industry focuses on developing solutions that mimic the effects of AGPs. However, the exact mode of action of the AGPs to improve poultry performance is not fully understood.
Most AGPs alternatives try to prevent the proliferation of pathogenic bacteria and to modulate indigenous bacteria to improve immune status and performance.
>As an industry, we have made limited progress in improving gut health. Maybe we need to change the approach to find the most optimal solution.
>As part of a stable ecological system, pathogens per se do not represent a threat to animal health. The dynamic nature of the gastrointestinal microflora in chickens makes maintaining the right balance in the microbial ecosystem.
>Despite a large amount of scientific work has been done on the topic, a lack of consistent improvement has been registered.
>To improve gut health more consistently, a broader approach, involving a combination of nutrition, feed technology and husbandry management needs to be taken.
>In addition, gut-health is too complex to be solved from
only one point of view. Input should be obtained from different disciplines, including food technology, human nutrition, veterinary and human medical sciences.
>DSM will start an holistic program to come to tailor made solutions to improve the gut ecosystem with the objective of reducing the use of antibiotics in the poultry industry.
Phytogenics as feed additives in poultry productionReza Vakili
1. Effects on egg production& egg quality
2.Growth promoting effect
3.Impact Influence on palatability and gut function
4. Antimicrobial action &Impact on pathogenic microorganisms
5. Antioxidant and anti-inflammatory action
6. Effect on immune system function
7. AntiCancer properties
Conclusions of the research:
Feeding 25OHD3 in place of the majority of dietary D3 improved broiler chicken vitamin D status and resulted in
a satellite cell-mediated muscle hypertrophy response in breast (PM), but not thigh (BF) muscles (Hutton et al.,
2013)
The differential response in functionally different muscles as well as the cell signaling mechanisms by which skeletal
muscle satellite cells respond to improved vitamin D status resulting from dietary Hy·D supplementation will
require further investigation.
Probiotics- unfolding their potential in boosting poultry industryX S
Definition:
“Living microorganisms when conferred in sufficient amount on the host, will render beneficial effects on health.”(FAO/WHO)
Lactobacillus, Candida, Streptococcus, Enterococcus, Bifidobacterium, Aspergillus, and Saccharomyces spp.
History
Élie Metchnikoff (20th century)
Werner Kolath(1953)
Probiotics for poultry
Need of Probiotics?
Selection criteria
Probiotics in poultry industry
First decisive incident
Commercial vs. wild chicken
Selection criteria
Probiotic requirement in poultry (concept)
How probiotics act?
Maintain normal intestinal microflora
competitive exclusion and resistance
Change metabolism
speeding digestive enzyme activity
Perk up feed intake and digestion
Diminish bacterial enzyme activity and ammonia production
Stimulate the immune system
Evaluation of probiotics on poultry
Growth performance
Intestinal microbiota and morphology
Immune response
Meat quality/chicken caracass
Side effects(toxicity of ingredients)
Growth performance
broilers fed with two probiotic species put on more weight(Lan et al.,2003 )
weight gain significantly higher in probiotic fed birds(Kabir et al.,2004) .
inactivated probiotics have constructive actions on the production achievement (Huang et al.,2004).
Cont’d
values of giblets and dressing percentage elevated for probiotic fed broilers (Mahanjan et al.,1999)
Intestinal microbiota and morphology
Probiotics inhibited pathogens by dwelling on intestinal wall space(Kabir et al.,2005 )
Birds fed dietary B. subtilis for 28 days displayed better growth and prominent intestinal histologies. (Samanya and Yamauchi.,2002)
Chicks given Lactobacillus strains had less amount of coliforms in cecal grindings(Watkins and Kratzer.,1983 ).
Cont’d
L. salivarius 3d strain decreased the number of Clostridium perfringens and Salmonella enteritidis (Kizerwetter-Swida and Binek., 2009).
Probiotic species have an implicit action on regulation of intestinal microflora and pathogen occlusion (Higgins et al., 2007)
Immune response
Higher amount of antibody production(Kabir et al.,2005 )
Improved serum and intestinal antibodies to a foreign antigens in chickens (Haghighi et al.,2005)
Probiotics protected broilers against Eimeria acervulina infection even with a moderate dose (Dalloul et al.,2003)
Cont’d
Better local immune defenses against coccidiosis.
