Glycolysis and the Krebs cycle are two key metabolic pathways. Glycolysis involves the breakdown of glucose into pyruvate through a 10 step process in the cytoplasm, producing ATP and NADH. The Krebs cycle then uses pyruvate and acetyl-CoA in the mitochondria to further oxidize carbon molecules and produce more ATP and NADH through 8 steps, extracting energy from acetyl groups and fully oxidizing them to carbon dioxide. These pathways are essential for cellular respiration and the production of energy in the form of ATP.
Glycolysis (from glycose, an older term for glucose + -lysis degradation) is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO− + H+. The free energy released in this process is used to form the high-energy molecules ATP (adenosine triphosphate) and NADH (reduced nicotinamide adenine ...
“TCA cycle is the series of chemical reactions used by all aerobic organisms to release stored energy through the oxidation of acetyl CoA derived from carbohydrates, fats, and proteins into ATP.” TCA cycle or Tricarboxylic Cycle is also known as Kreb's Cycle or Citric Acid Cycle.
what is photosynthesis?-history background-photosynthetic pigmment system-light harvesting complex-photo oxidation of water-photophosphorylation and mechanism of electron transport
Pentose phosphate pathway is also called Hexose monophosphate pathway/ HMP shunt/ Phosphogluconate pathway.
It is an alternative route for the metabolism of glucose.
It is more complex pathway than glycolysis.
It is more anabolic in nature.
It takesplace in cytosol.
The tissues such as liver, adipose tissue, adrenal gland, erythrocytes,testes and lactating mammary gland are highly active in HMP shunt.
It concern with the biosynthesis of NADPH and pentoses.
Glycolysis (from glycose, an older term for glucose + -lysis degradation) is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO− + H+. The free energy released in this process is used to form the high-energy molecules ATP (adenosine triphosphate) and NADH (reduced nicotinamide adenine ...
“TCA cycle is the series of chemical reactions used by all aerobic organisms to release stored energy through the oxidation of acetyl CoA derived from carbohydrates, fats, and proteins into ATP.” TCA cycle or Tricarboxylic Cycle is also known as Kreb's Cycle or Citric Acid Cycle.
what is photosynthesis?-history background-photosynthetic pigmment system-light harvesting complex-photo oxidation of water-photophosphorylation and mechanism of electron transport
Pentose phosphate pathway is also called Hexose monophosphate pathway/ HMP shunt/ Phosphogluconate pathway.
It is an alternative route for the metabolism of glucose.
It is more complex pathway than glycolysis.
It is more anabolic in nature.
It takesplace in cytosol.
The tissues such as liver, adipose tissue, adrenal gland, erythrocytes,testes and lactating mammary gland are highly active in HMP shunt.
It concern with the biosynthesis of NADPH and pentoses.
Glycolysis (from glycose, an older term for glucose + -lysis degradation) is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO− + H+.
All living cells require energy to carry out various cellular activities.
This energy is stored in organic molecules (e.g. carbohydrates, fats, proteins) that we eat as food.
These organic molecules are broken down into smaller units: proteins into amino acids, polysaccharides into simple sugars, and fats into fatty acids and glycerol by enzymatic reactions in cells to generate energy in the form of adenosine triphosphate (ATP).
The ATP generated by these pathways in cells is used to drive fundamental cellular processes.
Glucose is utilized as a source of energy, & stored as glycogen to release glucose as & when the need arises.
intro of glycolysis there cycle and step - function-significance-defination-glucogenesis cycle-significance of gluconeogenesis-function of gluconeogenesis-conclusion
A pest can be defined as a plant, animal, insect, or pathogen, acting singly or in combination, often aggravated by environmental stresses, which by its presence, abundance, or activity interferes with accomplishment of resource management goals and objectives.
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Production technology of tomato (Solanum lycopersicum L.)Muhammad Ammar
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in this power point presentation we see about alternate hosts Characteristic symptoms Disease-cycle and some management practices to manage disease.
Diseases of rose, Crown Gall Rot, Black Spot, Powdery mildew of Rose, Rust an...Muhammad Ammar
Diseases of rose:
Crown Gall Rot,
Black Spot,
Powdery mildew of Rose,
Rust and Anthracnose.
Besides rose diseases, environmental factors can effect your plants too, and they should be watched for an remedied when found. To keep most rose diseases under control, a commercial fungicide will take care of it. In other cases, proper pruning techniques and the maintenance of clean garden implements goes a long way in preventing such conditions from occurring in the first place.
I have found that only two sprays are needed to keep your plants healthy. The first is sulpher. This will work for most of the diseases. But not for black-spot: for this you need Capstan.
Citrus slow decline: Tylenchulus semipenetrans (Citrus nematode, Citrus root nematode) is a plant pathogenic nematode and the causal agent of slow decline of citrus
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Blackleg is a plant disease of potato caused by pectolytic bacteria that can result in stunting, wilting, chlorosis of leaves, necrosis of several tissues, a decline in yield, and at times the death of the potato plant.
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
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The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
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Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
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The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
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2. glycolysis
INTRODUCTION:
Glycolysis literally means "splitting sugars" and is the process of
releasing energy within sugars.
In the presence of oxygen, glycolysis is the first stage of cellular
respiration
Glycolysis takes place in the cytosol of the cell's cytoplasm.
