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GAS
GANGRENE
GAS
GANGRENE
GAS GANRENE
Definition
• It is an infective gangrene
caused by clostridial
organisms involving mainly
skeletal muscle as
oedematousmyonecrosis.
PREDISPOSINGFACTORS
• Contaminated, manured
or cultivated soil
• crushwounds
• road trafficaccidents
• after amputations
• ischaemiclimb
• necrosis
• Anaerobicenvironments
• clostridial sepsis
ORGANISMS
• ClostridiumWelchii
(perfringens)
• Clostridiumoedematiens.
• Clostridiumsepticum.
• Clostridiumhistolyticum
ORGANISMPRODUCING
TOXINS™
• Alpha (most
common)™
• Beta ™
• Epsilon™
• Exotoxins
• Lecithinase-
haemolytic,
membranolyticand
necrotic
EFFECTSOF TOXINS
• Extensive necrosis
brown or black
anaerobic
• myositis/myonecrosis.
• affects the liver—
foaming liver
• Limbs are commonly
involved
INCUBATIONPERIOD
• Incubationperiod is 1–2
days.
CLINICALFEATURES
• Toxaemia,
• Fever
• Tachycardia
• Pallor
• Foul smelling discharge
(sicklysweaty/decaying
apple odour).
• Khaki brown coloured skin
• Crepitus
• Jaundice
CLINICALTYPES
 Fulminanttype- causes
• toxaemia,
• renal failure
• Liver failure
• MODS
• ARDS.
 Massive type
• fully dark
coloured gas filled
areas.
 Group type
• Infectionof one group
of muscles
 Single muscle type
• affecting one single
muscle.
 Subcutaneous type
• involves only
subcutaneous tissue
COMPLICATION™
• Septicaemia
• Toxaemia
• Renal failure
• Liver failure.
• Circulatoryfailure
• DIC
INVESTIGATIONS
• X-ray
• Liver function tests
• Blood urea
• Serumcreatinine
• Total count, PO2, PCO2.
• Robertson’s cooked meat
media is used whichcauses
meat to turn pinkwithsour
smell and acidreaction
• ClostridiumWelchii is
grownin culturemedia &
In the other half part of the
platewhere there is
antitoxinthere is no
opacity—Nagler reaction.
TREATMENT
• Antibiotic&
Hyperbaricoxygen is
very useful.
• Amputationlife-saving
procedure—stump
should never be closed
REFERENCE
1. SRB's Manual of Surgery
by SriramBhatM
2. A Manual on Clinical
Surgeryby Das
3. A Concise textbookof
Surgeryby Das
A
Special Thanks
To A Very
Special Doctor

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Gas gangrene by Dr.AmrithaAnilkumar

  • 1. en love da Homoeopathy GAS GANGRENE
  • 3. GAS GANRENE Definition • It is an infective gangrene caused by clostridial organisms involving mainly skeletal muscle as oedematousmyonecrosis.
  • 4. PREDISPOSINGFACTORS • Contaminated, manured or cultivated soil • crushwounds • road trafficaccidents • after amputations • ischaemiclimb • necrosis • Anaerobicenvironments • clostridial sepsis
  • 5. ORGANISMS • ClostridiumWelchii (perfringens) • Clostridiumoedematiens. • Clostridiumsepticum. • Clostridiumhistolyticum ORGANISMPRODUCING TOXINS™ • Alpha (most common)™ • Beta ™ • Epsilon™ • Exotoxins • Lecithinase- haemolytic, membranolyticand necrotic
  • 6. EFFECTSOF TOXINS • Extensive necrosis brown or black anaerobic • myositis/myonecrosis. • affects the liver— foaming liver • Limbs are commonly involved INCUBATIONPERIOD • Incubationperiod is 1–2 days. CLINICALFEATURES • Toxaemia, • Fever • Tachycardia • Pallor • Foul smelling discharge (sicklysweaty/decaying apple odour). • Khaki brown coloured skin • Crepitus • Jaundice
  • 7. CLINICALTYPES  Fulminanttype- causes • toxaemia, • renal failure • Liver failure • MODS • ARDS.  Massive type • fully dark coloured gas filled areas.  Group type • Infectionof one group of muscles  Single muscle type • affecting one single muscle.  Subcutaneous type • involves only subcutaneous tissue COMPLICATION™ • Septicaemia • Toxaemia • Renal failure • Liver failure. • Circulatoryfailure • DIC
  • 8. INVESTIGATIONS • X-ray • Liver function tests • Blood urea • Serumcreatinine • Total count, PO2, PCO2. • Robertson’s cooked meat media is used whichcauses meat to turn pinkwithsour smell and acidreaction • ClostridiumWelchii is grownin culturemedia & In the other half part of the platewhere there is antitoxinthere is no opacity—Nagler reaction.
  • 9. TREATMENT • Antibiotic& Hyperbaricoxygen is very useful. • Amputationlife-saving procedure—stump should never be closed REFERENCE 1. SRB's Manual of Surgery by SriramBhatM 2. A Manual on Clinical Surgeryby Das 3. A Concise textbookof Surgeryby Das
  • 10. A Special Thanks To A Very Special Doctor