Splenocytes and cecal tonsil cells, STAT2 and STAT4 genes were greatly stimulated and the expression of STAT2, STAT4, IL-18, IFN-alpha, and IFN-gamma genes in cecal tonsil cells were up-regulated after treating with L. acidophilus DNA.
Additive probiotic supplements were ineffective on systemic IgG (Midilli et al.,2008 ).
>Since the ban of antibiotic growth promoters (AGPs) in the European Union, the industry has been looking for valid alternatives to improve health, immune status and performance in animal agriculture.
>The industry focuses on developing solutions that mimic the effects of AGPs. However, the exact mode of action of the AGPs to improve poultry performance is not fully understood.
Most AGPs alternatives try to prevent the proliferation of pathogenic bacteria and to modulate indigenous bacteria to improve immune status and performance.
>As an industry, we have made limited progress in improving gut health. Maybe we need to change the approach to find the most optimal solution.
>As part of a stable ecological system, pathogens per se do not represent a threat to animal health. The dynamic nature of the gastrointestinal microflora in chickens makes maintaining the right balance in the microbial ecosystem.
>Despite a large amount of scientific work has been done on the topic, a lack of consistent improvement has been registered.
>To improve gut health more consistently, a broader approach, involving a combination of nutrition, feed technology and husbandry management needs to be taken.
>In addition, gut-health is too complex to be solved from
only one point of view. Input should be obtained from different disciplines, including food technology, human nutrition, veterinary and human medical sciences.
>DSM will start an holistic program to come to tailor made solutions to improve the gut ecosystem with the objective of reducing the use of antibiotics in the poultry industry.
Phytogenics as feed additives in poultry productionReza Vakili
1. Effects on egg production& egg quality
2.Growth promoting effect
3.Impact Influence on palatability and gut function
4. Antimicrobial action &Impact on pathogenic microorganisms
5. Antioxidant and anti-inflammatory action
6. Effect on immune system function
7. AntiCancer properties
Conclusions of the research:
Feeding 25OHD3 in place of the majority of dietary D3 improved broiler chicken vitamin D status and resulted in
a satellite cell-mediated muscle hypertrophy response in breast (PM), but not thigh (BF) muscles (Hutton et al.,
2013)
The differential response in functionally different muscles as well as the cell signaling mechanisms by which skeletal
muscle satellite cells respond to improved vitamin D status resulting from dietary Hy·D supplementation will
require further investigation.
Plant phenolics in animal health and methane mitigation. avijit deyAvijit Dey
Phenolics are ubiquitous in all plant organs and integral part of animal and human foods. Phenolic acids, flavanoids and tannins are the most common phenolic compounds. Fruits and vegetables are rich source of polyphenols for humans. Whereas, tree leaves in tropical countries are potential sources phenolic compounds for animals. Researchers have become more interested in polyphenols due to their potent antioxidant properties and credible effects in the prevention of cardiovascular, neurodegenerative diseases and cancer. Condensed tannins (CT) and flavanoids have the ability to modify the rumen fermentation towards reduced methanogenesis by altering rumen microbial community and their supplementation reduces nitrogen excretion in ruminants by improving its utilization efficiency. Improvement in feed intake, growth rate, wool production, reproduction and milk production in ruminants fed CT containing diets were observed in a dose dependent manner. In ruminants, most proteins are rapidly solubilised and release 56- 65% N in the rumen during mastication; consequently large losses of N (25-35%) occur as ammonia absorbed from rumen. CT from tree leaves could be used as organic protectant of proteins to improve protein utilization by ruminants and reduce environmental pollution by minimising N losses through urine. Supplementation of CT through leaves of Artocarpus heterophyllus, Ficus infectoria, Ficus bengalensis and Ficus glomerata at 1.5- 2.0% levels was observed to reduce the rumen degradability of groundnut cake to 60-75 per cent from the normal value of 92 per cent. Controlling gastro-intestinal parasites by supplementation of CT through F. infectoria, Psidium guajava and Ficus bengalensis was effective to ameliorate drug resistance. Feeding study to lambs and crossbred cows with supplementation of CT (1.5%) either through F. Infectoria and F. bengalensis leaves was found to increase feed efficiency, growth rate, milk yield, fat yield, antioxidant status and immunity of animals. Flavanoids and tannin-rich feeds could reduce or inhibit rumen biohydrogenation of vaccenic acid to stearic acid, resulting in the accumulation of conjugated linoleic acids (CLA) in milk and meat which has hypolipidaemic and anti carcinogenic effects in humans. Judicious application of plant phenolics could improve overall health and production performance of animals.