In glycolysis, glucose (a six carbon sugar) is split into two molecules
of the three-carbon sugar pyruvate
3. History of glycolysis:
The pathway of glycolysis as it is known today took
almost 100 years to fully discover .The combined results
of many smaller experiments were required in order to
understand the pathway as a whole.
The first steps in understanding glycolysis began in the
nineteenth century with the wine industry
Louis Pasteur (1850s) fermentation occurs by the action
of living microorganisms
Eduard Buchner(1890s) Discovered cell-free fermentation.
Otto Meyerhof (1920s ) One of the main scientists
involved in completing the puzzle of glycolysis
With all of these pieces available by the 1930s, Gustav
Embden proposed a detailed, step-by-step outline of
that pathway we now know as glycolysis.
Eduard buncher
Otto Meyerhof
4. This multi-step process yields:
two molecules of ATP (free energy containing
molecule),
two molecules of pyruvate,
and two "high energy" electron carrying molecules of
NADH.
Glycolysis can occur with or without oxygen
However, the next stage of cellular respiration
known as the citric acid cycle, occurs in the matrix of
cell mitochondria.
7. Step 5
The enzyme triose phosphate isomerase rapidly inter-converts the
molecules dihydroxyacetone phosphate and glyceraldehyde 3-
phosphate. Glyceraldehyde 3-phosphate is removed as soon as it
is formed to be used in the next step of glycolysis.
Dihydroxyacetone phosphate (C3H7O6P) Glyceraldehyde 3-phosphate
(C3H7O6P)
Net result for steps 4 and 5:
Fructose 1, 6-bisphosphate (C6H14O12P2) ↔ 2 molecules of
glyceraldehyde 3-phosphate (C3H7O6P)
8. Step 6
Dehydrogenation:
The enzyme triose phosphate dehydrogenase serves 2 functions
1) Transfers a hydrogen (H-) from glyceraldehyde phosphate to the oxidizing
agent nicotinamide adenine dinucleotide (NAD+) to form NADH.
Triose phosphate dehydrogenase + 2 H- + 2 NAD+ → 2 NADH + 2 H+
2) . Next triose phosphate dehydrogenase adds a phosphate (P) from the
cytosol to the oxidized glyceraldehyde phosphate to form 1, 3-
bisphosphoglycerate
Triose phosphate dehydrogenase + 2 P + 2 glyceraldehyde 3-phosphate
(C3H7O6P) → 2 molecules of 1,3-bisphosphoglycerate (C3H8O10P2)
9. Step 7
2 molecules of 1,3-bisphoshoglycerate (C3H8O10P2) +
phosphoglycerokinase + 2 ADP → 2 molecules of 3-phosphoglycerate
(C3H7O7P) + 2 ATP
Step 8
2 molecules of 3-Phosphoglycerate (C3H7O7P) +
phosphoglyceromutase → 2 molecules of 2-Phosphoglycerate
(C3H7O7P)
Step 9
2 molecules of 2-Phosphoglycerate (C3H7O7P) + enolase → 2 molecules
of phosphoenolpyruvate (PEP)
Step 10
2 molecules of phosphoenolpyruvate (C3H5O6P) + pyruvate kinase + 2
ADP → 2 molecules of pyruvate (C3H3O3
-) + 2 ATP
11. Krebs cycle
Names:
The Citric Acid
Cycle
Tricarboxylic Acid
Cycle
Krebs Cycle
Hans Adolf Krebs.
Biochemist; born in
Germany. Worked in
Britain. His discovery in
1937 of the ‘Krebs cycle’
of chemical reactions
was critical to the
understanding of cell
metabolism and earned
him the 1953 Nobel Prize
for Physiology or
Medicine.
12. Conversion of pyruvate to activated acetate
This cycle involves a series of reactions :
a substrate, Oxaloacetate, that is modified in every
reaction
Acetyl–CoA, from which energy is extracted,
energy transport reactants, which collect the
extracted energy
the controlling enzymes, which regulate the steps of
the cycle.
13. 8 steps of krebs cycle
Step 1:
Citrate synthesis
The first step is to put energy into the system
14. Step 2
Citrate loses a molecule of water and another is added. In the process, citric acid is
converted to its isomer isocitrate.
Enzyme: aconitase.
Step 3
Isocitrate loses a molecule of carbon dioxide (CO2) and is oxidized forming the five-
carbon alpha ketoglutarate. Nicotinamide adenine dinucleotide (NAD+) is reduced to
NADH + H+ in the process.
Enzyme: isocitrate dehydrogenase.
Step 4
Alpha ketoglutarate is converted to the 4-carbon succinyl CoA. A molecule of CO2 is
removed and NAD+ is reduced to NADH + H+ in the process.
Enzyme: alpha ketoglutarate dehydrogenase.
Step 5
in mitochondria, the enzyme links to the Succinyl–CoA and uses the energy from releasing
the coenzyme, to add a phosphate (P) to GDP to produce GTP.
Enzyme:Succinyl-CoA synthetase
15. Step 6
Succinate is oxidized and fumarate is formed. Flavin adenine dinucleotide (FAD) is
reduced and forms FADH2 in the process.
Enzyme: succinate dehydrogenase.
Step 7
A water molecule is added and bonds between the carbons in fumarate are
rearranged forming malate.
Enzyme: fumarase.
Step 8
Malate is oxidized forming oxaloacetate, the beginning substrate in the cycle.
NAD+ is reduced to NADH + H+ in the process.
Enzyme: malate dehydrogenase.