Cytotoxicity of Blended Versus Single Medicinal Mushroom Extracts on Human Ca...Jolene1981
ABSTRACT: The use of mushrooms contributes to human nutrition by providing low lipid content of lipids and high dietary fiber content, as well as significant content of other biologically active compounds such as polysaccharides, minerals, vitamins, and polyphenolic antioxidants. This study aimed to determine the content of polyphenols and polysaccharides, as well as the cytotoxic and antioxidative properties of several medicinal mushroom preparations. The content of total phenols and flavonoids of preparations of blended mushroom extracts (Lentifom, Super Polyporin, Agarikon, Agarikon Plus, Agarikon.1, and Mykoprotect.1) was evaluated quantitatively by using ultraviolet–visible spectroscopy spectrophotometric methods. The antioxidant capacity of the preparations was evaluated using the ABTS (2,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) and ferric reducing/antioxidant power assays. The content of water-soluble polysaccharides was determined using a specific gravimetric method, based on ethanol precipitation. To determine cytotoxic effects of single and blended mushroom extracts, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and neutral red assays were conducted using human small cell lung cancer, lung adenocarcinoma, colon cancer, and brain astrocytoma cancer cells. The obtained results suggest that due to the significant content of beneficial polyphenolic antioxidants and soluble polysaccharides, use of these mushroom preparations is beneficial in maintaining good health, as well as in the prevention and adjuvant biotherapy of various human pathological aberrations. These results reveal that these extracts exhibit different cytotoxic effects on tumor cells originating from different tissues. In addition, the comparison of investigated blended mushroom extracts with three well-known commercial mushroom products derived from single mushroom species or single mushroom compounds shows that blended mushroom extracts exhibit significantly stronger cytotoxic effects on human tumor cell lines.
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Effects of flavonoids from Allium mongolicum Regel on growth performance and ...Faisal A. Alshamiry
flavonoids from Allium mongolicum Regel was to determined for use as a natural feed additive
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Research by Mahendra Kumar Trivedi - Evaluation of the Impact of Biofield Tre...john henrry
Research on Trivedi Effect - In the present study, the influence of biofield treatment on physical and thermal properties of Casein Enzyme Hydrolysate (CEH) and Casein Yeast Peptone (CYP) were investigated. The control and treated samples were characterized by Fourier transform infrared (FT-IR) spectroscopy, differential scanning calorimetry (DSC), Thermo Gravimetric Analysis (TGA), particle size and surface area analysis.to read more visit http://www.academicroom.com/article/evaluation-impact-biofield-treatment-physical-and-thermal-properties-casein-enzyme-hydrolysate-and-casein-yeas-t-peptone
Research by Mahendra Kumar Trivedi - Evaluation of the Impact of Biofield Tre...Abby Keif
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4. • More focus on growth and production
• adverse effect on the immunological
parameters of poultry, thereby damaging the
natural defensive mechanism against various
microorganisms
• Due to antibiotic resistance- researchers are
thinking about herbal immunomodulators
5. Immunomodulator
• Immunomodulator is a substance which
stimulates or suppresses the components of
immune system including both innate and
adaptive immune responses
• The modulation of immune system by various
medicinal plant products are called as herbal
immunomodulator.
6. • As India is having a rich biodiversity of herbs
and medicinal plants, efforts should be made
in their identification and testing or validation
for their immunomodulatory properties and
to prepare therapeutic formulations
7. IMMUNOMODULATORY PROPERTIES
OF HERBAL PLANTS
• Multiple immunomodulatory actions including
modulation of cytokine secretion,
• histamine release,
• immunoglobulin production,
• cellular co-receptor expression,
• lymphocyte proliferation
• and phagocytosis promotion.
8. MECHANISM OF ACTION OF THE
HERBAL IMMUNOMODULATORS
• The main target – macrophages
• stimulation of phagocytosis, activation of
macrophages
• intracellular killing of pathogens by producing
effector molecules like free radical and nitric
oxide and cytokine production
9. • These cytokines may have direct function of
other immune cell population such as
activation of natural killer cell mediated
cytotoxicity or generation of cytotoxic T-
lymphocytes
18. • Glycyrrhiza glabra (Liquorice), Allium
sativum (garlic) and they can improve the
functions of lymphocytes, macrophages and
NK cells a s well as increase phagocytosis and
stimulate the interferon synthesis.
• Echinacea stimulates macrophages, cytokine
production, Natural Killer (NK) cells,
neutrophil and B-lymphocyte activity.
22. Herbal Immunostimulants
–Improve the activity of lymphocytes,
macrophages and NK cells,
–increase phagocytosis or stimulate the
interpheron synthesis
23. Author Work Results
Bhardwaj et
al. (2012)
Efficacy of ashwagandha (Withania
somnifera) supplementation on
haematological and immunological
parameters of Japanese quails
T10.0%,
T2 0.5%,
T3 1.0% and
T4, 1.5%,
the supplementation of
Ashwagandha root powder at 1
percent significant effect on body
weight, FCR, haematological
parameters and Immunological
study indicated significantly
(P<0.05) higher immunonoglobulins
and skin thickness
Mushtaq et al.
2012
Effect of Administration of Withania
somnifera on Some Hematological
and Immunological
Profile of Broiler Chicks.
at 10, 20 and 30g/L
Significantly Higher body weight
in all treated groups. An
increase in the values of Hb,
PCV and TLC and Antibodies
titers against IB and IBD were
significantly higher in all
treatment
24. Author Work Results
Gatne et al,
2010
Evaluation of Immunodulatory
effect of Stresroak Premix in
Broiler chick,
T1negative control,
T2 levamisol @ 15 mg/kg body,
T3 Stresroak @ 1 kg /tone
Results revealed that
the antibody titre, total proteins
and globulins were increased
significantly in the birds receiving
Stresroak. Histopathologically
varying degrees of
lympho-proliferative changes noted
which reveals increase number of
lymphocytes
Dwivedi et al.
2015
Growth Performance, Blood
Constituents and Carcass Traits of
Broiler Chicken as Affected by
Supplementation of Ashwagandha
(Withania somnifera)
and Mangrail (Nigella sativa).
T1 0.5 % ashwagandha,
T2 Mangrail 0.5%,
T3 mixture
The Hb, PCV increased and
Lower (P<0.05) heterophil:
lymphocyte ratio, and
decreased serum cholesterol
25. Author Work Results
Joshi et al
2015
Effect of dietary addition of
ashwagandha (Withania
somnifera) 1 g /kg and
guduchi
(Tinospora cordifolia)
powder 2 g/kg on broiler
performance
Results indicated that ashwagandha
(Withania somnifera) and guduchi (Tinospora
cordifolia) powder improved growth
performance and reduced mortality, but did
not have any effect on feed conversion ratio
and economics of feeding in broilers
Prasad et al,
2012
Studies on
Immunomodulatory Effects of
Ocimum sanctum and
Levamisole in Broiler Chicks
Vaccinated against Newcastle
Disease
A potential effect was found in the form of
increase in mean haemagglutination
inhibition (HI) antibody titer, serum mean
total protein, albumin and globulin
concentrations in O. sanctum-treated groups
rather than the control group at different
post-vaccination intervals
26. Author Work Results
Jadhav et al,
2014
Heat stress amelioration and
production performance in
layers supplemented with
herbal liquid anti-stressor
and immunomodulator
product
T1 where vitamin C at 100
g/tonne. Groups T2 and T3
were supplemented with
herbal liquid through water
for 7 weeks at 3 and 5
ml/100 birds/day,
respectively.
Higher egg production, egg weight in T2
and T3.
And lower serum cortisol, alkaline
phosphatase (ALP), SGPT and SGOT in
treatment groups compared to control.
Shyma et al,
2013
AMELIORATIVE EFFECTS OF
FOUR HERBS (Withania
somnifera, Tinospora
cordifolia,
Azadirachta indica AND E
CARE SE HERBAL) ON THE
PATHOGENESIS OF CHICKEN
INFECTIOUS
The chicks of all the herbal treatment groups
showed ameliorative effects as revealed by
reduced pathological lesions and changes
when compared with the positive virus
control group
27. Effect of herbal immune modulator and anti stress products
on growth parameters of Japanese quails at 35 days age.
Paramete
rs
T1 T2(Stressr
oak liquid)
T3 Withania
and Phyllanthus
T4
Glycrrhiza
glabra, Tribulus
terrestris and
Asparagas
racemosus
liquid
SEM
P-value
overall
feed
intake (g)
537.46 535.93 538.55 541.83 1.97 0.778
overall
weight
gain (g)
159.43b 173.93a 172.29a 173.09
a
1.33 0.001
overall
FCR
3.37b 3.08a 3.12a 3.13a 0.02 0.001
28. Effect of Different Herbal Immunomodulators on Immune
Status, Haematological and Serum Biochemical Parameters of
Japanese Quails During Summer Stress
Table 3: Effect of supplementation of herbal immunomodulator products on immunological and
serum biochemical profile of Japanese quails
Treatment Parameter
Skin
thickness
(mm)
serum
immuno
globulin
(mg/dl)
total
serum
protein
(g/dl)
albumin
(g/dl)
globulin
(g/dl)
A/G ratio Trigly-
cerides
(mg/dl)
Cholestrol
(mg/dl)
glucose
(mg/dl)
T1 1.92b
±0.05
2.37b
±0.02
4.39±0.0
3
1.28±0.0
4
3.10±0.04 0.41±0.03 143.35±1.
14
143.24±1.
55
125.92±1
.34
T2 2.50a±
0.05
2.67a
±0.02
4.44±0.0
2
1.27±0.0
6
3.17±0.02 0.40±0.04 142.23±0.
74
141.08±1.
25
125.30±1
.32
T3 2.47a
±0.04
2.68a
±0.02
4.39±0.0
2
1.24±0.0
5
3.17±0.01 0.38±0.05 142.39±1.
04
144.47±1.
56
125.36±1
.53
T4 2.47a
±0.02
2.65a
±0.02
4.39±0.0
2
1.24±0.0
4
3.14±0.03 0.39±0.07 142.26±0.
83
143.12±1.
25
124.70±1
.42
30. Efficacy of Herbal immunomodulator & Antistressor Products in Ameliorating Stress
And Improving Performance & Immunity in Broiler Bird”
S.No TRT Weight
gain (g)
/bird
Feed
intake
(g)/bird
Feed/g
ain
Leg
yield
(%)
Abdomi
nal Fat
(%)
Spleen
(%)
Bursa
(%)
T1 Control 1889 b 3232 b 1.71 c
20.83 c 1.98 a 0.155 c 0.123 c
T2
Stressroak
liquid
2062a 3071 a 1.49 a
22.30 bc 0.96 b 0.171 ab 0.145 ab
T3
AV/ESL/16
liquid
1931 b 3082 a 1.60 b
23.51 ab 1.14 b 0.170 abc 0.140 abc
T4
Stressroak
premix
1886 b 3059 a 1.62 bc
24.00 a 1.08 b 0.165 bc 0.155 a
T5
Geriforte
liquid
1851 b 3104 a 1.68 bc
24.23 ab 1.19 b 0.183 a 0.131bc
T6
Stresscheck
1925 b 3071 a 1.60 b
22.36 bc 0.99 b 0.183 a 0.148 ab
SEM 18.002 17.435 0.017
0.297 0.078 0.002 0.002
P -value 0.007 0.027 0.002
0.002 0.001 0.003 0.011
31. Effect of herbal immune modulator and anti stress
products on different blood parameters during 6th
week of broilers
PARAMETER
S
T1 T2 T3 T4 T5 T6 SEM P -value
WBC (103/uL) 27.2 a 27.7 a 27.2 ab 26.6 b 27.7 a 26.7 ab 1.16 0.04
RBC (106/ul) 3.02 ab 3.15 a 2.98 ab 2.76 b 3.24 a 3.04 ab 0.04 0.03
HGB (g/dL) 10.1 bc 11.0 ab 10.1 bc 9.6 c 11.4 a 10.7 ab 0.16 0.001
PCV (%) 39.6 bc 41.7 ab 38.9 bc 37.0 c 43.8 a 40.1 abc 0.58 0.01
MCV (fL) 136.53 132.63 131.15 134.73 136.55 133.78 0.65 0.92
MCH (pg) 35.8 34.9 34.1 34.9 35.4 33.5 0.33 0.39
MCHC (g/dL) 26.2 26.3 27.7 26.0 26.1 26.3 0.29 0.64
RDW (%) 9.35 8.83 8.80 8.66 8.40 8.23 0.18 0.64
PLT (103/uL) 60.66 ab 55.16 abc 54.16 bc 46.83 c 66.83 a 56.66 abc 1.81 0.03
MPV (fL) 6.01 6.13 5.95 5.60 6.05 5.66 0.74 0.20
PDW 19.33 19.41 19.48 19.00 19.43 19.03 0.81 0.35
PCT (%) 0.036 a 0.033 ab 0.032 ab 0.025 b 0.040 a 0.031 ab 0.001 0.05
32. Effect of herbal immune modulator and anti stress products on different
blood glucose and serum cholesterol during 4th week of broilers
PARAMETERS T1 T2 T3 T4 T5 T6 SEM P VALUE
Blood glucose
(mg/dL)
214 cd 218 d 213 bcd 200 abc 196 ab 194 a 2.644 0.012
serum cholesterol
(mg/dL)
273 c 258 ab 259 ab 249 a 258 ab 264 bc 1.90 0.008
H/L ratio (%) 0.83 d 0.34 a 0.51 b 0.64 c 0.50 b 0.29 a 0.033 0.001
Cortisol ( mg/ml) 3.69 d 1.64 a 2.55 bc 3.21 cd 2.70 bc 2.02 ab 0.145 0.001
33. Effect of herbal immune modulator and anti stress products
on different blood glucose and serum cholesterol during 6th
week of broilers
PARAMETE
RS
T1 T2 T3 T4 T5 T6 SE
M
P VALUE
Blood glucose
(mg/dL)
209 c 185 a 198 abc 194 abc 202 bc 190 ab 2.31 0.03
serum
cholesterol
(mg/dL)
82.8 b 53.6 a 67.9 ab 76.6 b 72.0 b 68.7 ab 2.53 0.001
H/L ratio (%) 0.85 c 0.38 a 0.51 b 0.60 b 0.51 b 0.39 a 0.02
9
0.001
Cortisol
(mg/ml)
4.11 c 1.60 a 2.04 ab 2.43 b 2.17
ab
1.54 a 0.16
9
0.001
34. Returns over feed cost and Gain / loss over antibiotic or
control diet of broilers at market age (42 d).
Trt.
cod
e
Diets
Cumulati
ve feeding
cost / bird
(Rs)
Body wt
at
6 wks
(g)
Sale
amount*
(Rs / bird)
Returns
over feed
cost
(Rs / bird)
Gain / loss
over
control
(Rs / bird)
T1
Control 92.13 1933 164.31 72.17 0
T2
Stressroak liquid 88.37 2106 179.01 90.64 18.47
T3
AV/ESL/16
liquid
88.50 1975 167.88 79.37 7.20
T4
Stressroak
premix
87.47 1930 164.05 76.58 4.41
T5
Geriforte liquid 89.00 1895 161.08 72.08 -0.10
T6
Stresscheck 88.06 1969 167.37 79.31 7.14
35. CONCLUSION
• Herbs can be used as a good alternative
therapeutic aid to costly allopathic medicines
and boosting immune functions in poultry.
• Detailed scientific validation on different
HERBAL IMMUNOMADULATORS in poultry
would be a worthful research in future
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